The Effect of A2E on the Ca2+-PKC Signaling Pathway in Human RPE Cells Exposed to Blue Light by Maomei Luo, Shu Wang, Yun Tang, Chun Zeng, Shanjun Cai

“…Intracellular PKC activity was measured with a nonradioactive nuclide assay. Results. Among all cell groups, the levels of Ca2+, DAG, and IP3 were lowest in the control cells (P<0.05). …”
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A leap forward: exploring the advantages of single-step genome evaluation in Italian Mediterranean buffalo by Stefano Biffani, Mayra Gómez, Roberta Cimmino, Dario Rossi, Gianluigi Zullo, Riccardo Negrini, Alberto Cesarani, Giuseppe Campanile, Gianluca Neglia

“…The accuracy increase for these traits was above 20% when using the ssGBLUP. All LR statistics improved also for non-genotyped females. …”
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Implementation of multidisciplinary team decisions on the management of complex bone and joint infections: an observational study by Jaap L.J. Hanssen, Henrica M.J. van der Linden, Martha T. van der Beek, Robert J.P. van der Wal, Marco F. Termaat, Mark G.J. de Boer, Henk Scheper

“…Methods An observational study was conducted on all patients with a PJI or other BJI of which the management was discussed during MDT meetings between 2015 and 2022 in a tertiary care academic hospital. …”
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Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren’s Syndrome by Matteo Di Marino, Paola Conigliaro, Francesco Aiello, Claudia Valeri, Clarissa Giannini, Raffaele Mancino, Stella Modica, Carlo Nucci, Roberto Perricone, Massimo Cesareo

“…This is a monocentric, prospective, interventional study. At baseline, all the study patients (n = 20) were on tear substitute therapy and underwent Schirmer type-1 test and breakup time (BUT) test. …”
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The proper application of logistic regression model in complex survey data: a systematic review by Devjit Dey, Md. Samio Haque, Md. Mojahedul Islam, Umme Iffat Aishi, Sajida Sultana Shammy, Md. Sabbir Ahmed Mayen, Syed Toukir Ahmed Noor, Md. Jamal Uddin

“…Conclusions This systematic review highlights important gaps in the use of logistic regression with complex survey data, such as overlooking data dependencies, survey design, and proper validation techniques, along with neglecting outliers, missing data, and goodness-of-fit assessments, all of which point to the need for clearer methodological standards and more thorough reporting to improve the reliability of results. …”
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Call for Papers: Intergenerational Justice Prize 2020 by FRFG, IF (Foundation for the Rights of Future Generations, Intergenerational Foundation)

“…Instead, the state distributes them to all citizens. On the one hand, there is the view that the acceptance of private property implies that it should also be allowed in family relationships: wealth may accumulate along family lines, instead of being redistributed to society as a whole at every change of generation. …”
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Developing a method for root-zone soil moisture monitoring at the field scale using remote sensing and simulation modeling by Hamideh Noory, Morteza Khoshsima, Atsushi Tsunekawa, Mitsuru Tsubo, Nigussie Haregeweyn, Salar Pashapour

“…The proposed method showed promising results at all marked locations, study fields, study crops, crop growth stages, and monitored soil depths and layers. …”
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The system can change: a feasibility study of a doula-clinician collaborative at a large tertiary hospital in the United States by Jeannette C. Myrick, Lily Schneider, Christina Gebel, Kathleen Clarke, Stephanie Crawford, Lucy Chie, Chloe Zera, Karen M. Emmons, Elysia Larson

“…To evaluate change, process data were collected throughout, and implementation outcomes were measured in 2022 and again after one year of implementation via online surveys to all clinicians who provided labor and delivery care. …”
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Adaptation of an in vitro one-compartment pharmacodynamic chemostat for testing efficacy of ceftazidime against Burkholderia pseudomallei outside a BSL3 facility by Hana Farizah Zamri, Mohammad Ridhuan Mohd Ali, Ahmad Izzan Irfan Sha'ari, Nurul Husna Mohd Mazalan, Norazah Ahmad, Nur Asyura Nor Amdan, Nusaibah Abdul Rahim, Zakuan Zainy Deris

“…Briefly in this study, • All procedures involving active handling of live B. pseudomallei cultures were performed strictly inside a class II BSC in BSL-2 plus negative airflow laboratory. • The model was set to simulate B. pseudomallei-bacteremia treated with ceftazidime, a 1st-line anti-melioidosis drug with an approximate 2-hour half-life. …”
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Sustainable and Eco-Friendly Single- and Multilayer Polyester Foils (Laminates) from Polylactide and Poly(Ethylene 2,5-Furandicarboxylate) by Sandra Paszkiewicz, Izabela Irska, Konrad Walkowiak, Filip Włodarczyk, Magdalena Zdanowicz, Elżbieta Piesowicz, Mateusz Barczewski

“…PEF was also found to be a material that exhibited a limited formation of bacterial biofilm, particularly strains of <i>S. aureus</i> and <i>E. coli</i>. All of the above findings clearly confirm the sensibility of the research topic undertaken in this work on the application of biobased thermoplastic polyesters in the packaging industry.…”
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Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System by Shuaishuai Zhang, Junqin Li, Huijie Jiang, Yi Gao, Pengzhen Cheng, Tianqing Cao, Donglin Li, Jimeng Wang, Yue Song, Bin Liu, Hao Wu, Chunmei Wang, Liu Yang, Guoxian Pei

“…We found that the proliferation and multipotent differentiation of BMSCs were all enhanced in the coculture group compared to the BMSCs group. …”
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Isolation and molecular detection of Peste des petits ruminants virus in an outbreak investigation in Benishangul Gumuz, Ethiopia by Mengesha Abebe, Yimer Lama, Aliy Abdi, Shegu Dereje, Abdeta Debela, Waktole Hika, Hirpa Tola Eyob

“…Further analysis with conventional PCR revealed the presence of the N gene in all 17 positive samples with a 351bp fragment size. …”
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Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, E. E. Uldanova, E. А. Chuyko, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…In addition, neurogenesis was estimated in the DG region of the hippocampus; for this purpose, a primary antibody against doublecortin (anti-DCX) was used. In all cases Goat anti-rabbit IgG was used as the secondary antibody. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…ROC analysis showed clinical relevance of the immune-related hub genes, and the AUC of all genes was greater than 0.7. A miRNA-mRNA regulatory network was constructed from miRNA data, and three miRNAs were found to be significantly associated with the immune-related hub genes. …”
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Analysis of modified sitting positions for subarachnoid block: A prospective observational study by Nousheen Chowdhary, Ajaiz Rasool, Raja Suhail Shounthoo, Majid Jehangir, Rohey Jan, Showkat Ahmad Gurcoo

“…Results: Confirmation of subarachnoid placement of needle required the least time in RSP group (P=0.003), majority of patients in RSP required a single skin puncture (P=0.0237), clarity of the bony landmarks was similar in all the three positions (P=0.108), patients’ satisfaction score was highest in CSP group (P=0.012); however, anesthesiologists’ reported higher satisfaction levels in RSP group, although results were statistically non-significant (P=0.739). …”
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Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The findings revealed that M. koenigii predominantly contains alkaloids, terpenoids, saponins, flavonoids, and tannins, all of which exhibit antibacterial activity. The application of the crude M. koenigii extract had a substantial impact on the hematological profile of the infected gourami fish. …”
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Time and cost of linking administrative datasets for outcomes assessment in a follow-up study of participants from two randomised trials by Mohammad Shahbaz, Jane E. Harding, Barry Milne, Anthony Walters, Lisa Underwood, Martin von Randow, Lena Jacob, Greg D. Gamble, for the ANCHOR Study Group

“…Methods We applied to access administrative datasets from New Zealand government agencies. All actions of study team members, along with their corresponding dates, were recorded prospectively for accessing data from each agency. …”
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Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in... by Marta D. Van Loan, Nancy L. Keim, Sean H. Adams, Elaine Souza, Leslie R. Woodhouse, Anthony Thomas, Megan Witbracht, Erik R. Gertz, Brian Piccolo, Andrew A. Bremer, Michael Spurlock

“…A 3-week run-in to establish energy needs; a 12-week 500 kcal/d energy reduction with 71 low-dairy-consuming overweight and obese adults randomly assigned to diets: ≤1 serving dairy/d (low dairy, LD) or ≤4 servings dairy/d (adequate dairy, AD). All foods were weighed and provided by the metabolic kitchen. …”
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Magnetic susceptibility controlled by climate-driven weathering intensity by Aubineau Jérémie, Antonio Paul Y.J., El Bamiki Radouan, Parat Fleurice, Camps Pierre, Raji Otmane, Jourani Es-Said, Bodinier Jean-Louis, Macouin Mélina, Gilder Stuart, Rousse Sonia, Séranne Michel

“…Higher weathering intensity drove up the detrital magnetic material in all lithologies, which, in turn, increased the MS signal. …”
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Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status by Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J. Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard

“…Their immune response frequencies and intensities against all antigens except CagA declined below the detection limit. …”
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