Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…Safety and plasma complement protein levels were assessed throughout the studies and during 90-day follow-up periods. All subjects (54) completed the studies and no safety signals or clinically meaningful changes in blood chemistry, urinalysis, hematology, ECG, vital signs or ocular endpoints were observed. …”
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Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study by Yujiao Zheng, Fan Yang, Lin Han, Xiaowen Gou, Fengmei Lian, Wenke Liu, Linhua Zhao, Bing Pang, Xiyan Zhao, Xiaolin Tong

“…By searching through our medical records of all the diabetic patients from January 2006 to January 2012, we identified and enrolled 30 moderate and severe pDPN patients in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed. …”
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Difference in Optical Coherence Tomography Angiography Parameters After SARS-CoV-2 Infection During the Alpha and Delta Variant Dominance Periods by Magdalena Kal, Michał Brzdęk, Izabella Karska-Basta, Piotr Rzymski, Antonio Pinna, Jerzy Mackiewicz, Dominik Odrobina, Dorota Zarębska-Michaluk, Robert Flisiak

“…However, the Delta group showed significantly lower VD in the SCP and DCP across all quadrants (<i>p</i> < 0.001–0.039), while the Alpha group showed reduced VD in the foveal CCP (<i>p</i> = 0.005) and significantly wider FAZs and FAZd (<i>p</i> = 0.002 for both). …”
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Characterization of the Liquid Fuel Produced from Catalytic Depolymerization of Polymeric Waste Using Batch Reactor by O. L. Rominiyi, M. A. Akintunde, E. I Bello, L. Lajide, O. M. Ikumapayi, O. T. Laseinde and B. A. Adaramola

“…The high rate of generation of plastic waste in the country and the fact that all other means of Municipal Plastic Waste (MPW) management techniques had failed leading to the requirement of efficient and alternative disposal technique-depolymerization. …”
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Comparison of 2-D and 3-D Analysis of Running Kinematics and Actual Versus Predicted Running Kinetics by Caitlyn Martinez, Seth Garbett, Kristen Hiromasa, Rhandi Jackson, Eric Miya, Michelle Miya, Joshua D White, Brian S Baum, Mark F Reinking

“…Although significant differences existed, all 2D kinematic measures were within 2°-5° of 3D kinematic measures. …”
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Desert Dust Outbreaks over Mediterranean Basin: A Modeling, Observational, and Synoptic Analysis Approach by F. Calastrini, F. Guarnieri, S. Becagli, C. Busillo, M. Chiari, U. Dayan, F. Lucarelli, S. Nava, M. Pasqui, R. Traversi, R. Udisti, G. Zipoli

“…Furthermore, physical and chemical analyses (PIXE analysis and ion chromatography) were used to measure the concentration of all soil-related elements to quantify the contribution of dust particles to PM10. …”
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S‐PLM: Structure‐Aware Protein Language Model via Contrastive Learning Between Sequence and Structure by Duolin Wang, Mahdi Pourmirzaei, Usman L. Abbas, Shuai Zeng, Negin Manshour, Farzaneh Esmaili, Biplab Poudel, Yuexu Jiang, Qing Shao, Jin Chen, Dong Xu

“…The results demonstrate S‐PLM's superior performance over sequence‐only PLMs on all protein clustering and classification tasks, achieving competitiveness comparable to state‐of‐the‐art methods requiring both sequence and structure inputs. …”
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Diagnostic accuracy of drooling, reluctance, oropharynx, others, and leukocytosis score as a predictor of mortality and complications following acute corrosive ingestion by Fawaz Poonthottathil, Soorya Suresh, Jamshed Nayer, Praveen Aggarwal

“…METHODS: This was a diagnostic accuracy study conducted in the emergency department (ED) of a tertiary care hospital in North India. We screened all cases of acute corrosive ingestion presented to our ED. …”
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Quality Characteristics of Wheat Malts with Different Country of Origin and Their Effect on Beer Brewing by Yang Soo Byeon, Seung-Taik Lim, Hyun-Jin Kim, Han Sub Kwak, Sang Sook Kim

“…The extract (81.8–83.2%) and diastatic power (407–477 WK°) of all samples were in the brewing field’s recommended range. …”
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Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning by Hussein Dakhil, Mohammad Reza Deevband, Mahasti Amoui, Ahmad Mostaar, Mahdi Ghorbani, Mohsen Khosroabadi, Mohammad Ali Ghodsirad

“…Seven parameters were considered, including the contrast/noise ratio, injection activity, uptake duration, acquisition time per injection, frame time, measuring time, and type of filters. Results: In all cases, the application of different filters increased Contrast to Noise Ratio (CNR) (9.1%, 1.8%, 10.9%, 61.8%, 23.6%, 29.1%, and 58.2% for Wiener, Butterworth, Parzen, Metz, Ramp, Shepp-Logan, and Hamming filters, respectively). …”
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Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s by Berta Mosleh, Pavla Sarova, Sonja Zehetmayer, Felicitas Oberndorfer, Joachim Widder, Helmut Prosch, Marco Idzko, Clemens Aigner, Mir Alireza Hoda, Daniela Gompelmann

“…There were no significant differences in age at diagnosis, body mass index, lung function parameters, histological subtypes, PD-L1 protein expression, disease stage, and survival between men and women (all p > 0.05). Conclusion: Female Caucasian patients seem to have a higher susceptibility to lung cancer. …”
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Implications of irrigation water quality in tropical farms by B. Guerra Tamara, A. Torregroza-Espinosa, D. Pinto Osorio, M. Moreno Pallares, A. Corrales Paternina, A. Echeverría González

“…The purpose of this study was to assess the physicochemical quality of surface water in irrigation systems at 141 farms.METHODS: To this end, 141 water samples were taken to determine 22 physicochemical parameters. All in-situ measurements and laboratory analysis were performed using standard methods. …”
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A Tensioned Human Skin Explant Model Used for Preliminary Assessment of Chemexfoliant-Stimulated Bioeffects by Michael J. Conneely, Jin Namkoong, Francis Allison, S. Kyoko Hirata Tsutsumi, Dominic Grussu, Ryan Willis, Kyle Henderson, Paul A. Campbell, Melissa Moy, Ewelina Lesniak, Joanna Wu, Robyn P. Hickerson

“…The 3 commercial chemexfoliation agents employed all contained trichloroacetic acid at well-defined concentrations (6, 10, and 20%) and were applied to the explants’ stratum corneum. …”
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Microbial Predominance and Antimicrobial Resistance in a Tertiary Hospital in Northwest China: A Six-Year Retrospective Study of Outpatients and Patients Visiting the Emergency Dep... by Caifeng Wang, Wen Li, Juanjuan Gao, Dancheng Zhang, Yali Li, Fang Li, Jine Lei

“…The methicillin-resistant S. aureus and S. epidermidis rates were 25.1% and 74.6%, respectively. 60.9% E. coli and 33.5% K. pneumonia samples carried extended-spectrum-β-lactamase. All Staphylococci and Enterococci samples were not resistant to linezolid, vancomycin, and tigecycline. …”
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Soft Power and Stress: The Health Impacts of Indonesian Soap Operas on Malaysian Millennials by Rangga Cipta Perdana, Ernida Kadir, Genta Iverstika Gempita

“…The reason is that the Indonesian culture that is born in Indonesian soap operas is shredded and superstition and it is not in accordance with the culture in Malaysia. All of this raises concerns that the presence of Indonesian culture will affect the identity, religion, and language, of the local community. …”
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Hepatovirus infections in juvenile seals from the North Sea by Monica Mirolo, Bianca Kühl, Melvin Daniel Roji, Ana Rubio-García, Valéria Andrade Lima, Christina Puff, Byron Martina, Andreas Beineke, Peter Wohlsein, Wolfgang Baumgärtner, Martin Ludlow, Albert Osterhaus

“…Assessment of seal hepatovirus RNA loads in organs of all infected animals showed that the liver had the highest number of RNA copies with up to 107 RNA copies per mg of tissue. …”
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OPTIMIZATION OF ASYMMETRIC BILATERAL COMPLEX FENESTRATION SYSTEMS IN STATE ELEMENTARY SCHOOL CLASSROOMS IN INDONESIA by Dhafira Ramadhani, Rizki Armanto Mangkuto, R. Triyogo, Atthaillah

“…Optimization is conducted for all four cardinal orientations. The classroom's daylight performance is assessed using aUDI250-750lx, aUDI100-3000lx, sDA300/50%, and ASE1000,250 metrics. …”
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Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B by Guangyue Yang, Liping Zhuang, Tiantian Sun, Yee Hui Yeo, Le Tao, Wei Zhang, Wenting Ma, Liu Wu, Zongguo Yang, Yanqin Yang, Dongying Xue, Jie Zhang, Rilu Feng, Ebert Matthias P., Steven Dooley, Ekihiro Seki, Ping Liu, Cheng Liu

“…The sGDNF-high group had significantly larger Masson’s trichrome and reticulin staining-positive area, higher Scheuer score, and METAVIR fibrosis stage (all p<0.001) but not steatosis. On multivariable regression, sGDNF was independently associated with cirrhosis with an odds ratio of 6.98 (95% CI: 1.10–17.94). …”
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Surface topography modulates initial platelet adhesion to titanium substrata by Cecilia Yan Guo, Raymond Mo, Hugh Kim

“…There was greater platelet adhesion to the rougher AE and SB surfaces, however, the concentration of the secreted growth factors was comparable on all surfaces. We conclude that while surface topography can be engineered to modulate initial platelet adhesion, granule secretion is likely regulated as a separate and independent process.…”
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The experiences of organizational silence among nurses: a qualitative meta-synthesis by Jingyi Zou, Xiaoxia Zhu, Xue Fu, Xiaojia Zong, Jing Tang, Chunwei Chi, Jinxia Jiang

“…Data sources A comprehensive search of the following international databases was performed: PubMed, Embase, CINAHL, Psyinfo, Web of Science, Cochrane Library, Medline, and Ovid, as well as Chinese databases such as the China Biomedical Database (CBM), Wanfang Database (CECDB), Chinese National Knowledge Infrastructure (CNKI) and VIP Database. Review methods All articles concerning the experiences of organizational silence among nurses were included after thoroughly searching 12 databases. …”
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