CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Within the first week after a single infusion of Acellbia or MabThera, the level of  CD19 and CD20-positive cells rapidly decreased to almost undetectable values without any obvious recovery by the end of observation (upon intergroup comparison p>0.05 at all specified time points). 90% CI for the geometric mean of a Acellbia/MabThera  AUC0-t ratio fell within standard bioequivalence range 80-125% (80.1-118.2% for the ratio of AUC0-168 after a single dose). …”
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Heat stress on the feed consumption, biochemical indicators, production and milk quality of holstein and jersey cows by Adriana Hauser, Marciél França, Rainer Hauser, Laiz Perazzoli, Bruna Paula Bergamaschi Mendes, Izabelly Perdoncini Telles, Tatiane Camacho Mendes, Luiz Cláudio Miletti, André Thaler Neto

“…The experiment included 14 days of adaptation (all the cows were cooled) and 5 days of evaluation (only the VA cows were cooled). …”
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Sexual risky behaviors in violence survivors aged 14 to 18 who sought care at a tertiary-level hospital in Mexico by Eugenia Pérez-García, Ángel Eduardo Velasco-Rojano, Alejandra García-Saisó, Aarón Rodríguez-Caballero, Jorge Luis Montes-Domínguez, Yiblia Krystal Salgado-Cedano, Lydia Estela Zerón Gutiérrez

“…Three judges independently coded information on risky sexual behaviors, including unprotected sex, sexualized substance use, and relationships with older partners. Results: All participants reported at least one risky sexual behavior, with unprotected sex being the most common (68.78% of records). …”
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Cardiac hydatid cyst: case series and review of the literature by Jingjie Wang, Xing Liu, Yierzhati Aizezi, Wenzhe Li, Jingnan Xu, Yi Wang, Xiangyou Yu

“…The latter requires the expertise of a trained professional to accurately differentiate between cardiac-encapsulated cysts and other types of cysts. All patients in our study were examined as described above. …”
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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic... by EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Angela Botteon, Barizzone Fulvio, Sandra Correia, Lieve Herman

“…Of 54 microorganisms notified to EFSA between April and September 2024 (33 as feed additives, 17 as food enzymes or additives, 4 as novel foods), 50 were not evaluated because: 12 were filamentous fungi, 1 was Enterococcus faecium and 8 were Escherichia coli (all excluded from the QPS evaluation), and 29 were TUs that already have a QPS status. …”
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Pelvic Radiotherapy in Rectal Cancer Patients With Synchronous Potentially Treatable Liver Metastases by Yayu Huang, Genwen Chen, Xian Zhang, Yang Qian, Jian Wang

“…Methods and Results This retrospective study included 83 patients diagnosed with rectal cancer and synchronous liver metastases from June 2012 to January 2022. All patients underwent radical surgery for rectal cancer and treatment of synchronous liver metastases, as determined by a multidisciplinary team (MDT). …”
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SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome by Barbara Šenk, Katja Goričar, Nika Aleksandra Kravos, Mojca Jensterle Sever, Andrej Janež, Vita Dolžan

“…Oral glucose tolerance test was performed only in PCOS patients and basal- and glucose-stimulated blood glucose and insulin levels were measured. All the subjects were genotyped for 5HTR1A rs6295, 5HTR1B rs13212041, and SLC6A4 5HTTLPR polymorphisms in the serotonin system. …”
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Liver and Nutrition. An Optimal Diet for Non-Alcoholic Fatty Liver Disease by M. V. Mayevskaya, V. T. Ivashkin

“…Practical recommendations are given on changes in his lifestyle and the choice of optimal therapy with the application of multifunctional drugs affecting all disease aspects.Conclusion. The concepts of ‘correct or healthy’ nutrition and ‘lifestyle modification’ are increasingly attracting much attention both in terms of the prevention and treatment of liver diseases. …”
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The safety and efficacy of cannabinoids for the treatment of mental health and substance use disorders: protocol for a systematic review and meta-analysis by Jack Wilson, Andrew Langcake, Zachary Bryant, Tom P. Freeman, Janni Leung, Gary C. K. Chan, Amir Englund, Myfanwy Graham, Emily Stockings

“…Therefore, the current systematic review will (a) identify all RCTs examining the efficacy of cannabinoids in treating MH and SUD, (b) provide a quantitative or narrative synthesis of the evidence examining efficacy, and (c) synthesise adverse event data to examine evidence of harm. …”
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Measuring anti-transgender stigma in low-income and middle-income countries: a scoping review protocol by Clare Barrington, Jennifer Toller Erausquin, Amanda E Tanner, Tamar Goldenberg, Sulianie Mertus, Mohammed Sheikh Eldin Jibriel

“…Reviewers will independently screen all citations, full-text articles and abstract data. …”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. We propose a novel function for ORF3a as a lysosomal water-permeable channel, essential for lysosome deacidification and inactivation, key steps to promote virus egress.…”
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Monitoring and Prediction of Wild Blueberry Phenology Using a Multispectral Sensor by Kenneth Anku, David Percival, Mathew Vankoughnett, Rajasekaran Lada, Brandon Heung

“…The F4/F5 and F6/F7 stages showed significantly high correlation values among all growth stages. LAI, floral, and vegetative bud stages could be estimated at the tight cluster (F4/F5) and bloom (F6/F7) stages with R²/CCC = 0.90/0.84. …”
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Safety and Efficacy of Cryoballoon Ablation of Atrial Fibrillation in relation to the Patients’ Age: Results from a Large Real-World Multicenter Observational Project by Luigi Sciarra, Saverio Iacopino, Giuseppe Arena, Claudio Tondo, Paolo Pieragnoli, Giulio Molon, Massimiliano Manfrin, Antonio Curnis, Antonio Dello Russo, Giovanni Rovaris, Giuseppe Stabile, Leonardo Calò, Gabriele Boscolo, Roberto Verlato

“…The data demonstrated a high degree of safety during CBA across all patient ages. Procedural performance and complications were similar between different ages; AF recurrences seem to be more frequent in patients over 74 years.…”
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Influenza B virus infection alters the regenerative potential of murine alveolar type 2 pneumocytes by Satoko Nakano, Cait E. Hamele, Aleksandra Tata, Purushothama Rao Tata, Nicholas S. Heaton

“…Here, the authors report that during an influenza B virus infection, some of the actively infected AT2 pneumocytes can ultimately eliminate all traces of the viral RNA and persist in the host long term. …”
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The Recent Technologies to Curb the Second-Wave of COVID-19 Pandemic by M. Poongodi, Mohit Malviya, Mounir Hamdi, Hafiz Tayyab Rauf, Seifedine Kadry, Orawit Thinnukool

“…Various worldwide associations and different hierarchies of government fraternity are endeavoring to offer the necessary assistance in eliminating the infection impacts but unfortunately standing up to the non-appearance of resources and expertise. In contrast to all other pandemics, Coronavirus has proven to exhibit numerous requirements such that curated appropriation and determination of innovations are required to deal with the vigorous undertakings, which include precaution, detection, and medication. …”
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Susceptibility of European Agrilus beetle species to the biocontrol agents of Emerald Ash Borer in the laboratory by Katy Reed, Freya Cole, Neil Audsley, Anastasia Uglow, Rachel Down, Kerry Barnard, Daegan Inward

“…Oobius agrili, T. planipennisi and S. galinae all attacked A. biguttatus, and offspring were produced. …”
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Classifying tumour infiltrating lymphocytes in oral squamous cell carcinoma histopathology using joint learning framework by Barun Barua, Genevieve Chyrmang, Kangkana Bora, Gazi N. Ahmed, Lopamudra Kakoti, Manob Jyoti Saikia

“…Furthermore, TOPSIS analysis confirms that our method ranks first across all TILs infiltration categories. In summary, our proposed methodology outperforms single modality-representation learning approaches for accurate and automated TILs classification.…”
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Wish-Granting Interventions Promote Positive Emotions in Both the Short and Long Term in Children with Critical Illnesses and Their Families by Hannah Roberts, Jenny Cook, Apple Lee, Wei Kok Loh, Nigel Teo, Joanne Su Yin Yoong, Marguerite Gorter-Stam

“…Over 80% of children and parents felt the intervention created a happy memory and provided relief from their medical treatments. Nearly all children (96.8%) and parents (95.4%) viewed a wish-granting intervention as important for children with a critical illness. …”
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To study the role of tofacitinib and betamethasone pulse in the treatment of vitiligo at a tertiary care centre: an observational comparative study by Rashmi Singh, Surabhi Shandilya, Kamalpreet Kaur Bhaikhel, Gopi Krishna Maddali

“…The primary objective was to see the efficacy of tofacitinib over betamethasone in the treatment of vitiligo, and the secondary objective was to assess its safety in treating vitiligo patients. Methodology: All the patients with vitiligo of age >12 years attending the dermatology clinic of our institute and willing to give written informed consent were included in the study. …”
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The Effect Of Demographic Factors And Comorbidities On Ejection Fraction Outcome In Acute Myocardial Infarction Patients by Kausar Malik, Faiza Batool, Shazia Siddiq, Lubna Meraj

“…Non-probability convenience sampling technique was used to recruit the participants following informed consent. All patients aged 18 or more admitted with acute myocardial infarction confirmed by clinical, ECG findings and cardiac biomarkers were included in the study and patients with pre-existing valvular heart disease, previous history of myocardial infarction and history of cardiac surgery were excluded from the study. …”
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