Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study by Manuel R Blum, Patricia M Kearney, Rose Galvin, Christine Baumgartner, Anette Van Dorland, Stephen Byrne, Nicolas Rodondi, Simon P Mooijaart, Carol Sinnott, Rosalinde K E Poortvliet, Jacobijn Gussekloo, David O Riordan, Carole Elodie Aubert, Kieran A Walsh, Robert S Du Puy, J Wouter Jukema, Vera McCarthy, Elaine K Walsh, Tinh-Hai Collet, Olaf M Dekkers

“…The hypnotic Z-drugs were the most frequent PIP in Irish participants, (3.5%, n=4), while it was non-steroidal anti-inflammatory drug and oral anticoagulant combination, sulfonylureas with a long duration of action, and benzodiazepines (all 4.3%, n=7) in Swiss, and benzodiazepines (7.1%, n=18) in Dutch participants. …”
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Determinants of tobacco use transitions in smoker nursing students in Catalonia: A prospective longitudinal study by Kenza Laroussy, Esteve Fernández, Yolanda Castellano, Marcela Fu, Antoni Baena, Ariadna Feliu, Armando Peruga, Mercè Margalef, Olena Tigova, Jordi Galimany, Montserrat Puig, Carmen Moreno, Albert Bueno, Antonio López, Judith Roca, Judith Saura, Cristina Martínez

“…Among cigarette-only users, 14.2% transitioned to poly-tobacco use, while 48.4% of polytobacco users switched to exclusive cigarette use. Among all smokers (daily and non-daily smokers), 60.8% reduced their cigarette consumption by ≥5 CPD and 28.3% quit smoking. …”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…The correlation revealed that DE has a significant negative correlation with PG, ML, and CL, whereas PG, ML, and CL are all positively correlated with each other. The mapping population was genotyped with mid-density SNP assay (1k-RiCA), and a linkage map was established with 414 polymorphic SNP markers. …”
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Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography by Zhubin Lun, Jin Liu, Liwei Liu, Jingjing Liang, Guanzhong Chen, Shiqun Chen, Bo Wang, Qiang Li, Haozhang Huang, Zhidong Huang, Danyuan Xu, Yunzhao Hu, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye

“…The first endpoint of this study was long-term all-cause mortality. Kaplan–Meier analysis was used to count the cumulative mortality, and the log-rank test was used to assess differences between curves. …”
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Impact of primary care benefits on healthcare utilisation and estimated out-of-pocket expenses in urban, rural and remote settings in the Philippines by Antonio L Dans, Arianna Maever L Amit, Leonila F Dans, Gillian Sandigan, Regine Ynez H De Mesa, Mia P Rey, Josephine T Sanchez, Cara Lois T Galingana, Nannette Bernal-Sundiang, Maria Rhodora N Aquino, Johanna Faye E Lopez, Janelle Micaela S Panganiban, Romelei Camiling-Alfonso, Jose Rafael A Marfori, Ramon Pedro Paterno, Carol Stephanie Chua Tan-Lim, Noleen Marie Fabian, Chad Lester Lastrilla, Miguel Callo

“…In this study, two key outcomes were monitored: (1) monthly healthcare utilisation measured by the total number of outpatient consultations per site and (2) change in OOP expenses from baseline to endline within a 1 year study period.Results All sites had a positive trend in monthly outpatient consultations in healthcare utilisation over 1 year. …”
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Investigating the contribution of understory to radiative transfer simulations through reconstructing 3-D realistic temperate broadleaf forest scenes based on multi-platform laser... by Xiaohan Lin, Ainong Li, Jinhu Bian, Zhengjian Zhang, Xi Nan, Limin Chen, Yi Bai, Yi Deng, Siyuan Li

“…The results show that the understory influences the simulated BRF across all three forest scene reconstruction approaches, suggesting that canopy reflectance signals can be used to evaluate the understory information, which provides a theoretical foundation for the feasibility of retrieving understory parameters via remote sensing. …”
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Passive exposure and perceptions of smoke-free policies in hospital and university campuses among nursing students: A cross-sectional multicenter study by Marcela Fu, Yolanda Castellano, Kenza Laroussy, Antoni Baena, Mercè Margalef, Ariadna Feliu, Jordi Galimany-Masclans, Montse Puig-Llobet, Carmen Moreno-Arroyo, Raül Sancho, Albert Bueno, Antonio López, Joseph Guydish, Esteve Fernández, Cristina Martínez

“…Methods This was a cross-sectional multicenter study conducted in 2015–2016 in all 15 university nursing schools in Catalonia, Spain. …”
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The Importance of Dose Escalation in the Treatment of Pulmonary Arterial Hypertension with Treprostinil by Piotr Kędzierski, Marta Banaszkiewicz, Michał Florczyk, Michał Piłka, Rafał Mańczak, Maria Wieteska-Miłek, Piotr Szwed, Krzysztof Kasperowicz, Katarzyna Wrona, Szymon Darocha, Adam Torbicki, Marcin Kurzyna

“…In the group of patients younger than 50 years of age, a statistically significant correlation was observed between the dose of treprostinil achieved after three months of treatment and the parameters assessed after 12 months of treatment, including WHO FC, 6MWD, and NIFC prognostic scale scores (all <i>p</i> < 0.05). <b>Conclusions</b>: The clinical effect of treatment is critically dependent on the rapid escalation of the treprostinil dose during the first three months of treatment.…”
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Alkaloids extracted from Dendrobium officinale grown in diverse environments exhibited robust antioxidative and antiaging activity by Yichen Liu, Arome Solomon Odiba, Qi Yu, Jin Xie, Nkwachukwu Oziamara Okoro, Guiyan Liao, Xinchen Zhu, Bin He, Cheng Jin, Wenxia Fang, Bin Wang

“…RK-DOA, GH-DOA, and TR-DOA delayed paralysis (P < 0.0001, in all cases) and significantly increased worm activity (P < 0.001, P < 0.001, and P < 0.01, respectively). …”
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Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function by Si-yu Wang, Yu-xin Wang, Lu-shun Guan, Ao Shen, Run-jie Huang, Shu-qiang Yuan, Yu-long Xiao, Li-shuai Wang, Dan Lei, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan

“…For its mechanisms, consistently, for Camptothecin, Doxorubicin, Mitomycin, Docetaxel, Cisplatin, Vinblastine, Sorafenib and Paclitaxel, all of the IC50 values were significantly lower in the low ICI Score group compared to the high ICI Score group. …”
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Comparative Analysis of Prediction Models for Trawling Grounds of the Argentine Shortfin Squid <i>Illex argentinus</i> in the Southwest Atlantic High Seas Based on Vessel Position... by Delong Xiang, Yuyan Sun, Hanji Zhu, Jianhua Wang, Sisi Huang, Shengmao Zhang, Famou Zhang, Heng Zhang

“…Using CPUE from fishing logs as a reference, we found that the vessel position-based model performed well from January to April, whereas the CPUE-based model consistently maintained good accuracy across all months. The 2024 fishing season predictions indicated the formation of primary fishing grounds as early as January 2023, initially near the 46° S line of the Argentine Exclusive Economic Zone, with grounds shifting southeastward from March onward and reaching around 42° S by May and June. …”
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PERKEMBANGAN ENZIM PENCERNAAN LARVA IKAN PATIN, Pangasius hypophthalmus sp. by Irzal Effendi, . Widanarni, D. Augustine

“…Digestive enzymes development have a similar pattern in larvae for all feeding schedules.  Protease activity  decreased with the increasing of age until 3 dAH, then increased  until the larvae reached 7 dAH, and sharply decreased until 10 dAH and then slowly decreased thereafter. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Despite having opposed epigenetic functions, these mutations are associated with increased all-cause mortality and a low risk for progression to hematologic neoplasms. …”
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Scaling and intermittent properties of oceanic and atmospheric <i>p</i>CO₂ time series and their difference in a turbulence framework by K. Robache, F. G. Schmitt, Y. Huang, Y. Huang

“…Scaling exponents are estimated through Fourier analysis, and their average quantities were considered globally for all parameters, as well as for different ecosystems such as coastal shelf, coral reefs and open ocean. …”
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A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders by Marta Di Forti, Benjamin W. Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B.M. Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P. Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-Zimmerman, Tim Meynen, Diego Quattrone, Robin M. Murray

“…Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. …”
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Geological and Geochemical Characteristics of the First Member of the Cretaceous Qingshankou Formation in the Qijia Sag, Northern Songliao Basin, Northeast China: Implication for I... by Fei Xiao, Jianguo Yang, Shichao Li, Fanhao Gong, Jian Zhang, Yulai Yao, Ang Li, Liyan Zhang, Yiming Huang, Fei Su, Yunfeng Bai

“…(ii) The average OSI (oil saturation index) values of K2qn11, K2qn12, and K2qn13 are 110.54 mg/g, 171.74 mg/g, and 150.87 mg/g, respectively, which all reach the zone of oil crossover. The saturated hydrocarbon of EOM (extractable organic matter) in K2qn12 and K2qn13 is of higher content than that in K2qn11, while it is the opposite for the aromatic hydrocarbon, nonhydrocarbon, and asphaltene, indicating better oil mobility for K2qn12 and K2qn13. …”
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Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy by Beatrice Formenti, Roberto Benoni, Jacopo Testa, Giulia Bertoli, Giacomo Stroffolini, Maria Grazia Pizzi, Barbara Menzaghi, Niccolò Ronzoni, Paola Magro, Issa El Hamad, Carla Scolari, Angiola Spinetti, Serena Zaltron, Francesco Castelli, Valentina Marchese, Alberto Matteelli

“…Of 1,514 participants, 80.2 % underwent screening, with 87.3 % testing negative for all infections. For those with chronic infections, 20.8 % missed their first infectious disease consultation, and only 39.3 % were retained in care after one year. …”
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Release velocity ImprovemenT with a new Metronome guIding chest COmpressions: The RITMICO simulation study by Maria Luce Caputo, Giuliana Monachino, Ruggero Cresta, Alessia Currao, Enrico Baldi, Simone Savastano, Andrea Cortegiani, Mariachiara Ippolito, Sara Accetta, Alessandra Gargano, Camilla Metelmann, Bibiana Metelmann, Carlos Ramon Hölzing, Julian Ganter, Michael Patrick Müller, Claudio Benvenuti, Stefania Tomola, Pierangelo Pinetti, Pier Luigi Ingrassia, Francesca Dalia Faraci, Angelo Auricchio

“…The double-click metronome led to significant improvements in CC depth and CCRV across all volunteer categories, with the greater effect observed in first responders and in non-specialized healthcare personnel. …”
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Satellite quantification of methane emissions from South American countries: a high-resolution inversion of TROPOMI and GOSAT observations by S. E. Hancock, D. J. Jacob, Z. Chen, H. Nesser, A. Davitt, A. Davitt, D. J. Varon, M. P. Sulprizio, N. Balasus, L. A. Estrada, M. Cazorla, L. Dawidowski, S. Diez, J. D. East, E. Penn, C. A. Randles, C. A. Randles, J. Worden, I. Aben, R. J. Parker, R. J. Parker, J. D. Maasakkers

“…Our estimates align with the prior estimates for Brazil, Bolivia, and Paraguay but are significantly higher for other countries. Emissions in all countries are dominated by livestock (mainly enteric fermentation) except for oil–gas in Venezuela and landfills in Peru. …”
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Seasonality of host-seeking Ixodes ricinus nymph abundance in relation to climate by Hoch, Thierry, Madouasse, Aurélien, Jacquot, Maude, Wongnak, Phrutsamon, Beugnet, Fréderic, Bournez, Laure, Cosson, Jean-François, Huard, Frédéric, Moutailler, Sara, Plantard, Olivier, Poux, Valérie, René-Martellet, Magalie, Vayssier-Taussat, Muriel, Verheyden, Hélène, Vourc’h, Gwenaël, Chalvet-Monfray, Karine, Agoulon, Albert

“…The peak occurred in summer for the mountainous site, with an absence of ticks in winter. In all cases except the mountainous site, the timing of the spring peak could be related to the sum of degree days since the beginning of the year. …”
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