Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…Linkage disequilibrium analysis revealed that eight SNPs in hsp70 were significantly associated with low-temperature tolerance (P < 0.01), and 4 SNPs were moderately associated with low-temperature tolerance (P < 0.05). All 17 SNPs in hsp90 were significantly associated with low-temperature tolerance (P < 0.01). …”
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<i>ACE</i> I/D Genotype and Risk of Non-Contact Injury in Moroccan Elite Athletes: A Pilot Study by El Mokhtar El Ouali, Jihan Kartibou, Juan Del Coso, Rashmi Supriya, Ismail Laher, Zineb El Kettani, Hassan Ghazal, Najib Al Idrissi, Ayoub Saeidi, Abdelhalem Mesfioui, Hassane Zouhal

“…Non-contact injuries were recorded for all athletes and classified according to the IOC consensus statement by the medical staff of the teams. …”
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Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model by Matthieu Glorion, MD MSc, Joel Neves Briard, MD MSc, Louise Roquebert, Sabina Pizzi, Ahmed Menaouar, PhD, Mélanie Borie, MSc, Manon Robert, MSc, Dang Khoa Nguyen, MD PhD, Michaël Chassé, MD PhD, Basil Nasir, MD, Pasquale Ferraro, MD, Shant Der Sarkissian, PhD, MBA, Pierre-Emmanuel Noly, MD PhD, Nicolas Noiseux, MD PhD

“…No intracranial blood flow was observed. All electroencephalograms demonstrated absent brain electrical activity. …”
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Prevalence and clinical profile of comorbidity among newly diagnosed pulmonary tuberculosis patients: a multi-center observational study in eastern China by Wei Wang, Wei Wang, Xiaomeng Wang, Xiaomeng Wang, Songhua Chen, Jun Li, Qinglin Cheng, Yu Zhang, Qian Wu, Qian Wu, Kui Liu, Kui Liu, Xuli Jiang, Bin Chen, Bin Chen

“…Descriptive statistics were conducted to describe the composition of comorbidities of all participants. Univariate and multivariate logistic regression analyzes were performed to identify the effects of comorbidities on the clinical features of the participants.ResultsOf the 8,421 total participants, 27.6% reported cavities in the chest radiography results, 41.9% were Mycobacterium tuberculosis-positive in the etiology test results, and 38.7% (3,258/8,421) had at least one type of comorbidity. …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Based on the results retrieved from organ-specific irAEs, ‘aggregated’ burden scores were developed to distinguish ‘protective’ (endocrine and musculoskeletal) and ‘harmful’ (gastrointestinal, pneumonitis, neurological, hepatic) irAEs showing prognostic effects on OS and PFS.Conclusions Our results demonstrate that not all irAEs could exert a protective effect on oncologic outcome. …”
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Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…Comprehensive surveillance of AIVs targeting adaptive mutations with whole genome sequencing in animals and humans is essential for early detection of zoonotic AIVs and efficient implementation of control measures. All preparedness, preventive and control measures must be implemented under a One Health framework and tailored to the setting and the epidemiological situation; in particular, enhanced monitoring, biosecurity, genomic surveillance and global collaboration are critical for mitigating the zoonotic risks of AIV.…”
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MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy by Michael Thomas, Petros Christopoulos, Wade T Iams, Julien Mazieres, Alexis B Cortot, Nir Peled, Gabriele Minuti, Egbert F Smit, Francois Audhuy, Karin Berghoff, S Peter Eggleton, Frank Fries, Maike Hildenbrand, Peter Liu, Seyed Hamidreza Mahmoudpour, Christoph Menzel, Dina Oksen

“…Eligible systemic treatment includes all available anticancer therapies (approved, conditionally approved or provided through Early Access). …”

Dietary supplementation of Bacillus sp. NP5 and dayak onion simplicia powder Eleutherine bulbosa (Mill.) Urb. for the prevention of Aeromonas hydrophila in catfish Clarias sp. by R Herman Sudrajat, Munti Yuhana, Widanarni Widanarni, Julie Ekasari, Usamah Afiff

“…Fish were reared for 45 days and fed three times a day. On day 46, fish from all treatments, except negative control, were infected with an A. hydrophila dose of 106 CFU/mL injected intramuscularly. …”
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Life after prostate cancer diagnosis: protocol for a UK-wide patient-reported outcomes study by David H Brewster, Victoria Cairnduff, Eila Watson, Amy Downing, Adam W Glaser, Penny Wright, William Cross, Conan Donnelly, Anna Gavin, Carol Rivas, Richard Wagland, Peter Selby, Luke Hounsome, Therese Kearney, Rebecca Mottram, Majorie Allen, Oonagh McSorley, Hugh Butcher, Paul Kind, James W H Catto, Dyfed Huws, Emma McNair, Lauren Matheson, Johana Nayoan, Mike Horton, Jessica Corner, Julia Verne

“…The Life After Prostate Cancer Diagnosis (LAPCD) study is a UK-wide patient-reported outcomes study which will generate information to improve the health and well-being of men with prostate cancer.Methods and analysis Postal surveys will be sent to prostate cancer survivors (18–42 months postdiagnosis) in all 4 UK countries (n=∼70 000). Eligible men will be identified and/or verified through cancer registration systems. …”
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Editorial by Daniel Halliday

“…Again, such hierarchies might not be so profound in a society where all incomes were due to individuals’ own efforts. …”
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Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort by Antonio Liguori, Giorgio Esposto, Maria Elena Ainora, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Maria Cristina Giustiniani, Laura Riccardi, Matteo Garcovich, Antonio Gasbarrini, Luca Miele, Maria Assunta Zocco

“…<b>Methods:</b> This prospective study included 75 consecutive patients with MASLD who underwent liver biopsy for suspected MASH. All patients underwent S-Shearwave Imaging by Samsung and 2D-SWE with SSI on the same day of liver biopsy. …”
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Exploring the Genotype-Environment Interaction in Sugar Beet (Beta vulgaris L.) Genotypes for Optimal Selection by Mahdi Ramazi, Saeed Sadeghzadeh Hemayati, Heshmat Omidi, Amirmohammad Naji

“…A comparison of trait values in the selected genotypes revealed increased root yield and sugar content, alongside decreased levels of potassium, alpha-amino nitrogen, and sodium, showcasing overall improvements across all studied traits with high heritability. Conclusion: The results indicate that interactions between environmental factors and genetic makeup can influence the performance of different genotypes across varying conditions, leading to substantial variations in their outcomes. …”
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Utilisation of ChatGPT and other Artificial Intelligence tools among medical faculty in Uganda: a cross-sectional study [version 2; peer review: 1 approved, 2 approved with reserva... by Job Kuteesa, Faith Oguttu, Ian Guyton Munabi, Aloysius Gonzaga Mubuuke, Sarah Kiguli, Ritah Nantale, David Mukunya, Elizabeth Ajalo, Frank Kayemba, Jonathan Babuya, Kennedy Pangholi, Amelia Margaret Namiiro, Suzan Langoya Akuu, Steven Ekak, Ronald Tweheyo, Kirsten Nantongo, Brenda Nakitto, Milton W. Musaba, Joseph Luwaga Mpagi

“…The median age (interquartile range) was 41 years (34–50). Almost all medical faculty [90% (202/224)] had ever heard of AI tools such as ChatGPT. …”
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Pumpkin seed oil-loaded chitosan nanoparticles enhance growth, digestive enzymes, and immune response in whiteleg shrimp (Litopenaeus vannamei): Impacts on histopathology and survi... by El-Sayed Hemdan Eissa, Wesam Mohamed Salama, Samia Elbahnaswy, Mai A.M. El-Son, Zienab E. Eldin, Sara Amer, Layla A. Almutairi, Fatma Mohamed Ameen Khalil, Safia M.A. Bahshwan, Mada M. AL-Qurashi, Yasmin M. Abd El-Aziz, Moaheda E.H. Eissa, Aiman A. Alsaegh, Roshmon Thomas Mathew, El Sayed Taha Rizk

“…The survival rate after infection with V. parahaemolyticus was higher in all ChNPs/PSO-enriched groups compared to the control group. …”
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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…Methods: A total of 204 L. pneumophila clinical isolates were tested for sensitivity to 9 antibiotics using the broth microdilution assay (BMD). All isolates were typed by sequence-based typing, and Legionella pneumophila serogroup 1 (Lp1) isolates by monoclonal antibody subgrouping. …”
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Adaptation of Diverse Maize Germplasm to Spring Season Conditions in Northeast China by Yi Li, Zhiyuan Yang, Yong Shao, Zhenguo Jin, Li Gao, Yang Yu, Fengyi Zhang, Yuxing Zhang, Yuantao Nan, Mingshun Li, Degui Zhang, Zhuanfang Hao, Jianfeng Weng, Xinhai Li, Hongjun Yong

“…(BS13(S)C7 and BS31) and Chinese (Ji Syn A) populations exhibited more favorable alleles for high yield potential in all locations tested. Furthermore, the PH6WC × BS31 and PH6WC × Ji Syn A crosses had higher grain yields, and an appropriate number of days to silking, ear height, and resistance to lodging at Gongzhuling and Harbin in NEC. …”
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De Novo or inherited: gonosomal mosaicism in hereditary angioedema due to C1 inhibitor deficiency by Laura Batlle-Masó, Laura Batlle-Masó, Laura Batlle-Masó, Janire Perurena-Prieto, Janire Perurena-Prieto, Janire Perurena-Prieto, Laura Viñas-Giménez, Laura Viñas-Giménez, Laura Viñas-Giménez, Aina Aguiló-Cucurull, Aina Aguiló-Cucurull, Paula Fernández-Álvarez, Johana Gil-Serrano, Johana Gil-Serrano, Johana Gil-Serrano, Mar Guilarte, Mar Guilarte, Mar Guilarte, Roger Colobran, Roger Colobran, Roger Colobran, Roger Colobran

“…Our results underscore the importance of parental genetic testing in all patients, regardless of whether the parents are affected, and highlights the implications of gonosomal mosaicism for genetic counseling.…”
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Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study by Rui Zhang, Hao Wang, Chenxi Song, Rui Fu, Kefei Dou, Shuai Liu, Qianqian Liu, Xiaohui Bian, Weida Liu, Chengang Zhu, Jingjing Gao, Sheng Yuan, Xinming Cui, Sijia Qin, Yumeng Li

“…We aimed to investigate the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) among this critically ill population.Design The design of this study was a retrospective cohort study.Setting The study population was recruited in the Emergency Department of Fuwai hospital in China from 2018 to 2020.Participants We consecutively enrolled 829 patients with acute type A aortic dissection and measurable baseline NT-proBNP.Primary outcome The primary endpoint was 1-year all-cause death.Results Based on tertiles of NT-proBNP (pg/mL), patients were stratified into low (≤150.3, n=276), intermediate (150.3–667.6, n=277) and high (&gt;667.6, n=276) NT-proBNP groups. …”
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Mixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net by Kun Wang, Yong Han, Yuguang Ye, Yusi Chen, Daxin Zhu, Yifeng Huang, Ying Huang, Yijie Chen, Jianshe Shi, Bijiao Ding, Jianlong Huang

“…Results: The DSC, R and P values of the model introduced in this paper all exceed 90%, which has significant advantages compared with methods such as U-Net and Attention-Uet. …”
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Compositional Design, Microstructure, and Thermal Processing of Aluminum-Based Complex Concentrated Alloys by Spyridon Chaskis, Constantinos Tiktopoulos, Evangelos Gavalas, Marianthi Bouzouni, Fotis Tsiolis, Spyros Papaefthymiou

“…The electrical conductivity of all the alloys increased after the heat treatment, with the highest increase occurring during the first 4 h of the heat treatment.…”
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