Doença de chagas e seus vetores: Conhecer para prevenir! by Flavia dos Santos, Jairo Torres Magalhães-Junior, Ianei de Oliveira Carneiro, Ellenise Elsa Emidio Bicalho, Maurício dos Santos Conceição, Carlos Roberto Franke

“…In addition, volunteer scientific initiation scholarship holders and the professors involved in the study offered two short courses for the Veterinary Medicine course students at UFOB (n = 33). All activities carried out in the execution of this study contributed to clarifying the transmission of T. cruzi in the district, pointing out the main factors associated with this zoonosis, which allowed a more holistic approach to the disease, as well as showing possible methodological and thus helping to subsidize future activities in the areas of education, infrastructure (with the reactivation of the Triatomine Identification Post) and behavior (with community awareness to notify triatomines), which may result in the prevention and control of CD in regions with underreporting of triatomines. …”
Get full text

A Feasibility Randomised Controlled Trial of the New Orleans Intervention for Infant Mental Health: A Study Protocol by Rachel Pritchett, Bridie Fitzpatrick, Nicholas Watson, Richard Cotmore, Philip Wilson, Graham Bryce, Julia Donaldson, Kathleen Boyd, Charles Zeanah, John Norrie, Julie Taylor, Julie Larrieu, Martina Messow, Matt Forde, Fiona Turner, Susan Irving, Helen Minnis

“…The feasibility, reliability, and developmental appropriateness of all outcome measures are examined. Additionally, the potential for linkage with routinely collected data on health and social care and, in the future, education is explored. …”
Get full text

Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study by Huang Jingjie, Wu Bangqi, Qin Peng, Zhang Ziyi, Cheng Yupei, Wang Chaoran, Chen Yuyan, Bai Jing

“…Compared to patients with acute fever, those with intractable fever had higher NIHSS scores (33.3% vs. 15.5%, P < 0.05), a greater incidence of consciousness disorders (66.7% vs. 28.9%, P < 0.05), and a higher rate of tracheostomy (55.6% vs. 15.5%, P < 0.05). All patients received antibiotic treatment, and gabapentin was administered to 16 cases. …”
Get full text

plaTform fOr Urinary tract infection diagnostiC evAluatioN (TOUCAN): a protocol for a prospective diagnostic accuracy study of point-of-care testing in patients suspected of acute... by Thomas R Fanshawe, Philip J Turner, Gail N Hayward, Margaret Glogowska, Alastair D Hay, Michael Moore, Mark Lown, Christopher C Butler, Mandy Wootton, Mark H Wilcox, Jane Freeman, Nicola Kenealy, Valerie Tate, Owain Llion, Rebecca Lowe

“…Introduction Acute uncomplicated urinary tract infection (UTI) is a common condition with potentially serious sequelae that is mostly diagnosed and managed in primary care settings. Around half of all women have a UTI in their lifetime, and a quarter experience an infection caused by organisms resistant to more than one antibiotic. …”
Get full text

Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems by Nhat Minh Phan, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Trong Tuan Nguyen, Quoc Luan Ngo, Trong Duc Tran, Quan Hien Nguyen, Bui Linh Chi Huynh, Diep Xuan Ky Nguyen, Trong Dat Bui, Dinh Tri Mai, Tan Phat Nguyen

“…The study aims to determine the hepatoprotective effect of n-hexane, ethyl acetate, and methanol extracts of the leaves and stems of two Cleome species against carbon tetrachloride- (CCl4-) induced liver toxicity both in vitro using human hepatoma (HepG2) cells and in vivo in rats as well as the hepatoprotective property of all isolated compounds on HepG2. After 72 h of treatment, at the concentrations of 25, 50, and 100 μg/mL, the methanol of C. chelidonii stems (CCSM) ranged from 18.6% to 20.8%, whereas the methanol of C. chelidonii stems (CVSM) increased from 12.3% to 17.2% cell viability. …”
Get full text

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations by Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer

“…Applying a PS degradation assay, we found nine mostly secreted, PS-active hydrolases with varying hydrolytic activity. All active hydrolases showed a serine-histidine-aspartate/glutamate catalytical triad. …”
Get full text

Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…We aim to provide an overview of the characteristics of studies evaluating COVID-19 treatment.Design Rapid scoping reviewData sources Medline, Embase and biorxiv/medrxiv from inception to 15 May 2021.Setting Hospital and community care.Participants COVID-19 patients of all ages.Interventions COVID-19 treatment.Results The literature search identified 616 relevant primary studies of which 188 were randomised controlled trials and 299 relevant evidence syntheses. …”
Get full text

Identifikasi Emosi Manusia Berdasarkan Ucapan Menggunakan Metode Ekstraksi Ciri LPC dan Metode Euclidean Distance by Siti Helmiyah, Imam Riadi, Rusydi Umar, Abdullah Hanif, Anton Yudhana, Abdul Fadlil

“…The use of the LPC method as feature extraction gave unfavorable results in this study because the average accuracy was only 31.67% for the identification of all emotions. Voice data used with different sentences, actors, ages, and accents can influence the recognition of emotions, therefore the extraction of features in the recognition of speech patterns of human emotions is very important. …”
Get full text

Socioeconomic indicators related to the global burden of breast cancer in women in 2020: an analysis of WHO data by Tingting XU, Ruoyu YANG, Jingjing LI, Yiying FANG

“…Correlation analysis showed that the global MIR of breast cancer in women was positively correlated with urban particulate matter (r = 0. 480) and net ODA per capita (r = 0. 516) (both P < 0. 001) and negatively correlated with physician density (r = – 0.782), pharmacist density (r = – 0.639), average core capacity score (r = – 0.635), percentage of government health expenditure (r = – 0.614), population using sanitation services (r = – 0.624), and HDI (r = – 0.900) (all P < 0.001). Multiple linear regression analysis showed that net ODA per capita had a positive effect on the female breast cancer burden (β = 0.003, 95% confidence interval [95%CI]: 0.002 – 0.007), while total female population (β = – 0.004, 95%CI: – 0.005 to – 0.003), physician density (β = – 0.007, 95%CI: – 0.008 to – 0.006), pharmacist density (β = – 0.026, 95%CI: – 0.030 to – 0.021), average core capacity score (β = – 0.005, 95%CI: – 0.006 to – 0.004), and HDI (β = – 0.873, 95%CI: – 0.906 to – 0.574) had negative effects. …”
Get full text

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile by Min Li, Yuehui Shi, Lina Sun, Lin Liu, Chen Qu, Jun Zou

“…The changes in refraction 6 months after surgery comparing with 1 month after surgery were 0.12 ± 0.10 D in the Triple-A group and 0.13 ± 0.08 D in the TS group (P=0.56). All (100%) of the patients in the Triple-A group and 50% of the patients in the TS group had a UDVA of 20/16 at 6 months after surgery (P<0.01). …”
Get full text

Time Interval for Diagnosis of Tuberculosis and Related Expenditure in Selected Health Centers in Addis Ababa, Ethiopia by Ezra Shimeles, Melaku Tilahun, Tsegaye Hailu, Fikre Enquselassie, Abraham Aseffa, Alemayehu Mekonnen, Getachew Wondimagegn

“…The total combined expenditure for all the visits was estimated to be median (IQR) 172.65 birrs (12, 671). …”
Get full text

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis by Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo, Bo Jing, Siwei Zhang, Jianhua Xu, Beibei Sun, Xueqian Sun, Tingting Liu, Na Ni, Tongtong Zhang, Wenwen Cui, Xiaoyu Wu, Liping Xia, Feng Yao, Fang Zhang, Jing Du, Jiong Deng

“…Abstract Purpose Immune checkpoint blockades (ICBs) are promising, however they do not fit all types of tumor, such as those lack of tumor antigens. …”
Get full text

LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…In a humanized T-cell acute lymphoblastic leukemia (T-ALL) model, CD38 allogeneic universal CAR-T cells demonstrated superior survival rates and tumor clearance with reduced inflammatory responses. …”
Get full text

Eco-friendly sustainable farming: Enhancing summer tomato (Lycopersicon esculentum mill.) yield with jute non-woven agro textile Mulch by Nilimesh Mridha, Dipak Nayak, Ashok Yadav, Tilak Mondal, Rakesh Kr Ghosh, Manik Bhowmick, Atul Singha, D.P. Ray, B.S. Manjunatha, Avijit Das, D.B. Shakyawar, Sourav Paul, Amit Das, Santanu Mukherjee, Ravinder Kumar

“…The temperature throughout the soil depths for all mulch treatments was lower over no mulch, and for 650 GSM, it was the lowest. …”
Get full text

Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis by Tian-Yong Han, Tao Cheng, Bo-Fu Liu, Ya-Rong He, Pan Pan, Wen-Tao Yang, Qiang-Lai, Yu Cao

“…Demographic information and clinical and laboratory parameters of all enrolled patients after being admitted to ED were compared between the groups. …”
Get full text

Regarder au-delà des élections : l’historicité complexe de la participation politique dans la Libye contemporaine by Chiara Loschi, Chiara Pagano

“…However, these perspectives have been rarely applied to the analysis of post-Gaddafi Libya, where the axiomatic acquisition that a positive link exists between elections and democratic transition has obscured the potentialities of engaging into a scholarly debate encompassing all the “politics of becoming” that might be detected by looking even at those mobilisations that escape and often contest the electoral dynamic. …”
Get full text

Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved by Fernanda Gil-Almagro, Fernanda Gil-Almagro, Fernanda Gil-Almagro, F. Javier Carmona-Monge, Fernando J. García-Hedrera, Cecilia Peñacoba-Puente

“…However, when observing the evolution of each of the dimensions, it can be seen that emotional exhaustion has significantly decreased (p &lt; 0.001), while an increase in depersonalization (p &lt; 0.001) and a decrease in self-fulfillment (all p &lt; 0.001) are observed. The results of the repeated measures General Linear Models, after controlling for the effect of the covariates show that the evolution of emotional exhaustion is associated with the levels of depression at T1 (p = 0.031), of cognitive fusion at T2 (p &lt; 0.001) and of resilience at T2 (p = 0.039). …”
Get full text

Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area by Gloria Omaira Bautista, Axel Kroeger, Nelly Rosero Castillo, Eduardo Gabriel Osorio Sanchez, Dianne Sofía Gonzales Escobar, Rafael Olarte, Sonia Diaz Monsalve

“…Both groups, but particularly the migrants, belonged to the lower socioeconomic strata according to their educational levels and occupations (street vendors including street musicians and entertainers; 21.6% of migrants and 10.6% of Colombian neighbours). They all had stressful life events recently, with economic hardship being the most significant one, especially among migrants. …”
Get full text

Deployment and uptake of COVID-19 vaccines for refugees and migrants in regular and irregular situations: a mixed-method multicountry study by Biraj Man Karmacharya, Karl Blanchet, Jai K Das, Laetitia Nyirazinyoye, Maria Midea M Kabamalan, Nguyen Toan Tran, Zahra A Padhani, Anjali Joshi, Seyed-Moeen Hosseinalipour, Enrique Teran, Pierina Benavente, Vinay N Kampalath, Moussa Lonkila Zan, Elżbieta Anna Czapka, Cheryl Martens, Vicente B Jurlano

“…However, the qualitative phase reported delays and inequities in the early stage of the vaccination process in all countries. Overall, 64.2% of respondents perceived that government’ campaigns were successful. …”
Get full text

Dva příběhy z kriminálního podsvětí – padělatelé peněz na hradě Žampachu a přepadání Židů v roce 1542 by František Šebek

“…On July 20th he was interrogated on the rack in the royal town of Vysoké Mýto (district of Ústí nad Orlicí) and was also burnt there on the same day. The statements of all four criminals were transcribed in the Achtbuch kept in Pardubice. …”
Get full text