A novel way to use cross-validation to measure connectivity by machine learning allows epilepsy surgery outcome prediction by Karla Ivankovic, Alessandro Principe, Justo Montoya-Gálvez, Linus Manubens-Gil, Riccardo Zucca, Pablo Villoslada, Mara Dierssen, Rodrigo Rocamora

“…The framework was evaluated in a consecutive cohort of 21 patients with a post-surgical follow-up of minimum 3 years.The best overlap between connectivity change networks and resections was obtained at the transition from pre-seizure to seizure (surgical outcome prediction ROC-AUC=90.3 %). However, all patients except one were correctly classified when considering the most informative time intervals. …”
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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae by Qian Qin, Yanjing Dong, Jialong Chen, Bo Wang, Yuxin Peng, XinPeng Zhang, Xiaoyun Wang, Jinxiang Zeng, Guoyue Zhong, Shouwen Zhang, Xiaolang Du

“…Moreover, by using D. elegans as a reference, six genes (ycf4, clpP, ycf1, trnI-GAU, accD, rpl32) displayed high nucleotide polymorphism (Pi > 0.1), and the Ka/Ks ratio for all protein-coding genes was determined to be less than 1. …”
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Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study by Arthur Kavanaugh, Paul Emery, René Westhovens, Mark C Genovese, Kevin L Winthrop, Rieke Alten, Dick de Vries, Lorenzo Dagna, Patrick Verschueren, Maria Greenwald, Regina Cseuz, Robin Besuyen, Vikas Modgill, Ly Huong Le

“…Safety and efficacy analyses included all enrolled patients who received ≥1 dose of filgotinib in DARWIN 3.Results 739 patients entered the LTE. …”
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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy by Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj

“…Methods and results We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. …”
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Prediction Models of Severity in Acute Biliary Pancreatitis by Iulia Ratiu, Renata Bende, Camelia Nica, Oana Budii, Calin Burciu, Andreea Barbulescu, Tudor Moga, Bogdan Miutescu, Roxana Sirli, Mirela Danila, Alina Popescu, Felix Bende

“…In univariate analysis, the following parameterswere associatedwith at least a moderate–severe form of acute pancreatitis: Balthazar score, fasting blood glucose (mg/dL), modified CTSI score, CRP values at 48 h, BISAP score at admission, CTSI score, Ranson score, duration of hospitalization (days), and the presence of leukocytosis (×1000/µL) (all <i>p</i> < 0.05).BISAP score at admission (AUC-0.91), CRP levels at 48 h (AUC-0.92), mCTSI (AUC-0.94), and CTSI score (AUC-0.93) had the highest area under the curve (AUC) for predicting the severity of acute pancreatitis. …”
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Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

“…The efflux pump genes (<i>adeF</i>, <i>rsmA</i>, and <i>qacG</i>) were present in the genomes of all the strains used in this study. The amino acid sequences of <i>POM-1</i> in the strains shared a sequence homology with seven other sequences from different countries. …”
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Vitamin D deficiency and intracranial aneurysms: Systematic Review by Lívio Pereira de Macêdo, Glaudir Donato, Maria Eduarda d’Almeida Lins Regis, Isabela Fernandes de Melo Pereira, Gustavo Rodrigues Paulo, Kamilla Azevedo Bringel, Gabriel Carvalho Andrade Gadelha, Fábio Antônio Serra de Lima Júnior, Yally Dayanne Oliveira Ferreira, Renata de Castro Tavares, Arlindo Ugulino Netto, Kauê Franke, Pierre Vansant Oliveira Eugênio, Auricélio Batista Cezar-Junior, Igor Vilela Faquini, Eduardo Vieira de Carvalho Júnior, Nivaldo Sena de Almeida, Francisco Alfredo Bandeira e Farias, Marcelo Moraes Valença, Hildo Rocha Cirne Azevedo-Filho

“…A relationship between low vitamin D levels and IA incidence was detected in all studies. In terms of rupture and complications, there was a tendency of association with hypovitaminosis. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Materials and methods. 95 children aged 3 to 73 months with liver cirrhosis of various etiologies were surveyed. All the patients underwent liver transplantation (LT) from a living related donor. …”
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The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

“…The average cell yield per cell factory at passage 1 was of 21.93±12.81×106 cells, while at passage 2, it was of 83.05±114.72×106 cells. All final cellular products were free from contamination with aerobic/anaerobic pathogens, mycoplasma, and bacterial endotoxins. …”
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Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…Mean baseline CRT ± SD for Type 4 lesions was 492.1 ± 187.0 μm, and then 333.3 ± 137.5 μm, 354.4 ± 175.0 μm, and 326.7 ± 122.4 μm at 16, 32, and 48 weeks respectively. All these changes were statistically significant (p<0.005). …”
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Seaweed extract of Gracilaria verrucosa as an antibacterial and treatment against Vibrio harveyi infection of Litopenaeus vannamei by Mad Rudi, Sukenda Sukenda, Dinamella Wahjuningrum, Wesly Pasaribu, Dendi Hidayatullah

“…The first results of the inhibitory test showed that all the concentration of G. verrucosa extract was able to inhibit the growth of V. harveyi and the second result showed that the extract of G. verrucosa can increase the immune responses of shrimp. …”
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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker by Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

“…The predictive value of TyG-ABSI was greater than that of the TyG index, TyG-BMI, TyG-WC, and TyG-WHtR (Harrell’s C-index: 0.710 vs 0.623 vs 0.539 vs 0.612 vs 0.622, all p < 0.001). Conclusions The simultaneous assessment of the TyG index and ABSI revealed a synergistic effect on cardiovascular mortality. …”
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Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…Dosimetric parameters of all OARs were significantly higher than those in the original treatment plan (P < 0.01). …”
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Discussion Paper for the Foundation for the Rights of Future Generations - The housing crisis as a problem of intergenerational justice: The case of Germany by Elena Lutz

“…Yet, because of architectural and socio-economic differences between and within cities, there exists no one-sizefits-all solution. Nevertheless, the above measures can serve as a starting point for developing comprehensive measures to fight intergenerational injustice in the German housing market. …”
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Comparative efficacy and acceptability of psychotherapies for post-traumatic stress disorder in children and adolescents: a systematic review and network meta-analysis by Andrea Cipriani, Pim Cuijpers, Yuqing Zhang, David Cohen, Jürgen Barth, Peng Xie, Cinzia Del Giovane, Xinyu Zhou, Donna Gillies, Teng Teng, Xuemei Li, Li Fan, Yajie Xiang, John R. Weisz, Xueer Liu, Yuanliang Jiang, Kang Du, Arun V. Ravindran

“…For efficacy, cognitive processing therapy (CPT), behavioural therapy (BT), individual trauma-focused cognitive–behavioural therapy (TF-CBT), eye movement desensitisation and reprocessing, and group TF-CBT were significantly superior to all control conditions at post-treatment and follow-up (SMDs between −2.42 and −0.25). …”
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A SARS‐CoV‐2 EG.5 mRNA vaccine induces a broad‐spectrum immune response in mice by Hongyu Wang, Qinhua Peng, Xinxian Dai, Zhifang Ying, Xiaohong Wu, Xinyu Liu, Hongshan Xu, Jia Li, Leitai Shi, Jingjing Liu, Yunpeng Wang, Danhua Zhao, Yanqiu Huang, Lihong Yang, Ren Yang, Guangzhi Yue, Yue Suo, Qiang Ye, Shouchun Cao, Yuhua Li

“…Th1‐biased cellular immune response was induced in all vaccination groups. The antigen design and immunization strategy of this study have reference significance for the research of the next generation of COVID‐19 vaccine and other vaccines.…”
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Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar by Leila Almasi, Elham Arkan, Mohammad Hosein Farzaei, Amin Iranpanah, Cyrus Jalili, Fatemeh Abbaszadeh, Faranak Aghaz, Sajad Fakhri, Javier Echeverría

“…To evaluate the wound healing effects, rats were divided into four distinct groups, including negative control (untreated), phenytoin cream (as positive control), polymer (PVA/PEO/CS), and drug (nanofiber-containing 50% of TG extract; named PVA/PEO/CS/TG) groups. All treatments were administered topically once daily for 14 days. …”
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The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development by Lucile Guichard, Ronan Lagadec, Léo Michel, Hélène Mayeur, Michaël Fuentès, Jordan Pain, Noah Heier, Quentin Rougemont, Maria Celina Rodicio, Antón Barreiro-Iglesias, Antón Barreiro-Iglesias, Patrick Blader, Michael Schubert, Sylvie Mazan

“…The dorsal right subdomain forms and already expresses all identified signature markers in prolarval stages. …”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…The mean number of cigarettes consumed before enrollment was 17 ± 9 per day over a mean period of 40 ± 11 years. All patients had previously attempted to quit smoking and 97% had received advice from their surgeons or interventionalists to quit smoking in the prior year. …”
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Eco-friendly alginate/PCL-TiO2 hybrid biocomposites: Preparation, properties, and methylene blue photodegradation by Bunga Fisikanta Bukit, Agus Wedi Pratama, Erna Frida, Bakti Berlyanto Sedayu, Dina Fransiska, Deni Purnomo, Emma Rochima, Istiqomah Rahmawati, Sona Suhartana, Firda Aulya Syamani

“…TGA results showed that all samples exhibited two stages of decomposition. …”
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