Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives by Reşit Çakmak, Eyüp Başaran, Ömer Erdoğan, Suraj N. Mali, Semiha Köprü, Haya Yasin, Shailesh S. Gurav, Giray Topal

“…Compounds 2a, 3a, 3b, and 3c showed high gastrointestinal (GI) absorption, with all except 3a being non-permeable to the blood-brain barrier (BBB). …”
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Electrocardiography-based artificial intelligence predicts the upcoming future of heart failure with mildly reduced ejection fraction by Dae-Young Kim, Sang-Won Lee, Dong-Ho Lee, Sang-Chul Lee, Sang-Chul Lee, Ji-Hun Jang, Sung-Hee Shin, Dae-Hyeok Kim, Dae-Hyeok Kim, Wonik Choi, Wonik Choi, Yong-Soo Baek, Yong-Soo Baek, Yong-Soo Baek

“…The AI-ECG encompasses a novel model that combines an automatic labelling preprocessing method with a transformer architecture incorporating a triplet loss for HFmrEF analysis.ResultsThe receiver operating characteristic analyses revealed that the area under the curve of AI-ECG for identifying all types of HF was acceptable [0.873, 95% confidence interval (CI): 0.864–0.893], while that for identifying patients with HFmrEF was relatively lower (0.824, 95% CI: 0.794–0.863) than that for those with HF with reduced ejection fraction (EF) (0.875, 95% CI: 0.844–0.912) and those with normal EF (0.870, 95% CI: 0.842–0.894). …”
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Knowledge, attitude and practices regarding vitamin D among adults in Ghana: a cross-sectional study by Abraham Ameyaw Kwabena, Benedicta Appiah, Samuel Ankomah Danso, Samuel Kwame Sopuruchi Agomuo, Samuel Kwarteng, Ebenezer Senu, Alfred Effah, Samuel Asamoah Sakyi, Linda Ahenkorah Fondjo

“…SPSS (version 26.0) was used for all statistical analysis. P < 0.05 was considered statistically significant. …”
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Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations by Muhammad Asif, Abrar Hussain, Abdul Wali, Nazeer Ahmed, Irfan Ali, Zafar Iqbal, Muhammad Amir, Muhammad Shafiq, Mahmood Rasool

“…Complete blood cell count was performed at the time of diagnosis for all the patients. Cytogenetic (karyotyping) examination using bone marrow samples was conducted on 76 CML patients for the confirmation of Ph-positive (9;22)(q34;q11) standard translocation, complex variant translocation, and additional chromosome abnormalities. …”
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The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by I Kleinhans, S Mahanjana, F Els, M Mabona, L A Pitso, G Malatje, G Kok, J Raman

“…If malaria elimination is to be achieved, all aspects of the malaria programme must be strengthened urgently. …”
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Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights by Noor Ul Ain, Linzy Elton, Zahra Sadouki, Timothy D. McHugh, Saba Riaz

“…Result Most of the XDR strains (90%) were CREK, with K. pneumoniae (71.2%) more prevalent than E. coli (28.7%) (p < 0.05). All CREK strains exhibited complete resistance (100%) to multiple antibiotics with 66% showing sensitivity to levofloxacin. …”
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Organisational Enablers of Artificial Intelligence Adoption in Public Institutions: A Systematic Literature Review by Nina Tomaževič, Eva Murko, Aleksander Aristovnik

“…Therefore, the enablers identified in the study can serve as guidelines for decision-makers and implementers of AI at all levels of public institutions. Social implications: If adopted effectively and efficiently and used professionally and ethically, the use of AI in public institutions can bring many benefits to society, such as transparency, justice, cost and time efficiency, high quality services, and improved collaboration between different stakeholders in society. …”
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Interventions for Digital Addiction: Umbrella Review of Meta-Analyses by Peng Lu, Jiamin Qiu, Shiqi Huang, Xinman Wang, Shasha Han, Sui Zhu, Youjing Ning, Fang-fang Zeng, Yuan Yuan

“… BackgroundNumerous studies have explored interventions to reduce digital addiction outcomes, but inconclusive evidence makes it difficult for decision-makers, managers, and clinicians to become familiar with all available literature and find appropriate interventions. …”
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Difficultés diagnostiques de la tuberculose cérébrale by Chahrazed Benrabah

“…It constitutes a major public health problem, especially in developing countries, including Algeria. Globally and among all tuberculosis cases, WHO reports 14% extra-pulmonary tuberculosis (EPT) without concomitant pulmonary involvement. …”
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Feasibility pilot of a novel coaching intervention to optimize cannabis use for chronic pain management among Veterans by Kevin F. Boehnke, Gabrielle Bowyer, Jenna McAfee, Tristin Smith, Catherine Klida, Vivian Kurtz, Evangelos Litinas, Poonam Purohit, Anne Arewasikporn, Dana Horowitz, Laura Thomas, Jennifer Eckersley, Mia Railing, David A. Williams, Daniel J. Clauw, Kelley M. Kidwell, Amy S. B. Bohnert, Rachel S. Bergmans

“…Among those who completed end of intervention surveys (16/21), 87.5% were very or completely satisfied with the intervention and 81.3% rated coaching as very or extremely helpful. All participants reported improvement on the PGIC, with 63% reporting much or very much improvement. …”
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Innovative determination of phytohormones in Aloe vera by Muhammad K. Hakeem, Meera Maraqa, Sampath K. Elangovan, Sampath K. Elangovan, Esam Eldin Saeed, Ajay Kumar Mishra, Khaled M. Hazzouri, Iltaf Shah, Iltaf Shah, Khaled M. A. Amiri

“…The method’s performance was assessed in terms of linearity, sensitivity, and limits of detection.ResultsThe LC-MS/MS method exhibited excellent linearity (R2 &gt; 0.99) and low limits of detection for all six phytohormones. Four of the six analytes were identified as predominant in Aloe vera. …”
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Difficultés diagnostiques de la tuberculose cérébrale by Chahrazed Benrabah

“…It constitutes a major public health problem, especially in developing countries, including Algeria. Globally and among all tuberculosis cases, WHO reports 14% extra-pulmonary tuberculosis (EPT) without concomitant pulmonary involvement. …”
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Reduction of Lipid-Core Burden Index in Nonculprit Lesions at Follow-Up after ST-Elevation Myocardial Infarction: A Randomized Study of Bioresorbable Vascular Scaffold versus Optim... by Joelle Kefer, Patrick Chenu, Olivier Gurné, Frederic Maes, Théophile Tamakloé, Christophe Beauloye

“…At baseline, there were no differences in plaque characteristics between groups (fractional flow reserve: 0.85 ± 0.04 vs. 0.89 ± 0.06; diameter stenosis (DS): 43.4 ± 8 vs. 40.1 ± 10.7%; plaque burden 54.98 ± 5.8 vs. 49.76 ± 8.31%; and maxLCBI4 mm 402 [348; 564] vs. 373 [298; 516]; p=NS for all comparisons between groups 1 and 2, respectively). …”
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Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis by Tingting Wei, Can Huang, Yifan Zeng, Haoyong Yuan, Zhongshi Wu, Ting Lu, Yalin Liu

“…Safety endpoints included all-cause death, cardiac death, target vessel myocardial infarction and stent thrombosis (ST).Methods We searched PubMed, Medline, Embase and the Cochrane Controlled Register of Trials for comparative studies of BP-DES and DP-DES in patients with ACS from January 2000 to July 2021. …”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…The genome also contains multiple biosynthetic gene clusters such as lanthipeptide class IV, Type III polyketide synthase (T3PKS), and ribosomally synthesized, and post-translationally modified peptides (RiPP-like compounds), all of which are associated with antibacterial properties. …”
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Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps by Colinet, Dominique, Cavigliasso, Fanny, Leobold, Matthieu, Pichon, Apolline, Urbach, Serge, Cazes, Dominique, Poullet, Marine, Belghazi, Maya, Volkoff, Anne-Nathalie, Drezen, Jean-Michel, Gatti, Jean-Luc, Poirié, Marylène

“…We also show that both RhoGAP families have undergone evolution under positive selection and that almost all of these RhoGAPs lost their GAP activity and GTPase binding ability due to substitutions in key amino acids. …”
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Delayed completion of pneumococcal conjugate vaccination among children 4–48 months in rural Uganda: a socio-demographic inquiry by Herbert Malemo, Andrew Tamale, Paul Kakwangire, Matthew C. Igwe, Dickens R. Mwine, Isa Asiimwe, Solomon A. Mbina, Mary G. Abalinda

“…Abstract In spite of the commendable global Pneumococcal Conjugate Vaccine (PCV) coverage in the last two decades, completion and timeliness of receipt of all the required doses are still below target. In Uganda, the 3 + 0 PCV regimen has been reported to have a steady decline in the completion rate and the reasons for the delayed completion are unidentified. …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…Background/Objectives: A significant breakthrough in non-small-cell lung cancer (NSCLC) treatment has occurred with the introduction of targeted therapies and immunotherapy. However, not all patients treated with these therapies would respond to treatment, and patients who respond to treatment would acquire resistance at some time point. …”
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Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention by Runzhen Chen, Chen Liu, Peng Zhou, Yu Tan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Yi Chen, Li Song, Hanjun Zhao, Hongbing Yan

“…The primary outcome was all-cause death. Results. During a median follow-up of 727 days, mortality occurred in 207 (5.3%) patients. …”
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Effect of Channel Orientation and Rib Pitch-to-Height Ratio on Pressure Drop in a Rotating Square Channel with Ribs on Two Opposite Surfaces by Prabhu S. V., Arora Neelabh, Vedula R. P.

“…The overall pressure drop for a case with a rib pitch-to-height ratio of <math alttext="$5$"> <mn>5</mn> </math> on both surfaces is found to be the highest among all the rib pitch-to-height ratios covered in this study with the maximum increase in the overall pressure drop being as high as five times the corresponding no-rotation case at the highest rotation number of <math alttext="$0.38$"> <mn>0.38</mn> </math> and <math alttext="$90^{circ}$"> <msup> <mn>90</mn> <mo>&compfn;</mo> </msup> </math> orientation angle.…”
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