PET imaging of HIV-1 envelope protein gp120 using 18F-labeled nanobodies by Neysha Martinez-Orengo, Swati Shah, Jianhao Lai, Falguni Basuli, Anna Lyndaker, Mitchell L. Turner, Morteza Peiravi, Suman Sourabh, Kevon Sampson, Peng Zhang, Rolf E. Swenson, Paolo Lusso, Frank Maldarelli, Avindra Nath, Chuen-Yen Lau, Dima A. Hammoud

“…Switching from non-site-specific radiolabeling method to sortase A-mediated site-specific conjugation at the C-terminus improved binding to Env+ tumors for all nanobodies. Site-specifically 18F-labeled J3 nanobody is the most promising candidate with the highest level of binding. …”
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Spatial-temporal differentiation and influencing factors of ecosystem health in Three-River-Source national Park by Yanqin Wang, Huaju Xue, Aiqing Li, Xiaofan Ma, Ailing Sun, Jinhe Zhang

“…It also showed significant “high-high” and “low-low” clustering effects in the eastern and northwestern regions. (3) Among all the indicators assessed, ecosystem vigor was the indicator that contributed the most to the growth of the ecosystem health index. (4) Variations in ecosystem health of TNP were mainly shaped by land use intensity and precipitation, and interactions between natural environmental factors and human activity factors enhanced the explanation of these changes. …”
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Coupling natural-social models can better quantify the interactions in achieving carbon neutrality in China by Tianpeng Wang, Yixiong Lu, Fei Teng, Xiliang Zhang, Xiaoye Zhang, Min Wei, Tongwen Wu, Deying Wang, Jing Sun, Junting Zhong

“…Meanwhile, carbon neutrality does not eliminate all negative climate impacts and can substantially reduce the economic output of climate-vulnerable sectors in China, highlighting the need for early adaptation measures. …”
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Factors of progression to severity and death in COVID-19 patients at two health care sites in Bamako, Mali by Abdoulaye Mamadou Traore, Mamadou Karim Toure, Yaya Ibrahim Coulibaly, Modibo Keita, Bakary Diarra, Salif Sanafo, Garan Dabo, Mamoudou Kodio, Bourama Traore, Aminata Diarra, Adama Dicko, Hamar A. Traore, Ousmane Faye, Daouda K. Minta

“…Using binomial logistic regression method, age > 60 years, increased heart rate, disease severity level and mainly acute respiratory distress syndrome (polypnea, difficulty breathing) were the factors found associated with death. After adjusting for all the assessed factors, age < 60 years [aHR = 0.15 (0.06–0.35)] and administration of azithromycin [aHR = 0.31 (0.1–0.97)] were protective factors while higher respiratory rate [aHR = 1.14 (1.07–1.22)] and difficulty breathing [aHR = 3.06 (1.03–9.13)] were risk factors associated with death. …”
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Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel by Aneesa Motala, Susanne Hempel, Michelle Wong, Maria Bolshakova, Ning Fu, David Ganz, Sonali Saluja, Timothy Kim, Carolyn Turvey, Kristina Cordasco, Aashna Basu, Tonya Page, Reshma Mahmood, Jenny Barnard, Isomi M Miake-Lye

“…Agreed practice recommendations included educating external professionals about issues specific to the patients in the main healthcare system, educating professionals within the main healthcare system about the roles and responsibilities of all involved parties, and helping patients better understand the pros and cons of within-system and out-of-system care. …”
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« Paroles de flics ». Communications policières et actualité politique au Maroc (2005-2023) by Mériam Cheikh

“…The resurgence of police publishing (in Arabic and French) will mark the first milestone in the establishment of a system of communication that will be visible to all and which, over the course of the last two decades (2005-2023), will gradually become a fully-fledged professional service responsible, for the first time, not for denying but for addressing through discourse the strong tension between police action and civil liberties. …”
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Developing a comprehensive inventory to define harm reduction housing by Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green

“…Results HRH staff identified best practices, resources, and policies in HRH sites that were further contextualized with ethnographic field notes. Common to all were overdose prevention protocols, behavioral policies, security measures, and distribution of harm reduction supplies. …”
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A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients by Wang M, Yue X, Ding Y, Cai Z, Xiao H, Huang H, He J

“…The nomogram model exhibited acceptable discrimination, with C-index values of 0.777, 0.714, and 0.71 in the training cohort, validation cohort, and entire cohort, respectively, which was significantly higher than the C-indices of the three most extensively used staging systems for NDMM (D-S, ISS, and R-ISS). All calibration curves revealed good consistency between the predictive and actual survival outcomes. …”
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Peer-assisted telemedicine hepatitis-C treatment for people who use drugs in rural communities: a mixed methods study by Kim Hoffman, Gillian Leichtling, Sarah Shin, Andrew Seaman, Tonhi Gailey, Hunter C. Spencer, P. Todd Korthuis

“…., housing vouchers) (2) Key clinician-level factors such as capacity for unscheduled peer-facilitated appointments, having dedicated time for case consults with peers, and clinicians trained in working with PWUD and skilled in identifying related clinical concerns (3) Key systems-level elements such as standing lab orders, challenges related to specialty pharmacies and Medicaid managed care organizations, and streamlined communication strategies between peers and clinicians. Conclusion All participants reported that the Peer TeleHCV model built trust and eased barriers for PWUD initiating and remaining in HCV treatment. …”
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Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants by Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi

“…The results indicated that metformin significantly increased the activity of PP2A in the myotubes for all 8 lean insulin-sensitive nondiabetic participants, and the average fold increase is 1.54±0.11 (P<0.001). …”
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Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing by Xinyi Feng, Yu Zhang, Jun Feng, Zhongjun Li, Zhi Zhang, Lin Zhu, Ruoyu Zhou, Haibo Wang, Xiaojun Dai, Yanqing Liu

“…Result: A total of 152 differential metabolites were identified, and we screened 10 of them. All metabolites were enriched into 42 differential metabolic pathways, of which 13 have P values less than 0.05. 16S rDNA sequencing showed significant differences in 4 microbial communities at the phylum level. …”
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Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from companion animals and human infections in Europe by Adrien Biguenet, Benoit Valot, Farid El Garch, Xavier Bertrand, Didier Hocquet

“…The sequence type (ST) of all genomes were assessed by multilocus sequence typing. …”
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Sistem Pelacakan Dokumen Berbasis Seluler dan Kode QR by Monanta Alfiareza, Nori Wilantika

“…Proven by these tests, the system is ready to use. It can carry out all of its functions to facilitate PML to report the condition of the documents and to provide actual information centrally for the leaders. …”
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The analysis of losses in protected and non-insulated wires in stationary modes, taking into account weather conditions by E. V. Petrova, S. S. Girshin, V. A. Krivolapov, K. V. Khatsevskiy, V. N. Goryunov, V. M. Trotsenko

“…It is shown that the presence of insulation allows, under certain conditions, to reduce temperature and losses compared to wires without insulation, all other things being equal. The results obtained can be used to increase the capacity and reliability of power transmission lines.…”
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Biotechnological Phytocomplex of <i>Zanthoxylum piperitum</i> (L.) DC. Enhances Collagen Biosynthesis In Vitro and Improves Skin Elasticity In Vivo by Giovanna Rigillo, Giovanna Pressi, Oriana Bertaiola, Chiara Guarnerio, Matilde Merlin, Roberto Zambonin, Stefano Pandolfo, Angela Golosio, Francesca Masin, Fabio Tascedda, Marco Biagi, Giulia Baini

“…<b>Results:</b> In vitro, ZPP exhibited non-cytotoxicity at all concentrations tested. Under hyperosmotic stress, ZPP reduced cellular damage, suggesting enhanced resilience. …”
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Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration by Xuan Li, Yuan He, Fangyao Chen, Xin Tong, Yunlong Fan, Yuzhe Langzhou, Jie Liu, Kinon Chen

“…Application of this method revealed distinct injury-specific changes: dislocation caused the greatest axonal loss, while distraction led to the lowest myelin-to-axon-area ratio, indicating preserved axons but severe demyelination. All injuries resulted in increased axon diameter and a decreased myelin-sheath-thickness-to-axon-diameter ratio, suggesting disrupted myelination. …”
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An innovative approach to prioritizing soil conservation areas under diverse scenarios by leveraging the complementary roles of soil retention services and soil erosion indicators by Eshetu Shifaw, Jinming Sha, Xiaomei Li, Peng Zhao, Jianwan Ji, Hao Zhang, Ashenafi Yimam Kassaye, Shuhui Lai, Zhonglin Ji, Yusheng Yang

“…New hydrological insights for the region: The results revealed an initial decline in all indicators (2000–2010), followed by an increase (2010–2020). …”
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Teknologi Text To Speech Menggunakan Amazon Polly Untuk Meningkatkan Kemampuan Membaca Pada Anak Dengan Gejala Disleksia by Karlina Diah Fatmawati, Imam Tahyudin

“…Current technological developments can be utilized in all fields, including in the learning of children with special needs such as dyslexia. …”
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Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Here, we examined the complementary roles of tumor mutational burden (TMB) and programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) to inform first-line therapy using a large real-world (rw) data set.Materials and methods The study included patients with NSCLC from an rw de-identified clinico-genomic database. All patients underwent genomic testing using Foundation Medicine’s tissue comprehensive genomic profiling assay and PD-L1 IHC assay scored for tumor cell staining (TS).Results Of 2165 patients included in the analysis, 150 exhibited durable benefit from first-line ICPI regimens (these patients were enriched for PD-L1 TS ≥50, non-squamous histology, and TMB ≥20 mutations/megabase (muts/Mb)). …”
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不一樣的人生道路？STEM科系畢業生的薪資發展軌跡 Different Life Pathway: Earning Trajectory of the Graduates in STEM Majors by 張宜君 Yi-Chun Chang

“…In this study, the labor market uncertainty and unpredictability, and the diversity in all aspects of personal life, are incorporated into the life course trajectory. …”
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