Rapid method for identification of transgenic fish zygosity by . Alimuddin, G. Yoshizaki, O. Carman

“…The results demonstrated a clear-cut identification of all transgenic fish (n=20) classified as a homozygous or heterozygous.  …”
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Association of IL-8 and CXCR2 with AST/ALT Ratio in Liver Abnormalities Screening during Oxidative Stress Injury Caused by VCM by Yiwen Dong, Xingang Wang, Weijiang Hu, Xin Wang, Hongying Bian, Wencui Zhang, null Feng Han, Ning Kang, Lin Zhang, Meng Ye

“…ALT, AST, and AST/ALT ratio all contributed to liver abnormalities that contained fatty liver, liver calcification, and liver cysts, IL-8 and CXCR2 correlated with each other strongly and showed significant associations with oxidative stress markers, even AST/ALT ratio. …”
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ϵ-Confidence Approximately Correct (ϵ-CoAC) Learnability and Hyperparameter Selection in Linear Regression Modeling by Soosan Beheshti, Mahdi Shamsi

“…In a data based learning process, training data set is utilized to provide a hypothesis that can be generalized to explain all data points from a domain set. The hypothesis is chosen from classes with potentially different complexities. …”
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Pola Infeksi Oportunistik yang Menyebabkan Kematian pada Penyandang AIDS di RS Dr. M. Djamil Padang Tahun 2010-2012 by Aghnia Jolanda Putri, Eryati Darwin, Efrida .

“…Septic shock is the leading mechanism of cause of death among all.<br />Keywords: opportunistic infections, AIDS, death</p>…”
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Trends in the use and dual use of factory-made combustible cigarettes, other tobacco products and electronic cigarettes: Results from South African Social Attitudes Surveys during... by Catherine O. Egbe, Siphesihle Gwambe, Mukhethwa Londani, Olufemi Erinoso, Olalekan A. Ayo-Yusuf

“…Though dual use of FM cigarettes and SLT, waterpipe, or e-cigarettes was generally low, the prevalence of dual use significantly increased for all product combinations investigated: FM cigarettes and SLT (0.5% in 2007 to 1.3% in 2018, p=0.017), FM cigarettes and waterpipe (0.9% in 2010 to 2.5% in 2018, p=0.014), FM cigarettes and e-cigarettes (0.4% in 2010 to 1.8% in 2018, p<0.001). …”
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An NMR Study of the Bortezomib Degradation under Clinical Use Conditions by Adele Bolognese, Anna Esposito, Michele Manfra, Lucio Catalano, Fara Petruzziello, Maria Carmen Martorelli, Raffaella Pagliuca, Vittoria Mazzarelli, Maria Ottiero, Melania Scalfaro, Bruno Rotoli

“…Commercial BTZ samples, reconstituted according to the reported commercial instructions and stored at 4∘C, were analyzed by high-field nuclear magnetic resonance spectroscopy in comparison with identical samples bubbled with air and argon, respectively. All the samples remained unchanged for a week. After a month, the air filled samples showed the presence of two main degradation products (6% of starting material), the N-(1-(1-hydroxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl) pyrazine-2-carboxamide (BTZ1; 5%, determined from NMR integration) and the (S)-N-(1-(3-methylbutanamido)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (BTZ2; 1%, determined from NMR integration), identified on the basis of their chemical and spectroscopic properties. …”
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CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis by Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko

“…CX3CR1⁺CD4⁺ T cells were identified as a cytotoxic ThA subset, as nearly all of these cells specifically expressed granzyme B. …”
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It is time to tackle psychological determinants of obesity and eating disorders by Pietro Crescenzo

“…In developed countries, obesity and overweight are global public health challenges that are devastating health and economy, as they are increasing at an alarming rate, taking into account the fact that childhood obesity affects both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity [4]. …”
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Activity of oxidative processes and the state of the redox regulating system in tumor tissue in skin cancer by I. A. Goroshinskaya, E. M. Frantsiyants, N. I. Larina, Yu. V. Przhedetskiy, I. V. Kaplieva, L. A. Nemashkalova, V. A. Bandovkina, V. V. Pozdnyakova, V. Yu. Przhedetskaya

“…In women, the level of MDA was increased in all tissues: with superficial growth of BCC by 2.1–2.5 times (p ≤ 0.05), with solid growth by 1.6–2.1 times (p &lt; 0.05) relative to the “norm”. …”
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Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis by Juan R. Ulloque-Badaracco, Esteban A. Alarcon-Braga, Enrique A. Hernandez-Bustamante, Enrique A. Hernandez-Bustamante, Beatrix M. Von-Koeller-Jones, Miguel Huayta-Cortez, Esduardo Saavedra-Custodio, Percy Herrera-Añazco, Vicente A. Benites-Zapata

“…This study aimed to synthesize the available evidence regarding the differences in serum levels of vitamin B12, Hcy, and folate among children or adolescents with and without obesity.MethodsA random-effects meta-analysis using the Sidik-Jonkman method and corrected 95% confidence interval (CI) using the truncated Knapp-Hartung standard errors was used for all meta-analyses. Standardized mean difference (SMD) with the corresponding 95% CI was used as the only effect size. …”
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Gambaran Format dan Tata Cara Pengeluaran Surat Keterangan Kematian pada Rumah Sakit di Kota Padang by Abdullah Arief Syahputra, Rika Susanti, Henny Mulyani Mulyani

“…This is a descriptive study</em><em> that</em><em> </em><em>got</em><em> data from all public hospitals in the city of Padang. The samples for this study </em><em>were</em><em> 12 hospitals. …”
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PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

“…Zhaoqian He,1– 3,&ast; Hua Chen,1– 3,&ast; Chen Liang,1– 3,&ast; Xiang Tang,1– 3 Lingmin Jiang,1– 3 Feihu Xie,1– 3 Qi Liu,1– 3 Yun Zheng1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yun Zheng; Qi Liu, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People’s Republic of China, Email zhengyun@sysucc.org.cn; liuqi9@sysucc.org.cnPurpose: To compare the clinical outcomes of different systemic therapies, specifically PD(L)1 inhibitors plus Lenvatinib versus Atezolizumab plus Bevacizumab, when combined with hepatic arterial infusion chemotherapy (HAIC) based on the FOLFOX regimen (oxaliplatin, fluorouracil, and leucovorin) as first line treatment for unresectable hepatocellular carcinoma.Patients and Methods: This real-world retrospective study enrolled 294 patients with unresectable HCC. All patients received HAIC in combination with either PD(L)1 inhibitors plus Lenvatinib (PLEN-HAIC) or Atezolizumab plus Bevacizumab (AT-HAIC). …”
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Intraoperative haemodynamic optimisation using the Hypotension Prediction Index and its impact on tissular perfusion: a protocol for a randomised controlled trial by Javier Ripollés-Melchor, Ane Abad-motos, Juan Victor Lorente, Ignacio Jimenez, Alejandra Becerra, Wilbert Wesselink, Francesca Reguant, Irene Mojarro, Maria de los Angeles Fuentes, Elizabeth Agudelo, Francisco Herrero-Machancoses, Paula Callejo, Joan Bosch, Manuel Ignacio Monge

“…This study aims to determine whether a treatment protocol based on the prevention of arterial hypotension using the HPI algorithm reduces the duration and severity of intraoperative hypotension compared with the recommended goal-directed fluid therapy strategy and may improve tissue oxygenation and organ perfusion.Methods and analysis We will conduct a multicentre, randomised, controlled trial (N=80) in high-risk surgical patients scheduled for elective major abdominal surgery. All participants will be randomly assigned to a control or intervention group. …”
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Microplastics contamination in two peripheral fish species harvested from a downstream river by M.R. Maulana, S. Saiful, Z.A. Muchlisin

“…This study indicated fiber as the most dominant microplastic in the two fish species at all sampling locations. It also had three colors in the alimentary tract of mullet and bagok catfish, namely red, blue, and black, which was predominant. …”
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Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model by Ming-Hsien Tsai, How-Ran Chao, Jheng-Jie Jiang, Yu-Hsieh Su, Mariene-syne P. Cortez, Lemmuel L. Tayo, I-Cheng Lu, Hao Hsieh, Chih-Chung Lin, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang, Wen-Li Hsu

“…In the examination of the longevity of nematodes, it was found that the lifespan of all GO NP-exposed worms was significantly shortened as compared to the untreated worms. …”
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Pairs and his role in pattem of trade in Vilnius and Kaunas province in 1861-1914 by Aelita Ambrulevičiūtė

“…Wholesale warehouses, special consumer goods shops, and marts all decreased the importance of the fairs. Fairs became places for the realization of artisans' and farmers' production. …”
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Spondias purpurea L. (Anacardiaceae) fruits flours at different maturation stages: Drying kinetics, mathematical modelling, characterization and correlation analysis by Álvaro Gustavo Ferreira da Silva, Franciscleudo Bezerra da Costa, Ana Marinho do Nascimento, Giuliana Naiara Barros Sales, Jéssica Leite da Silva, Alzira Maria de Sousa Silva Neta, Wellington Souto Ribeiro, Toshik Iarley da Silva, Bruno Fonsêca Feitosa

“…The stabilization phase of S. purpurea fruit drying kinetics commenced at 420 min for maturation stages I and III, and at 480 min for the remaining stages. All employed mathematical models effectively characterized the drying process, exhibiting R2 values exceeding 0.99, MSD below 0.03, and X2 below 0.0009. …”
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The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…We examine the work of 20th-century researchers who developed models of landscape evolution; however, almost all of these models have been qualitative. With technological advancements, new quantitative techniques have emerged to provide evidence of landscape evolution events and to test previous models, and we present a brief overview of these methods. …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…Results Using two-way cross-validation, we show that vessels were accurately segmented, with Dice scores of 0.875 and 0.856, and were accurately identified, with F1 scores of 0.777 and 0.748. All vascular parameters exhibit strong ( $$r>0.7$$ r > 0.7 ) and significant (p<0.001) correlations with measurements taken from the manual ground truth vessel segmentations. …”
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Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

“…Background: Cerebral venous sinus thrombosis (CVT) is a rare cause of stroke, constituting 0.5–3% of all strokes with an extremely varied spectrum of presentation, predisposing factors, neuroimaging findings, and eventual outcomes. …”
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