Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…The grade ≥ 3 AEs was 66% (95%CI 0.06–0.98, I2 = 93%, P = 0.70), 34% (95%CI 0.07–0.78, I2 = 85%, P = 0.51) in neutropenia and thrombocytopenia, respectively. All AEs were tolerable and resolved with treatment. …”
Get full text

Electromyographic correlates of effortful listening in the vestigial auriculomotor system by Andreas Schroeer, Andreas Schroeer, Andreas Schroeer, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Ronny Hannemann, Ronny Hannemann, Steven A. Hackley, Daniel J. Strauss, Daniel J. Strauss, Daniel J. Strauss, Daniel J. Strauss

“…Three different conditions, each more difficult and requiring a higher amount of effortful listening, were generated by varying the number and pitch of distractor streams, as well as the signal-to-noise ratio. All audio streams were either presented from a loudspeaker placed in front of the participants (0°), or in the back (180°). …”
Get full text

Association Between Screen Time and Lifestyle Parameters with Executive Functions in Chilean Children and Adolescents: Potential Mediating Role of Health-Related Quality of Life by Felipe Caamaño-Navarrete, Carlos Arriagada-Hernández, Lorena Jara-Tomckowiack, Jordan Hernandez-Martinez, Pablo Valdés-Badilla, Guido Contreras-Díaz, Indya del-Cuerpo, Pedro Delgado-Floody

“…<b>Conclusions</b>: ST was inversely associated with all EFs assessed, and HRQoL showed a potential mediating role in these relationships.…”
Get full text

Pengembangan Sistem Manajemen Pengetahuan di Organisasi Asosiasi Alumni Program Beasiswa Amerika - Indonesia (ALPHA-I) by Muhammad Nurwegiono, Sri Nurdiati, Sony Hartono Wijaya

“…The result of black box testing from 36 case studies demonstrated that all functions in the system run according to the commands given. …”
Get full text

Aloe vera: A promising natural herbal supplement for enhancing growth, physiology, antioxidant activity and immunity in Catla catla by Zeeshan Yousaf, Syed Makhdoom Hussain, Shafaqat Ali, Dariusz Kucharczyk, Joanna Nowosad, Konrad Turkowski, Bilal Ahamad Paray, Adan Naeem

“…The findings determined that fish fed an A. vera supplemented diet exhibited significant improvements in all parameters. Supplementation with 3 % A. vera resulted in a significant (p < 0.05) increase in weight gain (%) and an improved feed conversion ratio. …”
Get full text

Luminescence Nanothermometry Based on Pr3+ : LaF3 Single Core and Pr3+ : LaF3/LaF3 Core/Shell Nanoparticles by M. S. Pudovkin, D. A. Koryakovtseva, E. V. Lukinova, S. L. Korableva, R. Sh. Khusnutdinova, A. G. Kiiamov, A. S. Nizamutdinov, V. V. Semashko

“…The values of absolute sensitivity Sa for fluorescence intensity ratio (FIR) thermometry was 0.01 K−1 at 300 K for all the samples. The FIR sensitivity can be attributed to the fact that 3P1 and 3P0 states share their electronic populations according to the Boltzmann process. …”
Get full text

Revealing the limitations of 10-year MACE observations: 20-year observed total cardiovascular burden in the EPIC-Norfolk study by Frank LJ Visseren, Harald T Jorstad, Marjolein Snaterse, S Matthijs Boekholdt, Tinka J van Trier, Jannick AN Dorresteijn, Manon van den Bogaart, Wilma JM Scholte op Reimer, Ron JG Peters

“…Therefore, we aimed to quantify how well 10-year observed incidence reflects 20-year observed incidence and how MACE reflects total CVD events across demographic groups, using observations in long-term prospective data.Methods In individuals aged 40–79 without CVD or diabetes from the population-based EPIC-Norfolk cohort, we compared the first occurrence of 10 and 20 years (1) 3-point MACE events (non-fatal myocardial infarction+non-fatal stroke+fatal CVD) and (2) total CVD events (all non-fatal and fatal CVD events leading to hospitalisation), stratified by sex and age.Results Among 22 569 participants (57% women), incident 10-year and 20-year 3-point MACE was 5.3% and 15.5%, respectively, yielding 20/10 year ratios from 2.2 (in older men) to 4.5 (in younger women). …”
Get full text

The Association of moisture intake and constipation among us adults: evidence from NHANES 2005–2010 by Deng-Chao Wang, Xue-Feng Peng, Wen-Xing Chen, Miao Yu

“…Moisture intake was assessed using dietary recall data, which included moisture from all food and beverages consumed. A weighted logistic regression model was used to assess the relationship between moisture intake and the risk of constipation, calculating the odds ratios (ORs) and their 95% confidence intervals (CIs), while controlling for potential confounders. …”
Get full text

A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets by Lin Li, Xin Zhang, Jiayao Yan, Jingyi Guo, Fangcen Liu, Xiao Wei, Qin Liu, Kongcheng Wang, Baorui Liu

“…Analysis of PFS showed that MAGE-A1 expression in HNSC (**p < 0.01), PRAME in LUSC (p = 0.008, **p < 0.01), MAGE-A10 (p = 0.012, *p < 0.05) and PRAME (p = 0.021, *p < 0.05) in ESCA were significantly correlated with PFS. In all three cancers, coexpression of three CTAs was used as a cutoff value for grouping, and the results showed a significant difference in PFS between these two groups. …”
Get full text

NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…Comprehensive performance evaluations demonstrated that NeuTox 2.0 has relatively higher predictive capability across all statistical metrics. Specifically, NeuTox 2.0 exhibits remarkable performance in three of the four datasets. …”
Get full text

Cohort profile: Anhui Maternal–Child Health Study in China by Yunxia Cao, Ruoling Chen, Weiju Zhou, Xiaofeng Xu, Xiaoqing Peng, Jiaqian Yin, Chunmei Liang, Ranjit Khutan, Fang-Biao Tao

“…AMCHS recruits participants from all couples who sought ART treatment in the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. …”
Get full text

CompositIA: an open-source automated quantification tool for body composition scores from thoraco-abdominal CT scans by Raffaella Fiamma Cabini, Andrea Cozzi, Svenja Leu, Benedikt Thelen, Rolf Krause, Filippo Del Grande, Diego Ulisse Pizzagalli, Stefania Maria Rita Rizzo

“…Regression and Bland–Altman analyses demonstrated a strong linear relationship and good agreement between automated and manual scores (p values < 0.001 for all indices), with mean PREs ranging from 5.13% to 15.18%. …”
Get full text

Analysis of Peripapillary and Macular Choroidal Thickness in Eyes with Pseudoexfoliative Glaucoma and Fellow Eyes by Fan Li, Qingli Shang, Guangxian Tang, Hengli Zhang, Xiaowei Yan, Lihua Ma, Yulei Geng, Qing Zhang

“…Peripapillary and macular choroidal thickness and volume were measured in all subjects via enhanced-depth imaging-optical coherence tomography. …”
Get full text

Retrospective analysis of trauma patients transported by dispatch monitored type B ambulances to Dhulikhel Hospital, Kavre, Nepal, 2019–2023 by Maxwell L. Mantych, Shiva Neupane, Machchendra Sapkota, Laura D. Cassidy, Sarah C. Young, Ronald Anguzu, Samjhana Basnet

“…Conclusion Trauma cases accounted for 15% (227/1541) of all patients who received transport and prehospital care services from a Type B ambulance monitored by the Dispatch Center between 2019 and 2023. …”
Get full text

Differentiation Potential of Early- and Late-Passage Adipose-Derived Mesenchymal Stem Cells Cultured under Hypoxia and Normoxia by Ashley G. Zhao, Kiran Shah, Julien Freitag, Brett Cromer, Huseyin Sumer

“…We confirmed by flow cytometry the presence of cell surface markers CD105, CD73, and CD90 and lack of expression of CD45, CD34, CD14, and CD19 across all conditions. Furthermore, in vitro differentiation confirmed that both early- and late-passage adipose-derived MSCs grown in hypoxia or normoxia could differentiate into chondrogenic and osteogenic cell types. …”
Get full text

Childhood BMI trajectories and sociodemographic factors in an Italian pediatric population by Erich Batzella, Joaquin Gutierrez de Rubalcava Doblas, Gloria Porcu, Silvia Bressan, Elisa Barbieri, Carlo Giaquinto, Anna Cantarutti, Cristina Canova

“…Four BMI z-scores trajectories, all with quadratic shape, were identified as the optimal fit: “stable-low-weight” (27.5%), “normal-weight” (40.9%), “stable-moderate-increase” (24.2%), and “overweight-to-obese” (7.5%). …”
Get full text

Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature by Eric Wierda, Cathelijne Dickhoff, Martin Louis Handoko, Liane Oosterom, Wouter Emmanuel Kok, Y. deRover, B.A.J.M. deMol, Loek vanHeerebeek, Jutta Maria Schroeder‐Tanka

“…Re‐hospitalization rates for HF at 30 and 180 days were 28 and 46%, respectively. All‐cause re‐hospitalization rates at 30 and 60 days were 18–37 and 22%, respectively. …”
Get full text

Assessment of vegetation in Murchison falls national park five years after the completion of oil and gas exploration by Hindrah Akisiimire, William Tinzaara, Keneth Tumwebaze, Charles K.Twesigye

“…This study sought to study the vegetation frequency index, relative abundance and diversity in former oil pads five years after the completion of oil and gas exploration in MFNP. We counted all observed plant species following a systematic random sampling technique using a (1mx1m) quadrat for herbs, (5mx5m) quadrat for shrubs, and (10mx10m) quadrat for trees. …”
Get full text

Co-creating and hosting PxP: a conference about patient engagement in research for and by patient partners by Dawn P. Richards, Hetty Mulhall, Joletta Belton, Savia de Souza, Trudy Flynn, Alex Haagaard, Linda Hunter, Amy Price, Sara Riggare, Janice Tufte, Rosie Twomey, Karim M. Khan

“…Patient partners conceived, planned, and decided on all aspects of a virtual conference. We present the work and processes we undertook throughout 2023 to create and produce a free conference called “PxP: For patients, by patients” or PxP for short, with a tagline of “Partnering to make research stronger.” …”
Get full text

In-hospital costs of diabetic foot infection at a national referral hospital in Jakarta, Indonesia by Fitrianingsih, Rani Sauriasari, Em Yunir, Agusdini Banun Saptaningsih

“…The total costs were estimated at IDR 64.95 ± 50.89 million per patient. All cost variables were driven by intervention costs estimated at IDR 5.176 billion (median IDR 19.676 [min – max; 1.245–136.348) million per patient). …”
Get full text