Genetically edited human placental organoids cast new light on the role of ACE2 by Anya L. Arthurs, Bianca Dietrich, Martin Knöfler, Caleb J. Lushington, Paul Q. Thomas, Fatwa Adikusuma, Jessica M. Williamson, Susan Babikha, Tyla Damhuis, Tanja Jankovic-Karasoulos, Melanie D. Smith, Kirsty G. Pringle, Claire T. Roberts

“…Parameters of cell and organoid growth were measured, together with qPCR, Western Blotting, and ELISA assessments, in all groups from both organoid models. Here, we report that ACE2 knockout results in delayed placental cell growth and increased cell death. …”
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Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study by Giorgio Bedogni, Roberto Berni Canani, Laura Carucci, Rita Nocerino, Serena Coppola, Pasqualina Capasso, Veronica Giglio

“…Anamnestic and clinical data were collected from all enrolled patients.Results 123 non-IgE-GIFA patients were enrolled (56% male, median age (IQR) 150 (60–300) days): FPE (39%), FPIES (17%), FPIAP (16%) and FPIMD (28%). 42% of patients had multiple food allergies (FAs) at baseline, and 64% had a positive family history of allergy. …”
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Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research by Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai

“…Furthermore, the proportion of reversal gene pairs among all gene pairs involving DEGs remained below 20% in the majority of comparisons. …”
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Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers by Lenzi, Omar, Grossenbacher, Kurt, Zumbach, Silvia, Lüscher, Beatrice, Althaus, Sarah, Schmocker, Daniela, Recher, Helmut, Thoma, Marco, Ozgul, Arpat, Schmidt, Benedikt R.

“…High temperatures and low snow cover in winter and spring, as well as reduced spring precipitation were all associated with earlier breeding. Additionally, we found evidence of males arriving on average before females at the breeding site but no clear and strong effect of the lunar cycle. …”
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Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis by Xavier Benarous, Hélène Lahaye, Angèle Consoli, David Cohen, Réal Labelle, Jean-Marc Guilé

“…The differences in the identification strategy of DMDD were associated with significant heterogeneity between studies in the community-based samples, with a prevalence of 0.82% (95% CI, 0.11–2.13) when all diagnosis criteria were considered. Anxiety, depressive disorders, and ADHD were the most frequent comorbidity present with DMDD. …”
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Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study by Runze Zhu, Wenxian Wang, Yan Gao, Junchuan Liu, Bowen Li, Rongxue Shan, Runjie Xue, Xianshun Yuan, Xi‐Ming Wang

“…Hypertensive patients with LVH exhibited larger indexed EAT volumes, more pronounced diffuse fibrosis, and reduced left ventricular strain compared to hypertensive patients without LVH (all p < 0.001), with results remaining stable after adjusting for confounding factors. …”
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Parental preference for influenza vaccine for children in China: a discrete choice experiment by Gang Chen, Ping Liu, Xiaochen Ma, Hai Fang, Zhiyuan Hou, Hongguo Rong, Xiaozhen Lai, Shunping Li, Tiantian Gong

“…In addition, sociodemographic characteristics were included to explore the preference heterogeneity.Results In general, respondents preferred to vaccinate their children. All attributes were statistically significant and among them, the risk of severe side effects was the most important attribute, followed by the protection rate and duration of vaccine-induced protection. …”
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Exploring the process—structure–property relationship of nylon aramid 3D printed composites and parameter optimization using supervised machine learning techniques by Mohammed Raffic Noor Mohamed, Ganesh Babu Karuppiah, Dharani Kumar Selvan, Rajasekaran Saminathan, Shubham Sharma, Shashi Prakash Dwivedi, Sandeep Kumar, Mohamed Abbas, Dražan Kozak, Jasmina Lozanovic

“…In an 80:20 train-test split, the decision tree approach outperformed the k -nearest neighbor algorithm for all four output responses, with classification accuracy ranging from 83.33% to 100%. …”
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Blood Transfusions in Total Hip and Knee Arthroplasty: An Analysis of Outcomes by Thomas Danninger, Rehana Rasul, Jashvant Poeran, Ottokar Stundner, Madhu Mazumdar, Peter M. Fleischut, Lazaros Poultsides, Stavros G. Memtsoudis

“…The need for a blood transfusion explained 9.51% (95% CI 9.12–9.90) of all major complications. Conclusions. Advanced age and high comorbidity may be responsible for a higher proportion of adverse outcomes in THA and TKA patients than blood transfusions.…”
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Pharmacy students’ opinion on mandatory summer internships carried out in community and hospital pharmacies by Lucyna Bułaś, Anna Gołda, Ewa Długosz, Artur Owczarek, Anna Zagaja, Mariola Drozd

“…For the majority of students the summer internship made them aware of the profession; however, the internship in some pharmacies did not always provide them with all aspects of pharmaceutical practice. 14–40% of students admitted that their mentors did not introduce the internship program at the beginning of the internship. …”
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Gambaran Karakteristik Ibu Hamil pada Persalinan Preterm di RSUP Dr. M. Djamil Padang Tahun 2012 by Verdani Leoni Edrin, Ariadi ., Lili Irawati

“…The population in this study were all of mother who delivered preterm were 72 people. …”
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Palliative care needs and quality of life among adults with advanced chronic illnesses in low-income communities of Bangladesh by Ahmed Hossain, Maruf Hasan, Taifur Rahman, Alounoud Almarzooqi, Syed Azizur Rahman, Heba Hijazi, Mohamad Alameddine

“…Female patients had poorer QOL than males across all domains, and those facing financial hardships also experienced significantly lower QOL. …”
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Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms by Jua Kim, Jeremy L. Gilbert, William W. Lv, Ping Du, Haobo Pan

“…It is still unclear how all these by-products and Mg ions concomitantly alter the microenvironment and cell behaviors spatially and temporally. …”
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Vitamin D Status in Central Europe by Pawel Pludowski, William B. Grant, Harjit Pal Bhattoa, Milan Bayer, Vladyslav Povoroznyuk, Ema Rudenka, Heorhi Ramanau, Szabolcs Varbiro, Alena Rudenka, Elzbieta Karczmarewicz, Roman Lorenc, Justyna Czech-Kowalska, Jerzy Konstantynowicz

“…The longitudinal study reported wintertime 25(OH)D values close to 21–23 ng/mL for all studied age groups, with a significant increase of 25(OH)D in August reaching 42 ng/mL for those aged 0–9 years, but only 21 ng/mL for the elderly aged 80–89 years. …”
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A novel method for calculating number buildup factor in gamma-ray transmission measurements using narrow beam geometry by Chuong Huynh Dinh, Trang Le Thi Ngoc, Linh Nguyen Thi Truc, Nguyen Vo Hoang, Thanh Tran Thien

“…The comparison showed relative deviations below 1 % for all the investigated cases, demonstrating the high accuracy and reliability of the fitting formula.…”
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The Number of Patients with Acute Myocardial Infarction Decreased and Door-to-Balloon Time Delayed in COVID-19 by Tianyi Ma, Yuli Huang, Wensheng Li, Jianghua Zhong, Hui Yang, Yilei Zhou, Meijun Li, Wenhao Zhong, Yue Cao, Shijuan Lu, Yunzhao Hu

“…At present, COVID-19 is sweeping the world, and all countries are actively responding. During the COVID-19 epidemic, the treatment of patients with acute myocardial infarction (AMI) may be affected. …”
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Ten Years of the Global Reform of Financial Regulation: What is ahead? by L. S. Khudyakova

“…That time a range of difficulties and contradictions between leading countries revealed. First of all these problems related to the spheres where the regulations of transnational activities of financial institutions had to be agreed. …”
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Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

“…After accounting for the random effects of the individual workers and working dates (evaluated per occupation) as well as the fixed effects of the determinants and their pairwise interaction terms (p < 0.001), we found that all four of the determinants significantly differed in their associated levels of BC exposure. …”
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A systematic review of serious games as tools for STEM education by Talia Tene, Diego Fabián Vique López, Paulina Elizabeth Valverde Aguirre, Nilo Israel Cabezas Oviedo, Cristian Vacacela Gomez, Stefano Bellucci

“…The analysis also explored challenges related to the implementation of serious games, including technological limitations, the need for comprehensive educator training, and ethical considerations around data privacy, all of which may impact adoption in educational settings.ResultsSerious games demonstrated a positive impact on learning outcomes, such as knowledge acquisition, skill retention, and the application of STEM concepts, along with increased student engagement and motivation. …”
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Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…The treatment of GBM varies from patient to patient, as conventional medical treatments do not apply to all patients with similar symptoms. Therefore, drug efficacy recommendation systems are very useful in the treatment of various types of cancers. …”
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