Understanding crystallinity indexes benchmarking concept from optimized parametric ionic liquid pretreatment using 1-ethyl-3-methylimidazolium Acetate [EMIM]Ac on oil palm biomass by Amizon Azizan, Rosmaria Abu Darim, Intan Suhada Azmi, Rafidah Jalil, Shareena Fairuz Abdul Manaf

“…For this, fifteen (15) sets of pretreatment optimization strategies with the Box-Behnken design method (Response Surface Methodology) solely on oil palm frond (OPF) were further proceeded with using [EMIM]Ac concentration percentages of 20, 40, and 60% (v/v), with OPF solid loading percentages of 5, 10, and 15% (w/v), as well as at reactor temperatures of 90, 110, and 130 °C. All the linear model terms of these independent variables, along with the 2-way interaction model between the ionic liquid and solid loading, were found to be significant to the effect of CrI on the pretreated OPF. …”
Get full text

Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro by Han T, Jia T, Wang J

“…Polymerase chain reaction assays and sequencing techniques were performed to detect well-known molecular determinants related to linezolid resistance, including the expression of optrA and cfr, mutations of 23S rRNA gene and ribosomal protein (L3, L4, L22) encoding genes (rplC, rplD, rplV).Results: After induction with sequentially increasing concentrations of linezolid, all four MRSA strains (L914, L860, L1096, and L2875) evolved into linezolid-resistant strains over various induction times (480, 384, 288, and 240 h) and universally formed small colony variants. …”
Get full text

Reproductive Diseases and Disorders of Female Camels: An Assessment and Pathological and Bacteriological Study in Eastern Ethiopia by Dinaol Belina, Amare Eshetu, Sisay Alemu, Bekyad Shasho, Tajudin Mohammed, Ahmedin Mohammed, Bahar Mummed, Dereje Regassa

“…A total of 155 study animals were examined by recruiting all she-camels slaughtered during every abattoir visit. …”
Get full text

Assessment of WRF Land Surface Model Performance over West Africa by Ifeanyi C. Achugbu, Jimy Dudhia, Ayorinde A. Olufayo, Ifeoluwa A. Balogun, Elijah A. Adefisan, Imoleayo E. Gbode

“…Based on precipitation and temperature, Noah-MP GW is overall the best for all the variables and seasons in combination, while Noah came last. …”
Get full text

Gambaran Klinis dan Endoskopi Saluran Cerna Bagian Atas Pasien Dispepsia di Bagian RSUP Dr. M. Djamil Padang by Citra Yuriana Putri, Arnelis ., Asterina .

“…<br clear="all" /><p><strong>Abstrak</strong></p><p>Dispepsia ialah suatu sindrom yang terdiri dari nyeri atau rasa tidak nyaman di ulu hati, kembung, mual, muntah, sendawa, rasa cepat kenyang, perut rasa penuh/begah. …”
Get full text

Detection and subtyping of Blastocystis sp. in human and animal stool samples using high-resolution melting analysis by Ghodratollah Salehi Sangani, Ahmad Hosseini-Safa, Bibi Razieh Hosseini Farash, Pooria Salehi Sangani, Mehdi Zarean, Elham Moghaddas, Saeid Zoghdar Moghadam, Lida Jarahi, Ali Gholizadeh, Fariba Berenji

“…Conclusion ST3 (28%) and ST7 (30%) were the most prevalent subtypes across all samples, with distinct distributions in human and animal hosts. …”
Get full text

In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications by Tan Dat Nguyen, Thanh Truc Nguyen, Khanh Loan Ly, Anh Hien Tran, Thi Thanh Ngoc Nguyen, Minh Thuy Vo, Hieu Minh Ho, Ngoc Thao Nhi Dang, Van Toi Vo, Dai Hai Nguyen, Thi Thu Hoai Nguyen, Thi Hiep Nguyen

“…The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.…”
Get full text

Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Pilot Randomized Controlled Trial by Hanna Johansson, Malin Freidle, Urban Ekman, Ellika Schalling, Breiffni Leavy, Per Svenningsson, Maria Hagströmer, Erika Franzén

“…With regard to dual-task gait performance, there appeared to be a ceiling effect of the cognitive tasks with seven participants scoring all correct answers at pretest. Blinding of group allocation was successful for one assessor but was broken for half of participants for the other. …”
Get full text

Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings by Hiroshi Hamada, Kenichi Kohashi, Takeshi Iwasaki, Mikiko Hashisako, Yuko Hino, Masahiro Fukuhara, Amane Kamouchi, Naonori Kawakubo, Tatsuro Tajiri, Yoshinao Oda

“…Reverse transcription-polymerase chain reaction was performed for the NTRK gene fusion and EGFR-ITDs in all cases. Comprehensive mRNA analysis was performed using the nCounter® Gene Expression Assay. …”
Get full text

Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…Generally, hepatic PPARα of mPPARα mice was more strongly activated than that of hPPARα mice when several target genes involving β-oxidation of fatty acids were evaluated. Interestingly, all plasticizers also activated hepatic constitutive androstane receptor (CAR) more in hPPARα mice than in mPPARα mice. …”
Get full text

Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers by Ping Jin, Juan Ma, Peng Wu, Yitong Bian, Xueping Ma, Shaobin Jia, Qiangsun Zheng

“…Both Hcy and PCSK9 levels were independently linked to a heightened risk of severe coronary lesions(ORs: 1.03–1.04 and 1.01–1.02, respectively, all P < 0.001). PCSK9 mediated 34.04% of Hcy’s effect on coronary lesion severity, whereas Hcy mediated 31.39% of PCSK9’s effect, indicating significant mutual mediation between these biomarkers. …”
Get full text

A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality by Jain Nem Kumar, Tailang Mukul, Thangavel Neelaveni, Makeen Hafiz A., Albratty Mohammed, Najmi Asim, Alhazmi Hassan Ahmad, Zoghebi Khalid, Alagusundaram Muthumanickam, Jain Hemant Kumar, Chandrasekaran Balakumar

“…This review highlights the current clinical progress concerning the safety and efficacy of all the approved FGFR-TKIs (tyrosine kinase inhibitors) and their ongoing investigations in clinical trials for other oncogenic FGFR-driven malignancies.…”
Get full text

The use of emergency medical services for palliative situations in Western Cape Province, South Africa: A retrospective, descriptive analysis of patient records by C Gage, B Spies, K Crombie, L Gwyther, W Stassen

“…An observational, descriptive, retrospective patient record review was employed at two hospitals with palliative care services in the WC. All patient records of those who arrived at the hospitals between 1 January 2020 and 31 December 2020 via EMS conveyance leading to palliative care provision were included in the study. …”
Get full text

Assessing the resilience of child immunisation programmes using geospatial modelling and interrupted time series analysis in Ethiopia and Kenya amidst the COVID-19 pandemic: tracki... by McEwen Khundi, Themba Mzembe, Michael Give Chipeta, Chimwemwe Chifungo, Nyovani Janet Madise, Chifuniro Somanje Mankhwala, Tabitha Ngwira, Maame B Peterson

“…Measles vaccine coverage experienced major changes across almost all regions of Ethiopia. In Kenya, full vaccination coverage experienced significant changes in eight counties, including Kisii, Turkana and Marsabit, with most Kenyan counties experiencing significant changes in measles vaccine coverage.Conclusion In conclusion, while routine immunisation services were mostly sustained with short-term disruptions at the national level in Ethiopia and Kenya, subnational levels experienced notable changes. …”
Get full text

Adaptation of the five-factor BFI-10 personality screening questionnaire and testing of its diagnostic properties on the example of drug users by О. О. Serdiuk, В. О. Bazyma

“…There is a positive correlation between the total values of the scales of all three questionnaires of the "big five", significant at the level of p <0.01. …”
Get full text

Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…Objective Our objective of this study was to analyse all oncological clinical trials using regorafenib to create a complete risk/benefit profile for the drug.Background Creating a novel chemotherapy is costly both in time and capital spent for drug manufacturers. …”
Get full text

Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab by Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh, Holland C. Detke

“…During the 3-month double-blind treatment period, a greater percentage of galcanezumab-treated patients shifted to EM frequency and maintained it across all 3 months (31.5%) than did placebo-treated patients (19.8%, p < 0.001). …”
Get full text

Itinerarios para la formación de la ciudadanía de acuerdo con la Agenda 2030. Literatura infantil y ODS / Itineraries for citizenship education in accordance with the 2030 Agenda.... by Lourdes Hernández Delgado, Amando López Valero

“…For these narratives, a dialogic proposal is chosen, which encourages critical knowledge of the texts and allows the reading and literary process to be understood in all its breadth. The conclusion reached allows us to understand that children's literature is not limited to a possible didacticism, but combines formative processes with playfulness. …”
Get full text

Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases by T. O. Holovko, L. F. Bohmat, N. S. Shevchenko, Yu. V. Volkova, L. L. Sukhova, O. S. Pavlova

“…Obtained results were compared with similar indicators of peers from the control group. All patients received basic therapy for 12 or more months at the time of examination. …”
Get full text

Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study by Stefan Teipel, Manas Akmatov, Bernhard Michalowsky, Steffi Riedel-Heller, Jens Bohlken, Jakob Holstiege

“…Of the 63 risk factors and prodromal features examined, 56 were associated with an increased risk of dementia in all years during the 10th and the 1st year before the index date. …”
Get full text