Pharmacometabolomics Enables Real-World Drug Metabolism Sciences by Fleur B. Nijdam, Marieke A. J. Hof, Hans Blokzijl, Stephan J. L. Bakker, Eelko Hak, Gérard Hopfgartner, Frank Klont, on behalf of the TransplantLines Investigators

“…However, these genotypes rely heavily on the availability and completeness of drug metabolism information and do not account for (all) “phenoconversion” factors, like drug–drug interactions and comorbidities. …”
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Assessment of improvement in functional outcomes between a novel knee replacement design and conventional designs in 240 patients: a randomized controlled trial by Tero Irmola, Aleksi Reito, Jarmo Kangas, Antti Eskelinen, Mika Niemeläinen, Ville M Mattila, Teemu Moilanen

“…The OKS exceeded minimal clinical important difference (MCID) from baseline to 2 years in all 3 treatment groups (Persona CR: 18.9 points, PFC CR: 20.3 points, NexGen CR: 19.4 points). …”
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Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China by Jin-Ping Zhang, Gonzalo Avila, Gang Ma, Qian-Qian Mi, Adriana Najar-Rodriguez, Ju-Hong Chen, Chun-Sen Ma, Feng Zhang

“…Results Although trapped BMSB numbers were generally low across all traps tested, the black corflute trap was found to attract the highest average number of BMSB males and females, followed by the wooden-made trap, the bee-hive box and finally the wooden-made locked trap, which attracted the lowest numbers of BMSB. …”
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Evaluation of the Clinical Efficacy of Prednisolone in the Treatment of Inflammatory Bowel Diseases with Different Dosage Methods by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…In this study were included 86 patients aged from 18 to 65 years with moderate or severe active inflammatory bowel disease (61 — UC, 25 — CD). All patients were treated with prednisolone at an initial daily dose from 30 to 60 mg with a subsequent tapering of dose. …”
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Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years by Christos Grigoroglou, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Salwa S Zghebi, Rosa Parisi, Brian McMillan

“…Three measures of diversity (Shannon entropy index of diversity, richness and evenness) were used to quantify changes in incident and total clinical codes.Results Overall, all examined conditions, except LD, showed positive monotonic correlation. …”
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Clinical characteristics, therapeutics, and treatment outcomes of adult patients with anti-melanoma differentiation-associated gene 5 dermatomyositis: A single-center experience fr... by Shivraj Padiyar, Aswin M Nair, Bijesh Yadav, Prathyusha Manikuppam, Jha Avanish, Abhilasha Arvind Manwatkar, John Mathew

“…Methods: This was a retrospective study done between 2019 and 2021 in a tertiary care center in South India. All consecutive patients, presenting to the adult rheumatology department, classified as idiopathic inflammatory myositis (IIM), and positive for anti-MDA5 antibodies, were included in the study. …”
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Tapinarof Improved Outcomes and Sleep for Patients and Families in Two Phase 3 Atopic Dermatitis Trials in Adults and Children by Eric L. Simpson, Adelaide A. Hebert, John Browning, Rocco T. Serrao, Howard Sofen, Philip M. Brown, Stephen C. Piscitelli, David S. Rubenstein, Anna M. Tallman

“…Tapinarof improved QoL versus vehicle across all endpoints at week 8: DLQI, − 6.2 vs − 3.5 (P = 0.0031) and − 5.5 vs − 3.5 (P = 0.0028); DFI, − 5.6 vs − 2.9 (P < 0.0001) and − 5.6 vs − 3.8 (P = 0.0037), in ADORING 1 and 2, respectively. …”
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Efek Pemberian Suntikan Subkutan Vitamin C Terhadap Luka Insisi Dermal by Surya Darma, Menkher Manjas, Deddy Saputra, Salmiah Agus, Erkadius .

“…Method:This experimental study used32 Wistar rats, divided into two group that is 16 rats as control and 16rats as experimental group. All groups underwent 2 cm long incision at the back. …”
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Role of Advanced Glycation End Products in Mediating Glycated Haemoglobin and Pulse Wave Velocity in Healthy Adults by Irene Martínez-García, Alicia Saz-Lara, Carlos Pascual-Morena, Ana Díez-Fernández, Sara Valladolid-Ayllón, Bruno Bizzozero-Peroni, Óscar Martínez-Cifuentes, Eva Rodríguez-Gutiérrez, Iván Cavero-Redondo

“…Descriptive and exploratory analyses revealed that when the models were adjusted to include all covariates, the statistical significance of the main association disappeared. …”
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Paraspinal muscle volume and fatty infiltration after circumferential minimally-invasive deformity correction by John Paul G. Kolcun, Ryan M. Kelly, Bradley L. Kolb, Dustin H. Kim, Alireza Borghei, John E. O'Toole, Richard G. Fessler

“…On average, patients underwent interbody fusion at 3.8 ± 0.9 disc levels and posterior instrumentation at 4.6 ± 1.7 vertebral levels. All constructs included lateral interbody fusion (average 2.7 ± 0.8 levels); 6 were from a right-sided approach. …”
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Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway by Laura Dougherty, Bret Cooper, James Bunce, Bryan Vinyard, John Stommel

“…The number of fruit was similarly greater (1.4- to 4.2-fold) in modified plants; however, average individual fruit weights were significantly less for all but one line. Among transformed lines, larger fruited lines had the lowest biomass, while the smaller fruited lines had the highest biomass. …”
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A Rare Malignant Peripheral Nerve Sheath Tumor of the Maxilla Mimicking a Periapical Lesion by José Alcides Arruda, Pamella Álvares, Luciano Silva, Alexandrino Pereira dos Santos Neto, Cleomar Donizeth Rodrigues, Antônio Caubi, Marcia Silveira, Sandra Sayão, Ana Paula Sobral

“…About 50% of this tumor occurs in patients with neurofibromatosis type I and comprises approximately 10% of all soft tissue sarcomas of head and neck region. …”
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The relationship between negative psychological state and quality of life among cardiovascular disease patients in China: the masking effect of abnormal dietary behavior by QingNing Chang, QingNing Chang, HaiBo Ma, Can Zhang, Xin Li, YiBo Wu, LiNa Ha

“…Data were collected using the Europe Quality of five-dimensional five-level questionnaire, Short-Form of the Eating Behavior Scale, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and the Chinese version of the short-form of the Family Health Scale. All data were analyzed using SPSS Statistics 23.0.Results(1) Depression was negatively associated with QoL (r = −0.386/−0.230, p &lt; 0.001), and was positively correlated with abnormal dietary behavior (r = 0.377, p &lt; 0.001). …”
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Tc99m-DTPA Study to Validate an Experimental Model of Ureteral Obstruction in Rabbits: Preliminary Results by Marcelo Lopes de Lima, Rodolfo Bertti, Juliano César Moro, Fábio Coltro Neto, Ricardo Miyaoka, Adriano Fregonesi, Mariana da Cunha Lopes de Lima, Celso Darío Ramos

“…Nine of the ten rabbits presented left renal unit obstruction and one nonobstructive on the Tc99m-DTPA and histopathological studies. All the right renal units, which were not submitted to surgical procedure, were nonobstructed by the studies. …”
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Treatment-related toxicity, utility and patient-reported outcomes of head and neck cancer patients treated with proton therapy: A longitudinal study by Yi Hsuan Chen, Michiel Kroesen, Mischa Hoogeman, Matthijs Versteegh, Carin Uyl-de Groot, Hedwig M. Blommestein

“…Symptom and function scores showed the deterioration of all reported functions during the period of treatment. …”
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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…Methods: Using the PubMed database, we searched for articles in English, published until June 1, 2023, whose title and/or abstract contained terms related to AMD and infections. All types of study design, infectious agents, AMD diagnostic methods, and AMD stages were considered. …”
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Irreducible representation of surface distributions and Piola transformation of external loads sustainable by third gradient continua by dell’Isola, Francesco, Fedele, Roberto

“…Moreover we find that: a) the virtual work expended by Eulerian surface triple force, when transformed into the Lagrangian description, must be represented as the work expended by all the kinds of external Lagrangian loads listed in i)-vii); b) Eulerian surface double force transforms into Lagrangian surface double force, surface contact force and edge contact line force; c) Eulerian edge contact line double force transforms into Lagrangian edge contact line double forces, edge line forces and point concentrated wedge forces; d) Eulerian edge and wedge contact line forces transforms into their Lagrangian counterpart only. …”
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Heatstroke characteristics and meteorological conditions in Hefei, China: thresholds and driving factors by Xueliang Deng, Liang Zhao, Changchun Xiao, Rui Dai, Qianqian Xu, Yeqing Yao, Caimeng Liang, Lei Yao, Dongyan He

“…Results The number of heatstroke cases fluctuated upward from 36 cases in 2008 to 1051 cases in 2022, with 71.5% of all cases for males and females accounting for 28.5%. …”
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Using Dose-Effect Relationship for Optimising Systemic Corticosteroid Dosage in Treatment of Inflammatory Bowel Diseases by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…The study included 86 patients with moderate to severe active disease (61 with UC and 25 with CD) aged 18 to 65 years. To induce remission, all patients had the first course of prednisone at a starting dose of 30 to 60 mg/day, with a subsequent reduction. …”
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Clinical and Radiographic Outcomes of Gap Osteotomy Versus Dorsal Opening Wedge Osteotomy for Extra-Articular Distal Radius Malunion and Internal Fixation Using a Volar Locking Pla... by Suhas Sondur, MS (Ortho), Anil K. Bhat, MS (Ortho), DNB (Ortho), Shyamasunder Bhat N, MS (Ortho), DNB (Ortho)

“…The functional assessment comprised the disabilities of arm, shoulder, and hand questionnaire and the patient-rated wrist evaluation scores. Results: All patients had a union of the osteotomy and statistically significant improvement in the radial height, inclination, ulnar variance, and tilt, irrespective of the osteotomy technique (P < .05). …”
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