Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines by David M. Renner, Nicholas A. Parenti, Nicole Bracci, Susan R. Weiss

“…We demonstrate that MERS-CoV, HCoV-OC43, and SARS-CoV-2 all activate PERK and induce responses downstream of p-eIF2α, while only SARS-CoV-2 induces detectable p-eIF2α during infection. …”
Get full text

STUDY OF VEGF-A AND TGF-Β LEVELS IN BIOPTATES OF SQUAMOUS CELL CARCINOMA OF THE TONGUE AND MOUTH FLOOR MUCOSA IN POLYCHEMOTHERAPY WITH MONOCLONAL ANTIBODIES – CETUXIMAB by O. I. Kit, E. M. Frantsiyants, I. V. Neskubina, L. Yu. Vladimirova, A. A. Lyanova, Yu. A. Pogorelova, E. V. Shalashnaya, M. A. Еngibaryan, Yu. S. Sidorenko

“…The study included 30 patients with squamous cell carcinoma of the tongue and mouth floor mucosa (T3-4N0-1M0). All patients received 2 cycles of therapy: cisplatin 100 mg/m2 , intravenously, day 1, 5-fluorouracil 1000 mg/m2 /day, intravenously, 96-hour continuous infusion in combination with targeted therapy (cetuximab 400 mg/ m2 on day 1 in a loading dose, then 250 mg/m2 on days 8 and 15). …”
Get full text

Association of only-child status and household pet ownership with attention-deficit/hyperactivity disorder among Chinese preschool children: a population-based study by Yuying Zhang, Shuangyan Qiu, Vivian Yawei Guo, Weiqing Chen, Xiaomei Han, Weikang Yang

“…ADHD symptoms were assessed using the 26-item Swanson, Nolan, and Pelham Rating Scale as reported by parents.ResultsThis study included 63,282 children (mean age: 4.86 ± 0.85 years, 53.6% boys), representing 72.6% of all preschool children in this district in 2021. …”
Get full text

A Pervasive Approach to EEG-Based Depression Detection by Hanshu Cai, Jiashuo Han, Yunfei Chen, Xiaocong Sha, Ziyang Wang, Bin Hu, Jing Yang, Lei Feng, Zhijie Ding, Yiqiang Chen, Jürg Gutknecht

“…The electroencephalogram (EEG) signals of all participants under resting state and sound stimulation were collected using a pervasive prefrontal-lobe three-electrode EEG system at Fp1, Fp2, and Fpz electrode sites. …”
Get full text

Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study by Neil A Harrison, Hugo D Critchley, Jessica Eccles, Kevin A Davies, Lisa Quadt, Rod Bond, Jenny Csecs

“…Inflammation at age 9 years mediated effects of neurodivergent traits on chronic disabling fatigue (indirect effect via IL-6: ADHD b=1.08 (95% CI=1.01 to 1.15); autism b=1.06; (95% CI=1.03 to 1.10)). All effects remained significant when controlling for the presence of depressive symptoms.Conclusions Our results indicate higher risk of chronic disabling fatigue for children with neurodivergent traits, likely linked to higher levels of inflammation. …”
Get full text

Clinical Comparative Study of Intravitreal Injection of Triamcinolone Acetonide and Aflibercept in the Treatment of Diabetic Retinopathy Cystoid Macular Edema by Yanxia Zhu, Jun Li, Songping Yu, Bangxun Mao, Jia Ying

“…According to random number table method, they were divided into the control group (intravitreal injection of triamcinolone acetonide) and the observation group (intravitreal injection of aflibercept), 51 cases in each group. All were followed up for half a year. The clinical curative effect, visual acuity, central subfield macular thickness (CSMT), macular volume, scores of quality of life, and levels of cytokines in aqueous humor (vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), human angiopoietin-like protein 4 (ANGPTL4)] at different time points (before and at 6 months after surgery) were compared between the two groups. …”
Get full text

Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Linear regression analysis revealed that glycemic status, circulating lipids, and sciatic nerve sorbitol level were all negatively associated with the small nerve fiber damage observed. …”
Get full text

FRR: A Fast Routing Recovery mechanism minimizing network formation time in smart grids by Giancarlo C. Heck, Ananias A. Quispe, Patryk H. da Fonseca, Osni S. Junior, Roberto A. Hexsel, Luiz C.P. Albini

“…The adopted standards allow Wi-SUN FAN networks to take advantage of features such as security, frequency hopping, multi-hop packet routing, and IPv6 addressing, ensuring a wide coverage area and immunity against electromagnetic interference. Despite all the advantages, a shortcoming of Wi-SUN FAN networks is the long network formation time. …”
Get full text

The Characteristic of Biofilm Formation in ESBL-Producing K. pneumoniae Isolates by Xiaofang Gao, Haili Wang, Zhijuan Wu, Pan Sun, Wei Yu, Donghua Chen, Yuhua Mao, Lili Fang, Jia Qian, Li Li, Qian Peng, Yanping Han

“…Approximately 84% (21/25) of the clinical patients had a history of surgery, urinary tract catheterization, and/or arteriovenous intubation, all of which may have increased the risk for nosocomial infections. …”
Get full text

Assessing prevalence and predictors of impaired awareness of hypoglycemia in type 2 diabetes patients with chronic kidney disease by Amin Soliman, Noran Atef El Kordy, Farouk Mostafa Faris, Rabab Mahmoud Ahmed

“…Abstract Background This study aims to determine the prevalence of impaired awareness of hypoglycemia (IAH) across all chronic kidney disease stages in patients with type 2 diabetes mellitus and to identify predictors of impaired awareness of hypoglycemia within these patients. …”
Get full text

<i>Toxoplasma gondii</i> and Rabies—The Parasite, the Virus, or Both? by Ragan Wilson, Shannon Caseltine, Edith Will, Jeremiah Saliki, Ruth C. Scimeca

“…Analysis among <i>T. gondii</i>-positive hosts revealed a statistically significant difference in dogs when comparing neutered vs. intact males, with 7.94% (5/63) <i>T. gondii</i>-positive neutered males and 1.61% (3/186) <i>T. gondii</i>-positive intact males (<i>p</i> = 0.02). All the <i>T. gondii</i>-positive samples were negative for rabies. …”
Get full text

Cooperative Overbooking-Based Resource Allocation and Application Placement in UAV-Mounted Edge Computing for Internet of Forestry Things by Xiaoyu Li, Long Suo, Wanguo Jiao, Xiaoming Liu, Yunfei Liu

“…Multiple IoFT applications can be consolidated into fewer UAV-mounted servers to improve the resource utilization and reduce deployment costs with the precondition that all applications’ Quality of Service (QoS) can be met. …”
Get full text

Intercostal Nerve Cryoablation During Lobectomy for Postsurgical Pain: A Safe and Cost-Effective Intervention by Daniel L. Miller, Jacob Hutchins, Michael A. Ferguson, Yazid Barhoush, Emily Achter, John P. Kuckelman

“…Methods A retrospective, propensity matched cohort of surgical patients treated between 2016 and 2022 from a US National All-Payer Database were used. Cost and outcome comparisons were made between groups using chi-square and t tests. …”
Get full text

Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…Results A total of 142 patients were enrolled and categorized into voriconazole group (n = 92), echinocandins group (n = 26) and a combination of voriconazole and echinocandins group (n = 24). The 28-day all-cause mortality was lower in voriconazole group compared to the other groups (p = 0.033). …”
Get full text

Multi-model Evaluation and Bayesian Model Averaging in Quantitative Air Quality Forecasting in Central China by Haixia Qi, Shuangliang Ma, Jing Chen, Junping Sun, Lingling Wang, Nan Wang, Weisi Wang, Xiefei Zhi, Hao Yang

“…The prediction effect for PM2.5 and O3 was ranked as CUACE > CMAQ > NAQP and the prediction effect for SO2, NO2 and CO was CMAQ > NAQP > CUACE. All the models systematically underestimated O3 and heavy PM2.5 pollution events. …”
Get full text

Advanced groundwater potential and contamination vulnerability assessment using integrated GIS-based AHP techniques: A case study from the Bizerte watershed, Tunisia by Cyrine Belhadj, Rihab Riahi, Abdelaziz Sebei, Sinda Sifi, Noamen Rebai

“…In Bizerte, Tunisia (Southwest Mediterranean region), this need is particularly urgent due to rising demand and contamination risks, aligning with Sustainable Development Goal 6 (SDG 6), which seeks to ensure the availability and sustainable management of water and sanitation for all. This research aims to enhance groundwater management and assess contamination risks in Bizerte using the Analytic Hierarchy Process (AHP). …”
Get full text

Bovine Tuberculosis in a Nebraska Herd of Farmed Elk and Fallow Deer: A Failure of the Tuberculin Skin Test and Opportunities for Serodiagnosis by W. Ray Waters, Gary E. Stevens, Mark A. Schoenbaum, Kathy A. Orloski, Suelee Robbe-Austerman, N. Beth Harris, S. Mark Hall, Bruce V. Thomsen, Arach J. Wilson, Roger E. Brannian, Jeffrey T. Nelson, Shawn Schafer, Javan Esfandiari, Meghan Dutton, Rena Greenwald, Konstantin P. Lyashchenko

“…One year ago, the majority of the elk had been tested for TB by single cervical test (SCT), and all were negative. After initial detection of a tuberculous elk in this herd, 42 of the 59 elk were tested by SCT. …”
Get full text

Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…It also showed excellent recoveries (79.24%∼94.16% for all analytes) and absence of significant matrix effect. …”
Get full text

Effect of integrated case-based and problem-based learning on clinical thinking skills of assistant general practitioner trainees: a randomized controlled trial by Dingyuan Jiang, Danpei Huang, Hua Wan, Wuliang Fu, Weidong Shi, Jin Li, Huan Zou, Niannan Hou, Qing Li, Nani Li

“…Results Compared with the LBL group, the CBL-PBL group showed significantly improved performance in all domains assessed by the CTSES in post-course tests (p < 0.001). …”
Get full text

Microbial Contamination and Food Safety Aspects of Cassava Roasted Flour (“Rale”) in Mozambique by Andreia Massamby, Su-lin L. Leong, Bettina Müller, Lucas Tivana, Volkmar Passoth, Custódia Macuamule, Mats Sandgren

“…The results revealed variation in terms of microbial diversity in all stages of cassava root processing. In samples collected in the warmer rainy season, molds, lactic acid bacteria, general aerobic bacteria and <i>Bacillus</i> spp. were isolated, whereas in samples collected in the cooler dry season, other groups of microorganisms such as yeasts and <i>Staphylococcus aureus</i> were present. …”
Get full text