Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes by Ying Yang, Tai-Cheng Zhou, Yong-Ying Liu, Xiao Li, Wen-Xue Wang, David M. Irwin, Ya-Ping Zhang

“…Maturity-onset diabetes of the young (MODY) is characterized by the onset of diabetes before the age of 25 years, positive family history, high genetic predisposition, monogenic mutations, and an autosomal dominant mode of inheritance. …”
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Insights into the tectonic evolution of the Svecofennian orogeny based on in situ Lu–Hf dating of garnet and apatite from Olkiluoto, southwestern Finland by J. Engström, J. Engström, K. Cutts, S. Glorie, E. Heilimo, E. M. Jolis, R. M. Michallik

“…Based on the metamorphic constraints and obtained ages, we link the Olkiluoto site to the Häme orogenic belt in southern Finland and also support the proposed thermal–tectonic connection with the Ljusdal lithotectonic unit in central Sweden.…”
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Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study by Sam Salek, Samantha Nier, Zack Pemberton-Whiteley, Tatyana Ionova, Giuseppe Ianni, Giovanni Tripepi, Nick York, Nicole Schroeter, Kathryn Huntley, Michael Rynne, Denis Costello, Lidija Pecova, Esther Natalie Oliva

“…HM-PRO scores were inversely correlated both with age (ρ= –0.24, p<0.001) and years living with the disease (ρ= –0.14, p<0.001).ConclusionPatients reported the greatest concerns over their future treatment and future health, as well as concerns over dying and being a burden to others. …”
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A Novel Myosin Essential Light Chain Mutation Causes Hypertrophic Cardiomyopathy with Late Onset and Low Expressivity by Paal Skytt Andersen, Paula Louise Hedley, Stephen P. Page, Petros Syrris, Johanna Catharina Moolman-Smook, William John McKenna, Perry Mark Elliott, Michael Christiansen

“…The penetrance, if we consider this borderline HCM the phenotype of the p.V79I mutation, was 40%, but the mean age of the nonpenetrant mutation carriers is 15, while the mean age of the penetrant mutation carriers is 47. …”
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The Outcomes of Gestational Diabetes Mellitus after a Telecare Approach Are Not Inferior to Traditional Outpatient Clinic Visits by Natalia Pérez-Ferre, Mercedes Galindo, M. Dolores Fernández, Victoria Velasco, Isabelle Runkle, M. José de la Cruz, Patricia Martín Rojas-Marcos, Laura del Valle, Alfonso L. Calle-Pascual

“…The percentage of women achieving HbA1c values <5.8%, normal vaginal delivery and having a large for-gestational-age newborn were evaluated. Results. Despite a significant reduction in outpatient clinic visits in the experimental group, particularly in insulin-treated women (2.4 versus 4.6 hours per insulin-treated woman resp.; P<.001), no significant differences were found between the experimental and traditional groups regarding HbA1c levels (all women had HbA1c <5.8% during pregnancy), normal vaginal delivery (40.8% versus 54.2%, resp.; P>.05) and large-for-gestational-age newborns (6.1% versus 8.3%, resp.; P>.05). …”
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Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation by Inmaculada Gayoso, Sara Cantisán, Carolina Cerrato, Joaquín Sánchez-García, Carmen Martin, Rafael Solana, Antonio Torres-Gomez, Julian Torre-Cisneros

“…In addition, a detectable IFN-γ production in response to HCMV peptides (cutoff 0.2 IU/mL IFN-γ; “reactive” QuantiFERON-HCMV test) was statistically associated with HCMV replication after transplantation (OR=11; P=0.026), recipients ≥40 versus <40 years old (OR=11; P=0.026), and the use of peripheral blood versus bone marrow as stem cell source (OR=17.5; P=0.024). In conclusion, donor age is the only factor significantly associated with the presence of the “differentiated phenotype” in HCMV-specific CD8+ T cells, whereas HCMV replication after transplantation, recipient age, and stem cell source are the factors associated with the production of IFN-γ in response to HCMV epitopes.…”
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iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study by Peter D. Westenskow, Felicitas Bucher, Stephen Bravo, Toshihide Kurihara, Daniel Feitelberg, Liliana P. Paris, Edith Aguilar, Jonathan H. Lin, Martin Friedlander

“…Photoreceptors rely heavily on the RPE, and death or dysfunction of RPE is characteristic of age-related macular degeneration (AMD), a very common neurodegenerative disease for which no cure exists. …”
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Uncovering antidepressant prescription patterns: a three-year analysis of outpatient trends by Hossein Karami, Reza Mehrizi, Mohammad Effatpanah, Azamsadat Rivandi, Rajabali Daroudi, Nezam Armand, Leila Ghamkhar

“…ADs prescriptions increased with age, and females were more likely to receive TCAs and SNRIs than males, who had higher rates of atypical ADs use. …”
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Identification of blood plasma protein ratios for distinguishing Alzheimer's disease from healthy controls using machine learning by Ali Safi, Elisa Giunti, Omar Melikechi, Weiming Xia, Noureddine Melikechi

“…In this study, we analyzed the plasma proteomic profiles of 38 healthy individuals, with an average age of 66.5 years, and 22 patients with Alzheimer's disease, with an average age of 79.7 years. …”
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Considerable decline in prostate cancer mortality in Nordic countries after 2000 by Rune Kvåle, Giske Ursin, Christian Ekanger, Bjørn Møller

“…Results: Between 1995–99 and 2018–22, mortality in men aged 40–84 years decreased from 38% in Denmark to 59% in Norway. …”
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Sex Differences in the Effect of Type 2 Diabetes on Major Cardiovascular Diseases: Results from a Population-Based Study in Italy by Paola Ballotari, Francesco Venturelli, Marina Greci, Paolo Giorgi Rossi, Valeria Manicardi

“…The age- and sex-specific event rates were graphed. …”
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Elevated Incidence of Fractures in Solid-Organ Transplant Recipients on Glucocorticoid-Sparing Immunosuppressive Regimens by B. J. Edwards, A. Desai, J. Tsai, H. Du, G. R. Edwards, A. D. Bunta, A. Hahr, M. Abecassis, S. Sprague

“…Transplants included 19 kidney/liver (50% male), 47 kidney/pancreas (53% male), 92 liver (65% male), and 17 pancreas transplants (41% male). Age at transplant was 50.8±10.3 years. Fractures were equally seen across both genders and transplant types. …”
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Clinical, Epidemiological and Therapeutic Characteristics of Patients Admitted for a Bronchial Asthma Attack by Juan Carlos Yanes Macías, Juan Camilo Díaz Ceballos, Mercedes Fonseca Hernández, Ileana García Rodríguez, Caridad Llul Tombo, Daimy Tio González

“…The variables were analyzed: age, sex, skin color, classification of the asthmatic disease, severity of the crisis on admission, and form of drug distribution. …”
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Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study by Yue Yang, Zheng Zhang, Hai-tao Lu, Qian-qian Xu, Li Zhuo, Wen-ge Li

“…This study applied bivariate causal analysis and two-sample Mendelian randomization (MR) methods to examine the association between various smoking behaviors – initiation, cessation, age at initiation, cigarettes smoked per day, and lifetime smoking – and CKD, using genome-wide data. …”
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Efficacy of identifying Treatment-Resistant and non-Treatment-Resistant Schizophrenia using niacin skin flushing response combined with clinical feature by Jizhi Wang, Jinfeng Wang, Siyuan Wang, Yu Gu, Kai Liang, Yingxu Li, Zheng Zhang, Yan Li, Xiaoping Wang, Huijuan Guo, Jiansong Zhou

“…Age of first onset, course of disease, RBANS total score, and NSFR were poor indicators for identifying TRS and NTRS. …”
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Role of Ultrasound-guided Tru-cut Needle Biopsy in the Diagnosis of Suspicious Breast Masses at South Valley University Hospitals by Ghada M. Abd ElRazik, Dalia Besharii Hamada, Mohammed M. Mubarak, Ahmed M. Khalaf-Awad

“…Results: Participants (mean age 50.9 ± 10.1 years) had palpable masses (96%), mainly on the right, and 84% used ultrasound. …”
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The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats by Shan Huang, Wenfang Peng, Xiaohong Jiang, Kan Shao, Lili Xia, Yubin Tang, Jiayin Qiu

“…In addition, the levels of serum NO and insulin were significantly increased and the serum levels of HbA1C, AGES, APN, and apelin were significantly decreased in groups 4 and 5 compared with group 2. …”
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Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure by Carlo Alberto Cutolo, Chiara Bonzano, Carlo Catti, Alessandro Bagnis, Riccardo Scotto, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso

“…Results. 44 patients with PAC were included in the study. The mean (SD) patient age was 71.6 (10.2) years; thirty-one (70.5%) of them were women. …”
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Early Maladaptive Schemas in the Patients with Somatoform Disorders by &Yacute;smet K&yacute;rp&yacute;nar, Erdem Deveci, Demet Zihni &Ccedil;amur, Alperen K&yacute;l&yacute;&ccedil;

“…Method: We investigated a total of 28 patients aged 18-65 years, were diagnosed as Hypochondriasis or Somatization Disorder according to DSM-IV and 30 healthy controls. …”
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Dog Bites and Rabies in the Eastern Region of Ghana in 2013–2015: A Call for a One-Health Approach by Boakye-Yiadom Adomako, Frank Baiden, Samuel Sackey, Donne Kofi Ameme, Fred Wurapa, Kofi Mensah Nyarko, Ernest Kenu, Edwin Afari

“…The median age of victims was 9 years (range: 3-72 years). …”
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