Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…It can act on mitogen-activated proteinase 1 (MAPK1), serine/threonine protein kinase (AKT1), tumor protein p53 (TP53), transcription factor AP-1 (JUN), tumor necrosis factor (TNF), interleukin-6 (IL-6), which can regulate MAPK, AGEs-RAGE, PI3K-Akt, Toll-like receptors, HIF-1, TNF signaling pathways, etc. ④ The molecular docking results showed that, the molecular docking affinity between the active ingredients of <italic>Coptis chinensis</italic> and the above core targets was less than -7.0 kcal/mol (1 kca/mol=4.186 kJ/mol), and the binding activity was better.Conclusion<italic>Coptis chinensis</italic> may play an important role in the treatment of type 2 diabetes mellitus and its complications by regulating glucose and lipid metabolism, inflammatory response, cell proliferation and apoptosis and promoting oxidative stress, etc.…”
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Understanding the relationship between the frequency of HbA1c monitoring, HbA1c changes over time, and the achievement of targets: a retrospective cohort study by Elton Mukonda, Diederick J. van der Westhuizen, Joel A. Dave, Susan Cleary, Luke Hannan, Jody A. Rusch, Maia Lesosky

“…Research design and methods The study utilised routinely collected HbA1c test data on patients with diabetes aged ≥ 18 years in the Western and Northern Cape between 2015 and 2020. …”
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Experiences of midwifery students and graduates in Somalia: evidence from qualitative data by Hawa Abdullahi, Asia Mohamed Mohamud, Maryan Abdulkadir Ahmed, Mohamed Ahmed Omar, Abdirisak A. Dalmar, Hannah Tappis, Shatha Elnakib

“…Participants stated that their age and gender undermined them professionally and noted the community's preference for older midwives and traditional birth attendants. …”
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Validity, Agreement and Reliability of the ForceFrame Dynamometer in Patients with Anterior Cruciate Ligament Injury by Kamilla Arp, Thomas Frydendal, Troels Kjeldsen, Ulrik Dalgas, Signe Timm, Bjarke Viberg, Kim Ingwersen, Claus Varnum

“… # Results Twenty-seven participants (10 females, 17 males) with a median age of 25 years (range 19-60) were included in this study. …”
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Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…<h4>Methods and findings</h4>The current study included 826 men and 1,148 women who were aged 50-70 years, from Beijing and Shanghai, and without T2D in 2005 and who were resurveyed in 2011. …”
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Cardiac Myosin-binding Protein-C as a Biomarker in the Early Diagnosis of Acute Coronary Syndrome and Differentiation of Its Types by Ali Abdul Rasool Hussein, Abdulkareem Hamadi Issa, Abbas Naji Muslem Al Shareeifi

“…Materials and Methods: One hundred and twenty patients (72 males and 48 females), aged ≥30 years selected from those who were admitted to emergency department (ED) of Al-Yarmouk teaching hospital and diagnosed with ACS by cardiologists. …”
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Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…., San Francisco, CA, USA; 6Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA; 7Ophthalmology Division, Creighton University School of Medicine, Phoenix, Arizona, USACorrespondence: Jordan M Graff, Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA, Tel +1 480 843 1868, Email JGraff@BDPEC.comPurpose: Faricimab, the first bispecific antibody designed for intraocular use, is approved for the treatment of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). …”
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Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…Additionally, this study aimed to explore the minimally important change (MIC) of each subthreshold group’s effectiveness outcome. MethodsParticipants aged 18-70 years from internet research monitors were categorized into SD, SI, and SP groups based on screening assessment. …”
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Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastoc... by Secil Irem Arik Alpcetin, Onur Ince, Bengisu Akcay, Munire Funda Cevher Akdulum, Erhan Demirdag, Ahmet Erdem, Ahmet Erdem, Mehmet Erdem, Mehmet Erdem

“…Regression analysis with a mixed model revealed that age, endometrial thickness, and estradiol levels were confounding factors as well as independent predictors of ongoing pregnancy rates (p&lt;0.05). …”
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Effects of tongue tamers and customized bonded spurs as an early treatment of anterior open bite: a randomized clinical study by Safa B. Alawy, Shaimaa S. EL-Desouky, Ibrahim A. Kabbash, Shimaa M. Hadwa

“…Materials and methods A sample of seventy-five children aged 7–9 years were assigned into three groups in which anterior open bite was treated using tongue tamers (group-I), customized composite bonded spurs(group-II), and conventional fixed palatal cribs (group-III). …”
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Is longer really better? Results of a retrospective real-life cohort study evaluating the benefit of adding a weekly educational session to a traditional 8-week home-based pulmonar... by Cécile Chenivesse, Olivier Le Rouzic, Jean-Marie Grosbois, Sarah Gephine, Sophie Peres

“…Primary hypothesis was that 8 home-based supervised sessions will be equivalent to 16 home-based supervised sessions at both short- and long-term after PR.Design Retrospective cohort study conducted on prospectively collected real-life data, from January 2010 to December 2021.Setting FormAction Santé, Pérenchies France.Participants Eligible individuals were aged &gt;18 years with a diagnosis of COPD and referred to the home-based PR programme by their respiratory physician. …”
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Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials by Qin Yang, Liuxin Zhang, Fangyuan Chang, Hongyi Yang, Bin Chen, Zhao Liu

“…MethodsA total of 4 web-based databases (Web of Science, PubMed, Embase, and Ovid) were searched up to December 30, 2023, for randomized controlled trials assessing the self-reported outcomes of VR-based technology on cognition, mood, quality of life, and physical fitness in older adults (aged ≥55 years) with MCI. Two reviewers independently screened the search results and reference lists of the identified papers and related reviews. …”
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Trends in depressive symptoms among high school students with and without health-risk behaviors in the United States: A population-based studyResearch in context by Tanner J. Bommersbach, Mark Olfson, Taeho Greg Rhee

“…Findings: Among 119,654 students (mean age, 16.0 [SD = 1.2] years; 50.1% females; and 45.3% non-Hispanic White), depressive symptoms increased from 28.4% (2007) to 42.3% (2021) (biennial average percent change (BAPC), 3.0% [95% confidence interval (CI), 2.6–3.4%]). …”
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Optic nerve sheath diameter in chronic myeloproliferative disorders by E.M. Yunusova, T.R. Mukhamadeev, B.A. Bakirov

“…</p> <p> <b>Patients and Methods:</b> the study included 32 patients (64 eyes) with established chronic MPD and 28 gender- and age-matched healthy volunteers (56 eyes) without chronic MPD. …”
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Educating the digital generation: the role of virtual communities by E. M. Kharlanova, N. V. Sivrikova, S. V. Roslyakova, E. G. Chernikova

“…Data collection was carried out in the form of an online survey using the Yandex Forms Internet service in 2022. 2996 school students of the Chelyabinsk region aged from 13 to 17 years took part in the survey. …”
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Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? by Nergiz Aydın, Sefa Tatar, Ahmet Taha Şahin, Yakup Alsancak

“…Results: A total of 103 patients (75 females) with a mean age of 41.81±14.83 years were enrolled in the study. …”
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Changes in hemodynamic parameters with different anaesthesia induction agents in elderly patients with coronary heart disease by A.R. Vitovskyi, O.A. Loskutov

“…A cohort prospective randomized study of 40 patients with ASA III–IV who underwent off-pump coronary artery bypass grafting. Their mean age was 67.00 ± 5.78 years. The participants were divided into 2 groups based on the type of induction agent: group 1 — propofol 1.5 mg/kg, fentanyl 2.0 μg/kg; group 2 — propofol 1.5 mg/kg, fentanyl 2.0 μg/kg, ketamine 0.5 mg/kg. …”
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Somatic comorbidities and health related uncertainty among Swedish adolescents with ADHD by Sara Lundqvist, Sara Lundqvist, Sara Röjås, Kourosh Bador, Maria Råstam, Nóra Kerekes, Nóra Kerekes

“…A cross-sectional study was conducted among a convenient sample of Swedish upper secondary school students aged 15 to 19 years. Data were collected using an electronic version of the “Mental and Somatic Health without borders” survey. …”
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Conditioning factors for the scientific productivity of undergraduate students of health sciences at a private Peruvian University: A cross-sectional analytical study [version 3; p... by Oriana Rivera-Lozada, Isabel Cristina Rivera-Lozada, César Antonio Bonilla-Asalde

“…Results From the total of 400 students, 74.5% were male, 57.25% were aged between 18 and 27 years, 17% belonged to the school of human medicine and 72% were in their sixth year of studies. …”
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Changes in the menstrual hygiene management facilities and usage among Bangladeshi school girls and its effect on school absenteeism from 2014 to 2018 by Farjana Jahan, Noshin Sayiara Shuchi, Abul Kasham Shoab, Mahbub-Ul Alam, Sk. Md. Kamrul Bashar, Khairul Islam, Hasin Jahan, Mahadi Hasan, Md. Masud Alam, Mahbubur Rahman

“…However, participant’s age, type of school, knowledge of menstruation before menarche, receiving information regarding MHM, separate place for changing absorbents, and separate latrine and urine facility were not significantly associated with the changes in absenteeism over time. …”
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