Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant by Antheia Kissopoulou, Eva Fernlund, Christina Holmgren, Eira Isaksson, Jan‐Erik Karlsson, Henrik Green, Jon Jonasson, Rada Ellegård, Hanna Klang Årstrand, Anneli Svensson, Cecilia Gunnarsson

“…The aim of this case presentation is to shed light upon a possible link between myocarditis, a desmoplakin (DSP) gene variant, and ARVC by describing a case of male monozygotic twins who presented with symptoms and signs of myocarditis at 17 and 18 years of age, respectively. One of them also had a recurrent episode of myocarditis. …”
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Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection by Juliane Lokau, Juliane Lokau, Yvonne Garbers, Manuel M. Vicente, Anna Dittrich, Stefan Meltendorf, Holger Lingel, Anja K. Münster-Kühnel, Monika Brunner-Weinzierl, Christoph Garbers, Christoph Garbers

“…Further, we identify IL-6 serum levels, age and the number of known pre-existing medical conditions as crucial determinants of disease outcome for the patients. …”
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Associations of Retinal Microvascular Density and Fractal Dimension with Glaucoma: A Prospective Study from UK Biobank by Qi Chen, MD, Suyu Miao, MD, Yuzhe Jiang, MD, Danli Shi, MD, PhD, Weiyun You, MD, Lin Liu, MD, PhD, Mayinuer Yusufu, MTI, Yufan Chen, MD, Ruobing Wang, MD, PhD

“…Subgroup analysis using covariates revealed that individuals aged ≥60 years, nonsmokers, moderate alcohol consumers, and those with hypertension and myopia exhibited P values <0.05 consistently prematching and postmatching, differing from other subgroups within this covariate. …”
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Safety and feasibility of En‐bloc holmium laser enucleation for very large prostates (> 200 cc) with trainee involvement by Feres C. Maluf, Ansh Bhatia, Archan Khandekar, Diana M. Lopategui, Joao G. Porto, Ryan R. Chen, Jean C. Daher, Mohamadhusni Zarli, Robert Marcovich, Hemendra N. Shah

“…Results The analysis included 89 patients with a mean age of 73.12 ± 8.10 years. Preoperative prostate weight ranged from 200 to 401 cc with a median of 245 cc, and median PSA was 7.71 ng/ml. …”
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Early initiation of intravenous cyclophosphamide and one‐year outcome in super‐refractory cryptogenic‐new onset refractory status epilepticus by Yasufumi Yorichika, Shuichiro Neshige, Hideaki Sakahara, Narumi Ono, Megumi Nonaka, Yuichiro Tagane, Tomoaki Watanabe, Keisuke Tachiyama, Haruka Ishibashi, Masahiro Nakamori, Takeo Shishido, Shiro Aoki, Hiroki Ueno, Yu Yamazaki, Takahiro Iizuka, Hirofumi Maruyama

“…We compared functional outcomes at 3 months and 1 year after the onset between patients who received IVCPA within 20 days (early‐treated) and those who received it later (late‐treated). All patients (median age: 43 years) had a prodromal fever. Brain MRI revealed symmetrically increased FLAIR signals in the medial temporal lobes of all patients. …”
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Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2–5 years old in 3 Canadian birth cohorts by Anne-Claire Binter, Dany Doiron, Martine Shareck, Tona Pitt, Sheila W. McDonald, Padmaja Subbarao, Wiliam D. Fraser, Suzanne C. Tough, Jeffrey Brook, Mònica Guxens

“…Validated neuropsychological tests were used to assess non-verbal and verbal abilities, gross and fine motor function, externalizing and internalizing symptoms at child’s age 2 to 5 years. We assessed associations of each environmental exposure indicator with each of the 6 outcomes, using multivariate linear regression models. …”
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Gut microbiota and kidney function in autosomal dominant polycystic kidney disease participants in Cameroon: a cross-sectional study by Inès Obolo Nwaga, Victorine Bandolo Nzana, Rhoda Nsen Bughe, Isaac Dah, Cheboh Cho-Fon, Maimouna Mahamat, Emmanuelle Ndjong, Aristide Nono, Jean Claude Mballa, Fon Abongwa Acho, Vicky Ama Moor, Wilfred Fon Mbacham, François Folefack Kaze

“…Differences between ADPKD subgroups and controls were assessed using nonparametric tests. Results The mean age (SD) of the 44 participants was 40.65 (± 11.9) years. …”
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Assessing gut barrier integrity and reproductive performance following pre-mating oral administration of solid-lipid-nanoparticles designed for drug delivery by Valentina Lacconi, Valentina Lacconi, Micol Massimiani, Micol Massimiani, Giulia Antonello, Paolo Gasco, Roberta Bernardini, Cristiana Ferrari, Lorenzo Ippoliti, Gina La Sala, Antonio Pietroiusti, Ivana Fenoglio, Chiara Riganti, Luisa Campagnolo

“…Considering that assumption of drug-delivering nanocarriers in reproductive age may potentially affect women’s reproductive health, the aim of the present study was to evaluate whether repeated oral administration of SLNs to female mice prior to mating would influence key pregnancy outcomes. …”
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Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history by Anh Pham, Robert El-Kareh, Frank Myers, Lucila Ohno-Machado, Tsung-Ting Kuo

“…Significant covariates that may affect risk include age, immuno-compromised treatments, past antibiotic uses, and some medications for the gastrointestinal tract. …”
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Analyzing practice pattern in treating partial-thickness rotator cuff tears: a dual perspective from national database and American Shoulder and Elbow Surgeons PARCIAL research gro... by H. Mike Kim, MD, Emily Leary, PhD, Champ L. Baker, 3rd, MD, Leslie A. Barnes, MD, R. Alexander Creighton, MD, Frances Cuomo, MD, Matthew J. DiPaola, MD, Abdullah Foad, MD, James M. Gregory, MD, Brian F. Grogan, MD, Scott G. Kaar, MD, MBA, Eitan M. Kohan, MD, Sumant G. Krishnan, MD, Eddie Y. Lo, MD, John T. Moor, MD, Michael Nguyen, BS, Monica DiFiori, MD, Gabriel Masters, BA, Te Feng Arthur Chou, MD, Riccardo Raganato, MD, Lucas P. Bowen, BS, Jordan J. Harmon, BS, Tessa C. Griffin, BS, Alec E. Winzenried, MD, Evan M. Polce, BS, Cory J. Call, BS, Benjamin Nwadike, MD, Alvin Ouseph, MS, Monia Nazemi, MS, Kyle McCall, BA

“…Collected data included age, sex, extent and type of rotator cuff tears, duration of symptoms prior to surgical repair, and type and duration of nonoperative treatment. …”
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Cohort profile: the potentially preventable burden of community-acquired pneumonia in South African adults in the era of widespread PCV13 immunisation and antiretroviral therapy ro... by Jo Southern, Kennedy Otwombe, Eileen Dunne, Khuthadzo Hlongwane, Bradford D Gessner, Michelle Wong, Cheryl Cohen, Anne von Gottberg, Elizabeth Begier, Sharon Gray, Ebrahim Variava, Tumelo Moloantoa, Neil Martinson, Firdaus Nabeemeeah, Nadia Sabet, Lebohang M Mlambo, Phetho Mangena, Pattamukkil Abraham, Floris Swanepoel, Fahima Moosa, Mark Fletcher, Bha Ndungane-Tlakula, Jerusha Naidoo, Minja Milovanovic

“…We aimed to investigate CAP incidence, recurrence, mortality, risk factors and microbiology before and during the COVID-19 pandemic.Participants Adults aged ≥18 years were enrolled in three South African provinces from March 2019 to October 2021, with a brief halt during the initial COVID-19 lockdown. …”
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From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…Patients’ nationality was then stratified by region of the world to understand geographic representation of border injury admissions.Results We identified 597 patients injured while crossing the US-Mexico border wall representing 38 different countries. The mean age of patients was 32.2±10.4 years and 446 (75%) were male. …”
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Data-driven insights into pre-slaughter mortality: Machine learning for predicting high dead on arrival in meat-type ducks by Chalita Jainonthee, Phutsadee Sanwisate, Panneepa Sivapirunthep, Chanporn Chaosap, Raktham Mektrirat, Sudarat Chadsuthi, Veerasak Punyapornwithaya

“…The objective of this study was twofold: first, to classify high DOA rates (≥ 0.15%) using several predictors, including season, period of the day, number of ducks per truckload, distance, duration of transportation, age, average body weight, lairage time, and temperature at the lairage area. …”
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Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study by Bienvenu Salim Camara, Alexandre Delamou, Haoua Dembele, Hamadoun Sangho, Birama Apho Ly, Sidikiba Sidibé, Alioune Camara, Cheick Sidya Sidibé, Alhassane Diallo, Abdoulaye Touré, Fatoumata Bintou Traoré, Elhadj Marouf Diallo, Fatimata Yaro, Mariam Traoré

“…More than 74% of sepsis cases were early onset (&lt;72 hours). Neonatal age &lt;7 days (AOR=2.79, 95% CI 1.59 to 4.89, p=0.000), low birth weight &lt;2500 g (AOR=2.88, 95% CI 1.41 to 5.86, p=0.003), Apgar score &lt;7 (AOR=4.03, 95% CI 3.09 to 5.24, p=0.000), mother with no education (AOR=2.24, 95% CI 1.15 to 4.33, p=0.02), maternal fever (AOR=2.31, 95% CI 1.53 to 3.53, p=0.000), prolonged rupture of membranes (AOR=1.87, 95% CI 1.01 to 3.54, p=0.04) and prolonged labour (AOR=2, 95% CI 1.03 to 3.88, p=0.04) were significantly associated with neonatal sepsis.Conclusion The prevalence of sepsis in Mali is still high. …”
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Designing a comprehensive behaviour change intervention to promote and monitor exclusive use of liquefied petroleum gas stoves for the Household Air Pollution Intervention Network... by J Jaime Miranda, William Checkley, Kyle Steenland, Vanessa Burrowes, Kirk R Smith, Aris Papageorghiou, Abigail Jones, Ghislaine Rosa, Anaité Díaz-Artiga, Gurusamy Thangavel, Kalpana Balakrishnan, Joshua P Rosenthal, Thomas F Clasen, Steven A Harvey, Amit Verma, Kendra N. Williams, Lisa M. Thompson, Zoe Sakas, Mayari Hengstermann, Ashlinn Quinn, Elisa Puzzolo, Jennifer Peel, Vigneswari Aravindalochanan, Dana Boyd Barr, Alejandra Bussalleu, Devan Campbell, Eduardo Canuz, Adly Castañaza, Howard Chang, Yunyun Chen, Marilú Chiang, Maggie L Clark, Rachel Craik, Mary Crocker, Victor Davila-Roman, Lisa de las Fuentes, Oscar De León, Ephrem Dusabimana, Lisa Elon, Juan Gabriel Espinoza, Irma Sayury Pineda Fuentes, Sarada Garg, Dina Goodman, Savannah Gupton, Meghan Hardison, Stella Hartinger, Phabiola M Herrera, Shakir Hossen, Penelope Howards, Lindsay Jaacks, Shirin Jabbarzadeh, Michael A Johnson, Katherine Kearns, Miles Kirby, Jacob Kremer, Margaret A Laws, Pattie Lenzen, Jiawen Liao, Amy E Lovvorn, Fiona Majorin, Eric McCollum, John McCracken, Julia N McPeek, Rachel Meyers, Erick Mollinedo, Lawrence Moulton, Krishnendu Mukhopadhyay, Luke Naeher, Abidan Nambajimana, Durairaj Natesan, Florien Ndagijimana, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Ricardo Piedrahita, Ajay Pillarisetti, Naveen Puttaswamy, Sarah Rajkumar, Usha Ramakrishnan, Rengaraj Ramasami, Davis Reardon, Barry Ryan, Sudhakar Saidam, Sankar Sambandam, Jeremy A Sarnat, Suzanne Simkovich, Sheela S Sinharoy, Damien Swearing, Ashley Toenjes, Lindsay Underhill, Jean Damascene Uwizeyimana, Viviane Valdes, Kayla Valentine, Lance Waller, Megan Warnock, Wenlu Ye, Bonnie Young

“…The HAPIN trial will assess the impact of exclusive LPG use on air pollution exposure and health of pregnant women, older adult women, and infants under 1 year of age in Guatemala, India, Peru, and Rwanda.Methods Using the Capability, Opportunity, Motivation–Behaviour (COM–B) framework and Behaviour Change Wheel (BCW) to guide formative research, we conducted in-depth interviews, focus group discussions, observations, key informant interviews and pilot studies to identify key influencers of cooking behaviours in the four countries. …”
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Prevalence of Corneal Astigmatism in Patients before Cataract Surgery in Western China by Wei Ma, Chengguo Zuo, Weirong Chen, Shaoyang Zheng, Jiangang Xu, Ruowen Gong, Maierhaba Mijiti, Kaidiliya Alifu, Lin Ding, Mingkai Lin

“…This study comprised 12,236 eyes of 7065 patients with a mean age of 64.75 ± 9.66 years, and 52.77% of the patients were female. …”
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Association between sleep duration and hypertension in southwest China: a population-based cross-sectional study by Yu Guo, Liming Li, Zhengming Chen, Qiang Sun, Pei Pei, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Guojin Luo, John S Ji, Xiaoyu Chang, Xiaofang Chen*

“…Participants were enrolled in 15 townships of Pengzhou city in Sichuan province during 2004–2008.Participants 55 687 participants aged 30–79 years were included. Sleep duration was assessed by a self-reported questionnaire.Main outcome measures Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or prior physician-diagnosed hypertension in hospitals at the township (community) level or above.Results The prevalence of hypertension was 25.17%. …”
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Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

“…Diabetic macular edema (DME) is the most common cause of blindness in the working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring of the edema and a detailed analysis of the retinal structure. …”
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Intramedullary Fixation for Metacarpal Fractures: A Multi-Institutional Prospective Outcomes Study by Michael B. Gehring, MD, Brandon Wolfe, BA, Riley Kahan, BS, Stephanie D. Malliaris, MD, Kia M. Washington, MD, Matthew D. Folchert, MD, Kyros Ipaktchi, MD, Mark A. Greyson, MD, Alexander Lauder, MD, Matthew L. Iorio, MD

“…Results: One-hundred-one fractures were treated in 82 patients with an average age of 33 years and mean follow-up of 69 days. Most patients were male (70%), nonlaborers (72%), and nonsmokers (74%). …”
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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…Background MLC1501, consisting of four herbs, that is, Radix Astragali, Radix Angelicae sinensis, Rhizoma Chuanxiong, Radix Polygalae, has the same pharmacological properties as its precursors MLC601 and MLC901 which contain extracts of nine herbs and showed neuroprotective, anti-inflammatory and neurorestorative properties in non-clinical models, as well as clinical benefits in improving functional and neurological recovery after brain injuries.Aims To determine the efficacy of MLC1501 on motor recovery as measured by Fugl-Meyer motor Assessment (FMA) total score at 24 weeks in patients with ischaemic stroke (IS).Design A total of 300 patients aged &gt;18 years, diagnosed with IS in the prior 2–10 days, with National Institute of Health Stroke Scale (NIHSS) total score of 8–18 and a combined score of ≥3 on NIHSS motor items 5A, 5B, 6A and/or 6B, will be randomised in a 1:1:1 ratio to receive oral placebo, MLC1501 low dose or MLC1501 high dose for 6 months. …”
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