Association of outpatient use of renin–angiotensin–aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study by Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio, Nathan W Cummins, Timothy M Dempsey, Vesna D Garovic, Andrew Limper

“…Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD), ARD syndrome (ARDS) and all-cause mortality, comparing COVID-19 to pre-COVID-19 influenza seasons.Results The cohort included 1 059 474 episodes of AVRI (653 797 filled an ACEi or ARB, and 405 677 other HTN medications). 58.6% were women and 72.9% with age ≥65. The ACEi/ARB cohort saw a larger increase in risk in the COVID-19 influenza season than the other HTN medication cohort for four out of five outcomes, with an additional 1.5 percentage point (pp) increase in risk of an inpatient stay (95% CI 1.2 to 1.9 pp) and of ICU/CCU use (95% CI 0.3 to 2.7 pp) as well as a 0.7 pp (0.1 to 1.2 pp) additional increase in risk of ARD and 0.9 pp (0.4 to 1.3 pp) additional increase in risk of ARDS. …”
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Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis by WU Hongliang, ZHENG Sihang, ZHANG Enchong, HOSSAIN Mohammad Showkat, GONG Helong, XING Ruida, JING Shengjie, LI Yan

“…The two groups were compared, and the fever rate and clinical characteristics of fever were summarized and further analyzed in the aspects of gender, age, count of white blood cells, neutrophils, lymphocytes, neutrophil-lymphocyte ratio (NLR), type of osteoporosis, degree of osteoporosis, fracture, surgery intervention, medication history, etc. …”
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Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism by Yuan Liu, Siyi Guo, Shaowei Sang, Jinbo Liu, Lin Qi, Bin Lv, Xiaoli Zhang

“…We retrospectively reviewed the medical records of 304 PHPT patients treated in our hospital between January 2009 and July 2020, including 217 females and 87 males with the average age of 53.27 ± 13.54 years. Of the 304 patients, 181 were symptomatic PHPT patients and 123 were asymptomatic PHPT patients. …”
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Multi-biofluid metabolomics analysis of allergic respiratory rhinitis and asthma in early childhood by Chih-Yung Chiu, MD, PhD, Meng-Han Chiang, MS, Chieh-Ni Kuo, BS, Mei-Ling Cheng, PhD, Gigin Lin, MD, PhD

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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Here, we aim to introduce the characteristics of their symptoms, lung function and chest imaging features to arouse the attention of physicians to know better of the disease.Patients and Methods: We retrospectively analyzed thirty-one patients who had been diagnosed with CPVA based on clinical data and positive bronchial provocation tests (BPTs).Results: The mean age of all enrolled patients was forty-seven years, and females accounted for 64.5%. …”
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Development and internal validation of a prognostic model for predicting tonic-clonic seizures during pregnancy in women with epilepsy by Yanru Du, Wenting Huang, Ying Wang, Jiahe Lin, Niange Xia, Zhenguo Zhu, Xinshi Wang, Yuchen Xu, Huiqin Xu

“…The WMU model included three predictors: age at the time of pregnancy, admission to hospital for seizures in previous pregnancy, and seizures in the 12 months before pregnancy. …”
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VANDAL BEHAVIOUR OF ADOLESCENTS AS A LEGAL AND PSYCHOLOGICAL PROBLEM by O. V. Gurova

“…The contradictions in the psychological theory, educational practice and consciousness of society were revealed: between the widespread occurrence of acts of vandal behaviour and the limited methods and means to prevent it; between the mass involvement of adolescents in vandalism and the lack of specialised age-based programmes to correct vandal behaviour; between the prevalence of unauthorized graphic activity of schoolchildren and other forms of vandal behaviour in the educational environment and the reluctance of teachers and administration of educational institutions to recognise this as a noteworthy problem; between the social significance of determination of lawful and effective punishment (in terms of prevention) and insufficient attention to personal reasons that encourage a person to commit or not to commit vandal acts; between common scientific interest in the individual psychological and socio-typological features of adolescents committing vandalism and inadequate attention to the socio-psychological motivational determinants, initiating and forming the readiness to commit vandal actions. …”
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Transition of clinical biomarker status from childhood into adolescence-A prospective study in children from eight European countries. by Anna Floegel, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Dénes Molnár, Lauren Lissner, Stefaan De Henauw, Luis A Moreno, Wolfgang Ahrens, Manuela Marron, Claudia Börnhorst

“…Clinical blood biomarkers including glycated hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL-cholesterol), triglycerides, C-reactive protein (CRP), interleukin 6, ferritin, leptin and insulin-like growth factor 1 (IGF-1) were repeatedly measured in 2007/2008 (age range: 3.0 to <10.0 years) and in 2013/2014. …”
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Knowledge regarding human monkeypox among a sample of undergraduate and post-graduate students from selected tertiary institutions in Bangladesh: An online-based cross-sectional st... by Md Hasan Al Banna, Abdul-Aziz Seidu, Trisha Mallick, Nahidur Rahman, Mst Sadia Sultana, Humayra Alam Mouly, Najim Z Alshahrani, Nargees Akter, Tareq Mahmud, Susmita Hossain, Anannya Sheikh, Ashish Biswas, Sumaia Sahrin, Md Nazmul Hassan, Md Shafiqul Islam Khan

“…<h4>Results</h4>The median age of the study participants was 23 years (IQR: 25-22). …”
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Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players by Mingbang Li, Liang Tan, Hong Wu, Jianwei Wu

“…This experimental study aimed to compare the impact of free-play SSGs (freeD) and limited-dribbling SSGs (limitedD) in SSGs on the aerobic and anaerobic adaptations of youth basketball players.MethodsForty-five youth basketball players (aged 15.7 ± 0.6 years, with 4.2 ± 0.7 years of experience) were randomly assigned to two experimental groups (freeD and limitedD) and a control group (not exposed to SSG interventions). …”
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Anxiety and depression in primary knee osteoarthritis patients: are they related to clinical features and radiographic changes? by Yasmin A. Abd Elhamid, Ghada S. Elazkalany, Marwa H. Niazy, Angie Y. Afifi

“…Material and methods Fifty patients fulfilling primary knee OA classification criteria were recruited for the study, and 50 age- and sex-matched healthy individuals served as a control group. …”
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Effectiveness of a Virtual Reality Serious Video Game (The Secret Trail of Moon) for Emotional Regulation in Children With Attention-Deficit/Hyperactivity Disorder: Randomized Clin... by Marina Martin-Moratinos, Marcos Bella-Fernández, María Rodrigo-Yanguas, Carlos González-Tardón, Chao Li, Ping Wang, Ana Royuela, Pilar Lopez-Garcia, Hilario Blasco-Fontecilla

“…Participants included individuals aged between 7 and 18 years who had a clinical diagnosis of ADHD and were receiving pharmacological treatment. …”
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A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…<h4>Methods</h4>In this cross-sectional study, we included all dyspnoeic ED visits of patients ≥ 18 years of age at the two EDs in the region of Halland, Sweden, 07/01/2017-12/31/2019. …”
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SUCCESSFUL REGISTRATION OF DOMESTIC BIOANALOGUE OF BEVACIZUMAB – NEW OPPORTUNITIES FOR EFFECTIVE TREA TMENT OF PATIENTS WITH NON-SQUAMOUS CELL NON-SMALL CELL LUNG CANCER by S. V. Orlov, S. N. Fogt, M. S. Shustova

“…The study included 138 patients, male and female aged 18 to 75 years with newly diagnosed inoperable or widespread metastatic NSCLC (except squamous cell NSCLC), relevant eligibility criteria. …”
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What Can Be Done to Improve the Mental Health of University Students? Identifying Determinants of Psychological Distress at an Australian University by Patrick J. Owen, Shane A. Kavanagh, Anthony D. LaMontagne

“…Results: Mutually-adjusted individual-level determinants were age (β [95% CI]: -0.50 [-0.60, -0.41]), LGBTQI+ identity (0.96 [0.52, 1.40]), having a current health condition (3.23 [2.85, 3.60]), being a current carer (0.68 [0.04, 1.32]), country of birth other than Australia (1.19 [0.84, 1.54]), financial stress (2.43 [1.99, 2.86]), being satisfied with housing (-0.84 [-1.18, -0.51]), and having full-time employment (-0.49 [-0.99, 0.00]). …”
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In Vivo Corneal Confocal Microscopy Detects Improvement of Corneal Nerve Parameters following Glycemic Control in Patients with Type 2 Diabetes by Xiaofan Jia, Xiaogang Wang, Xiaoxia Wang, Qi Pan, Tongzhang Xian, Xiaobin Yu, Lixin Guo

“…Thirty-two patients with diabetes complicated by DPN and 12 age-matched control subjects underwent detailed clinical examination and were assessed per the Toronto Clinical Scoring Scale for DPN, nerve conduction studies, and IVCCM at baseline and after approximately one year from the first visit. …”
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Prevalensi Depresi pada Pensiunan Pegawai Negeri Sipil yang Mengambil Dana Pensiun di Bank BTPN Cabang M. Yamin Padang by Finna Dwi Putri, Amel Yanis, Elmatris SY

“…Most of them are at the age category of ≥60 years, most of symptoms of depression is in men, the largest prevalence of depression in retired civil servant class IIIa. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Based on multivariate analysis, advanced age (OR: 1.855; p = 0.011), preoperative hypertension (OR: 1.91; p = 0.017), coronary heart disease (OR: 6.773; p &lt; 0.001), preoperative albumin (OR: 0.924; p = 0.015), D-Dimer (OR: 1.001; p = 0.038), plasma creatinine (OR: 1.025; p = 0.001), cardiopulmonary bypass (CPB) duration (OR: 1.011; p = 0.001), repeat CPB (OR: 6.195; p = 0.010), intraoperative red blood cell transfusion (OR: 2.560; p &lt; 0.001), urine volume (OR: 0.406 p &lt; 0.001) and vasoactive–inotropic score (OR: 1.135; p = 0.009) were independent risk factors for AKI. …”
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Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration by Betül Ayça Yamak, İbrahim Ethem Güven, Mustafa Candemir

“…A linear regression analysis confirmed that disease duration was a stronger predictor of frontal QRS-T angle widening (B: 0.389, 95% CI: 0.102–0.677, <i>p</i> < 0.001) compared to age (B: 0.184, 95% CI: 0.123–0.245, <i>p</i> = 0.008). …”
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Frailty Is Associated With Decreased Survival in Adult Patients With Nonoperative and Operative Traumatic Subdural Hemorrhage: A Retrospective Cohort Study of 381,754 Patients by Evan N. Courville, MD, Oluwafemi P. Owodunni, MD, MPH, Jordyn T. Courville, BS, Syed F. Kazim, MD, PhD, Alexander J. Kassicieh, BS, Allyson M. Hynes, MD, Meic H. Schmidt, MD, MBA, Christian A. Bowers, MD

“…There were 340,096 nonoperative and 41,658 operative patients. The median age was 70.0 (54.0–81.0) nonoperative, and 71.0 (57.0–80.0) operative cohorts. …”
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