Surgical Treatment of Idiopathic Macular Hole Using Different Types of Tamponades and Different Postoperative Positioning Regimens by M. Veith, J. Vránová, J. Němčanský, J. Studnička, M. Penčák, Z. Straňák, P. Mojžíš, P. Studený, D. P. Piñero

“…Prospective randomized clinical trial enrolling 104 eyes of 100 patients (age, 57–87 years) undergoing MH surgery. All patients were operated on by an experienced surgeon using 25-gauge pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling. …”
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Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial pro... by Zhihong Fan, Shenghong Jia, Xin Zhou, Chao Li, Jiahao Shao, Xiaofeng Liu, Yitao Liao, Yenan Xu, Dandan He, Shixiang Wu, Xian Zhang

“…A total of 166 patients with LDH (aged 18–65 years) were recruited from four centres and randomly assigned at a 1:1 ratio to two groups: the TCE group and the Tuina combined with the TCE group. …”
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A systematic review and meta-analysis of the effectiveness of perineural dextrose injection in peripheral compression neuropathies of the upper limbs by Fatemeh Azizi, Faezeh Saber Gharesoo, Fereshteh Eidy, Sama Heidari, Nastaran Maghbouli, Shirin Djalalinia, Amir Kasaeian

“…Our eligibility criteria included participants aged 18 and older who had peripheral upper limb nerve entrapment from non-metabolic and non-traumatic sources. …”
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Impact of Clinical Characteristics and Treatment on Cholangiocarcinoma Prognosis in Southern Thailand by Chirawadee Sathitruangsak, Tanawat Pattarapuntakul, Apichat Kaewdech, Tortrakoon Thongkan, Apinya Prisutkul, Phatcharaporn Thongwatchara, Hutcha Sriplung, Chanon Kongkamol, Kanyanatt Kanokwiroon, Sumalee Obchoei, Pimsiri Sripongpun

“…Overall survivals (OS) were determined by Kaplan–Meier method and multivariable Cox regressions. Results The mean age was 63.9 years; 50.7% were men. The most common subtype was iCCA (49.3%), followed by pCCA (36.3%) and dCCA (14.3%). …”
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Clinical results of autologous fat transfer for basal thumb arthritis with a minimum of three years’ follow-up by Elisabeth M. Haas-Lützenberger, Iana Emelianova, Moritz C. Bader, Sinan Mert, Nicholas Moellhoff, Wolfram Demmer, Ursula Berger, Riccardo Giunta

“…Pain, both at rest and during stress, significantly improved at one year and remained stable through three years. Sex, age, and stage of disease were not associated with postoperative pain levels. …”
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Laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres: a multicentre prospective cohort study by Paul Smith, Lucky Saraswat, Sanjay Vyas, Thomas Ind, Ertan Saridogan, Elizabeth Ball, Edward Morris, James Clark, Tony Chalhoub, David Rowlands, Moiad Alazzam, Dominic Byrne, Tamara Curnow, Alfred Cutner, T Justin Clark, Iris Menninger, Yousri Afifi, Kevin Phillips, Saikat Banerjee, Robert Richardson, Jeremy Hawe, Barry Whitlow, Emmanuel Ofuasia, Ashwini Trehan, Tyrone Carpenter, Christian Becker, Stuart Jack, Kumar Kunde, Chris Barnick, Alan Farthing, Graham Phillips, John Bidmead, Mohamed Abdel-aty, George Botros, Marlin Mubarak, Christian Kremer, Stanley Okolo, Edmond Edi-osagi, Kamel Shehata-iskander, Gaity Ahmad, Jonathan Frappell, Brice Rodriguez, Yemi Coker, Gourab Misra, Adam Moors, Chris Guyer, Caroline Overton, Suku George, Oliver Chappatte, Richard Penketh, Funlayo Odejinmi, Keith Louden, Jon Hughes

“…Objective To estimate the effectiveness and safety of laparoscopic surgical excision of rectovaginal endometriosis.Design A multicentre, prospective cohort study.Setting 51 hospitals accredited as specialist endometriosis centres.Participants 5162 women of reproductive age with rectovaginal endometriosis of which 4721 women had planned laparoscopic excision.Interventions Laparoscopic surgical excision of rectovaginal endometriosis requiring dissection of the pararectal space.Main outcome measures Standardised symptom questionnaires enquiring about chronic pelvic pain, bladder and bowel symptoms, analgesia use and quality of life (EuroQol) completed prior to surgery and at 6, 12 and 24 months postoperatively. …”
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Impaired Fibrinolysis in Angiographically Documented Coronary Artery Disease by Adriano Basques Fernandes, Luciana Moreira Lima, Marinez Oliveira Sousa, Vicente de Paulo Coelho Toledo, Rashid Saeed Kazmi, Bashir Abdulgader Lwaleed, Maria das Graças Carvalho

“…We measured plasma levels of PAI-1 and TAFI antigen in 123 patients with age ranging from 40 to 65 years who had been submitted to coronary angiography and assessed the association of these markers with the extent of stenosis in three groups: angiographically normal artery (NAn), mild to moderate atheromatosis (MA), and severe atheromatosis (SA). …”
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Assessing Nutritional Knowledge and Physical Health Among Football Players: A Pilot Study from Three Sports Clubs in Western Romania by Gabriel Roberto Marconi, Brigitte Osser, Gyongyi Osser, Caius Calin Miuța, Csongor Toth, Viorel Petru Ardelean, Anca Dicu, Corina Dalia Toderescu, Laura Ioana Bondar

“…This study investigates these factors in male football players aged 16–33 years. Methods: The study involved 60 male football players from three teams in Liga4Arad. …”
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Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…Being at-risk alcohol consumers decreased with decreasing economic status (P for trend <0.001), was less frequent among middle-aged compared to younger (OR 0.73; 95% CI, 0.60–0.89) and among divorced/separated (OR 0.77; 95% CI, 0.60–0.99) or single (OR 0.75; 95% CI, 0.64–0.89) compared to married individuals. …”
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Relationship between vaginal and gut microbiome and pregnancy outcomes in eastern Ethiopia: a protocol for a longitudinal maternal-infant cohort study (the EthiOMICS study) by Piet Cools, Alemseged Abdissa, Abera Kenay Tura, Nega Assefa, Merga Dheresa, Kedir Teji Roba, Tara Wilfong, Tesfaye Assebe Yadeta, Fitsum Weldegebreal, Desalegn Admassu Ayana, Akewok Sime Negesa, Yohannes Mulugeta Demmu, Tewodros Tesfa, Tegbaru Nibrat Alemu, Tadesse Gure Eticha, Abraham Geremew, Abel Abera Negash

“…Postnatally, newborns’ skin swabs (at birth) and rectal swabs will be obtained until 2 years of age. Moreover, breast milk samples at birth and 6 months and environmental samples (water, indoor air and soil) will be collected at enrolment, birth, 6, 12 and 24 months post partum. …”
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Perspectives of proteomic analysis in ophthalmology by A.A. Krylova, A.V. Zakharchuk, O.I. Krivosheina, S.I. Pekov, I.A. Popov

“…The results of proteomic mapping of tear and aqueous humor in dry eye disease, keratoconus, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy are described. …”
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Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial by Yongli Tao, Yuan Gao, Lu Zhao, Yafang Xu, Chenyang Jiang, Kai Liu, Hui Fang, Lulu Pei, Xin Wang, Rui Zhang, Jun Wu, Jing Yang, Xinsheng Han, Hongling Guo, Baoguo Xue, Jinlou Li, Yuqian Liu, Hongqiu Gu, Kejin Du, Xin Cheng, Qiang Dong, Duolao Wang, Ferdinando S. Buonanno, MingMing Ning, Yuming Xu, Bo Song, the TRUST Trial Investigators

“…Results A total of 999 patients were enrolled in the trial, the median age was 64 years, 371 (36.9%) were women; the median (IQR) NIHSS score was 3 (2–4). …”
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Enhancing newborn screening sensitivity and specificity for missed NICCD using selected amino acids and acylcarnitines by Peiyao Wang, Lingwei Hu, Yuhe Chen, Duo Zhou, Shasha Zhu, Ting Zhang, Ziyan Cen, Qimin He, Benqing Wu, Xinwen Huang

“…Receiver Operating Characteristic (ROC) analysis evaluated the predictive value of amino acids and acylcarnitines in dried blood spots (DBS) for identifying missed patients including 40 missed patients and 17,269 healthy individuals, with additional validation using 12 missed patients and 454 healthy controls. Results The age of diagnosis was significantly higher in the “Missed Screening” group compared to the “Newborn Screening” group (74.50 vs. 18.00 days, P < 0.001). …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Additionally, advanced age may be associated with higher mortality in LP. …”
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The influencing factors of the erythropoietin resistance index and its association with all-cause mortality in maintenance hemodialysis patients by Xinju Zhao, Liangying Gan, Fan Fan Hou, Xinling Liang, Xiaonong Chen, Yuqing Chen, Zhaohui Ni, Li Zuo

“…A total of 1270 MHD subjects (687 males and 583 females) were included, with an average age of 60 (49.0, 71.0) years. All subjects were divided into two groups by the median ERI of 14.03. …”
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Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry by Tetsuhisa Kitamura, Shungo Hikoso, Takahisa Yamada, Yoshio Yasumura, Akito Nakagawa, Toshihiro Takeda, Hirota Kida, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yasushi Matsumura, Yasushi Sakata, Shunsuke Tamaki, Takaharu Hayashi, Yoshiharu Higuchi, Masaharu Masuda, Mitsutoshi Asai, Toshiaki Mano, Hisakazu Fuji, Daisaku Masuda, Shizuya Yamashita, Masami Sairyo, Yusuke Nakagawa, Haruhiko Abe, Yasunori Ueda, Kunihiko Nagai, Masamichi Yano, Masami Nishino, Jun Tanouchi, Yoh Arita, Shinji Hasegawa, Takamaru Ishizu, Minoru Ichikawa, Yuzuru Takano, Eisai Rin, Tetsuya Watanabe, Shiro Hoshida, Masahiro Izumi, Hiroyoshi Yamamoto, Hiroyasu Kato, Kazuhiro Nakatani, Mayu Nishio, Keiji Hirooka, Takahiro Yoshimura, Akihiro Tani, Yasushi Okumoto, Yasunaka Makino, Katsuomi Iwakura, Yoshiyuki Kijima, Takashi Kitao, Masashi Fujita, Koichiro Harada, Masahiro Kumada, Osamu Nakagawa, Ryo Araki, Takayuki Yamada, Fusako Sera, Kei Nakamoto, Hidetaka Kioka, Tomohito Ohtani, Nobuyuki Ogasawara, Yukinori Shinoda, Koichi Tachibana, Yohei Sotomi, Taiki Sato, Yuji Yasuga, Toshinari Onishi, Kazunori Kashiwase, Ryu Shutta, Masahiro Seo, Yuki Matsuoka, Yasuhiro Akazawa, Daisuke Sakamoto

“…The primary endpoint was a composite of all-cause death and hospitalisation for HF.Results In this analysis population, the median age was 81 (75–85) years, with 48% male patients. …”
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Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…Where relevant, we will adjust for predetermined characteristics (age, grade of training and session duration) using multivariate regression analyses.Ethics and dissemination Web-Ed was designed by doctors in training to address their learning needs and evaluate the preferred mode of learning. …”
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Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis by P. P. Sainaghi, L. Collimedaglia, F. Alciato, R. Molinari, D. Sola, E. Ranza, P. Naldi, F. Monaco, M. Leone, M. Pirisi, G. C. Avanzi

“…Clinical characteristics of the relapse, duration, Expanded-Disability-Status Scale (EDSS) change, number of FS involved, completeness of recovery, age, steroid therapy, were categorised. Patients were followed at 6-month intervals to assess relapse rate and EDSS progression. …”
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Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old by Yingsi Zeng, Zijun Chen, Qinkai Chen, Xiaojiang Zhan, Haibo Long, Fenfen Peng, Fengping Zhang, Xiaoran Feng, Qian Zhou, Lingling Liu, Xuan Peng, Evergreen Tree Nephrology Association, Guanhua Guo, Yujing Zhang, Zebin Wang, Yueqiang Wen, Jiao Li, Jianbo Liang

“…In subgroups, with each 1 increased in the NLR level, adjusted HR of new-onset CV event was 2.02 (95%CI=1.26−3.23, P=0.003) and CVD mortality was 2.98 (95%CI=1.58−5.62, P=0.001) in the younger group (age<60 years). Conclusions. NLR is an independent risk factor for adverse CV prognosis in PD patients younger than 60 years old.…”
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Methicillin-Resistant Staphylococcus aureus (MRSA): Prevalence and Antimicrobial Sensitivity Pattern among Patients—A Multicenter Study in Asmara, Eritrea by Eyob Yohaness Garoy, Yacob Berhane Gebreab, Oliver Okoth Achila, Daniel Goitom Tekeste, Robel Kesete, Robel Ghirmay, Ruta Kiflay, Thomas Tesfu

“…S. aureus isolation rate from the 130 samples was 82 (63.1%). Patients <18 years of age were more likely to be colonized by S. aureus compared to patients above 61 years. …”
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