Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans by Giovanni Cirillo, Giuseppina Caiazzo, Federica Franza, Mario Cirillo, Michele Papa, Fabrizio Esposito

“…Two MRI data sets were serially acquired using MS-HARDI schemes from ADNI and HCP neuroimaging initiatives in a group of 10 healthy human subjects (5 males, age range: 25–30 years). High resolution 3D-T1 images were independently acquired to individually segment the thalamus and the SNc. …”
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Carbon dioxide net assimilation exchange in a young pecan nut orchard during the growth cycle by A. Zermeño-Gonzalez, E.A. Jimenez-Alcala, J.A. Gil-Marin, H. Ramirez-Rodriguez, M. Cadena-Zapata, A.I. Melendres-Alvarez

“…From March to September, the carbon sequestration of the young pecan nuts was 0.962 tons of carbon per hectare.CONCLUSION: The highest carbon dioxide diurnal assimilation rate was observed in May, at 5 717.95 millimoles per square meter. Despite the young age of the pecan trees, the orchard has a retention capacity of 0.962 tons of carbon per hectare for the months evaluated. …”
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The INFLUENCE 3.0 model: Updated predictions of locoregional recurrence and contralateral breast cancer, now also suitable for patients treated with neoadjuvant systemic therapy by M.C. Van Maaren, T.A. Hueting, D.J.P. van Uden, M. van Hezewijk, L. de Munck, M.A.M. Mureau, P.A. Seegers, Q.J.M. Voorham, M.K. Schmidt, G.S. Sonke, C.G.M. Groothuis-Oudshoorn, S. Siesling

“…Results: In the non-NST and NST group, 49,631 and 10,154 patients were included, respectively. Age, mode of detection, histology, sublocalisation, grade, pT, pN, hormonal receptor status ± endocrine treatment, HER2 status ± targeted treatment, surgery ± immediate reconstruction ± radiation therapy, and chemotherapy were significant predictors for LRR and/or CBC in non-NST patients. …”
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Physical impairments in individuals with Long COVID by Imane Salmam, Imane Salmam, Kadija Perreault, Kadija Perreault, Krista L. Best, Krista L. Best, Imane Zahouani, Gilles Drouin, Jean Tittley, François Desmeules, François Desmeules, Alexandre Campeau-Lecours, Alexandre Campeau-Lecours, Simon Beaulieu-Bonneau, Simon Beaulieu-Bonneau, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Simon Deslauriers, Sarah-Maude Brouillard, Katherine Lepage, Jean-Sébastien Roy, Jean-Sébastien Roy

“…Physical assessments included handgrip strength (HGS), Short Physical Performance Battery (SPPB), 6-minute-walk-test (6MWT), perceived exertion during the 6MWT (Modified-Borg Scale), and daily step count during a 7-day period.ResultsMean age (mean [SD]) for LCG, SCG, and CG was 44.2 [11.2], 42.1 [16.4], and 46[15.9], respectively. …”
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Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

“…Persistent and new lymphopenia were associated with older age, male sex; prior immunosuppression, heart failure, aspirin use, and normal body mass index; biomarkers of organ damage (renal and lung), and ineffective immune response (elevated IL-6 and viral nucleocapsid antigen levels). …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…An early and significant morphological hallmark of HD is the activation of astrocytes triggered by mutant huntingtin, leading to the release of inflammatory mediators.Fingolimod (FTY), an FDA-approved sphingosine-1-phosphate (S1P) receptor agonist is used to treat multiple sclerosis (MS), a neuroinflammatory disease, and has shown therapeutic promise in other neurological conditions.Our study aimed to investigate the therapeutic potential of FTY for treating HD by utilizing a well-characterized mouse model of HD (zQ175dn) and wild-type littermates.The study design included a crossover, long-term oral treatment with 1 mg/kg to 2 mg/kg FTY from the age of 15–46 weeks (n = 128). Different motor behavior and physiological parameters were assessed throughout the study.The findings revealed that FTY rescued disease-related body weight loss in a sex-dependent manner, indicating its potential to regulate metabolic disturbances and to counteract neurodegenerative processes in HD. …”
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Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma by María L. Espejo-Cruz, Sandra González-Rubio, Juan J. Espejo, Javier M. Zamora-Olaya, María Prieto-Torre, Clara I. Linares, Álvaro Ruiz-Ramas, Álvaro Jiménez-Arranz, Marta Guerrero-Misas, Pilar Barrera-Baena, Antonio Poyato-González, José L. Montero, Marina Sánchez-Frías, María D. Ayllón, Manuel L. Rodríguez-Perálvarez, Manuel de la Mata, Gustavo Ferrín

“…Results In all, 48 patients with HCC undergoing TACE were included (age 64.2 ± 7.6 years, 14.6% women). CTC levels increased at D1 (114.0% [IQR 76.5%-178.0%], p = 0.019) and normalized to baseline levels in the first month after TACE (76.5% [IQR 41.3%-131.8%], p = 0.263). …”
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An exploration of healthcare professionals’ knowledge and perceived barriers about acute oxygen therapy: a survey in a tertiary care hospital, Sudan by Mustafa Sabir Abakar Awad, Mohammed Fadlelmola Abdalla Mohamednour, Fakher Aldeen Rafat, Mohaned Altijani Abdalgadir Hamdnaalla, Abdelrahman Elfatih, Faris Jamalaldeen Mohammed Hamed, Abubakr Muhammed, Ibrahim Awad, Mohammed Alsiddig AlKheder, Mohamed Almubarak Omer Elhado, Ayman Yahya, Salama Salah Alrawa, Munir Rafat Munir Lawis

“…Results A total of 184 medical professionals were included in the survey. The mean age of the study participants was 26 years, and 66.2% of all participants were male. …”
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Sickness absence trajectories among young employees in their first full-time employment and subsequent long-term sickness absence: a Danish register-based cohort study by Naja Hulvej Rod, Tea Lallukka, Ida Madsen, Ute Bültmann, Maria Melchior, Reiner Rugulies, Jacob Pedersen, Stephen Stansfeld, Jeppe Karl Sørensen, Karl Bang Christensen, Jimmi Mathisen

“…We aimed to identify SA trajectories in young full-time employees and explore them as risk markers for subsequent long-term SA (LTSA).Method In a nationwide register-based cohort of 91 633 young employees (aged 15–30) entering the Danish labour market between 2010 and 2018, we applied group-based multi-trajectory modelling to identify SA trajectories based on daily information on SA during the first year of full-time employment. …”
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Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews by Keith Wilson, Nigel Westwood, Catherine Wloch, Pauline Harrington, Luke J Rogers, Judith Tanner, Gavin Murphy, Colin S Brown, Jeremy Dearling, Ricky Vaja, Melissa Rochon, Lyn Brierley Jones

“…Interviewees were recruited through the survey.Participants Seventy participants completed the survey: 74% patients and 26% carers. A range of ages, sex, ethnicities and geographical locations were represented. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…The isolated eMSCs from IUA and controls show similar functions from the perspectives of cell morphology, proliferation, colony formation, exosome secretion, positive ratio of eMSC markers and conventional MSC markers, tri-differentiation efficiency, the ability of suppressing lymphocyte proliferation, cell aging, and promoting vascular tube formation. However, the eMSCs from IUA have reduced levels of decidualization and higher levels of cell migration, invasion, and also myofibroblast differentiation. …”
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Changes in African lion demography and population growth with increased protection in a large, prey‐depleted ecosystem by Scott Creel, Matthew S. Becker, Ben Goodheart, Anna Kusler, Kachama Banda, Kambwiri Banda, Milan Vinks, Catherine Sun, Chase Dart, Stephi Matsushima, Ruth Kabwe, Will Donald, Luka Zyambo, Peter Indala, Adrian Kaluka, Clive Chifunte, Craig Reid

“…In areas with high protection, lion fecundity was 29% higher, and mean annual apparent survival (φ) was 8.3% higher (with a minimum difference of 6.0% for prime‐aged adult females and a maximum difference of 11.9% for sub‐adult males). …”
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Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery by Reza Rezvani, Jessica Smith, Marc Lapointe, Picard Marceau, Andre Tchernof, Katherine Cianflone

“…Hepatic C5L2 mRNA expression was elevated in pre- versus postmenopausal women (P<0.01) and correlated positively with circulating estradiol, estrone, ApoB, ApoA1, ApoA1/B, waist circumference, age, and LDL-C (all P<0.05). While plasma ASP was lower in pre- versus postmenopausal women (P<0.01), the hepatic C5L2/C5aR mRNA ratio was increased (P<0.001) and correlated positively with estrone (P<0.01) and estradiol (P<0.001) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (all P<0.05). …”
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The association between ambient air pollution and the risk of incident nasopharyngeal carcinoma in Hangzhou, China by Zesheng Chen, Zongxue Cheng, Yaoyao Wu, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…The effects of ambient air pollution exposure on NPC were also discussed in subgroups by age, gender, region, and season. A total of 3121 NPC incident cases were included during the study period. …”
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Reducing health inequalities in disasters: A cross-sectional study of the viability of ‘vulnerability’ terminology and of priority lists in the UK by Poppy Ellis Logan, Gabriella Rundblad, Marian Brooke Rogers, Richard Amlôt, Gideon James Rubin

“…Study design: We collected data from 5148 UK-based adults using a cross-sectional online survey from July–September 2022, using nationally representative quotas for age, gender, disability, and social grade. Methods: We calculated the proportions of respondents with perceived indicators of ‘vulnerability’ who self-described as 'vulnerable during a disaster’, and who reported being on a Priority Service Register or another ‘vulnerability list’. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Though our data point to the potential clinical utility of FNDC5/irisin-targeted agents in the treatment of chemotherapy-induced cardiotoxicity, we also found significant down regulation in FNDC5 expression in the hearts of aged mice that attenuated the cardioprotective impacts of FNDC5 overexpression following doxorubicin exposure. …”
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Effects of adding a kind of compound bio-enzyme to the diet on the production performance, serum immunity, and intestinal health of Pekin ducks by Yuxiao Li, Jie Zhou, Tong Guo, Huiya Zhang, Chang Cao, Yingjie Cai, Jiqiao Zhang, Tao Li, Jianqin Zhang

“…Ducks were raised until 35 days of age, with weekly measurements of growth performance. …”
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Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice by Saleh Aldasouqi, Samia Mora, Gaurav Bhalla, Naveen Kakumanu, William Corser, George Abela, Mohammad Dlewati, Kathleen Estrada, Abdul Almounajed, Tarek Tabbaa, Jamal Hammoud, Cathy Newkirk

“…A total of 363 patients with complete data were analyzed, with a mean age of 60.6 (SD 12.5) years. A total of 62 (17.1%) patients reported having experienced one or more FEEHD events in the prior 12 months. …”
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Protocol for a feasibility study and process evaluation of a psychosocially modelled diabetes education programme for young people with type 1 diabetes: the Youth Empowerment Skill... by Nick Sevdalis, Khalida Ismail, Tayana Soukup, Trevor Murrells, Dulmini Kariyawasam, Stephen Thomas, Judith Parsons, Angus Forbes, Rita Forde, Maria Baldellou Lopez, Marie Jones, Martha Ford-Adams, Nardos Yemane, Siobhan Pender, Alex Silverstien

“…Fifty young people with type 1 diabetes (aged 14–19 years) will be randomly allocated to either the YES intervention or a waiting-list control. …”
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Predictive value of CT-based and AI-reconstructed 3D-TAPSE in patients undergoing transcatheter tricuspid valve repair by Johannes Kirchner, Muhammed Gerçek, Hazem Omran, Kai Peter Friedrichs, Felix Rudolph, Tobias Rossnagel, Misagh Piran, Arseniy Goncharov, Maria Ivannikova, Volker Rudolph, Tanja Katharina Rudolph

“…Thus, this study aimed to analyze whether CT-captured TAPSE provides additional value in predicting outcomes after TTVI.Methods and resultsFor TTVI procedure planning, 75 patients (mean age, 77 ± 8 years; 61% female) with severe TR underwent full cardiac cycle CT. …”
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