Estimation of the incidence of invasive meningococcal disease using a capture–recapture model based on two independent surveillance systems in Catalonia, Spain by Pilar Ciruela, Carmen Munoz-Almagro, Cristina Rius, Tomas Pumarola, Frederic Gomez-Bertomeu, Núria Soldevila, Ángela Domínguez, LAURA RUIZ, Ana Calderon, Ana Martinez, M Ángeles Domínguez, Mercé Garcia, Dionisia Fontanals, Gloria Carmona, Pere Godoy, Goretti Sauca, Jordi Vila, Marta Vilaró, Mireia Jané, Tomás Garcia, Sergi Hernández, Maria Teresa Bastida, Frederic Ballester, Isabel Pujol, Miguel Angel Benítez, Alba Cebollero, Jordi Bosch, Margarida Curriu, Fe Tubau Quintano, Jose Manuel Ramirez, Ma Jose Fusté, Carme Gallés, Pilar Hernandez Pérez, ElisendaCapdevila GildeBernabe, Paula Gassiot, Araceli González-Cuevas, Marius Juanpere, Amaresch Perez Arguello, Carmina Martí, Nuria Margall, Lurdes Matas, Montserrat Giménez, Montserrat Morta, Gloria Trujillo, Silvia Noguer, Montserrat Olsina, Amaia Oteiza Ubanell, Pepa Perez, Mar Olga Pérez-Moreno, Juanjo Gonzales, Xavier Raga, Mercè Ribelles, Esther Sanfeliu, Isabel Sanfeliu, Anna Vilamala, César Arias, Irene Barrabeig, Neus Camps, Mònica Carol, Núria Follia, Sofia Minguell, Ignasi Parron, Ma Rosa Sala-Farré, Ariadna Rovira

“…Multivariate vector generalised linear model was performed for adjusted estimation.Measures The variables collected were age, sex, year of report, size of municipality (<10 000 and ≥10 000), clinical form, death, serogroup, country of birth and type of reporting centre (private and public).Results The sensitivity of the two combined surveillance systems was 88.5% (85.0–92.0). …”
Get full text

Abnormal EEG Spectral Power and Coherence Measures During Pre-Motor Stage in Amyotrophic Lateral Sclerosis by Saroj Bista, Amina Coffey, Matthew Mitchell, Antonio Fasano, Stefan Dukic, Teresa Buxo, Eileen Giglia, Mark Heverin, Muthuraman Muthuraman, Richard G. Carson, Madeleine Lowery, Lara McManus, Orla Hardiman, Bahman Nasseroleslami

“…We recorded EEG in 22 people with ALS (PwALS) and 16 age-matched healthy controls during rest and isometric pincer-grip tasks. …”
Get full text

Body mass index and B‐lines on lung ultrasonography in chronic and acute heart failure by Philip Brainin, Brian Claggett, Eldrin F. Lewis, Kristin H. Dwyer, Allison A. Merz, Montane B. Silverman, Varsha Swamy, Tor Biering‐Sørensen, Jose Rivero, Susan Cheng, John J.V. McMurray, Scott D. Solomon, Elke Platz

“…Methods and results We analysed ambulatory chronic HF (n = 118) and hospitalized AHF (n = 177) patients (mean age 70 years, 64% men, mean BMI 29 kg/m2, mean ejection fraction 42%) undergoing echocardiography and LUS in eight chest zones. …”
Get full text

Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic by Roman Chlibek, Jan Smetana, Kateřina Kybicová, Martina Malikova, Frederick J. Angulo, Alexandra Loew-Baselli, Ye Tan, Aleš Ondřejíček, Gordon Brestrich, Andreas Pilz, Jennifer C. Moïsi, James H. Stark

“…Results: Samples from 1996 adults were tested; the median age (range) was 45 (18 −87) years; 1037 (52.0 %) were female. …”
Get full text

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination by Yingling Liu, Yuli Cai, Si Chen, Yawen Gou, Qiaomin Wang, Mingli Zhang, Yetao Wang, Haiou Hong, Kaiguang Zhang

“…Risk factors including age, H. pylori infection, history of antibiotic misuse, and spicy and high-fat diet (all P<0.05) were further verified by multivariate analysis as independent risk factors. …”
Get full text

Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
Get full text

Risk Factors and Circulating Subtypes of <i>Cryptosporidium</i> spp. and <i>Giardia duodenalis</i> in Hospitalized Children in Mozambique by Ofélia Nhambirre, Maria Luísa Lobo, Idalécia Cossa-Moiane, Adilson Bauhofer, Nilsa de Deus, Olga Matos

“…The location (odds ratio [OR] 3.499), mother’s education level (OR 2.150) and age were significant factors for acquiring infection by <i>Cryptosporidium</i> spp. …”
Get full text

Canonical correlation analysis of family burden of disease and quality of life in caregivers of people living with schizophrenia: evidence from Schizophrenia-specific cohort in the... by Ximei Wang, Teng Zhang, Mingsong Li, Bo Yang, Liming Wang, Chuanwen Fu, Nishang Zhang, Zhengxu Li, Ce Yang, Zhimin Zhao, Qiong Meng, Yuemei Feng, Jianzhong Yin

“…In our study, we found that gender, age, education level, personal monthly income, history of smoking and alcohol consumption, subjective sleep quality, relation to the patient, degree of self-care and the number of relapses in patient all influence 1 to 4 domains of quality of life for caregivers, stratified analysis was conducted to minimize the effect of gender on the results, we still found that history of smoking could positively predict the score of psychological domain and history of alcohol consumption could positively predict the score of social relationships domain. …”
Get full text

The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous univ... by Abdulmuminu Isah, Gabriel Ezenri, Ogechi Obi, Nnamdi A. Okibe, Hadiza Usman Ma’aji, Ezinwanne J. Ugochukwu, Cynthia C. Eze, Chisom M. Amoke, Augustus Ezeodimegwu, Charles C. Idabor, Mustapha Muhammed Abubakar, Francis Iloabuchi, Ikenna John Ugwu, Chukwuebuka M. Asogwa, Chinwe V. Ukwe, Blessing Onyinye Ukoha-kalu

“…Results 1017 students responded to the questionnaire. The modal age was 18–24 years (754 [74.1%]), and most of them (886 [87.1%]) were unmarried. …”
Get full text

Diagnostic disparities in inborn errors of immunity: From clinical suspicion to diagnosis by Karen M. Gilbert, PhD, Robert F. LeCates, MA, Alison A. Galbraith, MD, MPH, Paul J. Maglione, MD, PhD, Stephanie Argetsinger, MPH, Nicholas L. Rider, DO, Jocelyn R. Farmer, MD, PhD, Mei-Sing Ong, PhD

“…Residence in neighborhoods with greater deprivation was also associated with more severe IEI-related symptoms and greater health care utilization in the year after uID diagnosis. Older age was associated with longer diagnostic interval (P < .001). …”
Get full text

Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium by Jessy Xinyi Han, Min Jung Koh, Leora Boussi, Mark Sorial, Sean M. McCabe, Luke Peng, Shambhavi Singh, Ijeoma Julie Eche-Ugwu, Judith Gabler, Maria J. Fernandez Turizo, Caroline T. MacVicar, Aditya Garg, Alexander Disciullo, Kusha Chopra, Alexandra Lenart, Emmanuel Nwodo, Jeffrey Barnes, Min Ji Koh, Eliana Miranda, Carlos Chiattone, Robert Stuver, Steven M. Horwitz, Mwanasha Merrill, Eric Jacobsen, Martina Manni, Monica Civallero, Tetiana Skrypets, Athina Lymboussaki, Massimo Federico, Yuri Kim, Jin Seok Kim, Jae Yong Cho, Thomas Eipe, Tanuja Shet, Epari Sridhar, Alok Shetty, Saswata Saha, Hasmukh Jain, Manju Sengar, Carrie Van Der Weyden, Henry Miles Prince, Ramzi Hamouche, Tinatin Murdashvili, Francine Foss, Marianna Gentilini, Beatrice Casadei, Pier Luigi Zinzani, Takeshi Okatani, Noriaki Yoshida, Sang Eun Yoon, Won-Seog Kim, Girisha Panchoo, Zainab Mohamed, Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al-Mansour, Josie Ford, Maria Elena Cabrera, Amy Ku, Govind Bhagat, Helen Ma, Ahmed Sawas, Khyati Maulik Kariya, Makoto Iwasaki, Forum Bhanushali, Owen A. O’Connor, Enrica Marchi, Changyu Shen, Devavrat Shah, Salvia Jain

“…We identified several independent predictors of OS for R/R lymphoma including age >60 years, primary refractory disease, histological subtype other than angioimmunoblastic T-cell lymphoma (AITL), extranodal sites >1, Ki67 ≥40%, and absolute lymphocyte count less than the lower limit of normal. …”
Get full text

Parameters Suggesting Spontaneous Passage of Stones from Common Bile Duct: A Retrospective Study by Tawfik Khoury, Mohamed Adileh, Ashraf Imam, Yosef Azraq, Avital Bilitzky-Kopit, Muhamad Massarwa, Ari Benson, Zaher Bahouth, Samir Abu-Gazaleh, Wisam Sbeit, Rifaat Safadi, Abed Khalaileh

“…Comparing groups D versus E, it was found that male gender (P=0.03), older age (P<0.001), high levels of GGT (P=0.022), high levels of alkaline phosphatase (P=0.011), high levels of total bilirubin (P=0.007), and lower levels of amylase (P<0.001) are predictors for positive MRCP studies for CBD stones. …”
Get full text

Prevalence and risk factors of postpartum depression, general depressive symptoms, anxiety and stress (PODSAS) among mothers during their 4-week postnatal follow-up in five public... by Boon How Chew, Subashini Ambigapathy, Saidatul Akmar Mohammad Redzuan, Priyasini Suntharalingam, Thenmoli Palaniyappan, Venotha Ganasan, Puteri Normalina Megat Abu Bakar, Paream Kaur, Lili Zuryani Marmuji, V Paranthaman

“…Participants will be mothers aged 18 years and above at 4 weeks postdelivery who are able to understand the English and Malay languages. …”
Get full text

The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study by Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda

“…PSM was performed between the OPEN and CLOSED groups on the basis of the following 13 factors: age, sex, BMI, diabetes mellitus (DM), smoking history, modified Glasgow prognostic score (mGPS), ASA-PS, location of distal tumor edge, operative procedure, surgical approach, operative time, intraoperative blood loss, and pathological stage. …”
Get full text

The impact of food-based incentive behaviors on oral health among Saudi children: a cross-sectional study by Yasir Dilshad Siddiqui, Saud Hamdan Almaeen, Ahmed Shawkat Hashem, Ahmed Ali Ahmed Almuntashiri, Mohammed Nadeem Baig, Abdullah Hammad Alshammari, Rital Jamal Alwaqid, Haifa Ali Almutairi, Raha Ahmed, Rakhi Issrani, Farooq Ahmad Chaudhary

“…The study included 316 medically healthy children aged 4 to 10 years and their Arabic or English-speaking guardians. …”
Get full text

Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol by Joht Singh Chandan, Emmanuela Gakidou, Jaidev Kaur Chandan, Nicholas Metheny, Mariam Khalil, Cory N Spencer, María Jose Baeza, Alexandra Debure, Molly Herbert, Teresa Jewell, Rachel Qian Hui Lim, Sonica Minhas

“…Where possible, variations in associations by subgroup, that is, age, sex or gender, will be explored.Ethics and dissemination Formal ethical approval is not required. …”
Get full text

Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MI... by Fiona McNicholas, Dieter Wolke, Jason Madan, Jatinder Singh, Federico Fiori, Paramala Santosh, Jane Warwick, Helena Tuomainen, Swaran Singh, Laura Adams, Mathilde Mastroianni, Natalie Heaney, Kate Lievesley, Ilyas Sagar-Ouriaghli, Giovanni Allibrio, Rebecca Appleton, Nikolina Davidović, Giovanni de Girolamo, Gwen Dieleman, Katarina Dodig-Ćurković, Tomislav Franić, Charlotte Gatherer, Suzanne Gerritsen, Elisa Gheza, Lidia Manenti, Athanasios Maras, Francesco Margari, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Francesco Rinaldi, Vehbi Sakar, Ulrike Schulze, Giulia Signorini, Cathy Street, Priya Tah, Sabine Tremmery, Amanda Tuffrey, Frank Verhulst, Anna Wilson

“…To improve this state of affairs, there needs to be a recognition of the problem and initiatives and an urgent requirement for appropriate tools for measuring readiness and outcomes at the transfer boundary (16–18 years of age in Europe). The objective of this study was to develop and validate the Transition Readiness and Appropriateness Measure (TRAM) for assessing a young person’s readiness for transition, and their outcomes at the transfer boundary.Design MILESTONE prospective study.Setting Eight European Union (EU) countries participating in the EU-funded MILESTONE study.Participants The first phase (MILESTONE validation study) involved 100 adolescents (pre-transition), young adults (post-transition), parents/carers and both CAMHS and AMHS clinicians. …”
Get full text

Assessment of risk communication and community engagement interventions during the Marburg virus disease outbreak in Kagera region, Northwestern Tanzania by Mololo Noah Mwanjala, Emmanuel Mnkeni, Mikidadi Issanudia Mtalika, Marcelina Mponela, Atuganile Musyani, George Mrema, Amour Seleman, Catherine Gitige, Kokuhabwa Mukurasi, Gloria Macha, Hussein Mohamed, Pius Horumpende, Leopord Sibomana Leonard, Jonathan Mcharo, Wangeci Gatei, Salum Manyatta

“…The majority 628 (88%) were aged 18 years and above. There were 393 (55%) females, and 407 (57%) of respondents had completed primary education. …”
Get full text

Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Factors associated with mortality included male gender (HR: 3.63, p=0.02), diabetes (HR: 2.49, p=0.03), oxygen saturation below 90% at admission (HR: 5.23, p&lt;0.01), high blood glucose levels (HR: 3.68, p=0.01), age (HR: 1.04, p=0.02), and more than 25% lesion extension on chest CT scan (HR: 2.28, p=0.03).ConclusionsLPV/r, but not DRV/r, showed a survival benefit in patients hospitalised with COVID-19, but these findings deserve further investigation in a randomised clinical trial.…”
Get full text

Association of Delayed Denosumab Dosing with Increased Risk of Fractures: A Population-Based Retrospective Study by Kyoung Min Kim, Seol A Jang, Nam Ki Hong, Chul Sik Kim, Yumie Rhee, Seok Won Park, Steven R. Cummings, Gi Hyeon Seo

“…Methods The study cohort included women aged 45 to 89 years who were started on denosumab for osteoporosis between October 2017 and December 2019 using data from the Korean Health Insurance Review and Assessment service. …”
Get full text