Zinc absorption from maize-based meals enriched with edible house crickets: a randomized crossover stable-isotope study in Kenyan pre-school children by Nikolin Hilaj, Tele Boit, Pauline Andang’o, Christophe Zeder, Martin N. Mwangi, Marijke Hummel, Ornella Necochea Velazco, Joop J. A. van Loon, Marcel Dicke, Michael B. Zimmermann, Alida Melse-Boonstra

“…We investigated zinc absorption from house crickets (Acheta domesticus) in a single-center and single-blinded cross-over study with children aged 24–36 months old in Kenya from September-November 2021. …”
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Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA... by Sho Furusawa, Hiroshi Nomoto, Chiho Oba-Yamamoto, Jun Takeuchi, Miki Ito, Hiroyoshi Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. …”
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Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization by Yeon-Su Gwak, Seo-Yeon Kim, Chae-Eon Woo, Kihyuk Shin, Eunjeong Son, Jin-Woo Kim, Sung-Jin Kim, Tae-Jin Song, Hae Ryoun Park, Kihun Kim, Dai Sik Ko, Yun Hak Kim

“…The adjustment accounted for various factors, including sex, age, smoking status, and other medical comorbidities, along with several additional variables. …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing’s syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
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Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study by Bo Zhang, Archana A Patel, Gretchen L Birbeck, Maitreyi Mazumdar, Suzanna Mwanza, Rosemary Nyirongo, Dixon Berejena, Joseph Kasolo, Tina Mwale, Violet Nambeye, Kafula Lisa Nkole, Nfwama Kawatu, Alexander Rotenberg

“…Our goal is to develop a predictive PME index composed of EEG and clinical history metrics that are highly feasible to obtain in low-resourced regions.Methods and analyses This prospective observational study being conducted in Eastern Zambia will recruit 250 children aged 6 months to 11 years presenting with acute CM and follow them for two years. …”
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Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

“…Donor demographics between the two groups were similar, with a mean age of 31.5±10 years. There was a non-significant trend towards higher acceptance rates by local surgeons compared to recipient center surgeons (96% vs 82.9%, p=0.139). …”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Results In the tDCS study, of 141 participants (102 [72.3%] women; mean age 35.7 years, standard deviation 12.7), 95 completed the trial. …”
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SMRT sequencing and ddPCR reveal the complexity of developmental trajectories and temporal dynamics of gut bifidobacterial communities in infants by Xu Gao, Tao Zhang, Xiaoye Bai, Qiannan Wen, Dongyu Li, Lai-Yu Kwok, Heping Zhang, Zhihong Sun

“…Thus, this was a pilot study aiming to describe the developmental trajectories and temporal dynamics of bifidobacterial communities in infants before 6 months of age. A total of 28 fecal samples from 4 infants (GF, ZZ, QM, TN, respectively) were collected and analyzed after 5, 15, 30, 60, 90, 120, 150, and 180 days of birth by a bifidobacteria-target method (based on single-molecule real-time sequencing of partial bifidobacterial rpsK genes) in conjunction with droplet digital polymerase chain reaction (ddPCR). …”
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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general popu... by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

“…B‐mode ultrasonography was used to assess hepatic steatosis. Results The mean age and body mass index (BMI) of participants were 63.5 ± 10.2 years and 23.0 ± 3.1 kg/m2, respectively. …”
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Biomarkers for Predicting Left Atrial or Left Atrial Appendage Thrombus in Anticoagulated Patients with Nonvalvular Atrial Fibrillation by Xue Zhou, Zuolan Wang, Shuang Dou, Kangyin Chen, Enzhao Liu, Tong Liu, Guangping Li, Jingjin Che

“…Of the 260 consecutive subjects (mean age: 63.67 ± 9.39 years; 42% women), 45 (17.3%) patients were with LA/LAA thrombus, 131 (50.4%) were with SEC, and 84 (32.3%) were with neither thrombus nor SEC. …”
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Association between body size and atrial myopathy: Investigation using the prevalence of left atrial low-voltage areas by Yasuhiro Matsuda, Masaharu Masuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Masaya Kusuda, Toshiaki Mano

“…Methods: In total, 1,479 (age, 68 ± 10 years; female, 500 [34 %]) consecutive patients who underwent initial AF ablation were enrolled. …”
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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

“…The analytic sample consisted of n=4598 participants, median age 26 and 73% female.Interventions At each site, participants were randomly assigned to either immediate receipt of a self-directed forgiveness workbook intervention, or to receipt after a 2 week delay.Main outcomes measures The primary outcomes were unforgiveness (Transgression-Related Interpersonal Motivations Inventory-18), depression symptoms, and anxiety symptoms (Brief Symptom Inventory-18) measured at 2 weeks following intervention assignment.Results At 2 weeks follow-up, unforgiveness was lower among the immediate-treatment group compared with the delayed-treatment group (standardised mean difference=−0.53 (95% CI=−0.58 to –0.47)); similar patterns were found for depression (standardised mean difference=−0.22 (95% CI=−0.28 to –0.16)) and anxiety symptoms (standardised mean difference=−0.21 (95% CI=−0.27 to –0.15)).Conclusions A brief workbook intervention promoted forgiveness and reduced depression and anxiety symptoms. …”
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Racial Disparities in Cancer Guideline-Concordant Treatment Using Surveillance, Epidemiology, and End Results Data for Patients With NSCLC by Eric Ababio Anyimadu, MS, Jacklyn M. Engelbart, MD, Jason Semprini, PhD, Amanda Kahl, MPH, Cameron Trentz, MS, John M. Buatti, MD, Thomas L. Casavant, PhD, Mary E. Charlton, PhD, Guadalupe Canahuate, PhD

“…Observed probabilities and logistic regression models adjusted for age, disease stage, and race were used to assess racial disparities in treatment and survival, with the Kaplan-Meier method evaluating survival rates. …”
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Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence by John McLaughlin, Dipesh H Vasant, Asbjørn Mohr Drewes, Abhiram Sharma, Matthew Davenport, Edward Kiff, Karen Telford, Alexander O'Connor, Donghua Liao, Niels Klarskov

“…FI severity was assessed with the Vaizey score and quality-of-life with the Manchester Health Questionnaire.Results 40 patients (39 women, median age: 62 (range: 38–85)) were recruited with 27 (67.5%) reporting urge FI, 8 (20%) mixed and 5 (12.5%) passive incontinence. …”
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Development and cross-validation of predictive equations for fat-free mass estimation by bioelectrical impedance analysis in Brazilian subjects with overweight and obesity by Kalina Veruska Da Silva Bezerra Masset, Analiza M. Silva, Analiza M. Silva, Gerson Ferrari, Gerson Ferrari, Breno Guilherme De Araújo Tinoco Cabral, Paulo Moreira Silva Dantas, Roberto Fernandes Da Costa

“…Thus, the objectives of this study were: (1) to test the validity of four BIA equations used for fat-free mass (FFM) estimation and one model for fat mass (FM) estimation in adults with overweight or obesity; (2) develop and cross-validate new equations to estimate FFM to adults with overweight or obesity, and specific for those with obesity.MethodsThe non-probabilistic sample included 269 individuals, 53.2% with overweight and 46.8% with obesity, aged 18–79 years, randomly divided into two groups: development (n = 178) and cross-validation (n = 91), stratified by sex and classification as overweight or obese. …”
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Effectiveness of an Impella Versus Intra‐Aortic Balloon Pump in Patients Who Received Extracorporeal Membrane Oxygenation by Yuji Nishimoto, Hiroyuki Ohbe, Jun Nakata, Toru Takiguchi, Mikio Nakajima, Yusuke Sasabuchi, Toshiaki Isogai, Hiroki Matsui, Yukihito Sato, Tetsuya Watanabe, Takahisa Yamada, Masatake Fukunami, Hideo Yasunaga

“…Results Of 14 319 eligible patients, 590 (4.1%) received ECPella and 13 729 (96%) received ECMO+IABP. The mean age of patients was 65 years, 77% were men, and 57% had acute coronary syndrome. …”
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The association Malnutrition-Inflammation Score with chronic kidney disease-associated pruritus and quality of life in hemodialysis patients: a multicenter cross-sectional study by Hossein Bavi Behbahani, Meysam Alipour, Ahmad Zare Javid, Hamidreza Razmi, Pardis Tofighzadeh, Fatemeh Fayazfar, Sara Keramatzadeh, Shiva Shokri, Haleh Soltaniyan Dehkordi, Kian Khosravi, Siavash Babajafari Esfandabad, Shokouh Shayanpour

“…Significant differences were observed across MIS quartiles in terms of age, dialysis vintage, dialysis time, and urine volume (p < 0.05 for all). …”
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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

“…Objectives The aim of this study is to derive and validate a reliable indicator for predicting an increased risk of postoperative mortality in elderly patients undergoing curative resection for colorectal cancer (CRC).Design This study is of multicentre retrospective design.Setting and participants A total of 1227 CRC patients undergoing curative resection (age ≥65 years) from three distinct cohorts were retrospective enrolled. …”
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Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production by Beatriz Castro-Robles, Francisco J. Cimas, Francisco J. Cimas, Lourdes Arias-Salazar, Jesús Ontañón, Julia Lozano, Susana López-López, Fernando Andrés-Pretel, María Ángeles Requena-Calleja, Antonio Mas, Antonio Mas, Antonio Mas, Gemma Serrano-Heras, Tomás Segura, Tomás Segura, Javier Solera

“…Incremental and decremental response groups did not differ in terms of age, sex, cardiovascular risk factors, previous SARS-CoV-2 infection and influenza vaccine co-administration. …”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…The expression of FNDCs and GPR116 was independent of age and sex. Conclusions. FNDC1 and FNDC4 may play a relevant role in the pathobiology of IBD, but none of the investigated FNDCs is regulated in CRC. …”
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