Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma by Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang

Get full text

Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study by Shibo Guo MD, Zhehao Lyu PhD, Chunyu Duan MD, Hui Wang PhD, Peng Xu MD, Wei Han BD, Peng Fu PhD

“…Results A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). …”
Get full text

Elevational ranges of pioneer marsh species are site specific and likely shaped by different abiotic and biotic factors by Charlotte S. Steinigeweg, Ole J. Siebeneicher, Boris Schröder, Michael Kleyer, Kertu Lõhmus, Swantje Löbel

“…To test the hypothesis that species have different elevational ranges, which are shaped by local abiotic conditions and biotic interactions, salt marsh species occurrences and covers were recorded along 65 seaward–landward transects at two study sites on the back‐barrier island Spiekeroog in the German Wadden Sea, differing in topography, site age, and history. Elevations were extracted from a digital terrain model. …”
Get full text

The relationship between sarcopenia and mental health status in Chinese older adults: the mediating role of activities of daily living by Huaiju Ge, Shilan Yang, Wenyu Su, Weimin Guan, Shihong Dong, Wenjing Chang, Huiyu Jia, Shan Jiang, Di Qin, Guifeng Ma

“…Methods This study used data from the 2015 and 2018 China Health and Retirement Longitudinal Study, including a total of 3,552 older adults aged 60 and above. We conducted descriptive statistical analysis and correlation analysis on the data and used seemingly unrelated regression to examine the relationship between sarcopenia, depressive symptoms, and cognitive functions in older adults. …”
Get full text

Effectiveness and utilization of a cognitive screening program for primary geriatric care by David P. Salmon, Anna Malkina, Melanie L. Johnson, Christina Gigliotti, Emily A. Little, Douglas Galasko

“…Results The 638 patients screened (mean age = 75.9 years; mean education = 14.9 years; 58% women) were classified by screening as having normal cognition (n = 177), depression (with possible cognitive changes; n = 115), mild cognitive impairment (MCI; n = 107), or dementia (n = 239). …”
Get full text

The role of the left primary motor cortex in apraxia by Ksenia Perlova, Claudia C. Schmidt, Gereon R. Fink, Peter H. Weiss

“…Results Patients with and without M1 involvement did not differ in age and time post-stroke but in lesion size. When controlling for lesion size, the total apraxia scores did not differ significantly between groups. …”
Get full text

Prognostic importance of human leukocyte antigen DRβ1 gene and protein tyrosine phosphatase nonreceptor Type 22 gene polymorphism in rheumatoid arthritis by Pramod Kumar Verma, Usha Singh, Shyam Kumar Saraf, Narendra Kumar Singh

“…DRβ1*10 positive patients had negative correlation with the age of the RA patients. These patients have shown early onset of disease. …”
Get full text

Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort st... by Peter D Sly, Md Jobayer Chisti, Abdullah Mamun, K M Shahunja

“…We identified three distinct asthma symptom trajectories from age 0/1 year to 14/15 years: ‘low/no’ (69%), ‘transient high’ (17%) and ‘persistent high’ (14%). …”
Get full text

Assessment of Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer Changes following Cataract Surgery in Patients with Pseudoexfoliation Glaucoma by Ahmed A. Abdelghany, Moataz A. Sallam, Abdallah A. Ellabban

“…There was no difference in the mean age and glaucoma stage in both groups (P=0.242 and 0.70, respectively). …”
Get full text

Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database by Hanzhang Yuan, Jingsheng Cheng, Jun Xia, Zeng Yang, Lixin Xu

“…These 3 genes were found significantly correlated with clinicopathological features (age, WHO grade, IDH mutation status, 1p19q codeletion status). …”
Get full text

Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…Of 329 participants screened, 215 (65%) received sotrovimab (median age 39 [range 19–65] years; 57% female; mean body mass index 25.4 kg/m2). …”
Get full text

The safety and efficacy of immune checkpoint blockade in children, adolescents, and young adults: A systematic review and meta-analysis by Pedro C.A. Reis, João Evangelista Ponte Conrado, Mariana Macambira Noronha, Luís Felipe Leite da Silva, Erick Figueiredo Saldanha, Jonathan Metts

“…Results: 15 trials were included, comprising 797 patients (median age ranging from 6.5 to 16.0 years). All-grade TRAE rate of 66 % was found (95 % CI 60–71), while the proportion of grade 3/4 TRAEs was 19 % (95 % CI 14–27). …”
Get full text

Eye removal surgical techniques by M.B. Gushсhina, N.S. Yuzhakova, N.A. Gavrilova, T.S. Kondratenko

“…More than 50% of these patients are young working age individuals. Two major techniques of eye removal are used in clinical practice, i.e., evisceration and enucleation. …”
Get full text

Sleep patterns and cardiovascular disease risk in US participants: a comprehensive analysis by Yue Wu, Zhizheng Li, Peng Zhao, Jiajing Xu, Min Yuan

“…Our study also suggested an interaction between sleep patterns and age (P for interaction = 0.002).ConclusionThis study highlights the significant association between poor sleep patterns and an increased risk of CVD in US participants.…”
Get full text

Is the convergence insufficiency symptom survey applicable to elderly individuals? by Saeid Abdi, Haleh Kangari, Saeed Rahmani, Alireza Akbarzadeh Baghban, Zahra Kamary Rad

“…Classical and Rasch analyses were conducted. Results The mean ages and gender ratios in the CI group and normal group were 49.70 ± 5.96 and 49.82 ± 5.64 years with a 50% female distribution among individuals. …”
Get full text

Association between oral microbiome diversity and all-cause mortality: a longitudinal study of NHANES, 2009–2012 by Bo Lin, Liang Zheng, Wanna Chen, Ju Yu, Zhanqiang Zhang, Weiming Lv

“…Cox proportional hazards regression models were used to estimate the HR and 95% CI for all-cause mortality according to the quartiles of ASV number, adjusted for potential confounders.Results Among the 8224 participants (mean (SD) age: 42.0 (15.1) years; 49.9% male; 37.2% white, 23.8% black, 27.2% Hispanic and 11.8% other race/ethnicity), the median follow-up time was 108 months (IQR, 95–120 months) and 429 (5.2%) deaths were identified. …”
Get full text

Understanding trends in osteoporosis drug prescribing: implications for reducing futile biomedical research by Jonathan R. Guillemot, Jonathan R. Guillemot, John W. Abraham, Anthea Tinker

“…The interplay of clinical evidence, diagnostic tools availability, and broader societal attitudes toward aging and treatment efficacy affect medical attitude and prescribing behaviors. …”
Get full text

Swiss chiropractic practice-based research network and musculoskeletal pain cohort pilot study: protocol of a nationwide resource to advance musculoskeletal health services researc... by Milo A Puhan, Viktor von Wyl, Alice Kongsted, Cesar A Hincapié, Léonie Hofstetter, Rahim Lalji

“…Phase II will recruit consecutive patients aged 18 years or older with MSK pain from community-based chiropractic practices participating in the PBRN into a prospective chiropractic cohort pilot study. …”
Get full text

Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection by Yong-yu Mei, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, Wen-xiong Xu

“…A total of 54 patients were included. Age was 42.5 ± 10.4 years. Baseline HCV RNA was 6.29 ± 0.89log10 IU/mL. …”
Get full text

CHRONOTYPE AND DAILY FUNCTIONING OF PATIENTS WITH DIFFERENT MOTOR SUBTYPES OF PARKINSON DISEASE by A.D. Shkodina, M. Bardhan, K.A. Tarianyk, M. Yu. Delva

“…Thus, we have found that patients with PD differ from age-matched controls without neurodegenerative diseases by chronotype and circadian pattern of functioning. …”
Get full text