Influence of intravenous lidocaine infusion on haemodynamic response to tracheal intubation and metabolic-hormonal responses during laparoscopic procedures in children: a randomise... by Maciej Kaszyński, Alicja Kuczerowska, Justyna Pietrzyk, Piotr Sawicki, Paweł Witt, Barbara Stankiewicz, Marek Darowski, Izabela Pągowska-Klimek

“…Methods A single-centre, parallel, double-masked, randomised, placebo-controlled trial. 132 patients, aged 18 months to 18 years, with no contraindications to lidocaine administration and qualified for laparoscopic appendectomy were enrolled. …”
Get full text

Prescription of Strong Opioids in Chronic Non-Cancer Pain in the Province of Valladolid (Spain) by Rodrigo Enríquez de Salamanca Gambara, Ana María Sierra Santos, Ana María Ruiz San Pedro, Federico Montero Cuadrado, Irene Muñoz León, Miguel Ángel Castro Villamor, Alicia Córdoba Romero, Ana María Del Olmo Tornero, Lucía Pérez Pérez, León Morales-Quezada

“…Of the patients, 62.4% were aged 70 or older, 39.8% lived in rural areas, and 9.9% resided in nursing homes. …”
Get full text

Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner by Wenxiang Qing, Huimin Chen, Xin Ma, Jie Chen, Yuan Le, Hui Chen, Jianhua Tong, Kaiming Duan, Daqing Ma, Wen Ouyang, Jianbin Tong

“…Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. …”
Get full text

Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…However, trends in post‐transplant pulmonary function vary due to factors such as pre‐transplant lung conditions, patient age, and treatment protocols. Innovative diagnostic methods, such as parametric response mapping (PRM) and multiple breath washout (MBW), show promise in enhancing early detection and management of pulmonary complications. …”
Get full text

Clinical characteristics and treatment outcomes of patients with insulinoma–a single center's experience of 76 cases over a 10-year period by Wei Li, Yali Cheng, Qingyong Ma, Zheng Wu, Zheng Wang

“…Results: Our cohort consisted of 48 females and 28 males with an average diagnosis age of 52 years. Loss of consciousness (68 %), sweating (59 %), vertigo (56 %) are three most shown symptoms. …”
Get full text

Sex similarities and differences in the reverse and anti-remodeling effect of pressure unloading therapy in a rat model of aortic banding and debanding by Tímea Bálint, Mihály Ruppert, Bálint András Barta, Korkmaz-Icöz Sevil, Loganathan Sivakkanan, Attila Oláh, Sayour Alex Ali, Kálmán Benke, Dávid Nagy, Karck Matthias, Oliver Schilling, Béla Merkely, Gábor Szabó

“…Methods: Pressure overload was induced in male and female rats by aortic banding (AB) for 6 and 12 weeks. Age-matched sham operated animals served as controls. …”
Get full text

Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis by Yuichiro Iwamoto, Tomohiko Kimura, Takashi Itoh, Shigehito Mori, Taku Sasaki, Mana Ohnishi, Haruka Takenouchi, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…We compared the clinical parameters and computed tomography (CT) between the groups. The mean age of participants was 57.7 ± 20.4 years, and their mean HbA1c was 11.1 ± 3.3%. …”
Get full text

Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency by Haishao Yu, Haishao Yu, Shuangzhu Lin, Lin Li, Jiayi Li, Qiandui Chen, Yuheng Wu, Yangfan Qi, Wanqi Wang, Xingzhi Chang, Jie Zhang

“…Case presentationA girl aged 2 years and 5 months presented to the hospital with chief complaints of intermittent fever and weakness of the left limb for more than 1 month. …”
Get full text

A 10-year review of isoniazid-resistant TB management in Uzbekistan 2009-2020 by M.L. Rekart, P. Thit, M. Oluya, S. Moe, T. Hasan, N. Parpieva, K. Safaev, A. Khristusev, T. Zinaida, J. Singh, S. Allamuratova, I. Azamat, C.G. Restrepo, N. Sitali, J. Achar, J.L. Alvaraez, A. Sinha

“…Unsuccessful outcomes were more common with older age, diabetes, chest X-ray cavities, smear positivity, smear-positive persistence, and male sex. …”
Get full text

Comparison of In Vitro Fertilization Outcomes between Normal and T-Shaped Uteri, Diagnosed by Hysterosalpingography in Women with infertility: A Retrospective Cohort Study by Fattaneh Pahlavan, Shohreh Irani, Mehri Mashayekhi, Samira Vesali, Fatemeh Niknejad, Firoozeh Ahmadi, Narges Bagheri-Lankarani

“…Using the Chi-square test, the success rate of IVF in those groups was compared.Results: Of 468 cases, 91 cases had T-shaped uterus and 377 cases had normal uterus. The mean age of patients was34 ± 3. The frequency of positive chemical pregnancy in the T-shaped uterus group was 42.9%, but 48% in the normaluterus group. …”
Get full text

Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury by Bharti Sharma, Winston Jiang, Munirah M. Hasan, George Agriantonis, Navin D. Bhatia, Zahra Shafaee, Kate Twelker, Jennifer Whittington

“…<b>Result</b>: Variations in hospital (H) admission SLs were statistically significant across four age ranges (pediatric, young adult, older adults, and elderly). …”
Get full text

Clinical Characteristics and Prognostic Factors of Posterior Segment Intraocular Foreign Body: Canadian Experience from a Tertiary University Hospital in Quebec by Jean-Philippe Rozon, Guillaume Lavertu, Mélanie Hébert, Eunice You, Serge Bourgault, Mathieu Caissie, Eric Tourville, Ali Dirani

“…Ninety-three percent of patients were men, with a mean age of 40.4 ± 12.6 years. Metallic IOFB comprised 88% of cases with a mean ± standard deviation (SD) size of 5.31 ± 4.62 mm. …”
Get full text

Acute Stroke in northern Portugal: outcomes and characteristics of patients in a Medical-Surgical Emergency Department by Sandra Domingues, Tiago Barros, João Correia, Arlindo Cruz, Nuno Araújo, Liliana Silva

“…Thrombolysis rates increased from 21.96% to 27.27% (p<0.01), and thrombectomy from 4.67% to 21.21% (p<0.001). Age >70 years (OR 1.8, 95% CI: 1.3-2.5) and arrival within 3 hours (OR 2.3, 95% CI: 1.7-3.1) predicted reperfusion therapy. …”
Get full text

Management of acute bacterial meningitis in a limited resource setting: an Egyptian consensus model by Samy Zaky, Mohamed Elbadry, Maysaa A. Saeed, Hanaa Fathelbab, Fatma Abdelsalam, Mohammed Gamal Abdel-Hamid, Alshaimaa Eid, Asmaa Bakr, Amira Maher, Mona Mohammed Abdelrahman, Mohamed A. Metwally, Mahmoud Saad Berengy, Enaam Ali AlMowafy, Hassan Goabar, Amin Abdel Baki, Ahmed Corie, Osama Hammad, Entesar Elsharkawy, Ahmed Saad, Fatma Ali-Eldin, Ahmed Mahdy, Ramadan Zaky, Reham Hammad, Gamal Essmat

“…It is a globally serious disease and is considered endemic in Egypt, affecting all age groups and being common in low-standard and overcrowded areas. …”
Get full text

High-grade liver injury: outcomes with a trauma surgery–liver surgery collaborative approach by J Wallis Marsh, Abhinav Humar, Jason L Sperry, David A Geller, Deepika Mohan, Timothy R Billiar, Juan Carlos Puyana, Brian Zuckerbraun, Joshua B Brown, Matthew D Neal, Matthew R Rosengart, David Newhouse, Christine Leeper, Andrew B Peitzman, Raquel Forsythe, Rafael G Ramos-Jimenez, Andrew-Paul Deeb, Evelyn I Truong, Sowmya Narayanan, Louis Alarcon, Graciela M Bauza, Vaishali Dixit Schuchert, Gregory Watson, Amit D Tevar

“…The objective of this study was to evaluate mortality and complications of operative and nonoperative management (OM and NOM) of HGLI at our institution, characterized by a trauma surgery–liver surgery collaborative approach to trauma care.Methods This was an observational cohort study of adult patients (age ≥16) with HGLI (The American Association for Surgery of Trauma (AAST) grades IV and V) admitted to an urban level I trauma center from January 2010 to November 2021. …”
Get full text

Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson&#x2019;s Disease by Nina Omejc, Tomislav Stankovski, Manca Peskar, Milos Kalc, Paolo Manganotti, Klaus Gramann, Saso Dzeroski, Uros Marusic

“…Methodology: Fifteen individuals with early-stage PD and sixteen age-matched controls performed an isometric knee extension task, a cognitive task, and a combined dual task, while EEG (128 channels) and EMG (2x32 channels) were recorded. …”
Get full text

Intestinal tissue levels of anti-TNF alpha, antibodies, and cytokines in paediatric Crohn disease by Vojtech Dotlacil, Stepan Coufal, Tereza Lerchova, Kristyna Zarubova, Barbora Kucerova, Helena Tlaskalova-Hogenova, Miloslav Kverka, Richard Skaba, Jiri Bronsky, Ondrej Hradsky, Michal Rygl

“…Patients treated longer with anti-TNF had increased IL-17 levels (β = 0.19, 95% CI 0.05–0.33), independent of disease duration and age. IFN-γ levels were linked with both follow-up duration and anti-TNF length. …”
Get full text

Unravelling distinct patterns of metagenomic surveillance and respiratory microbiota between two P1 genotypes of Mycoplasma pneumoniae by Hailong You, Bin Yang, Huifang Liu, Wencai Wu, Fei Yu, Nan Lin, WenJiao Yang, Bingxue Hu, Yong Liu, Hongyan Zou, Sijia Hao, Yunping Xiao, Teng Xu, Yanfang Jiang

“…However, no significant differences were observed in the co-detection odds ratio between children and other age groups in P1-2. This study is the first to demonstrate differences in relative abundance, diversity of respiratory microbiota and co-detection rate of opportunistic pathogen between M. pneumoniae P1-1 and P1-2. …”
Get full text

Mitral Valve Repair in Pediatric Patients with Dilated Cardiomyopathy and Mitral Insufficiency: Single-Center Experience and Results by Mustafa Yılmaz, Başak Soran Türkcan, Ata Niyazi Ecevit, İbrahim Ece, Hazım Alper Gürsu, Atakan Atalay

“…Results: Mitral repair was performed in 3 patients during the study period. The mean age of the patients was 4.66 months (±3.05) and body weight was 5.25 kg (±0.25). …”
Get full text

Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing by Ahmed Bouhouche, Houyam Tibar, Yamna Kriouale, Mohammed Jiddane, Imane Smaili, Naima Bouslam, Ali Benomar, Mohamed Yahyaoui, Elmostafa El Fahime

“…It is usually classified into three forms, infantile, juvenile, or adult, based on age at onset and severity of central nervous system involvement. …”
Get full text