Association of arm circumference with the prevalence of gallstones in United States adults: a retrospective analysis on US National Health and Nutrition Examination Survey by Jianjun Wang, Xi Chen, Wei He, Xintao Zeng, Pei Yang, Jianping Gong, Decai Wang

“…Dose–response relationships were evaluated using generalized additive models with smoothed curve fitting, and subgroup analyses were conducted to explore effect modification by key covariates such as age, sex, race, hypertension, diabetes, and body mass index.ResultsOverall, a total of 8,081 participants were included in this study, with 849 reporting a history of GS. …”
Get full text

Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

“…Our objective is to elucidate whether there is a difference in endometrial receptivity parameters (ie, steroid metabolism, uNK cells and the microbiome) between women aged 18–38 years with reproductive failure (RIF and RM), and fertile controls.Methods and analysis Single-centre, observational cohort study. …”
Get full text

A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient by Li Yang, Xingyu Wan, Ran Hua, Junhong Jiang, Baotian Wang, Rui Tao, De Wu

“…Results The 6‐year‐old male proband presented with seizures starting at age two, along with global developmental delay and hypotonia. …”
Get full text

Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality by Keke Fang, Lianjie Niu, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Ying Hou, Shaoqiang Han, Xianfu Sun, Wenzhou Zhang

“…In MDD patients, these extreme functional connections were linked to age of onset and reward-related processes. Using these features, we identified two subtypes with distinct patterns of functional connectivity abnormalities compared to healthy controls (p < 0.05, Bonferroni correction). …”
Get full text

Influence of the Multifunctional Biological Product Phytop 26.82 on the Growth and Development of Seed Potatoes by Vladislava Maslennikova, Vera Tsvetkova, Andrey Petrov, Rinat Galeev, Maxim Shulga, Natalia Gavrilets, Sergey Ryumkin, Anastasia Shulga, Evgeniy Ryadskiy, Kristina Koloshina, Inga Ryumkina

“…The authors revealed the degree of influence of the natural effect Phytop 26.82 on the Colorado potato beetle’s larvae of different ages. The larvae were counted on the 5th, 7th, and 10th days of the experiment. …”
Get full text

Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer... by Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink

“…Methods: A PubMed search, focused on clinical and pre-clinical efficacy, safety, and pharmacokinetics of local STS application in cisplatin-exposed subjects of all ages was performed. Findings: From 256 studies, ten studies met the inclusion criteria, including seven preclinical studies, and three clinical studies. …”
Get full text

Impact in Clinical Practice of the European Medicines Agency Health Alert About the Restriction of the Use of JAK Inhibitors by Elisabet Castañeda-Estévez, Cristina Vergara-Dangond, Martina Steiner, Maria Beatriz Paredes-Romero, Ana Esteban-Vázquez, Tatiana Cobo-Ibañez, Laura Trives-Folguera, Maria Liz Romero-Bogado, Isabel De La Cámara-Fernández, Patricia Richi-Alberti, Ana Acosta-Alfaro, Iría De la Osa-Subtil, Santiago Muñoz-Fernández

“…<b>Results:</b> In this retrospective, observational study, 101 patients were analysed, predominantly women (72.3%), with a mean age of 57.6 years. The most common diagnoses were rheumatoid arthritis (60.4%) and psoriatic arthritis (18.8%). …”
Get full text

Modified Trochanteric Flip Osteotomy in Varus Intertrochanteric Osteotomy for Treatment of Legg–Calvé–Perthes Disease by Andrea Laufer, Carina Antfang, Georg Gosheger, Adrien Frommer, Gregor Toporowski, Henning Tretow, Robert Roedl, Bjoern Vogt

“…Nine patients (ten hips, mean age 8 years) with LCPD were treated using this technique. …”
Get full text

Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf^®) in kidney transplantation: a phase IV study by Behzad Einollahi, Mohsen Nafar, Mohammad Javanbakht, Amirhesam Alirezaei, Jalal Azmandian, Abbas Etminan, Mohammad Reza Ardalan, Jalal Etemadi, Roghayeh Akbari, Vahid Pourfarziani, Seyed Sadraddin Rasi Hashemi, Seyed Maryam Rahbar, Shahrzad Shahidi, Javid Safa, Hamid Tayyebi Khosroshahi, Sima Abedi Azar, Shahrzad Ossareh, Abdolamir Atapour, Bahareh Marghoob, Fatemeh Nazemian, Hamidreza Kafi, Araz Sabzvari

“…Methods: In this two-armed, open-label, parallel, active-controlled, and cohort study, de novo kidney transplant recipients aging 18 to 65 years were prescribed Suprotac® or Prograf® as part of the immunosuppressant protocol. …”
Get full text

Heart rate cost as a tool for monitoring recovery between acute training sessions by José Morais Souto Filho, Milton Rocha de Moraes, Patrício Lopes de Araújo Leite, Larissa Alves Maciel, Andréa Cândida Arruda Andrade Rezende, Thiago dos Santos Rosa, Fabiana Andrade Machado, Sergio Rodrigues Moreira, Ricardo Yukio Assano, Marcelo Magalhães Sales, Herbert Gustavo Simões

“…Methods Fifteen male recreational runners (aged 18–31 years) participated in this investigation. …”
Get full text

Major adverse cardiovascular events among Black and White Veterans receiving androgen deprivation therapy for prostate cancer: a retrospective cohort study by Alexander R. Lucas, Dustin Bastiach, Bassam Dahman, Asit K. Paul, Samina Hirani, Vanessa B. Sheppard, W. Gregory Hundley, Bhaumik B. Patel, Rhonda L. Bitting, Michael G. Chang

“…At PC diagnosis, the mean age was 65.9 years. The majority had stage 2 disease (83.0%) classified as intermediate risk (43.1%). …”
Get full text

A systematic review on gut microbiota in type 2 diabetes mellitus by Serena Chong, Serena Chong, Mike Lin, Mike Lin, Deborah Chong, Slade Jensen, Slade Jensen, Slade Jensen, Namson S. Lau, Namson S. Lau, Namson S. Lau

“…Future research should incorporate age, diet and medication-matched controls, and include functional analysis of these gut microbes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023459937.…”
Get full text

Pulmonary hypertension in Finland 2008-2020: A descriptive real-world cohort study (FINPAH) by Markku Pentikäinen, Piia Simonen, Helena Tuunanen, Pauliina Leskelä, Terttu Harju, Pertti Jääskeläinen, Christian Asseburg, Minna Oksanen, Erkki Soini, Christina Wennerström, Airi Puhakka, Terttu Harju, Elina Heliövaara, Pertti Jääskeläinen, Katriina Kahlos, Pentti Korhonen, Tiina Kyllönen, Pauliina Leskelä, Kirsi Majamaa-Voltti, Piia Simonen, Anu Turpeinen, Helena Tuunanen, Ville Vepsäläinen, Tapani Vihinen

“…The median time from symptoms to diagnosis was 1 year. Mean age at diagnosis of PAH patients (n = 268) was 57 years, 73% were women, 40% had idiopathic PAH, 28% associated with connective tissue diseases, and 15% with congenital heart disease, 9% had ≥3 cardiovascular comorbidities. …”
Get full text

Comparative evaluation of management practices among large-scale broiler farms of Punjab, Pakistan by Muhammad Tahir Amin, Muhammad Usman, Hafiz Muhammad Ishaq, Asad Ali, Muzamal Tariq, Mian Mubashar Saleem, Syed Ghulam Mohayud Din Hashmi, Kinza Saleem, Sohail Ahmad

“…Better FCR, adjusted FCR, and market age were observed in broilers in the Multan area while those in the areas of Sheikhupura and Kasur showed poor performance due to improper management practices. …”
Get full text

Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Methods This is an epidemiological, ecological study using secondary data on vaccination coverage, dropout rates, and homogeneity of vaccination coverage (HCV) for ten immunobiologicals recommended for children under 2 years of age. The study aims to compare the years 2022 and 2023 in Brazil. …”
Get full text

Ocular inoculation of toad venom: toxic cataract and proteomic profiling by Danni Lyu, Danni Lyu, Shuang Ni, Shuang Ni, Jia Xu, Jia Xu, Sha Zhu, Sha Zhu, Jing-Wei Xu, Jing-Wei Xu, Yixuan Feng, Yixuan Feng, Ce Shi, Ce Shi, Wen Xu, Wen Xu

“…Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.ResultsA multitude of differentially expressed proteins (DEPs) were identified in the patient’s lens compared to those in the controls. …”
Get full text

Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa [version 2; peer review: 1 approved, 2 approved with reservations] by Jane E Hirst, Ana Bonell, Abdul Sesay, Leonidas G. Ioannou, Bubacarr Bah, Kris A. Murray, Andy Haines, Sophie E. Moore, David Jeffries, Neil S Maxwell, Ana Vicero-Cabrera, Apolline Saucy, Cally Tan, Emmanuel Okoh, Dorothy Watters, Bakary Sonko, Williams Oluwatosin Adefila, Yahaya Idris, Mam Leigh-Nabou, Jarra Manneh, Andreas Flouris, Sainabou Bojang, Amanda N Sferruzzi-Perri, Andrew Prentice

“…Participants will be asked to wear a watch-style device at 28- and 35-weeks gestational age to evaluate maternal heart rate, activity and sleep. …”
Get full text

Evaluating the implementation of a multicomponent intervention to improve faecal immunochemical test-based (FIT) colorectal cancer screening in primary care by Kamala Adhikari, James Whitworth, Gary F Teare, Muhammad Kashif Mughal, Danica Hignell, Barbara Moysey, Jawad Chishtie

“…The faecal immunochemical test (FIT) is recommended for screening people aged 50–74 years at average risk of CRC in Alberta, Canada. …”
Get full text

Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease by Maria Olaru, Amelia Hahn, Maria Shcherbakova, Simon Little, Wolf-Julian Neumann, Reza Abbasi-Asl, Philip A. Starr

“…Methods: We used a sensing-enabled deep brain stimulator system, attached to both motor cortex and subthalamic (n = 15) or pallidal (n = 5) leads, to record 993 h of multisite field potentials, with 656 h recorded prior to initiating stimulation. 13 subjects (20 hemispheres) with Parkinson's disease (1/13 female, mean age 59 ± 9 years) streamed data while at home on their usual antiparkinsonian medication. …”
Get full text

Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…ROC analysis revealed MTX elimination t½ calculated from the second and third time periods had the highest AUC for AKI at 0.62 (interquartile range [IQR] 0.56–0.69) and DME at 0.86 (IQR 0.73–1.00). After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65. …”
Get full text