Temporal Changes in Plasmodium Falciparum Genetic Diversity and Multiplicity of Infection Across Three Areas of Varying Malaria Transmission Intensities in Uganda. by Mwesigwa, Alex, Kiwuwa, Steven M., Musinguzi, Benson, Kawalya, Hakiim, Katumba, James Davis, Baguma, Andrew, Mutuku, Irene M., Adebayo, Ismail Abiola, Nsobya, Samuel L., Byakika‐Kibwika, Pauline, Kalyango, Joan N., Karamagi, Charles, Nankabirwa, Joaniter I.

“…The majority of participants were males (50.6%) and children aged 5–11 years (46.7%). Genetic diversity remained high, with mean expected heterozygosity (He) showing a slight decrease over time (range: 0.73–0.82). …”
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Assessing the Potential of Cultural Tourism Development in Kabale District by Simon, Otebwa

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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality by Patricia de Sequera, Javier Arias, Borja Quiroga, María Benavent, Fabio Procaccini, Iago Romero, Guillermo López, Javier Diez, Alberto Ortiz

“…This result is surprisingly consistent across time and in all age groups. This is the first time that gender disparities in the assessment of albuminuria have been revealed. …”
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600 meters to VO2max: Predicting Cardiorespiratory Fitness with an Uphill Run by Kübra Stoican, Regina Oeschger

“…In addition to the user’s anthropometric data (age, gender, body mass index) and time, we also used the speed to heart rate (HR) ratio as a predictor variable, since a previous study has shown its importance [8]. …”
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Providing a model of emotional and rational appeals in video marketing based on social networks by Moohan Mohammadi, payam paslari, saeed moradpour, sadegh masjoodi

“…The statistical population of the research includes 200 male and female students between the ages of 25 and 35, selected as a sample and exposed to two types of short-term video advertisement stimuli. …”
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Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…Several factors, including age, genetics, diet, oral hygiene practices, fluoride exposure, and acidic challenges, can influence enamel translucency. …”
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Prioritizing breast cancer surgeries: insights from the KRONOS SCORE by Lucía Navarro, Lucía Navarro, Lucía Navarro, Luis Perez-Bartivas, Luis Perez-Bartivas, Luis Perez-Bartivas, David Ponferrada, David Ponferrada, David Ponferrada, Javier Cejas, Javier Cejas, Javier Cejas, Juan Adrián Camús, Juan Adrián Camús, Juan Adrián Camús, Natalia Rangel, Natalia Rangel, Natalia Rangel, Maria Porras, Cristina Morales Estevez, Cristina Morales Estevez, Cristina Morales Estevez, Amalia Palacios Eito, Amalia Palacios Eito, Amalia Palacios Eito, Pilar Rioja, Pilar Rioja, Pilar Rioja, Marina Alvarez, Marina Alvarez, Marina Alvarez, Enrique Aranda, Enrique Aranda, Enrique Aranda, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez

“…The KRONOS SCORE, based on age, tumor grade, and size, was validated, showing a higher risk of lymph node involvement with higher scores.DiscussionAlthough TTS did not significantly affect most clinical and pathological parameters, a trend towards increased lymph node involvement with prolonged TTS was observed, particularly in patients with poorly differentiated tumors (G3). …”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…These phenotypes did not differ by age, sex, or years of education. The APOE ɛ4 genotype was enriched in the Amnestic Predominant group, who were also rated as least impaired. …”
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Factors associated with breast lymphedema after adjuvant radiation therapy in women undergoing breast conservation therapy by Summer Sami Yono, Cara Cannella, Madeleine Gonte, Sanjay Rama, Simeng Zhu, Jenna Luker, Maristella S. Evangelista, Jessica Bensenhaver, Eleanor M. Walker, Dunya Atisha

“…The mean ± standard deviation age was 62.9 ± 11.1 years and the mean breast volume was 1352.0 ± 744.9 cm3. …”
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Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets by Long Wang, Ruizhi Hu, Siqi Ma, Xizi Yang, Jiatai Gong, Hongkun Xiang, Mingkun Shi, Xupeng Yuan, Liang Chen, Hongfu Zhang, Bie Tan, Xi He, Jianhua He, Shusong Wu

“…A total of 108 healthy Duroc × Landrace × Yorkshire weaned piglets, aged 21 d, were randomly allocated into 3 groups with 6 replicates and 6 piglets per replicate. …”
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Duration of Disease and Long‐Term Outcomes in Patients With Difficult‐To‐Treat Recurrent Pericarditis: A Chronic Condition Treated With Nonsteroidal Anti‐Inflammatory Drugs, Colchi... by Elisa Ceriani, Francesco Agozzino, Silvia Berra, Antonio Gidaro, Paolo Bindi, Alberto Pavarani, Silvia Macchi, Letizia Vena, Francesco Moda, Ludovico Luca Sicignano, Celeste Ambra Murace, Laura Gerardino, Elena Verrecchia, Caterina Chiara De Carlini, Silvia Maestroni, Gabriella Marinaro, Emanuele Bizzi, Antonio Brucato, Massimo Imazio

“…Results The median follow‐up was 4.9 (interquartile range [IQR] 2.8–8.4) years, and the median age at the end of follow‐up was 49 (IQR 37–60) years. …”
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The impact of preoperative venous thromboembolism on patients undergoing TURBT: Perioperative outcomes and healthcare costs from US insurance claims data by Anas S. Tresh, Francesco Del Giudice, Shufeng Li, Satvir Basran, Ettore De Berardinis, Dalila Carino, Valerio Santarelli, Bernardo Rocco, Maria Chiara Shighinolfi, Roman Mayr, Matteo Ferro, Riccardo Autorino, Gabriele Bignante, Felice Crocetto, Biagio Barone, Renate Pichler, José Daniel Subiela, Jorge Caño Velasco, Marco Moschini, Andrea Mari, Andrea Gallioli, Francesco Soria, Simone Albisinni, Wojciech Krajewski, Jan Łaszkiewicz, Łukasz Nowak, Tomasz Szydełko, Benjamin Challacombe, Rajesh Nair, Benjamin I. Chung

“…Patients and Methods Patients aged ≥18 years with a BCa diagnosis undergoing TURBT were identified in the Merative® Marketscan® Research de‐identified databases between 2007 and 2021. …”
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A randomised, double-masked, placebo-controlled trial evaluating the efficacy and safety of teprotumumab for active thyroid eye disease in Japanese patientsResearch in context by Yuji Hiromatsu, Eri Ishikawa, Ai Kozaki, Yasuhiro Takahashi, Mika Tanabe, Ken Hayashi, Yukihiro Imagawa, Kazutoyo Kaneda, Masashi Mimura, Xiaoxian Dai, Tomoko Hayashida, Takashi Akamizu

“…Main inclusion criteria were as follows: age 20–80 years; Graves’ disease, in a euthyroid or mild hypo/hyperthyroid state; clinical activity score (CAS) ≥3; moderate-to-severe TED; ≥3-mm increase in proptosis before TED onset and/or proptosis ≥18 mm at baseline; and TED duration ≤9 months. …”
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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…Very early-onset breast cancer, which is diagnosed before the age of 35, was identified as an independent prognostic factor for poor progression-free survival. …”
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Surgical Injury and Ischemia Prime the Adipose Stromal Vascular Fraction and Increase Angiogenic Capacity in a Mouse Limb Ischemia Model by Satoko Kishimoto, Ken-ichi Inoue, Ryoichi Sohma, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Ken-ichiro Yoshida

“…However, the quality and quantity of SVFs vary depending on the patient’s age, complications, and other factors. In this study, we developed a method to reproducibly increase the cell number and improve the quality of adipose-derived SVFs by surgical procedures, which we term “wound repair priming.” …”
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Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLU... by Brian Hiestand, Phillip Levy, W Frank Peacock, Brigitte M Baumann, Richard M Nowak, Amy Hsu, Joseph Varon, Chad M Cannon, David M Cline, Pierre Borczuk, Abhinav Chandra, Deborah B Diercks, Preeti Jois, Brian Kaminski, Jon W Schrock

“…Objective To compare the efficacy of Food and Drug Administration recommended dosing of nicardipine versus labetalol for the management of hypertensive patients with signs and/or symptoms (S/S) suggestive of end-organ damage (EOD).Design Secondary analysis of the multicentre prospective, randomised CLUE trial.Setting 13 academic emergency departments in the USA.Participants Eligible patients had two systolic blood pressure (SBP) measures ≥180 mm Hg at least 10 min apart, no contraindications to nicardipine or labetalol and predefined S/S suggestive of EOD on arrival.Interventions Medications were administered by continuous infusion (nicardipine) or repeat intravenous bolus (labetalol) for a study period of 30 min or until a specified target SBP ±20 mm Hg was achieved.Primary outcome measure Percentage of participants achieving a predefined target SBP range (TR) defined as an SBP within ±20 mm Hg as established by the treating physician.Results Of the 141 eligible patients, 49.6% received nicardipine, 51.7% were women and 81.6% were black. Mean age was 52.2±13.9 years. Median initial SBP did not differ in the nicardipine (210.5 (IQR 197–226) mm Hg) and labetalol (210 (200–226) mm Hg) groups (p=0.862). …”
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CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study by Yangyang Li, Li Jin, Jing Yan, Hong Zhang, Rong Zhang, Cheng Hu

“…Under additive genetic models, CD28-rs3116494 (OR=1.29 [95% CI 1.11, 1.51], P=0.0011) and CD80-rs3850890 (OR=1.16 [95% CI 1.02, 1.31], P=0.0283) were associated with DKD susceptibility adjusted for age, gender, body mass index (BMI), duration of diabetes, and HbA1c. …”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…This research explored the relationship between the microbiomes of the upper respiratory and GI tracts in patients with COVID-19 and examined Extraesophageal reflux (EOR), a mechanism which could contribute to dysregulated communication between the GI and respiratory tract (as identified in COVID-19). 97 patients with a laboratory diagnosis of COVID-19 infection, and 50 age-matched controls were recruited and stool, saliva and sputum were obtained from each participant. …”
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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016–2021) by El Khalef Ishagh, Marc Talatou Ouédraogo, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N.’Zue Kofi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Charles S. Wiysonge, Blanche-Philomene Melanga Anya, Manengu Casimir Tshikolasoni

“…Most cases (79.85%) were aged 1 to 4 years, and 79.44% received three or more doses of oral polio vaccine (OPV). …”
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The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis by Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Matthew P. Smeltzer, Howard H. Chang, John L. Jefferies, Csaba P. Kovesdy, Xichen Mou, Abu Mohd Naser

“…Models had participant-level random intercepts and were adjusted for age, sex, body mass index (BMI), religion, exercise, smoking status, sleep hours, alcohol consumption, urine creatinine, time trend, household assets, drinking water salinity, and seasonality. …”
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