Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…The fundamental rationale for promoting health resilience in T2DM stems from its high prevalence of 10.5% of the world’s adult population and its contribution to many adverse health events.Methods AI-READI is a cross-sectional study whose target enrollment is 4000 people aged 40 and older, triple-balanced by self-reported race/ethnicity (Asian, black, Hispanic, white), T2DM (no diabetes, pre-diabetes and lifestyle-controlled diabetes, diabetes treated with oral medications or non-insulin injections and insulin-controlled diabetes) and biological sex (male, female) (Clinicaltrials.org approval number STUDY00016228). …”
Get full text

Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…For this reason, the growing tendency to build sumptuous dwellings, with an enviable viewpoint overlooking the Sarno plain below, led to buildings being extended above and beyond the defensive walls, even reusing structural parts that were no longer considered necessary.In the same way, many of the cisterns behind them lost their function, being converted into rooms in the house or used as stairways or corridors.The large basins seem to have retained their function until the advent of the aqueduct system, introduced in Pompeii in the Augustan age. The cisterns initially coexisted with these without significant changes, except for a gradual decline in the maintenance of the structures.On the other hand, a sharp interruption would seem to have occurred between the earthquakes in the 1960s AD and the subsequent reconstruction phases, a period in which many of the old reservoirs, which had long since lost their meaning and function, were probably definitively dismantled and converted into usable spaces.…”
Get full text

Long-term outcomes after AKI in hospitalized patients with COVID-19 by Bernardo Marques da Silva, Joana Gameiro, Joana Lei Teixeira, Cláudia Costa, Carolina Branco, João Oliveira, João Bernardo, Filipe Marques, José Agapito Fonseca, José António Lopes

“…Older age (adjusted HR 1.06 (95% CI: 1.04–1.08), p < 0.001) and neoplasia (adjusted HR 4.88 (95% CI: 2.37–10.04), p < 0.001) were independent predictors of mortality. …”
Get full text

HEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese... by Alexandre Chan PharmD, Daniella Chan BS, Ding Quan Ng BSPharm, Huang Fang Zheng MD, Quan Ming Tan MCM, Chia Jie Tan PhD, Jolene Hui Min Toh BS, Ning Yi Yap PhD, Yi Long Toh PhD, Yu Ke PhD, Edmund Chun Ann Wang BS, Queenie Pei Ni Lim BSocSc, Han Kiat Ho PhD, Lita Chew MMS, Tira J. Tan MBBS

“…Of the eligible, 15 XBYRT and 13 placebo subjects with similar mean ages (58.5 vs 58.4) were recruited. Both groups were predominantly Chinese (93% vs 62%), breast cancer patients (87% vs 62%), and diagnosed with stage 2 cancer (60% vs 46%). …”
Get full text

Survey of Firearm Storage Practices and Preferences Among Parents and Caregivers of Children by Meredith B. Haag, Catlin H. Dennis, Steven McGaughey, Tess A. Gilbert, Susan DeFrancesco, Adrienne R. Gallardo, Benjamin D. Hoffman, Kathleen F. Carlson

“…Methods: Between April 2018–November 2019, we conducted and analyzed an in-person survey of 294 caregivers, aged ≥18, with both children and firearms in the home. …”
Get full text

Terlipressin at esophageal varicose bleeding at liver cirrhosis with portal hypertension syndrome by B. N. Kotiv, I. I. Dzidzava, D. P. Kashkin, A. V. Smorodsky, A. V. Slobodyanik, S. A. Soldatov, M. V. Koldin

“…Both groups have been comparable by age, gender, etiology of cirrhosis, degree of varicose dilation of esophageal veins and severity of liver dysfunction.Results. …”
Get full text

Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…All analyses were adjusted for sex, age, and chlorpromazine equivalent dose. Results: Higher plasma IL-6 levels were related to more severe depressive symptoms in early schizophrenia (p < .05) and negative symptoms in established schizophrenia (p < .05). …”
Get full text

Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry... by Timothy Howarth, Subash Heraganahally, Claire Gibbs, Lata Jayaram, Asanga Abeyaratne, Shiidheshwar J Ravichandran, Davaadorj Erdenebayar, Winnie Chen, Hubertus Jersmann

“…This study assessed the clinical profile of bronchiectasis among adult Aboriginal Australians and compared against previously published international bronchiectasis registry reports.Methods Aboriginal Australians aged &gt;18 years with chest CT confirmed bronchiectasis between 2011 and 2020 in the Top End Northern Territory of Australia were included. …”
Get full text

Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study by Jie Yuan, Hai Long, Min Liu, Juan He, Jue Liu, Yu Wu, Wenzhan Jing, Min Du, Manna Zhang, Yaping Wang, Su Song, Siqi Liu, Guiying Cao, Yuedong Liang, Xiaoxin Xie, Yanhua Fu

“…Objectives To estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).Design A cross-sectional study.Setting PLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021.Participants A total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study.Primary and secondary outcome measures Anaemia was diagnosed as a haemoglobin concentration &lt;120 g/L for non-pregnant females and &lt;130 g/L for males. …”
Get full text

Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials by Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga, Masanori Shigeno, Ichiro Kawahata, Rizky Abdulah, Takuya Sasaki

“…However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.…”
Get full text

Reconstructing prevalence dynamics of wildlife pathogens from pooled and individual samples by Borremans, Benny, Falvo, Caylee A, Crowley, Daniel E, Hoegh, Andrew, Lloyd-Smith, James O, Peel, Alison J, Restif, Olivier, Ruiz-Aravena, Manuel, Plowright, Raina K

“…As it is challenging to link individual-level metrics such as age, sex, or immune markers to infection status when using pooled samples, the model also allows the incorporation of individual-level samples. …”
Get full text

Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes by Anoushka Saxena, Minal, Prabhjyoti Pahwa, Jaswinder Singh Maras, Hamda Siddiqui, Jayesh Kumar Sevak, Yedla Manikya Mala, Shakun Tyagi, Shiv K. Sarin, Nirupama Trehanpati

“…ALF-E showed increased naive T/B cells, decreased CD4, CD8 Tcm, Tem, and plasmablasts, compared to AVH-E contributing to higher failed inductions, preterm births, maternal complications like eclampsia, disseminated intravascular coagulation, preterm premature rupture of membranes, small-for-gestational-age infants, higher rates of intrauterine death, abortion, and mortality. …”
Get full text

Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, fro... by Wei Cui, Hongxia Gao, Liran Zhu, Yuanyuan Xu, Haipeng Liu

“…Data on daily outpatient visits for NAR among children aged 0–18 years from 2015 to 2021 were obtained from Anhui Provincial Children’s Hospital. …”
Get full text

Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer by Li Lin, Li Lin, Man He, Yanyan Zeng, Xiaoxiao Ni, Yequn Guo, Xiaojuan Xie, Lingling Sun, Huai Huang

“…To the best of our knowledge, this report represents the first documented case of hematuria resolution in a patient over 90 years old with severe RHC.ConclusionThis case represents the first documented instance of successful hematuria resolution in a patient over 90 years of age with severe RHC. The positive therapeutic outcome achieved with personal protocol (1.4-1.6 ATA) in this 95-year-old patient, expands hyperbaric oxygen pressure options for elderly patients. …”
Get full text

Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Here, we summarise an ethically approved protocol for a double-blind, randomised controlled trial investigating the effect of the 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPV23) on pneumococcal nasopharyngeal colonisation acquisition, density and duration using experimental human pneumococcal challenge (EHPC).Methods and analysis Healthy adult participants aged 18–50 years will be randomised to receive PCV13, PPV23 or placebo and then undergo one or two EHPCs involving intranasal administration of SPN at 1-month post-vaccination with serotype 3 (SPN3) and 6 months with serotype 6B (SPN6B). …”
Get full text

Arthralgia and Extraintestinal Manifestations in Crohn’s Disease Elevate the Risk of IBD-Related Arthritis over Sacroiliitis by Ivan Giovannini, Nicola Cabas, Marco Marino, Annarita Tullio, Ilaria Tinazzi, Angela Variola, Carmelo Cicciò, Fabro Cinzia, Berretti Debora, Chiara Zuiani, Rossano Girometti, Luca Quartuccio, Alen Zabotti, Lorenzo Cereser

“…Results Ninety-five patients, mean age 43.9 years (standard deviation [SD] ± 16.6), 52.6% female were enrolled in the study with a median follow-up of 83 months (Q25:75 25:143). …”
Get full text

The Importance of Radiological Patterns and Small Airway Disease in Long-Term Follow-Up of Postacute COVID-19: A Preliminary Study by Roberto Mogami, Ronaldo Carvalho Araújo Filho, Carolina Gianella Cobo Chantong, Fernando Carlos Santos de Almeida, Ana Célia Baptista Koifman, Gustavo Federico Jauregui, Thiago Thomaz Mafort, Hanna da Silva Bessa da Costa, Glenda Aparecida Peres dos Santos, Bruna Zangerolame de Carvalho, Gabriel da Silva Passos, Erick de Souza Barbosa, Angelo Thomaz Abalada Ghetti, Laura Braga Monnerat, Mariana Soares da Cal, Desiree Louise Souza Santos Batista, Helen Aksenow Affonso, Gabriel Oliveira Bousquet, Jose Ignacio Marenco Avila, Anna Luiza Bento Dutra, Caio Leal Leidersnaider, Alexandre Malta da Costa Messeder, Alexandra Monteiro, Agnaldo José Lopes

“…The inclusion criteria were age >18 years and persistent respiratory symptoms after four weeks. …”
Get full text

Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma by Nailya Kubysheva, Marina Boldina, Tatyana Eliseeva, Svetlana Soodaeva, Igor Klimanov, Anastasia Khaletskaya, Venera Bayrasheva, Valery Solovyev, Luis Alfonso Villa-Vargas, Marco Antonio Ramírez-Salinas, Moisés Salinas-Rosales, Dmitry Yu. Ovsyannikov, Ildar Batyrshin

“…The control group included 21 healthy nonsmokers with similar sex-age indicators. Serum levels of IL-17, IL-18, and TNF-α were determined by ELISA. …”
Get full text

Effect of photobiomodulation as preventive treatment of diabetic foot ulcer: randomised, controlled, double-blind, clinical trial protocol by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Roselene Lourenço, Silvana Torres Perez, Cinthya Cosme Gutierrez Duran, Alexandre Rocha Santos Padilha, Tainá Caroline dos Santos Malavazzi

“…Individuals from 18 to 75 years of age of both sexes with type 2 diabetes mellitus (DM) at moderate to high risk of developing DFU will be randomly allocated to two groups of 32 participants each. …”
Get full text

Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children by Rana Tafrishi, Hamid Ahanchian, Seyed ali Jafari, Abolfazl Pahlevanloo, Hamidreza Kianifar, Mohammadali Kiani, Nasrin Moazzen, Tahereh sadeghi, Peter D. Sly

“…Methods &amp; materials: In this randomized trial, 69 children aged 7–11 years with mild intermittent asthma were randomized to receive probiotic candy (containing 1010 CFU probiotic Bacillus coagulans) or placebo candy, daily for 2 months. …”
Get full text