Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus by Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, Gerardo Garcia-Rivas

“…A cross-sample of 40 Mexican children and adolescents aged 7-17 were recruited, 20 diagnosed with T2DM and 20 healthy controls. …”
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Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

“…., obesity), and generate an age-stratified sample. Champions at four sites reviewed charts to confirm eligibility and contacted Veterans to offer further evaluation with elastography. …”
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Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context by Charlotte Ocana de Sentuary, Clara Testard, Marion Lagrée, Maxime Leroy, Lisa Gasnier, Alicia Enes-Dias, Constance Leruste, Diariatou Diallo, Michael Génin, Thameur Rakza, François Dubos

“…In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. …”
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Risk of residual/recurrent cervical diseases in HPV-positive women post-conization depends on HPV integration status by Wenyu Lin, Yuxuan Huang, Yan Zhang, Lixiang Huang, Hongning Cai, Guanxiang Huang, Ye Li, Qiaoyu Zhang, Huifeng Xue, Binhua Dong, Pengming Sun

“…According to the Kaplan-Meier analysis, age ≥ 45 years (p = 0.016) and HPV integration (p = 0.035) were associated with a higher risk of residual/recurrent CIN at the 1-year follow-up. …”
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Invited review: Improved control of Johne's disease in dairy cattle through advancements in diagnostics, testing, and management of young stock by Larissa Martins, Karin Orsel, Razieh Eshraghisamani, Jose Miguel Hernández-Agudelo, A. Caroline Pereira, Waseem Shaukat, Ad P. Koets, John P. Bannantine, Caroline Ritter, David F. Kelton, Richard J. Whittington, Maarten F. Weber, Antonio Facciuolo, Navneet K. Dhand, Karsten Donat, Susanne Eisenberg, Miguel A. Salgado, John P. Kastelic, Jeroen De Buck, Herman W. Barkema

“…Studies on IGRA and ELISA have focused on evaluation of new antigens and optimal age of testing. New diagnostics have been developed, including phage-based tests to detect viable MAP, as well as gene expression patterns and metabolomics to detect MAP-infected young stock. …”
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Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

“…<b>Results</b>: Patients had a median age of 74, 53% were female, and 28% were traditionally under-represented in Black, Hispanic, and Asian groups. …”
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Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…Despite a likely overestimation of saline interface movement, the model required 492 000 years to reach a near-steady state, indicating that the saline groundwater distribution in North America has likely been evolving since before the end of the last ice age, approximately 20 000 years ago.…”
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Interpretation of indoor air surveillance for respiratory infections: a prospective longitudinal observational study in a childcare settingResearch in context by Caspar Geenen, Steven Traets, Sarah Gorissen, Michiel Happaerts, Kurt Beuselinck, Lies Laenen, Jens Swinnen, Sien Ombelet, Joren Raymenants, Els Keyaerts, Emmanuel André

“…Concurrently, we collected the paper tissues used to wipe the noses of 23 regular attendees: children aged zero to three and childcare workers. All samples were tested for 29 respiratory pathogens using PCR. …”
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The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study by Juanjuan Zou, Fan Song, Huajun Xu, Yiqun Fu, Yunyan Xia, Yingjun Qian, Jianyin Zou, Suru Liu, Fang Fang, Lili Meng, Hongliang Yi, Jian Guan, Huaming Zhu, Bin Chen, Shankai Yin

“…The polynomial linear trend test was used to assess the linear trend across snoring intensity for metabolic score, and logistic regression was used to evaluate the odds ratios (ORs) for MetS after controlling for age, sex, obesity, smoking status, and alcohol consumption. …”
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Vision Improvement after Osimertinib Treatment in Paraneoplastic Optic Neuropathy Associated with Lung Adenocarcinoma by Masaomi Kubota, Nobumasa Tamura, Takaaki Hayashi, Euido Nishijima, Haruhiko Yanagisawa, Akira Kojima, Tadashi Nakano

“…Her final BCVA was 0.01 in the RE, counting fingers 10 cm in the LE. She died at the age of 79 years. To our knowledge, no reports have shown improvement in BCVA in patients with PON after changing EGFR-TKI treatments. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). …”
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Who Are Suitable Patients for Omitting Breast Surgery as an Exceptional Responder in Selected Molecular Subtypes of Breast Cancer After Neoadjuvant Systemic Treatment? by Ebru Sen, Mehmet Ali Nazlı, Göktürk Maralcan, Bekir Sıtkı Said Ulusoy, Mahmut Kaan Demircioğlu, Tuce Söylemez Akkurt, Mehmet Sökücü, Gökmen Umut Erdem, Mustafa Yıldırım

“…<i>Results</i>: The study included 20 patients. The mean age of the patients was 47.3 years. The median tumour size at diagnosis was 23.1 mm. …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized con... by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…This study aimed to evaluate the effects of intranasal versus intravenous dexmedetomidine on emergence recovery and hemodynamics in children undergoing adenotonsillectomy.MethodsA total of 139 children, aged 3–10 years, who were scheduled for elective adenotonsillectomy were randomly assigned to receive intravenous dexmedetomidine (IV DEX group) or intranasal dexmedetomidine (IN DEX group), or saline (control group) after anesthesia induction. …”
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Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score by Noor K. Abassi, Nina Nouhravesh, Mariam Elmegaard, Marte Austreim, Deewa Zahir, Caroline Hartwell Garred, Jawad H. Butt, Camilla Fuchs Andersen, Jarl E. Strange, Caroline Sindet‐Pedersen, Daniel M. Christensen, Emil Fosbøl, Charlotte Andersson, Lars Køber, Morten Schou

“…Methods and Results We identified 131 235 patients with new‐onset HF (median age 74 years, 39.7% women) from Danish nationwide registers in 1999 to 2017. …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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Comparing short‐term outcome after implantation of the HeartWare® HVAD® and the Abbott® HeartMate 3® by Rene Schramm, Armin Zittermann, Michiel Morshuis, Michael Schoenbrodt, Ellen vonRoessing, Vera vonDossow, Andreas Koster, Henrik Fox, Kavous Hakim‐Meibodi, Jan F. Gummert

“…Patient matching was performed for age, sex, Interagency Registry for Mechanically Assisted Circulatory Support level at the time of implant, perioperative right heart failure, and implantation strategy, that is, bridge to transplant or destination therapy, as well as preoperative renal function, that is, as indicated by serum creatinine levels. …”
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Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China by Xiaolong Cao, Zexuan Song, Ping He, Xinyue Li, Nan Lei, Qian Sun, Xue Wang, Ruida Xing, Bing Zhao, Xinyu Yang, Zhiguo Zhang, Yanlin Zhao

“…A statistically significant difference in cavity formation across different age groups was observed (r = -0.198, P < 0.05). …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…This trend remained unaffected by adjustment for age, baseline eGFR, and 24 h-proteinuria.ConclusionIn individuals with non-advanced CKD, very low urinary excretion of MBG reflects a more sustained risk of CKD progression over time. …”
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Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation by Tharusan Thevathasan, Vanessa Wahl, Joshua Boettel, Megan Kenny, Julia Paul, Sophie Selzer, Abdulla Al Harbi, Eva-Maria Dorsch, Heinrich Audebert, Matthias Rose, Christoph Paul Klapproth, Sonia Lech, Katharina Schmitt, Steffen Desch, Ulf Landmesser, Ralf Westenfeld, Fabian Voss, Carsten Skurk

“…Results: This study included 33 ECPR survivors, who were predominantly male (70%) with a mean age of 55 years. Left-ventricular ejection fraction improved significantly, from 22% during ICU stay to 51% at follow-up in the ECMELLA group and from 31% to 51% in the VA-ECMO group (p = 0.006). …”
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