Beeswax Alcohol (BWA, Raydel^®) Improved Blood Oxidative Variables and Ameliorated Severe Damage of Zebrafish Kidneys, Testes, and Ovaries Impaired by 24-Week Consumption... by Kyung-Hyun Cho, Ashutosh Bahuguna, Ji-Eun Kim, Yunki Lee, Sang Hyuk Lee, Cheolmin Jeon, Cheol-Hee Kim

“…Conclusion: BWA demonstrated a greater ability than CoQ₁₀ to enhance plasma antioxidant status, suppress ROS generation, delay organ aging and alleviate HC+Gal-induced adversity in zebrafish.…”
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Changes in quality of life 5 years after sleeve gastrectomy: a prospective cohort study by Karl Ove Hufthammer, Tone Merete Norekvål, Grethe S Tell, Ronette L Kolotkin, Tone Nygaard Flølo, Anny Aasprang, Villy Våge, John Roger Andersen

“…We investigated 5-year trajectories in QOL and their associations with weight loss after SG.Design A prospective cohort study.Setting The study was conducted in a single Norwegian bariatric surgery centre.Participants Out of 150 operated patients, 127 were included. Mean age was 41 years, 68% were women and the follow-up rate at 1 year was 85% and 64% at 1 and 5 years, respectively.Outcome measures Data were collected preoperatively, and 1 and 5 years after surgery assessing three different levels of QOL. …”
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Clinical Burden and Healthcare Resource Use of Asthma in Children in the UK by Gouia I, Joulain F, Zhang Y, Morgan CL, Khan AH

“…We assessed the clinical and economic burden of asthma in children in the UK to better understand the impact of pediatric asthma.Methods: This was a retrospective, case-matched, longitudinal analysis using the Clinical Practice Research Datalink GOLD database and linked patient-level data (Hospital Episode Statistics and Office for National Statistics datasets) of selected patient (aged 6– 11 years) records in 2017. Severe exacerbation and re-exacerbation rates per patient-year (PPY), all-cause healthcare resource utilization (HCRU), and HCRU-related costs were assessed in asthma patients versus matched non-asthma controls, stratified by severity.Results: Among 5950 patients, severe exacerbation rate was 0.06, 0.17 and 0.31 PPY for mild, moderate, and severe asthma, respectively. …”
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Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation by Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen

“…SHAP analysis identified maximum lactate levels, age, and minimum SpO2 as the strongest predictors of mortality, while CRRT timing showed relatively lower impact on outcome prediction.ConclusionWhile later initiation of CRRT in S-AKI patients was associated with improved survival, this benefit comes with increased healthcare resource utilization. …”
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A Study of Trichomonas vaginalis Infection and Correlates in Women with Vaginal Discharge Referred at Fann Teaching Hospital in Senegal by Roger C. Tine, Khadime Sylla, Rougyatou Ka, Lamine Dia, Doudou Sow, Souleye Lelo, Khardiata Diallo, Babacar Faye, Thérèse Dieng, Cheikh T. Ndour, Ahmet Y. Sow

“…Overall, 3893 women were enrolled with a mean age at 31.2 ± 10 years. The prevalence of Trichomoniasis represented 4.8%, 95%CI(3.1-5.7) and it was lower among women less than 30 years (4.1%), while divorced women more likely to be infected compared to married and single women (aOR:2.1, 95%CI (1.2-3.7)). …”
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Increased Plasma Levels of 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in Patients with Pseudoexfoliation Glaucoma by Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Lubna Tabussum, Essam A. Osman, Saleh A. Al-Obeidan

“…However, the effect was lost when age, sex, and rs1048661 were included. A significant positive correlation was observed between 8-OHdG levels and intraocular pressure (R=0.284, p=0.008) and cup/disc ratio (R=0.233, p=0.031). …”
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The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data by Xiaomin Zhang, Zhiqi Chen, Yi Xiang, Yiquan Zhou, Molian Tang, Jun Cai, Xinyi Xu, Hongyuan Cui, Yi Feng, Renying Xu

“…A total number of 35,528 hospitalized adult patients (21,171 men and 14,357 women) were included. The average age and BMI were 57.5 ± 16.2 years and 23.4 ± 3.7 kg/m2, respectively, while medium vitamin D level was 16.1 ng/mL (interquartile range: 11.4 ng/mL, 21.6 ng/mL) and median CCI was one point (interquartile range: 0 point, two points). …”
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Fecal carriage of carbapenemase and AmpC-β-lactamase producers among extended spectrum β-Lactamase-producing E. coli and Klebsiella spp. isolates in patients attending hospitals by Zakaria Garba, Isidore J. O. Bonkoungou, Namwin Siourimè Somda, Magloire H. Natama, Georges Somé, Lassana Sangaré, Nicolas Barro, Halidou Tinto

“…The carbapenemase producers were detected at tertiary and secondary hospitals, mainly in hospitalized patients and females, whereas AmpC-β-lactamase producers were detected at all levels of healthcare, predominantly in non-hospitalized patients, male, and under 15 years of age. The co-resistance rates were as high as 82% for fluoroquinolones, 91% for aminoglycosides, and 94% for sulfonamides. …”
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Developing a virtual reality application for online arts and psychomotor therapies using action research by Nathalie Jans, Nathalie Jans, Hans Wouters, Joep Kolijn, Suzanne Haeyen, Suzanne Haeyen, Suzanne Haeyen

“…The Action Research concerned a one-year co-creation project involving 17 arts and psychomotor therapists (Mean age 44.1 years, SD 11.3) together with input from media designers in education and technical VR developers. …”
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Impact on clinical outcomes, surgical interventions, anaesthetic decisions and complication rates following implementation of the NICE obstructive sleep apnoea guidelines during pr... by Gabrielle Shaw, Ricki Leggatt, Paige Roberts, Amanda Peace Witton, Nicole Moll, Akshay Dwarakanath

“…Results: 450 patients (Age 55 ± 14 years, male 69%, Epworth Sleepiness Scale (ESS) 7 ± 5) with a STOP-Bang score of 3 or more underwent overnight oximetry (32%; normal, 44%; mild, 15%; moderate and 9%; severe OSA). …”
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HOLSEA-NL: a Holocene water level and sea level indicator dataset for the Netherlands by K. de Wit, K. M. Cohen, R. S. W. van de Wal, R. S. W. van de Wal

“…Northern indicators of Middle Holocene age (8–5 ka cal BP) generally lie 2–3 m lower than those in the south. …”
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Reduction on Proinflammatory Cytokines after Application of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients with a Breast Cancer: A Nonrandomized, Open, and Single-A... by Tábata Cristina do Carmo Almeida, Simone Meneghette Zatta, Laércio da Silva Paiva, Luís Eduardo Werneck de Carvalho, Jean Schoueri, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami

“…This study will evaluate at least 59 patients, over 18 years of age, diagnosed with breast cancer, but who have not yet started any treatment. …”
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The effect of SARS-CoV-2 Omicron BA. 5.2 infection on perioperative physiological indicators in orthopedic patients by Hao Wu, JunZhe Yang, YuQin Yan, Xiao Hu, BiXi Li, PengFei Cheng, XiaoYang Song

“…Multivariate regression analysis revealed that Omicron BA 5.2 infection, older age and a history of cerebral infarction were associated with increased D-dimer and FDP levels, and their odds ratios (ORs) and confidence intervals are 3.339 [95% CI, 1.372–8.419], P = 0.008; OR, 1.080 [95% CI, 1.023–1.139]; P = 0.005; OR, 10.644 [95% CI, 1.352–83.320], P = 0.025, respectively. …”
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Correlation between Galectin-3 and Early Herpes Zoster Neuralgia and Postherpetic Neuralgia: A Retrospective Clinical Observation by Tingting Wang, Yong Fei, Ming Yao, Jiachun Tao, Jiajia Deng, Bing Huang

“…The changes of galectin-3 in patients with early HZN and PHN were analyzed by single-factor analysis and multifactor analysis. The age (P=0.012) and NRS scores (P<0.001) of PHN patients were significantly higher than those of non-PHN patients and other neuralgia patients. …”
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Greenness and averted mortality in 390 cities in China (2000–2020)Research in context by John S. Ji, Zheng Tao, Hui Miao, Tom Cole-Hunter, Xuecao Li, David Rojas-Rueda, Wenjia Cai

“…Methods: In China, we mapped the urban human population distribution aged 20 and above with a 1 km grid (30 arc-second) and used satellite-based remote sensing to measure green space over time to create population-weighted normalized difference vegetation index (NDVI). …”
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Demographic disparities in access to COVID-19 clinical trial sites across the United States: a geospatial analysis by Raphael Cuomo, Tiana McMann, Qing Xu, Zhuoran Li, Joshua Yang, Julie Hsieh, Christine Lee, Milena Lolic, Richardae Araojo, Tim Mackey

“…Independent variables included eight racial and ethnic covariates, both sexes, and twelve age categories, all of which were population-normalized. …”
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Opioid sparing anesthesia in patients with liver cirrhosis undergoing liver resection: a controlled randomized double-blind study by Eman Sayed Ibrahim, Ahmed A. Metwally, Mohamed Abdullatif, Essam A. Eid, Mahmoud G. Mousa, Amany A. Sultan

“…Methods This study was a randomized controlled double-blind trial. 92 adult patients of both sex with Child class (A) liver cirrhosis aged 18 to 65 years entering and completing the study. …”
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Impact of COVID-19 restrictions on behavioural and psychological symptoms in home-dwelling people with dementia: a prospective cohort study (PAN.DEM) by Maarja Vislapuu, Mala Naik, Bettina S Husebø, Marie H Gedde, Ipsit V Vahia, Janne Mannseth, Line I Berge

“…Objectives To investigate the impact of the COVID-19 restrictions on behavioural and psychological symptoms of dementia (BPSD).Design Prospective cohort study (PAN.DEM) nested within the halted parent trial (LIVE@Home.Path).Setting Households in Norway immediate before and 6–9 weeks into the COVID-19 restrictions.Participants 104 dyads (persons with mild to moderate dementia aged ≥65 and their informal carers) completed both prepandemic and pandemic assessments, among 237 in the parent trial. …”
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Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study by Daniel Kuebler, Alexandra Schnee, Lisa Moore, Jason Kouri, Alexis McLaughlin, Robert Hanson, Patrick Kuebler, Ignacio Dallo, Alberto Gobbi

“…Changes in visual analog scores (VAS) for overall daily activity were examined over a six-month time frame in these patients (63.5±0.97 years of age; 48.1% male). In addition, changes in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Patient Global Impression of Change (PGIC scores) were examined over the same time frame in a smaller subset of patients (95 patients including 172 knees). …”
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Tuberculosis and Sudden Death in Lithuania by Gintarė Zarembaitė, Gabrielė Žiūkaitė, Sigitas Chmieliauskas, Diana Vasiljevaitė, Sigitas Laima, Jurgita Stasiūnienė

“…Results: The study revealed that out of 100 pulmonary tuberculosis cases, 90% were male with the mean age of 53.48 ± 11.12 years old. In the case of sudden death where tuberculosis was found, a significant portion of the sample (91%) was not followed up at any medical institution. …”
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