Effects of Switching to Netarsudil/Latanoprost Fixed Dose Combination from Various Latanoprost Regimens: The Phase 4 MORE Study by Bacharach J, Sadri E, Sawhney G, Kopczynski C, Merchea MM

“…Eligible participants were aged ≥ 18 years and had a current diagnosis of open-angle glaucoma or ocular hypertension. …”
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LIPS and PaO2/FiO2 Combined Plasma Biomarkers Predict Onset of Acute Respiratory Distress Syndrome in Patients of High Risks in SICU: A Prospective Exploratory Study by Ziyuan Shen, Zhongnan Yin, Senhao Wei, Zhukai Cong, Feng Zhao, Hua Zhang, Xi Zhu

“…Univariate analysis found 15 risk factors showed differences between ARDS and non-ARDS, namely, interleukin 6, interleukin 8 (IL-8), angiopoietin Ⅱ, LIPS, APACHEⅡ, SOFA, PaO2/FiO2, age, sex, shock, sepsis, acute abdomen, pulmonary contusion, pneumonia, hepatic dysfunction. …”
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Association of outpatient use of renin–angiotensin–aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study by Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio, Nathan W Cummins, Timothy M Dempsey, Vesna D Garovic, Andrew Limper

“…Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD), ARD syndrome (ARDS) and all-cause mortality, comparing COVID-19 to pre-COVID-19 influenza seasons.Results The cohort included 1 059 474 episodes of AVRI (653 797 filled an ACEi or ARB, and 405 677 other HTN medications). 58.6% were women and 72.9% with age ≥65. The ACEi/ARB cohort saw a larger increase in risk in the COVID-19 influenza season than the other HTN medication cohort for four out of five outcomes, with an additional 1.5 percentage point (pp) increase in risk of an inpatient stay (95% CI 1.2 to 1.9 pp) and of ICU/CCU use (95% CI 0.3 to 2.7 pp) as well as a 0.7 pp (0.1 to 1.2 pp) additional increase in risk of ARD and 0.9 pp (0.4 to 1.3 pp) additional increase in risk of ARDS. …”
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Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism by Yuan Liu, Siyi Guo, Shaowei Sang, Jinbo Liu, Lin Qi, Bin Lv, Xiaoli Zhang

“…We retrospectively reviewed the medical records of 304 PHPT patients treated in our hospital between January 2009 and July 2020, including 217 females and 87 males with the average age of 53.27 ± 13.54 years. Of the 304 patients, 181 were symptomatic PHPT patients and 123 were asymptomatic PHPT patients. …”
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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Here, we aim to introduce the characteristics of their symptoms, lung function and chest imaging features to arouse the attention of physicians to know better of the disease.Patients and Methods: We retrospectively analyzed thirty-one patients who had been diagnosed with CPVA based on clinical data and positive bronchial provocation tests (BPTs).Results: The mean age of all enrolled patients was forty-seven years, and females accounted for 64.5%. …”
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VANDAL BEHAVIOUR OF ADOLESCENTS AS A LEGAL AND PSYCHOLOGICAL PROBLEM by O. V. Gurova

“…The contradictions in the psychological theory, educational practice and consciousness of society were revealed: between the widespread occurrence of acts of vandal behaviour and the limited methods and means to prevent it; between the mass involvement of adolescents in vandalism and the lack of specialised age-based programmes to correct vandal behaviour; between the prevalence of unauthorized graphic activity of schoolchildren and other forms of vandal behaviour in the educational environment and the reluctance of teachers and administration of educational institutions to recognise this as a noteworthy problem; between the social significance of determination of lawful and effective punishment (in terms of prevention) and insufficient attention to personal reasons that encourage a person to commit or not to commit vandal acts; between common scientific interest in the individual psychological and socio-typological features of adolescents committing vandalism and inadequate attention to the socio-psychological motivational determinants, initiating and forming the readiness to commit vandal actions. …”
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Body weight gain and development of reproductive tract in crossbred Murrah × Mediterranean water buffalo heifers by Oswaldo J. González, Amílcar Acuña, Solaine Bradley, Ysis Cañizalez, Jorge Espinoza, Cindy Paniagua, María Virginia Suárez, Mónica Fuentes

“…The buffalo heifers (middle age: 710 days old and middleweight: 237 Kg) were randomly assigned to one of two treatments for 174 days. …”
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Transition of clinical biomarker status from childhood into adolescence-A prospective study in children from eight European countries. by Anna Floegel, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Dénes Molnár, Lauren Lissner, Stefaan De Henauw, Luis A Moreno, Wolfgang Ahrens, Manuela Marron, Claudia Börnhorst

“…Clinical blood biomarkers including glycated hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL-cholesterol), triglycerides, C-reactive protein (CRP), interleukin 6, ferritin, leptin and insulin-like growth factor 1 (IGF-1) were repeatedly measured in 2007/2008 (age range: 3.0 to <10.0 years) and in 2013/2014. …”
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Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players by Mingbang Li, Liang Tan, Hong Wu, Jianwei Wu

“…This experimental study aimed to compare the impact of free-play SSGs (freeD) and limited-dribbling SSGs (limitedD) in SSGs on the aerobic and anaerobic adaptations of youth basketball players.MethodsForty-five youth basketball players (aged 15.7 ± 0.6 years, with 4.2 ± 0.7 years of experience) were randomly assigned to two experimental groups (freeD and limitedD) and a control group (not exposed to SSG interventions). …”
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Anxiety and depression in primary knee osteoarthritis patients: are they related to clinical features and radiographic changes? by Yasmin A. Abd Elhamid, Ghada S. Elazkalany, Marwa H. Niazy, Angie Y. Afifi

“…Material and methods Fifty patients fulfilling primary knee OA classification criteria were recruited for the study, and 50 age- and sex-matched healthy individuals served as a control group. …”
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Work loss in patients with rheumatoid arthritis treated with abatacept, rituximab, tocilizumab or TNF inhibitors: a nationwide direct drug-to-drug comparison by Ulf Lindström, Johan Askling, Katerina Chatzidionysiou, Lotta Ljung, Lars Klareskog, Martin Neovius, Nils Feltelius, Eva Baecklund, Christopher Sjöwall, Helena Forsblad-d’Elia, Carl Turesson, Elisabet Lindqvist, Thomas Frisell, Alf Kastbom, Helena Forsblad-d'Elia, Jonas Söderling, Ann Knight, Gerd-Marie Alenius, Gustaf Magnus Bruze

“…Objective To compare work loss after starting tumour necrosis factor inhibitors (TNFi), rituximab, abatacept or tocilizumab in patients with rheumatoid arthritis (RA).Methods We used data from the Swedish Rheumatology Quality Register to identify patients aged 19-62 years who were treated with TNFi (n=15 093), rituximab (n=2123), abatacept (n=1877) or tocilizumab (n=1720) between 2007 and 2020. …”
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Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes by Xiaojing Wang, Tong Wang, Qian Zhang, Li Xu, Xinhua Xiao

“…Intestinal microbiota profile was evaluated using the Illumina MiSeq platform based on V3-V4 bacterial 16S rRNA gene. Results. The mean age of 49 subjects was 56.6 ± 6.9 years and BMI was 25.07 ± 3.02 kg/m2. …”
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Evaluating Tech Neck: A Pilot Study Using a Self-Developed Questionnaire on Symptoms, Posture, and Preventive Measures by Brigitte Osser, Csongor Toth, Carmen Delia Nistor-Cseppento, Gyongyi Osser, Caius Calin Miuța, Iosif Ilia, Diana Carina Iovanovici, Cristina Aur, Laura Ioana Bondar

“…Methods: This cross-sectional pilot study used a self-developed questionnaire to assess the prevalence and intensity of musculoskeletal symptoms among participants aged 6–18 years. The survey collected data on ergonomic tool usage, break frequency, posture awareness, and proactive measures (such as taking breaks and seeking professional help). …”
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What Can Be Done to Improve the Mental Health of University Students? Identifying Determinants of Psychological Distress at an Australian University by Patrick J. Owen, Shane A. Kavanagh, Anthony D. LaMontagne

“…Results: Mutually-adjusted individual-level determinants were age (β [95% CI]: -0.50 [-0.60, -0.41]), LGBTQI+ identity (0.96 [0.52, 1.40]), having a current health condition (3.23 [2.85, 3.60]), being a current carer (0.68 [0.04, 1.32]), country of birth other than Australia (1.19 [0.84, 1.54]), financial stress (2.43 [1.99, 2.86]), being satisfied with housing (-0.84 [-1.18, -0.51]), and having full-time employment (-0.49 [-0.99, 0.00]). …”
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In Vivo Corneal Confocal Microscopy Detects Improvement of Corneal Nerve Parameters following Glycemic Control in Patients with Type 2 Diabetes by Xiaofan Jia, Xiaogang Wang, Xiaoxia Wang, Qi Pan, Tongzhang Xian, Xiaobin Yu, Lixin Guo

“…Thirty-two patients with diabetes complicated by DPN and 12 age-matched control subjects underwent detailed clinical examination and were assessed per the Toronto Clinical Scoring Scale for DPN, nerve conduction studies, and IVCCM at baseline and after approximately one year from the first visit. …”
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Prevalensi Depresi pada Pensiunan Pegawai Negeri Sipil yang Mengambil Dana Pensiun di Bank BTPN Cabang M. Yamin Padang by Finna Dwi Putri, Amel Yanis, Elmatris SY

“…Most of them are at the age category of ≥60 years, most of symptoms of depression is in men, the largest prevalence of depression in retired civil servant class IIIa. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Based on multivariate analysis, advanced age (OR: 1.855; p = 0.011), preoperative hypertension (OR: 1.91; p = 0.017), coronary heart disease (OR: 6.773; p &lt; 0.001), preoperative albumin (OR: 0.924; p = 0.015), D-Dimer (OR: 1.001; p = 0.038), plasma creatinine (OR: 1.025; p = 0.001), cardiopulmonary bypass (CPB) duration (OR: 1.011; p = 0.001), repeat CPB (OR: 6.195; p = 0.010), intraoperative red blood cell transfusion (OR: 2.560; p &lt; 0.001), urine volume (OR: 0.406 p &lt; 0.001) and vasoactive–inotropic score (OR: 1.135; p = 0.009) were independent risk factors for AKI. …”
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Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration by Betül Ayça Yamak, İbrahim Ethem Güven, Mustafa Candemir

“…A linear regression analysis confirmed that disease duration was a stronger predictor of frontal QRS-T angle widening (B: 0.389, 95% CI: 0.102–0.677, <i>p</i> < 0.001) compared to age (B: 0.184, 95% CI: 0.123–0.245, <i>p</i> = 0.008). …”
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Frailty Is Associated With Decreased Survival in Adult Patients With Nonoperative and Operative Traumatic Subdural Hemorrhage: A Retrospective Cohort Study of 381,754 Patients by Evan N. Courville, MD, Oluwafemi P. Owodunni, MD, MPH, Jordyn T. Courville, BS, Syed F. Kazim, MD, PhD, Alexander J. Kassicieh, BS, Allyson M. Hynes, MD, Meic H. Schmidt, MD, MBA, Christian A. Bowers, MD

“…There were 340,096 nonoperative and 41,658 operative patients. The median age was 70.0 (54.0–81.0) nonoperative, and 71.0 (57.0–80.0) operative cohorts. …”
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…Results Among 21,245 patients (mean age 70.2 ± 10.3 years, 44.9% females), we identified 6 patterns: i) Low Medicated pattern (18.3%); ii) Hypertension pattern (21.1%); iii) Heart Failure pattern (20.0%); iv) CV Prevention pattern (21.0%); v) Mixed Morbidity pattern (4.5%); and vi) High Medicated pattern (15.0%). …”
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