QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) by Osama Dasa, Eileen Handberg, Damini Dey, Pinaki Sarder, Margaret C. Lo, Balaji K. Tamarappoo, Steven M. Smith, Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine

“…In many cases, coronary angiography does not reveal obstructive coronary artery disease (CAD) despite increased risk for major adverse cardiac events (MACE) compared with sex and age-matched asymptomatic cohorts. Objectives: The Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) evaluates intensive medical treatment for women with Ischemia with No Obstructive Coronary Arteries (INOCA). …”
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Colorectal Cancer and Polyps in Diverticulosis Patients: A 10-Year Retrospective Study in 13680 Patients by Fadi Abu Baker, Jesus Alonso Z'cruz De La Garza, Amir Mari, Abdel-Rauf Zeina, Amani Bishara, Oren Gal, Yael Kopelman

“…Each diverticulosis patient was matched with 1 control by age, gender, setting (inpatient/outpatient), and procedure’s indication. …”
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A nomogram prediction model for mild cognitive impairment in non-dialysis outpatient patients with chronic kidney disease by Qin Yang, Yuhe Xiang, Guoting Ma, Min Cao, Yixi Fang, Wenbin Xu, Lin Li, Qin Li, Yu Feng, Qian Yang

“…Logistic regression analysis revealed that age, educational level, occupational status, use of smartphones, sleep disorder, and hemoglobin were independent influencing factors of MCI (all p<.05). …”
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Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy by Wassapol Sornthai, Achiraya Teyateeti, Tawatchai Taweemonkongsap, Siros Jitpraphai, Varat Woranisarakul, Kantima Jongjitaree, Katunyou Mahamongkol, Nattaporn Wanvimolkul, Thitipat Hansomwong

“…Multivariate analysis reveals associations between myosteatosis, aging, and anemia. Myosteatosis and perioperative serum chloride levels are significant predictors of major complications after RC for MIBC. …”
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Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior by A. O. Bragin, O. V. Saik, I. V. Chadaeva, P. S. Demenkov, A. L. Markel, Yu. L. Orlov, E. I.  Rogaev, I. N. Lavrik, V. A. Ivanisenko

“…Alterations in neuronal apoptosis are observed in aging and neuropathologies accompanied by changes in psycho­emo­ tional state (epilepsy, Alzheimer’s disease, neurotrauma). …”
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Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation by Roberto Carnevale, Daniele Pastori, Mariangela Peruzzi, Elena De Falco, Isotta Chimenti, Giuseppe Biondi-Zoccai, Ernesto Greco, Antonino G. M. Marullo, Cristina Nocella, Francesco Violi, Pasquale Pignatelli, Camilla Calvieri, Giacomo Frati

“…Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer. Results. Mean age was 72.9 (±8.7) years and 41.6% were female. …”
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Association of quality of life in older patients with breast cancer: a cross-sectional study from China by Xi Chen, Qing Li, Xiang Wang, Lei Ji, Jintao Zhang, Qiao Li, Min Xiao, Shanshan Chen, Pin Zhang, Jiani Wang, Heng Cao, Xiaoyan Qian, Meng Xiu, Zhuoran Li, Yiqun Li, Xiaojuan Zheng

“…Objectives The purpose of this study was to investigate the quality of life (QoL) of older Chinese patients with breast cancer and to explore further the associations of functions, symptoms, financial burdens and comorbidities with global health/quality of life (gQoL).Design This was a cross-sectional study carried out following the Strengthening the Reporting of Observational Studies in Epidemiology checklist.Setting This study was conducted in two hospitals in Beijing from October 2021 to November 2022.Participants Patients with breast cancer aged over 65 years were included in the final analysis, which comprised a total of 481 patients.Primary and secondary outcome measures The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Charlson Comorbidity Index (CCI) were used to assess patients’ QoL and comorbidities. …”
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Virtual biopsy for non-invasive identification of follicular lymphoma histologic transformation using radiomics-based imaging biomarker from PET/CT by Chong Jiang, Chunjun Qian, Qiuhui Jiang, Hang Zhou, Zekun Jiang, Yue Teng, Bing Xu, Xin Li, Chongyang Ding, Rong Tian

“…Furthermore, the t-FL scoring system, incorporating the R-signature along with clinical parameters (age, LDH, and ECOG PS) and SUVmax, achieved an AUC of 0.820, facilitating the stratification of patients into low, medium, and high transformation risk groups. …”
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Adherence to the ISHLT Protocol for the Referral of Patients with Idiopathic Pulmonary Fibrosis to the Transplantation Center among of Czech Centers for Interstitial Lung Diseases by Martina Sterclova, Martina Doubkova, Lubica Sykorova, Vladimir Bartos, Monika Zurkova, Vladimira Lostakova, Radka Mokosova, Martina Plackova, Ladislav Lacina, Michaela Cimrova, Radka Bittenglova, Pavlina Lisa, Pavla Musilova, Daniel Dolezal, Jana Psikalova, Petra Ovesna, Martina Koziar Vasakova

“…Thirty percent of potentially eligible patients not referred to the transplant center were considered to have too many comorbidities by the reporting physician, 19% of IPF patients denied lung transplantation, and 17% were not referred due to age. Among Czech patients with IPF, there may be a larger pool of potential lung transplant candidates than has been reported to the transplant center to date.…”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…Results A total of 5,046 adults (representing 42,753,806 individuals, weighted mean age 61.08 years [SE: 0.24]; 49.35% female) were analyzed. …”
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Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia a... by Joelle I. Rosser, John J. Openshaw, Audrie Lin, Ruzka R. Taruc, Autiko Tela, Nursehang Tamodding, Nurul Pausi Emelia Abdullah, Murni Amiruddin, Esra Buyukcangaz, S. Fiona Barker, Amelia Turagabeci, Ansariadi, Karin Leder, Isra Wahid, on behalf of the RISE Consortium

“…We used a catalytic model using seroprevalence and mean age to estimate annual incidence of dengue in each country. …”
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Signs and symptoms of vulvovaginal atrophy (VVA) in clinical practice – the possible involvement of thyroid autoimmunity in genitourinary syndrome of menopause (GSM) by Laura Cucinella, Federica Barbagallo, Mariacristina Erroi, Chiara Procaccianti, Ellis Martini, Lara Tiranini, Giorgia E. Parrotta, Greta Monne, Giulia M. Colombo, Aldo Calogero, Rossella E. Nappi

“…A higher percentage of women with thyroid ADs experienced severe dyspareunia (45 vs. 20.6%, p < .05), severe burning/itching (33.3 vs. 9.1%, p < .05), and severe stress urinary incontinence (17.9 vs. 3.6%, p < 0.05).Conclusions This study suggests that thyroid ADs may contribute to genital aging, with an apparent greater involvement in vaginal signs of atrophy. …”
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Impact of distress and anxiety due to COVID-19 on digital addictions in university students in the third wave period  [version 2; peer review: 3 approved] by Yovana Pardavé-Livia, Armando Martínez-Portillo, Evelyn Barboza-Navarro, Luz Elizabeth Mayorga-Falcón, Walter Capa-Luque, Catalina Bello-Vidal, Aldo Bazán-Ramírez, Edmundo Hervias-Guerra

“…A total of 802 students from public and private universities residing in the city of Lima and Callao (Peru), with a mean age of 21.68 (SD = 3.11), selected by convenience sampling, participated in the study. …”
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Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? by Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marko Stojanovic, Sasa Ilic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Toplica Milojevic, Mihailo Milicevic, Marija Jovanovic, Milica Medic Stojanoska, Bojana Carić, Nevena Radic, Sanja Medenica, Emilija Manojlovic Gacic, Milan Petakov

“…We identified 16 patients (11 male), mean age 44.8 ± 22.3 years, diagnosed with pituitary XG. …”
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Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis by Dongkai Li, Jiahui Zhang, Wei Cheng, Guoyu Zhao, Xianli Lei, Yawen Xie, Na Cui, Hao Wang

“…Multivariable regression demonstrated that age, Acute Physiology and Chronic Health Evaluation-II score, heart rate, natural killer cell count, infection source, and lymphocyte trajectory phenotype were independent predictors of 28-day mortality. …”
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Drivers of Palliative Care and Hospice Use Among Patients With Advanced Lung Cancer by Megan C. Edmonds, Melissa Mazor, Mayuri Jain, Lihua Li, Marsha Augustin, José Morillo, Olivia S. Allen, Amina Avril, Juan P. Wisnivesky, Cardinale B. Smith

“…Results Ninety‐nine of the enrolled participants had a mean age of 64 years. Minority patients were more likely to receive a palliative care referral (p < 0.001) and attend a consult (p = 0.003). …”
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Studying the Humoral Response against SARS-CoV-2 in Cuban COVID-19 Recovered Patients by Ivette Orosa Vázquez, Marianniz Díaz, Yaima Zúñiga Rosales, Klayris Amada, Janoi Chang, Ernesto Relova Hernández, Yaima Tundidor, Hilda Roblejo Balbuena, Giselle Monzón, Bárbara Torres Rives, Enrique Noa Romero, Danay Carrillo Valdés, Irinia Valdivia Álvarez, Aurora Delahanty Fernández, Claudia Díaz, Joaquín Solozabal, Mileidys Gil, Belinda Sánchez, Gertrudis Rojas, Beatriz Marcheco, Tania Carmenate

“…Our results suggest that disease severity, and not demographic features such as age, sex, and skin color, is the main determinant of the magnitude and neutralizing ability of the anti-RBD antibody response. …”
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Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty by Drenka Trivanović, Marko Vujačić, Aleksandra Arsić, Tamara Kukolj, Milica Rajković, Nikola Bogosavljević, Zoran Baščarević, Mirjana Maljković Ružičić, Jovana Kovačević, Aleksandra Jauković

“…BMAT undergoes metabolic and cellular adaptations with age and disease, being a source of potential biomarkers. …”
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Artificial intelligence‐based body composition analysis using computed tomography images predicts both prevalence and incidence of diabetes mellitus by Yoo Hyung Kim, Ji Won Yoon, Bon Hyang Lee, Jeong Hee Yoon, Hun Jee Choe, Tae Jung Oh, Jeong Min Lee, Young Min Cho

“…Results Visceral fat (VF) proportion and VF/subcutaneous fat (SF) ratio increased with age, and both strongly predicted the presence and risk of developing diabetes. …”
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Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study by Huanhuan Ren, Junhao Huang, Yao Huang, Bangyuan Long, Mei Zhang, Jing Zhang, Huarong Li, Tingting Huang, Daihong Liu, Ying Wang, Jiuquan Zhang

“…Results A total of 321 patients were included in the study, predominantly male [247 (76.9%)] with an average age of 52.04 ± 10.87 years. The training cohort (Center 1) comprised 252 patients, while the test cohort (Center 2) comprised 69 patients. …”
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