The clinical utility of tissue polymerase chain reaction, tissue culture and tissue histology in blood culture-negative infective endocarditis in South Africa – insights from the G... by W Endres, P Mkoko, M Ntsekhe

“…Among patients undergoing surgery for IE, valve tissue may be evaluated for additional microbiological information by performing a broad-range 16S rDNA polymerase chain reaction (PCR) test, tissue culture and tissue histopathology. …”
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Clinical spectrum, treatment and outcomes of the m.10197G>A mutation in MT-ND3: a case report, systematic review and meta-analysis by YuZhi Shi, Bin Chen, SongTao Niu, XinGao Wang, ZaiQiang Zhang

“…Methods This study reports a rare case of adult-onset Leigh syndrome (LS) and Leber hereditary optic neuropathy and dystonia (LDYT) overlap syndrome caused by the m.10197G>A mutation in ND3. …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

“…Nocturnal polyuria (NP) is a leading cause of nocturia in adults. While diagnostic criteria for NP have been established in adult men, they have not been validated in other demographic groups including women, adolescents, and children, and little is known about appropriate reference values in these populations. …”
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Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study by Maaike Rijpstra, Kris Vissers, Alazne Belar, Michael Van der Elst, Séverine Marie Surges, Claudio Adile, Rocío Rojí, Yasmine Grassi, Ewald Bronkhorst, Sebastiano Mercadante, Lukas Radbruch, Johan Menten, Carlos Centeno, Evelien Kuip, Jeroen Hasselaar

“…Methods In this prospective observational study, adult patients with advanced malignancies were recruited from hospice units, palliative care units, and hospital wards in five European countries. …”
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Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic by Roman Chlibek, Jan Smetana, Kateřina Kybicová, Martina Malikova, Frederick J. Angulo, Alexandra Loew-Baselli, Ye Tan, Aleš Ondřejíček, Gordon Brestrich, Andreas Pilz, Jennifer C. Moïsi, James H. Stark

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Accuracy of Two Methods in Estimating Target Muscle Force During Shoulder Submaximal Isometric Contractions by Sean F. Griech, Christos Karagiannopoulos

“…Significant moderate - good correlations were found between both methods for both ER \[RR (r = 0.717) and NR (r = 0.614)\] and IR \[RR (r = 0.669) and NR (r = 0.628)\]…”
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Distribution, abundance, and size structure of the Pacific cupped oyster Magallana gigas in northern Patagonia by Leandro A. Hünicken, Raúl González, Dennis Landete, Maité A. Barrena, Juan F. Saad, Maite A. Narvarte

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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

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Action Planning for Daily Mouth Care in Long-Term Care: The Brushing Up on Mouth Care Project by Mary E. McNally, Ruth Martin-Misener, Christopher C. L. Wyatt, Karen P. McNeil, Sandra J. Crowell, Debora C. Matthews, Joanne B. Clovis

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Effects of Fast Simple Numerical Calculation Training on Neural Systems by Hikaru Takeuchi, Tomomi Nagase, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Rui Nouchi, Ryuta Kawashima

“…We investigated the effects of 1-week intensive FSNC training on cognitive function, regional gray matter volume (rGMV), and regional cerebral blood flow at rest (resting rCBF) in healthy young adults. …”
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Real-world cost-effectiveness analysis of thymoglobulin versus no induction therapy in kidney transplant recipients at low risk of graft loss by Adrieli Barros Bessa, Marina Pontello Cristelli, Claudia Rosso Felipe, Renato Demarchi Foresto, Marcelo Cunio Machado Fonseca, Jose Medina Pestana, Helio Tedesco-Silva

“…Abstract Background: A new induction therapy strategy of a single 3 mg/kg dose of rabbit antithymocyte globulin (r-ATG) showed a lower incidence of acute rejection. …”
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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

“…Background Tisagenlecleucel, a CD19 chimeric antigen receptor T-cell therapy, is approved for adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL) after ≥2 lines of therapy. …”
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The association between obesity indicators and mortality among individuals with hyperlipidemia: evidence from the NHANES 2003–2018 by Yiheng Zhang, Yajun Yao

“…The area under ROC indicated that WWI was more effective than for BMI and WHtR in predicting overall and CVD deaths. Conclusions In US adults with hyperlipidemia, the connection between BMI, WHtR, with overall and CVD mortality followed a U-shaped pattern, whereas a positive linear correlation was identified between WWI and mortality. …”
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Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation by Aaron L. Slusher, Tiffany M. Zúñiga, Edmund O. Acevedo

“…In addition, shorter telomere lengths in middle-aged compared to young adults (p=0.011) were negatively associated with age, body fat percentages, and plasma TNF-α (r=−0.404, p=0.027; r=−0.427, p=0.019; and r=−0.323, p=0.041, respectively). …”
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The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004 by Xu Sun, Jimei Song, Rixun Yan, Jianwei Diao, Yibo Liu, Zhangzhi Zhu, Weichi Lu

“…After adjusting for relevant covariables, WHtR, BRI, BMI, LAP, WTI and VAI were all associated with migraine and WHtR (OR = 6.38, 95% CI: 2.25,18.09, P < 0.01) showed the best predictive ability. …”
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Self-Care Interventions as a Health Technology for Managing Type 2 Diabetes: A Population-Based Study in Iran by Zahra Yousefi Malekroodi, Seyed Ali Majidi, Amirmohammad Taalipasand

“…Conversely, a negative relationship was observed between perceived stress and self-care (r = -0.22). Conclusions: These findings can assist healthcare providers in expanding existing knowledge and designing diabetes self-care management education programs tailored to the psychosocial and cultural needs of adults in the study region. …”
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Experimental infection of wild boars (Sus scrofa) with Rickettsia rickettsii and evaluation of the transmission potential to Amblyomma sculptum ticks by Lucianne Cardoso Neves, Lina de Campos Binder, Warley Vieira de Freitas Paula, Nicolas Jalowitzki de Lima, Ennya Rafaella Neves Cardoso, Rayane Almeida Santos, Raphaela Bueno Mendes Bittencourt, Gracielle Teles Pádua, Gabriel Cândido dos Santos, Mariana Avelar Tavares, Maria Carolina de Azevedo Serpa, Adriano Pinter, Artur Luiz de Almeida Felicio, Marcelo B. Labruna, Felipe da Silva Krawczak

“…Methods Four wild boars were infected with R. rickettsii through infestation with R. rickettsii-infected A. sculptum adults (infected group); a fifth wild boar was infested with uninfected A. sculptum adults (control group). …”
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Kidney Disease and Youth Onset Type 2 Diabetes: Considerations for the General Practitioner by Allison B. Dart, Elizabeth A. Sellers, Heather J. Dean

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Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma by Jiahui Lin, Jiahui Lin, Aiting Jiang, Juntao Zheng, Jingjing Wu, Hao Li, Hao Li, Shirong Cai, Yulong He, Xiao Chen, Guoping Zhong, Ke-Jing Tang, Ke-Jing Tang, Xinhua Zhang, Yanzhe Xia

“…BackgroundRipretinib, a broad-spectrum tyrosine kinase inhibitor, has been approved for the treatment of advanced gastrointestinal stromal tumors in adult patients. Clinical studies have shown that higher in vivo exposure of ripretinib correlates with improved efficacy, highlighting the potential clinical significance of therapeutic drug monitoring. …”
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Association of Fontan Pathophysiology With Plasma Bile Acids by Ashish H. Shah, MD, MD-Research, Arun Surendran, MSc, Pedram Hassan-Tash, BSc, MD, C. Nolan Turnbull, BSc, Nicole Johnston, MSc, David Goodlett, BSc, PhD, Jun Han, PhD, Robin A. Ducas, MD, James W. Tam, MD, Eberhard Renner, MD, Todd A. Duhamel, PhD, Michel Aliani, MSc, PhD, Amir Ravandi, MD, PhD, Richard A. Krasuski, MD

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