Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities by Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales

“…Compounds 2, 6, and 7 crystallize in the E conformation about the N1-C6, N1-C11, and N1-C11 bonds, respectively, while 8 adopts the Z conformation about the N1-C12 bond with the presence of an intramolecular N2-H…O2 hydrogen bond. …”
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Measurement and Evaluation of Social Resilience Indicators in the Historical Neighborhoods of Tabriz City (Case Study: Sorkhab Neighborhood of Tabriz) by Leila Rahimi, Mahta Choobineh

“…Materials and MethodsThis research adopted a descriptive-analytical approach in terms of its nature and methodology. …”
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Designing the behavioral model of managers in the digital age with the foundation's data approach by Farahangiz Abdollahzadeh Namini, Rouhollah Samiei, Alireza Mazidi

“…The results of the investigated research indicate that managers and leaders who have a higher level of emotional intelligence have a more favorable and effective leadership, because this group of managers has the ability to adopt the appropriate interactive style to guide and lead the organization effectively by understanding the requirements and environmental situation.  …”
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Application of Sherlock 3CG tip confirmation system for positioning the tip of peripheral inserted central catheter in ICU patients (Sherlock 3CG尖端定位技术在ICU患者经外周置入中心静脉导管尖端定位中的应用)... by LI Zhouwei (李周伟), WEI Jiejing (韦洁静), LIN Songfei (林颂霏), XIONG Yumei (熊玉梅), HUANG Yunhua (黄芸华), HUANG Debin (黄德斌)

“…The intracavitary electrocardiogram was used to guide tip positioning of PICC in the control group, while the Sherlock 3CG tip confirmation system was adopted for positioning the tip of PICC in the observation group. …”
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Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry by Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini

“…On the other side, the study provides scientific background for reconsidering the microbiological criteria adopted by the food safety legislation of many countries that ask for the absence of Salmonella in foods, regardless of any virulence evaluation of the detected strain. …”
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Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients by Zhang Dai, Xuhong Lan, Minjing Cai, Yunhui Liao, Jingwen Zhang, Naifang Ye, Xinxin Lu, Jiajia Wang, Yun Xiao, Yan Zhang, Yihui Yao, Xianming Liang

“…Five independent factors included Candida albicans, decreased albumin, multiple organ dysfunction syndrome, solid tumor and septic shock were adopted in a nomogram for 30-days mortality of candidemia. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…The translational potential of this article: As a recently developed procedure for treating osteochondral defects, AOPT has shown promising repair effect and is being increasingly adopted in clinical practice. This study presents histological evidence of the progressive transformation of the periosteum graft into cartilage-like tissue and demonstrates its ability to integrate with the surrounding tissue.…”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…Policy needs to go beyond the mere support of agroecological practices on livestock farms and adopt a systems approach looking downstream and upstream if it is to enable a large-scale agroecological transition with EU public policies. …”
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Application of the academic evaluation by oral defense in training of nurses in the operating room (答辩式考核在手术室进修护士培训中的应用) by LI Wenjing (李文静), HU Juanjuan (胡娟娟), LIU Juan (刘娟), ZHAO Jing (赵晶)

“…A personalized training program was developed for the nurses and standardized teaching method was carried out. The control group adopted routing evaluation in theory and practice skills, and the observation group implemented the academic evaluation by oral defense in addition to the routine evaluation. …”
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Practice and experience of pre-examination triage mode in the emergency department during COVID-19 epidemic (新型冠状病毒感染流行期间急诊科预检分诊模式的实践及体会)... by HOU Pengxiao (候朋晓), LI Ying (李影), LIU Fusheng (刘福生), REN Yaxing (任亚星), QIN Shasha (秦沙沙), HAN Jianping (韩建萍)

“…It is directly related to medical safety in screening of patients' conditions and adopting appropriate classification and zone management. …”
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Epilepsy care pathway: The Finnish model by Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group

“…The resulting pathway was adopted into the current Finnish evidence‐based current care guidelines for epilepsy. …”
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Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…Currently, there is an urgent need to stratify patients before treatment to adopt the appropriate neoadjuvant strategies. Our previous study has shown that circulating tumour DNA (ctDNA) effectively reflects tumour burden and genetic characteristics and has significant predictive value for tumour recurrence, demonstrating great potential in guiding the choice of neoadjuvant strategies.Methods and analysis The CINTS-R trial is a multicentre, open-label, randomised controlled trial designed to evaluate the efficacy and safety of a ctDNA-guided neoadjuvant treatment strategy compared with conventional neoadjuvant therapy regime in patients with LARC. …”
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Precise Acetabular Prosthesis Positioning Using a Novel Robot‐Assisted Total Hip Arthroplasty System: A Multicenter, Randomized Controlled Trial by Xiao Geng, Ziyang Dong, Yang Li, Minwei Zhao, Yanqing Liu, Zijian Li, Hong Cai, Ming Zhang, Xinfeng Yan, Zhiwen Sun, Xin Lv, Feng Guo, Feng Li, Hua Tian

“…Method A multicenter, prospective, randomized controlled, superiority study design was adopted with statistical methods of t test and Chi‐squared test. …”
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Application of Six Sigma methodology in the homogeneous nursing management for patients with acute pancreatitis (六西格玛管理法在急性胰腺炎患者同质化护理管理中的应用)... by LYU Jian (吕健), ZHOU Qun (周群), WEI Yanli (魏艳丽), XIE Lan (谢岚)

“…Results Scores for assessment of emergency nursing ability and homogeneous management procedure increased significantly after implementation of Six Sigma methodology (P＜0. 01) . Conclusion Adopting the Six Sigma methodology in the homogeneous nursing management is potentially effective to enhance the emergency nursing ability of emergency nurses and improve the quality of emergency care for AP. …”
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An investigation on demands of clinical teaching among nursing undergraduates at school (在校本科护生临床教学需求调查分析) by GAN Lu (甘露), XIE Wei (谢薇), SHUAI Xuemei (帅雪梅), XUE Ting (徐婷), NI Dangcheng (倪当承), RAO Liu (饶柳), YUAN Zheng (袁铮), JIN Liping (金莉萍), TANG Jia (唐佳), LI Wei (李伟)

“…Conclusion Clinical teachers should help students build clinical thinking ability by adopting the teaching method combining theory with practice. …”
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Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht) by Steven J R Meex, Walther N K A van Mook, Iwan C C van der Horst, Jeanette Tas, Coen D A Stehouwer, Rob J J van Gassel, Serge J H Heines, Mark M G Mulder, Nanon F L Heijnen, Melanie J Acampo-de Jong, Julia L M Bels, Frank C Bennis, Marcel Koelmann, Rald V M Groven, Moniek A Donkers, Frank van Rosmalen, Ben J M Hermans, Otto Bekers, Astrid M L Oude Lashof, Fabian H Tijssen, Jan-Willem E M Sels, Chahinda Ghossein-Doha, Rob G H Driessen, Pieter L Kubben, Marcus L F Janssen, Gerry A F Nicolaes, Ulrich Strauch, Zafer Geyik, Thijs S R Delnoij, Kim H M Walraven, Jeanine A M C F Verbunt, Susanne van Santen, Ronny M Schnabel, Marcel J H Aries, Marcel C G van de Poll, Bas C T van Bussel, Joachim E Wildberger, Sander M J van Kuijk, Dennis C J J Bergmans, Paul H M Savelkoul, Alma M A Mingels, Wolfgang F F A Buhre

“…During the pandemic, the board of directors of Maastricht UMC+ adopted a policy to inform patients and ask their consent to use the collected data and to store serum samples for COVID-19 research purposes. …”
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Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

“…Participants reported that this cultural alignment made the coping strategies more relatable and easier to adopt, contributing to improvements in both their mental health and somatic symptoms.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04981522, identifier NCT04981522.…”
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Application of multiple interactive teaching methods in clinical nursing teaching (多元互动式教学方法在临床护理教学中的应用) by WANG Shangying (王尚莹), LI Tong (李彤), LI Qingling (李庆玲), GAO Donghua (高冬华), TANG Ling (唐玲)

“…The conventional teaching method was used in the control group, while the multiple interactive teaching method was adopted in the observation group. The theoretical knowledge, operational skills and satisfaction with different teaching methods were compared between the two groups, and the application effect of different teaching methods was comprehensively analyzed. …”
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Refining Established Practices for Research Question Definition to Foster Interdisciplinary Research Skills in a Digital Age: Consensus Study With Nominal Group Technique by Jana Sedlakova, Mina Stanikić, Felix Gille, Jürgen Bernard, Andrea B Horn, Markus Wolf, Christina Haag, Joel Floris, Gabriela Morgenshtern, Gerold Schneider, Aleksandra Zumbrunn Wojczyńska, Corine Mouton Dorey, Dominik Alois Ettlin, Daniel Gero, Thomas Friemel, Ziyuan Lu, Kimon Papadopoulos, Sonja Schläpfer, Ning Wang, Viktor von Wyl

“…For the workshops and the subsequent manuscript writing process, we adopted a consensus study methodology. …”
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A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…Methods In this phase Ia trial, a modified 3 + 3 study design was adopted during dose escalation phase. Eligible patients were enrolled, and GQ1001 monotherapy was administered intravenously every 3 weeks. …”
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