Utilization of primary tumor samples for cancer neoantigen discovery by Yong Li, Steven A Rosenberg, Paul Robbins, Billel Gasmi, Todd D Prickett, Jared J Gartner, Devikala Gurusamy, Stephanie L Goff, Vid Leko, Victoria Hill, Frank J Lowery, Bradley Sinclair White, Sivasish Sindiri, Maria Parkhust, Noam Levin, Eric Groh, Shoshana T Levi, Amy R Copeland, Sanghyun Peter Kim

“…This included all 12 neoantigens encoded by putative cancer driver genes, which are generally regarded as superior targets for adoptive cell therapy. The detection rate for other neoantigens, representing mutations without an established role in cancer biology, was 50% (13/26). …”
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Radiation knowledge and anxiety levels among residents proximity to the world’s first AP1000 nuclear power unit by Jiadi Guo, Zhiqiang Xuan, Cuiping Lei, Taotao Zheng, Zhongjun Lai, Xiaoji Hao, Shunfei Yu, Yiyao Cao

“…ObjectiveAssess the level of radiation-related knowledge (RRK) and nuclear energy-related knowledge (NERK) among residents near the Sanmen Nuclear Power Plant, the first project adopted the Advanced Passive Pressurized Water Reactor (AP1000) technology.MethodsIn this study, respondents were selected using stratified multi-stage random sampling for residents aged 18 years and above living within 30 kilometers of the Sanmen Nuclear Power Station. …”
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Efficient Therapeutic Function and Mechanisms of Human Polyclonal CD8+CD103+Foxp3+ Regulatory T Cells on Collagen-Induced Arthritis in Mice by Juan Sun, Yiming Yang, Xiaona Huo, Beibei Zhu, Zhenhua Li, Xueyu Jiang, Rufeng Xie, Li Gao, Ying Sun, Huahua Fan, Yongming Zhu, Jie Yang

“…In CIA mice, the clinical scores, levels of anti-collagen IgG antibody, and cartilage destruction were significantly reduced after adoptive transfusion with hCD8+Tregs. Moreover, hCD8+Treg treatment significantly reduced the number of Th17 cells, increased the number of CD4+IFN-γ+T cells, and produced self CD4+Foxp3+Tregs in vivo. …”
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Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…During debris clearance, MDMs adopt a proinflammatory phenotype that exacerbates neurodegeneration and hinders recovery. …”
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Design and application of a pharyngeal swab samples collection device (一种咽拭子采集装置的设计及应用) by KANG Jie (康杰), LU Minghui (路明惠), TIAN Ruixi (田润溪), FAN Jiao (范姣), WANG Lin (王琳)

“…Methods A total of 120 hospital staff members who conducted nucleic acid testing were randomly divided into the control group and study group, with 60 cases in each group. The control group adopted regular method of pharyngeal swab samples collection, while the study group used the new type device for pharyngeal swab samples collection. …”
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A qualitative research on health education needs of pregnant women with gestational diabetes mellitus (妊娠期糖尿病孕产妇健康教育需求的质性研究) by TAN Minjing (覃敏静), YANG Miaomiao (杨苗苗), WANG Kaihua (王凯华), LUO Chunmiao (罗春苗), ZHOU Jinchang (周金嫦)

“…Methods From October to December 2020, the purposive sampling was adopted to select 12 pregnant women with diabetes mellitus who gave birth in our hospital as the research objects. …”
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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…Introduction Robot-assisted surgery (RAS) and kinematic alignment (KA) are being increasingly adopted to improve patient outcomes in total knee arthroplasty (TKA). …”
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Application of nursing skills competition in teaching of Surgical Nursing (护理技能竞赛在《外科护理学》教学中的应用研究) by FENG Lin (冯琳), LI Ping (李萍), LU Fang (卢放)

“…Conventional teaching method was adopted in the control group, and the nursing skills competition combined with practical teaching was used in teaching of Surgical Nursing in the observation group. …”
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Community-based model for management and follow-up by non-physician healthcare workers to improve awareness, treatment, and control of hypertension: The COTRACO study protocolDetai... by A.J. Lora Mantilla, L.A. Parra Gomez, P.A. Camacho-López, J. Otero-Wandurraga, B. Novella, A. González-Medina, O. Valdez-Tiburcio, F. Lanas, M.C. Rocha-Lezama, J. Alonzo-Arias, C. Rivilla-Piñango, C. Cáceres-Ramírez, S.J. Villabona-Flórez, Y.M. Giraldo-Castrillón, P. López-Jaramillo

“…Recommendations: If this model demonstrates superior outcomes compared to usual care, it is recommended that health authorities in low- and middle-income regions adopt and implement this approach. Using non-medical health professionals, standardized treatment algorithms and free access to antihypertensive medications, these regions can significantly improve awareness, diagnosis and management of hypertension. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…Objectives: To explore healthcare professionals’ perceptions and expectations regarding the multidisciplinary approach to chronic pediatric pain, and identify areas for improvement to optimise rehabilitative practices. Methods: The study adopted a qualitative design, utilizing the Focus Group technique and unstructured interviews, following Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. …”
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Application of case-based learning combined with problem-based learning in standardized training of cerebrospinal fluid drainage (CBL结合PBL教学模式在脑脊液外引流规范化培训中的应用)... by YIN Yating (殷亚婷), ZHEN Qin (郑琴), LIU Fang (刘芳), CHEN Lishan (陈丽珊), XUE Qiang (薛强)

“…The conventional teaching model was adopted in the control group, while a combined teaching methods of CBL and PBL was used in the study group. …”
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Assessing the Impact of Climate Change on the Landscape Stability in the Mediterranean World Heritage Site Based on Multi-Sourced Remote Sensing Data: A Case Study of the Causses a... by Mingzhuo Zhu, Daoye Zhu, Min Huang, Daohong Gong, Shun Li, Yu Xia, Hui Lin, Orhan Altan

“…The landscape stability model was developed utilizing land cover information and landscape indicators to explore the landscape stability and its distribution features within the study area. Finally, we adopted the Geographical Detector to quantify the extent to which climatic factors influence the landscape stability’s spatial distribution across different periods. …”
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Application of Minocycline-Containing Bismuth Quadruple Therapies as First-Line Regimens in the Treatment of Helicobacter pylori by Lingyun Zhang, Yu Lan, Qi Wang, Yuexia Zhang, Xiaobei Si

“…A 3 to 5-day follow-up was adopted to evaluate the safety and compliance of medications after medicine administration. 13C-urea breath test was performed to confirm the eradication of H. pylori 4-12 weeks after therapy. …”
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Evaluation of Health Science Students’ Knowledge, Attitudes, and Practices Toward Artificial Intelligence in Northern Saudi Arabia: Implications for Curriculum Refinement and... by ALruwail BF, Alshalan AM, Thirunavukkarasu A, Alibrahim A, Alenezi AM, Aldhuwayhi TZA

“…Therefore, formal and integrated training programs tailored to suit the local setting can effectively prepare health science students to adopt AI technologies in ways that enhance patient care.Keywords: artificial intelligence, Vision 2030, curriculum refinement, AI training program, nursing, AI readiness…”
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Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…However, it is still largely unknown which B cell lineages are involved in the formation of antibodies in response to lymphopenia and what functional properties these antibodies have. Employing adoptive transfer of different mature B cell subsets into lymphopenic Rag2-/- hosts, we here show that not only innate B cells – MZBs and B1a cells – but also adaptive FoBs were capable to differentiate into PCs and to produce IgM and class-switched IgA serum antibodies in a T cell-independent fashion during homeostatic proliferation. …”
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Exploration of urease-aided calcium carbonate mineralization by enzyme analyses of Neobacillus mesonae strain NS-6 by Zhiwei Ma, Mengyao Chen, Juncheng Lu, Shichuang Liu, Yanling Ma

“…Homology modeling and molecular docking were employed to construct the three-dimensional structure of urease and seek the key residues involved in nickel binding process, and virtual mutation technology was adopted to inform three key residues coordinated with nickel ions and urea, His249, His275, and Asp363. …”
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Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, follo... by G. Menardi, A. Castellino, C. Castellino, M. E. Bersia, E. Grande, G. Fraternali, M. Massaia, C. Fruttero

“…Conclusions In conclusion, this article offers valuable insights into the challenges of managing chimeric antigen receptor T-cell-related toxicities through a detailed case presentation and highlights the significance of adopting multidisciplinary approaches to enhance patient outcomes and safety. …”
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Prediction of growth and feed efficiency in mink using machine learning algorithms by A. Shirzadifar, G. Manafiazar, P. Davoudi, D. Do, G. Hu, Y. Miar

“…However, the FE measures have not been widely adopted for the mink due to the high cost of periodically measuring BW and daily feed intake. …”
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…This occurred in 5/20 and 1/30 of participants in the sarilumab and SOC arms respectively, with the majority occurring in the initial 9 participants (3/4 in the sarilumab and 1/5 in the SOC) before the sarilumab dose was increased to 400 mg and before remdesivir and dexamethasone were widely adopted. After interim review, the unblinded Data Monitoring Committee recommended that the study be stopped due to concern for safety: a high probability that rates of intubation or death were higher with addition of sarilumab to SOC (92.6%), and a very low probability (3.4%) that sarilumab would be found to be superior.…”
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Supplemental Intervention for Alcohol Use Disorder Treatment Patients With a Co-Occurring Anxiety Disorder: Technical Development and Functional Testing of an Autonomous Digital Pr... by Linda Marie Rinehart, Justin Anker, Amanda Unruh, Nikki Degeneffe, Paul Thuras, Amie Norden, Lilly Hartnett, Matt Kushner

“…This phenomenon—empirically validated treatments that fail to be widely adopted in community care—has been termed the “research-to-practice gap.” …”
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