Barriers and facilitators to implementation of a home-based cardiac rehabilitation programme for patients with heart failure in the NHS: a mixed-methods study by Rod S Taylor, Paulina Daw, Samantha B van Beurden, Jet J C S Veldhuijzen van Zanten, Alexander Harrison, Sinead T J McDonagh, Patrick J Doherty, Colin J Greaves, Hasnain M Dalal, Grace E R Wood

“…REACH-HF is an effective and cost-effective 12-week home-based cardiac rehabilitation programme for patients with heart failure.Setting/participants In 2019, four early adopter ‘Beacon Sites’ were set up to deliver REACH-HF to 200 patients. …”
Get full text

Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…We construct a photometric redshift catalog based on deep ( i  ∼ 26, K _s  ∼ 24) multiwavelength photometry from the u * band to the K band gathered from the Hyper Suprime-Cam Subaru Strategic Program and other collaborative/public surveys. We adopt a Gaussian kernel density estimate with two different spatial scales (10″ and 60″) to draw a density map of massive ( $\mathrm{log}({M}_{* }/{M}_{\odot })\gt 10.5$ ) and quiescent ( $\mathrm{log}(\mathrm{sSFR}\,[{\mathrm{yr}}^{-1}])\lt -10$ ) galaxies at z  ∼ 2. …”
Get full text

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…Interestingly, the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity, without impacting antitumor efficacy.Conclusions Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.…”
Get full text

Network Meta-Analysis and Trial Sequential Analysis of Randomised Controlled Trials Comparing Robotic, Laparoscopic, and Open Pancreatoduodenectomy by Nejo Joseph, MBChB, Chris Varghese, MBChB, James Lucocq, MBChB, Matthew J. McGuinness, MBChB, Samuel Tingle, MBChB, Giovanni Marchegiani, PhD, Kjetil Soreide, PhD, Mohammed Abu-Hilal, Jas Samra, Marc Besselink, PhD, Steve White, Sanjay Pandanaboyana, FRCS

“…The use of minimally invasive (laparoscopic and robotic) pancreatoduodenectomy (PD) is being increasingly adopted despite the lack of hard evidence to support its utilisation. …”
Get full text

First aid guidelines for Bites and Stings: Educational Approach and Adaptation: Educational approach & Adaptation

“…Cette approche a été conçue de manière à ce que les utilisateurs des lignes directrices puissent facilement les appliquer aux contextes pertinents des apprenants par le biais de leur adaptation, adoptant à cette fin des niveaux variés de ressources et de soins médicaux et des stratégies de mise en œuvre localisées. …”
Get full text

Application of Minocycline-Containing Bismuth Quadruple Therapies as First-Line Regimens in the Treatment of Helicobacter pylori by Lingyun Zhang, Yu Lan, Qi Wang, Yuexia Zhang, Xiaobei Si

“…A 3 to 5-day follow-up was adopted to evaluate the safety and compliance of medications after medicine administration. 13C-urea breath test was performed to confirm the eradication of H. pylori 4-12 weeks after therapy. …”
Get full text

Heart Rate in Hypertension: Review and Expert Opinion by Jamshed Dalal, Arup Dasbiswas, Immaneni Sathyamurthy, Srinivasa Rao Maddury, Prafulla Kerkar, Sandeep Bansal, Joy Thomas, Sankar Chandra Mandal, Soura Mookerjee, Sivakadaksham Natarajan, Viveka Kumar, Nishith Chandra, Aziz Khan, R. Vijayakumar, J. P. S. Sawhney

“…Generally, HR<70 bpm on beta blocker (BB) treatment is advised which may be further lowered in patients with comorbidities like heart failure and coronary artery disease. (vii) Adopting healthy lifestyle approaches to keep check on BP and HR is essential. …”
Get full text

Evaluation of Health Science Students&rsquo; Knowledge, Attitudes, and Practices Toward Artificial Intelligence in Northern Saudi Arabia: Implications for Curriculum Refinement and... by ALruwail BF, Alshalan AM, Thirunavukkarasu A, Alibrahim A, Alenezi AM, Aldhuwayhi TZA

“…Therefore, formal and integrated training programs tailored to suit the local setting can effectively prepare health science students to adopt AI technologies in ways that enhance patient care.Keywords: artificial intelligence, Vision 2030, curriculum refinement, AI training program, nursing, AI readiness…”
Get full text

Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…However, it is still largely unknown which B cell lineages are involved in the formation of antibodies in response to lymphopenia and what functional properties these antibodies have. Employing adoptive transfer of different mature B cell subsets into lymphopenic Rag2-/- hosts, we here show that not only innate B cells – MZBs and B1a cells – but also adaptive FoBs were capable to differentiate into PCs and to produce IgM and class-switched IgA serum antibodies in a T cell-independent fashion during homeostatic proliferation. …”
Get full text

Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, follo... by G. Menardi, A. Castellino, C. Castellino, M. E. Bersia, E. Grande, G. Fraternali, M. Massaia, C. Fruttero

“…Conclusions In conclusion, this article offers valuable insights into the challenges of managing chimeric antigen receptor T-cell-related toxicities through a detailed case presentation and highlights the significance of adopting multidisciplinary approaches to enhance patient outcomes and safety. …”
Get full text

Prediction of growth and feed efficiency in mink using machine learning algorithms by A. Shirzadifar, G. Manafiazar, P. Davoudi, D. Do, G. Hu, Y. Miar

“…However, the FE measures have not been widely adopted for the mink due to the high cost of periodically measuring BW and daily feed intake. …”
Get full text

Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…This occurred in 5/20 and 1/30 of participants in the sarilumab and SOC arms respectively, with the majority occurring in the initial 9 participants (3/4 in the sarilumab and 1/5 in the SOC) before the sarilumab dose was increased to 400 mg and before remdesivir and dexamethasone were widely adopted. After interim review, the unblinded Data Monitoring Committee recommended that the study be stopped due to concern for safety: a high probability that rates of intubation or death were higher with addition of sarilumab to SOC (92.6%), and a very low probability (3.4%) that sarilumab would be found to be superior.…”
Get full text

Assessment of mental health literacy using a multifaceted measure among a Chinese rural population by Liang Zhou, Shui-yuan Xiao, Mi Hu, Hui-ming Liu, Yu Yu, Zi-wei Liu, Xi-guang Liu, Joyce P Yang

“…A multistage cluster-sampling method was adopted, leading to a final sampling frame of 2377 residents aged 18–60 years from four villages of Liuyang county. …”
Get full text

Conservation in action: Cost-effective UAVs and real-time detection of the globally threatened swamp deer (Rucervus duvaucelii) by Ravindra Nath Tripathi, Karan Agarwal, Vikas Tripathi, Ruchi Badola, Syed Ainul Hussain

“…This study exemplifies how combining UAVs with deep learning can facilitate species monitoring and population count estimation and be adopted by forest managers to support conservation decisions.…”
Get full text

Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract by Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu

“…Quantitative PCR and flow cytometry were adopted for monitoring CART cell kinetics and function, with a focus on gastrointestinal AEs during treatment. …”
Get full text

Public Benefit and Public Interest – Two Sides of the Same Coin? by Tina Sever

“…To distinguish between public benefit and public interest, the analysis adopts a comparative approach, examining how each concept is defined, applied, and balanced in different legal contexts. …”
Get full text

Tradition and Development of Lithuanian Terminology by Antanas Smetona

“…Terminology work has become much more lively and varied, acquiring a truly international character, and Western ideas of terminology have been widely adopted. A national language policy has emerged. Unfortunately, against the background of the general equality of the languages of the European Union, the language of science is increasingly becoming English, and the number of scientific publications in Lithuanian is decreasing. …”
Get full text

Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…Besides, we conducted weighted gene co-expression network analysis (WGCNA) to identify hub genes. And then, we adopted the quantitative real-time PCR (RT-qPCR) assay to validate the hub genes among several CKD animal models. …”
Get full text

Mediating effects of occupational self-efficacy on the relationship of authentic leadership and job engagement by Popy Podder, Hillol Saha

“…Research limitations/implications – The limitations of this study were the shortage of time constraints, due to which a quantitative method was adopted to gather the data. The sample size was comprised of 95 respondents and does not represent the entire population of Bangladesh. …”
Get full text

A Hybrid Dynamic Principal Component Analysis Feature Extraction Method to Identify Piston Pin Wear for Binary Classifier Modeling by Hao Yang, Yubin Zhai, Mengkun Zheng, Tan Wang, Dongliang Guo, Jianhui Liang, Xincheng Li, Xianliang Liu, Mingtao Jia, Rui Zhang

“…A modeling dataset containing 80 samples (40 normal samples and 40 worn samples) is employed, and five-round cross-validation is adopted. For each round, two binary classifier models are trained by features extracted by the proposed method and the empirical mode decomposition (EMD)–auto regressive (AR) spectrum method, fast Fourier transform (FFT) and continuous wavelet transform (CWT), respectively; the classification precision, recall ratio, accuracy and F1 ratio are obtained on the testing set by contrasting the overall performances of the five-round cross-validation, and the proposed method is proved to be more effective in noise reduction and significant feature extraction, which is able to improve the accuracy and efficiency of binary classification for piston pin wear identification.…”
Get full text