Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…Abstract Sepsis-induced acute respiratory distress syndrome (ARDS) is a severe complication of sepsis and the leading cause of mortality. …”
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Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation by Zhong-Hui Wang, Wei-Ying Ren, Lei Zhu, Li-Juan Hu

“…The mechanisms by which plasminogen activator inhibitor-1 (PAI-1) regulates inflammation, especially in acute respiratory distress syndrome (ARDS), are largely unknown. …”
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The Role of Therapeutic Anticoagulation in COVID-19 by Ruth McGovern, Patrick Conway, Isabell Pekrul, Omar Tujjar

“…We report the case of a patient admitted to our intensive care unit (ICU) with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19 whose clinical trajectory improved dramatically after initiation of a therapeutic dose of LMWH. …”
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Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response by Yaoqin Hu, Chaojin Qin, Guoping Zheng, Dengming Lai, Huikang Tao, Yan Zhang, Guanguan Qiu, Menghua Ge, Lanfang Huang, Lina Chen, Baoli Cheng, Qiang Shu, Jianguo Xu

“…In vitro, ASCs increased expression of M2 macrophages independent of direct cell-to-cell contact when macrophages were treated with LPS or serum from patients with acute respiratory distress syndrome (ARDS). When macrophages were cultured with serum from ARDS patients who were treated with ASCs or placebo in our previous clinical trial, there was no difference in M2 macrophage levels before and after ASCs treatment indicating a suboptimal response to the treatment protocol. …”
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Clinical Characteristics and Outcomes of Acute Lung Injury Caused by Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Retrospective Cohort Study from a Sing... by Liang-jie Fang, Lu-yan Chen, Jun-hui Sun, Jian-ying Zhou

“…Of the 14 patients, 8 patients (57.1%) developed acute respiratory distress syndrome (ARDS). 7 patients (50%) had underlying chronic respiratory disease and hepatic arteriovenous fistula was detected in 6 patients (42.6%), both of which were significantly higher than control group (P<0.05). …”
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Design and application of a pressure relief pad for preventing pressure injuries (一种防压力性损伤减压垫的设计与应用) by ZHANG Yitian (张怡天), SUN Xiumei (孙秀梅), LI Jingwen (李静文)

“…Prone position ventilation is a kind of ventilation strategy for severe patients, especially patients with acute respiratory distress syndrome. Pressure injury is the most common complication of prone position ventilation, and effective preventive and decompression tools can reduce the occurrence of stress injury during prone position. …”
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Clinical Outcome Discrimination in Pediatric ARDS by Chest Radiograph Severity Scoring by Yu-Chun Yan, Wen-Han Hao, Feng-Sen Bai, Shuang Liu, Dong Qu, Xin-Yu Yuan

“…There is no accurate radiological measurement to estimate the severity of pediatrics acute respiratory distress syndrome (PARDS). We validated the effectiveness of an adult radiographic assessment of lung edema (RALE) score in PARDS. …”
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Outcome of Concurrent Occult Hemothorax and Pneumothorax in Trauma Patients Who Required Assisted Ventilation by Ismail Mahmood, Zainab Tawfeek, Ayman El-Menyar, Ahmad Zarour, Ibrahim Afifi, Suresh Kumar, Ruben Peralta, Rifat Latifi, Hassan Al-Thani

“…Hemopneumothorax was managed conservatively in 72% cases and 28% underwent tube thoracostomy as indicated. 29% of patients developed pneumonia, 16% had Acute Respiratory Distress Syndrome (ARDS), and 7% died. Thickness of hemothorax, duration of mechanical ventilation, and development of ARDS were significantly associated with tube thoracostomy in comparison to no-chest tube group. …”
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The clinical features and outcomes of diabetes patients infected with COVID-19: a systematic review and meta-analysis comprising 192,693 patients by Kai Liu, Shu Liu, Ting-ting Xu, Hong Qiao

“…Compared with the non-diabetic group, the diabetic group had a higher incidence of complications in acute respiratory distress syndrome (ARDS), shock, acute heart injury, acute kidney injury and more regularly used oxygen therapy, invasive ventilation, non-invasive ventilation, continuous renal replacement therapy (CRRT), extracorporeal membrane oxygenation (ECMO) treatment. …”
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Activation of PPARγ Protects Obese Mice from Acute Lung Injury by Inhibiting Endoplasmic Reticulum Stress and Promoting Mitochondrial Biogenesis by Yin Tang, Ke Wei, Ling Liu, Jingyue Ma, Siqi Wu, Wenjing Tang

“…Obesity-induced endoplasmic reticulum (ER) stress plays a role in increased susceptibility to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The activation of peroxisome proliferator-activated receptor-γ (PPARγ) is associated with lung protection and is effective in ameliorating ER stress and mitochondrial dysfunction. …”
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Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…She had numerous complications including significant facial edema, seizures, bacterial pneumonia, sepsis, hypovolemic shock, acute respiratory distress syndrome, diabetic ketoacidosis, nonalcoholic steatohepatitis, liver failure, and recurring DRESS rashes despite treatment with high-dose intravenous steroids and immunosuppressants. …”
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Impact of gas flaring on acute respiratory distress among pregnant women and newborn babies in Delta State Central Senatorial District, Nigeria by Omatseye Alero Akuirene, John Esimaje Moyegbone, Charity Omoikhekpen Chukumah, Mercy Ebiyemi Kalaroo, Josiah Obaghwerhievwo Adjene, Emmanuel Agbonomhen Agege, Joseph Onyedenyifa Odoko, Ezekiel Uba Nwose

“…The researchers aimed to examine how gas flaring impact acute Respiratory Distress Syndrome (RDS) in women that were pregnant and newborn babies. …”
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An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…ABSTRACT Influenza, as well as other respiratory viruses, can trigger local and systemic inflammation resulting in an overall “cytokine storm” that produces serious outcomes such as acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). We hypothesized that gene therapy platforms could be useful in these cases if the production of an anti-inflammatory protein reflects the intensity and duration of the inflammatory condition. …”
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Immune system effectors as biomarkers of prognosis after acute burns in a case-control study by Alejandro Ferrari, Lorena Di Croce, Sabrina Saavedra, Marisel Hartwig, Omar Perrone, María Alejandra Guzmán

“… Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distress syndrome, multiorgan dysfunction, and death. …”
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Efficacy of Amflow®, a Real-Time-Portable Feedback Device for Delivering Appropriate Ventilation in Critically Ill Patients: A Randomised, Controlled, Cross-Over Simulation Study by Jong Won Kim, Sang O Park, Kyeong Ryong Lee, Dae Young Hong, Kwang Je Baek

“…Using a SB with or without Amflow® alternately, participants delivered ventilations to test lungs connected to a gas flow analyser in each of three different scenarios: acute respiratory distress syndrome (ARDS; 315–385 ml ranges for 350 ml target VT, with 20 breaths/min); cardiopulmonary resuscitation (CPR; 450–550 ml ranges for 500 ml target VT with 10 breaths/min); and adult head trauma (630–770 ml ranges for 700 ml target VT with 15 breaths/min). …”
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…Inflammatory disease characterized by clinical destructive respiratory disorder is called acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Studies have shown that luteolin exerts anti-inflammatory effects by increasing regulatory T cells (Tregs). …”
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Using a clinical decision support system to reduce excess driving pressure: the ALARM trial by Ursula Burger-Klepp, Mathias Maleczek, Robin Ristl, Bettina Kroyer, Marcus Raudner, Claus G. Krenn, Roman Ullrich

“…Abstract Background Patients at need for ventilation often are at risk of acute respiratory distress syndrome (ARDS). Although lung-protective ventilation strategies, including low driving pressure settings, are well known to improve outcomes, clinical practice often diverges from these strategies. …”
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Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model by Qiong Liang, Qiqing Lin, Yueyong Li, Weigui Luo, Xia Huang, Yujie Jiang, Chunyan Qin, Jin Nong, Xiang Chen, Suren Rao Sooranna, Liao Pinhu

“…The remodeling of the extracellular matrix (ECM) in the parenchyma plays an important role in the development of acute respiratory distress syndrome (ARDS), a disease characterized by lung injury. …”
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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are challenging diseases with the high mortality in a clinical setting. …”
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Impact of Prone Position on 12-Lead Electrocardiogram in Healthy Adults: A Comparison Study with Standard Electrocardiogram by Yunis Daralammouri, Murad Azamtta, Hamza Hamayel, Amro Adas, Osama Sawalmeh, Yahia Ismail, Saed H. Zyoud

“…It may be difficult to report ECG in a supine posture for those who are unable to adopt the supine posture because of certain circumstances such as acute respiratory distress syndrome—patients who are placed in a prone position for long periods to improve oxygenation. …”
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