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49501
Jargon and Readability in Plain Language Summaries of Health Research: Cross-Sectional Observational Study
Published 2025-01-01“… BackgroundThe idea of making science more accessible to nonscientists has prompted health researchers to involve patients and the public more actively in their research. This sometimes involves writing a plain language summary (PLS), a short summary intended to make research findings accessible to nonspecialists. …”
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49502
Preservative-free IOP-lowering medications: potential advantages
Published 2019-09-01“…In these cases, fixed-dose combinations containing several active ingredients are beneficial. Potential advantages of fixed-dose combinations include reduced costs, lower risk of washout, less instillations, reduced medication regimen complexity, and saved time. …”
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49503
Clinical and imaging features of co-existent pulmonary tuberculosis and lung cancer: a population-based matching study in China
Published 2025-01-01“…Methods Patients diagnosed with active PTB-LC (APTB-LC), inactive PTB-LC (IAPTB), and LC alone without PTB between 2010 and 2022 at our institute were retrospectively collected and 1:1:1 matched based on gender, age, and time of admission. …”
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49504
Lowering light intensity while extending photoperiod at a constant daily light integral synergistically interacts with warm temperature to enhance leaf expansion and crop yield in...
Published 2025-01-01“…Applying FR light or lowering light intensity over a longer photoperiod at a constant daily light integral (DLI) can increase crop yield by enhancing leaf expansion and photon capture. However, PHY activity is also dependent on temperature. We aimed to investigate the interactive effects of FR light, light intensity, photoperiod, and temperature on plant growth and morphology.MethodsLettuce (Lactuca sativa L.) …”
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49505
Terpinen-4-ol Improves the Intestinal Barrier Function of the Colon in Immune-Stressed Weaning Piglets
Published 2024-12-01“…The malondialdehyde (MDA) content was greater in the colon of the LPS group than in that of the CON group, while the activities of glutathione peroxidase (<i>GSH-Px</i>), superoxide dismutase (<i>SOD</i>), and catalase (<i>CAT</i>) were lower in the colon of the LPS group; conversely, the MDA content was lower in the colons of the PLT and PMT groups than in those of the LPS group (<i>p</i> < 0.05). …”
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49506
Digital Information Exchange Between the Public and Researchers in Health Studies: Scoping Review
Published 2025-01-01“…Interactivity (ie, if digital information exchange is or should be active or passive) was addressed in half of the studies. …”
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49507
Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia
Published 2020-03-01“…A functional significance of these changes suggests that a wide distribution of the strains with the novel GII.P16 polymerase may be associated both with several amino acid substitutions in the polymerase active center and with the insertion of glutamic acid or glycine in an N-terminal p48 protein that blocks the secretory immunity of intestinal epithelial cells. …”
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49508
Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma
Published 2025-01-01“…GO and KEGG pathway enrichment analyses revealed a substantial enrichment of terms associated with cell division, whereas gene set enrichment analysis (GSEA) revealed correlations between increased DBF4 expression and the activation of cell cycle-related pathways. Subsequent in vitro and in vivo experiments demonstrated that DBF4 knockdown in ccRCC cells not only suppressed proliferation and migration in vitro but also significantly inhibited tumor growth in xenograft mice by arresting the cell cycle at the G1/G0 phase, which was mediated by the inhibition of MCM2 phosphorylation and cyclin D1 and CDK4 expression. …”
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49509
Effects of the Paediatric Regulation funding on the development of off-patent medicines in children
Published 2025-01-01“…A survey to project coordinators was also conducted to explore the challenges faced during paediatric drug development plans.ResultsThe 20 FP7-funded projects studied 24 off-patent active substances. Eighteen substances had agreed PIPs with the European Medicines Agency paediatric Committee (PDCO). …”
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49510
Sparse attention convolution-ViT model for working condition recognition in zinc flotation
Published 2025-02-01“…Moreover, gradient-weighted class activation mapping was used to visualize feature weights, confirming the model’s capability to effectively characterize froth images by identifying both local and global features. …”
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49511
The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment
Published 2025-01-01“…Participants prioritized improvement in cognitive abilities (87.5%), followed by quality of life (63.6%), daily activities (55.7%), sleep (55.7%), pain (52.3%), mood (52.3%), behavior (48.9%), and anxiety (43.2%). …”
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49512
Turning crisis into chances: Tourism entrepreneurs’ timing strategies amidst emergencies
Published 2024-01-01“…Therefore, chance management can be very useful in their activity and our research findings can be also useful regarding its theoretical and practical implications. …”
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49513
Health system costs of a breast cancer early diagnosis programme in a rural district of Rwanda: a retrospective, cross-sectional economic analysis
Published 2022-06-01“…We also aimed to estimate the cost of implementing the programme in other districts with different referral pathways and identify opportunities for enhanced cost efficiency.Design Retrospective, cross-sectional analysis using time-driven activity-based costing, based on timed patient clinical encounters, retrospective patient data and unit costs of resources abstracted from administrative and finance records.Setting The BCED programme focused on timely evaluation of individuals with breast symptoms. …”
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49514
The Lived Experience of Adult Cancer Survivors After Hematopoietic Stem Cell Transplantation: A Qualitative Study From Saudi Arabia
Published 2025-01-01“…Participants were asked about their daily activities, problems with coping, quality of life, and personal stress/worries about the future. …”
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49515
Blood Glukose Response of Giant Gouramy (Osphronemus gaouramy, Lac.) to the Stress of Environmental Temperature Changes
Published 2007-08-01“…To study the role of insulin activation on reducing the stress effects, thirty fish were injected with insulin 2 IU/100 g body weight before subjected them to stressar. …”
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49516
Exogenous ALA applied on different plant parts promotes tomato fruit quality and GABA synthesis
Published 2025-01-01“…Exogenous ALA application at different sites regulates the activity of glutamate acid decarboxylase (GAD) and increases the content of glutamate for GABA synthesis pathway during tomato fruit development, thereby affecting the GABA content. …”
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49517
Capital formation and production of carbon emissions in low-carbon development
Published 2024-01-01“…The government must strive for promoting eco-friendly agricultural practices with mitigated through outreach programs involving experts who educate farmers on minimizing emissions, reducing carbon emissions from pesticide with using biochar sourced from empty palm fruit bunches and also rice straw which is very easy to obtain at a low cost and is environmentally friendly, and emphasizing environmental preservation policies in the industrial sector like industrial transformation efforts with an effective approach to reducing carbon emissions such as restructuring various aspects of industrial activities, including investment, final demand, intensity and production methods. …”
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49518
OUR EXPERIENCE IN TREATMENT OF ENTEROATMOSPHERIC FISTULAS FORMED AS A RESULT OF MINE-EXPLOSIVE INJURY
Published 2024-10-01“…Next, VAC bandages were installed for active drainage. After debridement, tissue defects of the anterior abdominal wall were plasticized with own tissues or ointment bandages were used, sites were formed for the calorimeter (if there is a discharge of intestinal contents from the fistula) or places for an ointment bandage (if there is no secretion of intestinal contents). …”
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49519
Phytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment
Published 2025-01-01“…Moreover, in vivo anti-tumor studies demonstrated that Phy-Mast-M exhibited superior curative inhibitory effects on tumor growth and favorable biocompatibility.Conclusion: Phy-Mast-M demonstrates significant anti-tumor activity both in vitro and in vivo. Moreover, its potential for clinical translation suggests promising prospects for cancer therapy, offering more drug options for breast cancer patients. …”
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49520
An exploratory analysis of differences in serum protein expression by sex in patients with systemic sclerosis associated interstitial lung disease
Published 2025-01-01“…Autotaxin, known to activate lysophosphatidic acid and promote fibrosis, suggests a potential role in modulating fibrotic processes in SSc-ILD. …”
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