Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Han... by Chunlai Feng, Jiaxi Cheng, Mengqiu Sun, Chunxue Qiao, Qiuqi Feng, Naying Fang, Yingying Ge, Mengjie Rui

“…These combinations, at their actual concentrations in extracts, demonstrated superior anti-breast cancer activity compared to the corresponding extracts. The bioinformatics analysis revealed that these compounds could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing cell apoptosis, and blocking cell cycle progression. …”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

“…Women will be eligible if they have undergone active surveillance and have no previous record of hysterectomy, cone biopsy, and CIN2 or worse. …”
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Using remote sensing and machine learning to generate 100-cm soil moisture at 30-m resolution for the black soil region of China: Implication for agricultural water management by Liwen Chen, Boting Hu, Jingxuan Sun, Y. Jun Xu, Guangxin Zhang, Hongbo Ma, Jingquan Ren

“…To assess the applicability of our research methodology, we selected the typical black soil zone in Northeast of China, which is one of the four major black soil regions globally and characterized by intensive agricultural activities. We estimated the long-term time series of soil moisture information during the growing seasons from 2000 to 2020 in this study area. …”
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Sexually transmitted infections and associated factors among Wollo University students, Northeast Ethiopia by Hilina Ayalew, Gedefaw Abeje, Elsabeth Addisu, Natnael Kebede, Ayalew Hassen Mohammed

“…Results Self-reported STIs prevalence in the last 12 months prior to the study was 59 (21.5%; 95% CI: 16.5-26.5%) among students who were sexually active. Non-dormitory students (adjusted odds ratio (AOR) = 4.56, 95% CI: 1.21-17.21%), having sex with a casual partner (AOR = 2.98, 95% CI: 1.14-7.81%), and poor knowledge on STIs (AOR = 2.95, 95% CI: 1.28-6.81%) were found significantly associated with a history of STIs in the past 12 months among Wollo University students. …”
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The Impact of Dermal Characteristics on Low-Level Laser Power Measurement in Postmortem Zoological Species by Faith Ramsey, Michelle Borsdorf, John Ladner, Anne White, Tara M. Harrison

“…Additional studies evaluating biologically active tissues would be needed as a next step, as photobiomodulation has an effect at the cellular level and the exact amount of medical benefit is not measurable in skin samples that are separate from a living organism.…”
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Polyphenolic compounds in Sauvignon Blanc - from grapes to wine by Davin Williams, Anscha Zietsman, Jeanne Brand, Hans Eyeghe-Bickong, Melané Vivier

“…Juice processing was noted for dramatic fluctuations in metabolite concentrations suggesting intense metabolic activity in this pre-fermentation matrix. Both skin contact and sediment contact treatments delivered wines with higher concentrations of coutaric acid (the ester formed from coumaric and tartaric acid) and the flavanol catechin while epicatechin concentrations was unaffected.  …”
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Systematic review and meta-analysis on the prevalence and risk factors of oral frailty among older adults by Pingping Huang, Linjing Wu, Rongxiang Zhang, Rongxiang Zhang, Shiqi Chen, Shiqi Chen, Yu Zhang, Yuan Chen, Yuan Chen

“…Healthcare professionals are encouraged to actively implement preventive and treatment measures addressing the controllable factors associated with oral frailty. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…Recently, the role of the SLC26A6 transporter in the etiopathogenesis of this disease has been identified. This transporter is active at both the intestinal and renal levels, and its mechanism of action is disrupted during systemic inflammation and metabolic syndrome, which could explain the rising incidence of secondary hyperoxaluria in recent decades. …”
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Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies by Oluwole Solomon Oladeji, Abimbola Peter Oluyori, Deborah Temitope Bankole, Tokunbo Yemisi Afolabi

“…The Efficiency Levels (ELs) of 11 different medicinal plants stated by the respondents were Azadirachta indica, Cassia fistula and Morinda lucida (12), Chromolaena odorata (10), Mangifera indica, Enantia chlorantha and Helianthus annuus (8), Cymbopogon citratus (7), Gossypium arboretum (4), Landolphia dulcis (3), and Aloe vera (2) Cocos nucifera, Curcuma longa, Forkia biglobosa, and Musa acuminate are mentioned for the first time in the study area with little or no reported antiplasmodial activities. Conclusion. The study appraised the commonly used antimalarial plants in the study areas. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…The odontogenic phenotype is associated with metabolic remodeling marked by enhanced glycolytic flux and attenuated mitochondrial metabolic enzyme activities. Conclusions Atoh1, despite being a proneural transcription factor in development, possesses a novel odontogenic function upon ectopic expression in DPSCs. …”
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The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy by Ricardo Pardillo-Díaz, Patricia Pérez-García, María Ortego-Domínguez, Ricardo Gómez-Oliva, Nora Martínez-Gómez, Samuel Domínguez-García, Francisco García-Cózar, Juan Pedro Muñoz-Miranda, Rosario Hernández-Galán, Livia Carrascal, Carmen Castro, Pedro Nunez-Abades

“…However, in response to cortical injuries, the neurogenic activity of the SVZ is significantly altered, leading to increased number of neuroblasts with a modified migration pattern that leads cells towards the site of injury. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Recently, many researchers suggested that the periodontal pathogenic bacteria Fusobacterium (F.) nucleatum has the TLR4-associated strong activator of the colorectal inflammation and cancer. …”
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Reloading mechanical characteristics of cemented tailings backfill after dynamic loading action by Xuepeng SONG, Bowen FAN, Shi WANG, Hongwei ZHANG

“…Due to the difference in the initial damage degree, the rate, number and scale of cracks sprouting, expanding and propagating within the matrix of the dynamically damaged filling body are significantly different. The activity and sparsity of the AE signal initially decrease, then increase, and finally decrease again with the increase in impact amplitude. …”
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Evaluation of the Knowledge, Attitudes and Practice of Veterinary Professionals and Senior Animal Health Students in Central Gondar Zone, Gondar, Ethiopia: Antimicrobial Use and Re... by Abibo Wondie Mekonen, Yesuneh Tefera Mekasha, Melaku Getahun Feleke, Atsede Getaneh, Meron Dereje, Misganew Bafe, Sete Nigussie, Achenef Melaku Beyene

“…Therefore, to fill the observed gaps, activities that enhance the skills of veterinary professionals and students should be implemented. …”
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Analysis of Mannose‐Binding Lectin Protein and mRNA Levels on Selected Chicken Breeds in South Africa by Peter Ayodeji Idowu, Takalani J. Mpofu, Oliver T. Zishiri, Khathutshelo A. Nephawe, Bohani Mtileni

“…ABSTRACT Background Mannose‐binding lectin (MBL) is a key component of the innate immune system that plays a crucial role in binding to the microbial sugar surface to recognize and eliminate pathogens by activating the complement system. Objective To detect and quantify the MBL protein concentration and chicken MBL expression in selected chicken breeds in South Africa. …”
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Efeitos da fisioterapia na função pélvica e qualidade de vida em mulheres com incontinência urinária – uma revisão sistemática by Elisabete Matos, Telma Pires, Fátima Santos, Patrícia Pires, Sara Viana, Rui Viana

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KULTŪRINIO IR SIMBOLINIO KAPITALO GAMYBA: "DISNEY" FENOMENAS by Gintautas Mažeikis

“…Humanistic and individualistic activities of Disney corporation's creation, co-operation with consumers, and development of education programs are emphasized in the article. …”
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Multimodel Combination Bathymetry Inversion Approach Based on Geomorphic Segmentation in Coral Reef Habitats Using ICESat-2 and Multispectral Satellite Images by Xiuling Zuo, Juncan Teng, Fenzhen Su, Zhengxian Duan, Kefu Yu

“…Validated by the in situ bathymetric data and ICESat-2 data, the bathymetry inverted using the PMCGS had an RMSE of 0.91 m in GF-1 image and 0.70–0.88 m in WV-2/3 images when extrapolated to other reefs, which is significantly more accurate than active–passive one entire model methods with the same resolution. …”
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Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscl... by Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade de Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

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Mechanistic insights into “Three Methods and Three Acupoints” Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats by Hanyu Zhang, Yingqi Zhang, Hourong Wang, Jiayue Liu, Jiawei Sun, Jinping Chen, Zhifeng Liu, Tianyuan Yu, Jian Shu

“…The mechanism may involve the activation of the PI3K/Akt signaling pathway.…”
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