Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells by Arie O. Verkerk, Marcel M. G. J. van Borren, Ronald Wilders

“…In our contribution to this journal’s “Special Issue on Cardiac Electrophysiology,” we present a numerical reconstruction of If and INaCa in isolated rabbit and human SAN pacemaker cells based on experimental data on action potentials, If, and intracellular calcium concentration ([Ca2+]i) that we have acquired from these cells. …”
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Pseudomyopathic Changes in Needle Electromyography in Lambert-Eaton Myasthenic Syndrome by Teppei Komatsu, Kota Bokuda, Toshio Shimizu, Tetsuo Komori, Reiji Koide

“…The diagnosis of LEMS is based on the combination of fluctuating muscle weakness, diminished or absent reflexes, and a more than 60% increment of compound muscle action potential (CMAP) amplitude after brief exercise or 50 Hz stimulation for 1 s in a repetitive nerve stimulation (RNS) test (Oh et al., 2005). …”
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Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes by Asuka Hatano, Leighton T. Izu, Ye Chen-Izu, Daisuke Sato

“…The model recapitulates the experimental data showing that the mechanical load on cardiomyocytes during contraction increases the L-type Ca2+ current, action potential duration, sarcoplasmic reticulum (SR) Ca2+ content, and SR Ca2+ release, giving rise to increased cytosolic Ca2+ transient (MCT-Ca2+ gain) and enhanced contraction. …”
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Distal muscle weakness as the main onset symptom in thymoma-associated myasthenia gravis: a case report and literature review by Xuan Wu, Xiao-tian Xu, Lin Zhou, Kai Qiao, Chong-bo Zhao, Su-shan Luo

“…The patient was finally diagnosed with MG by a significant decrement of Compound Muscle Action Potential in repetitive nerve stimuli, positive anti-acetylcholine receptor antibodies as well as the presence of a mass located in the anterior mediastinum. …”
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Peripheral Nerve Regeneration with Acellular Nerve Allografts Seeded with Amniotic Fluid-Derived Stem Cells by Xue Ma, Eileen Elsner, Jiaozhong Cai, Thomas L. Smith, Zhongyu Li

“…The ANA plus AFS cell group also demonstrated greater gastrocnemius compound muscle action potential (CMAP) ratio, sciatic axon diameter, fiber diameter, myelin thickness, G ratio (average axonal diameter (AD)/fiber diameter (FD)), and neuromuscular junction (NMJ) numbers compared to ANA. …”
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Narrative Literature Review of Potential Atrial Fibrillation Mechanism of Action Induced by Discontinuation of Benzodiazepines by Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė

“…The interaction between benzodiazepines and peripheral benzodiazepine receptors may influence calcium ion channels, affecting cardiac action potential and contractility, and discontinuation of these medications can potentially contribute to atrial fibrillation. …”
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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

“…P4 administrations shortened the prolongation of QTC intervals and action potential duration (APD) that occurred during pregnancy, which was mainly attributable to the reduction in the voltage-gated potassium (Kv) current under basal conditions. …”
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Maximizing information in neuron populations for neuromorphic spike encoding by Ahmad El Ferdaoussi, Eric Plourde, Jean Rouat

“…Two applications are presented: blood pressure pulse wave classification, and neural action potential waveform classification. In both tasks, the data is encoded into spikes and the encoding parameters of the neuron populations are tuned to maximize the encoded information using the proposed algorithm. …”
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Ischemic monomelic neuropathy following arteriovenous fistula surgery: a case report by Da Woon Kim, You Hyun Jeon, Miju Bae, Sang Heon Song

“…A nerve conduction study above the wrist revealed reduced compound muscle action potential (CMAP) of the left ulnar nerve and no CMAP of the left median nerve. …”
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The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons by Na Shen, Lei Zhou, Bin Lai, Shufeng Li

“…After 48 h treatment by 50 μA or 100 μA electrical stimulation, the action potential (AP) and voltage depended calcium current (ICa) of SGNs are recorded using whole-cell electrophysiological method. …”
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General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form by Edina Horváth, Zsuzsanna Máté, Szabolcs Takács, Péter Pusztai, András Sápi, Zoltán Kónya, László Nagymajtényi, András Papp

“…Changes in evoked electrophysiological responses (cortical sensory evoked potential and nerve action potential) indicated that the 3 plus 3 weeks combined exposure caused equal or higher changes in the latency of these responses than 6 weeks of exposure, although the calculated summed Mn dose in the former case was lower. …”
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Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model by Musaad A. Alshammari, Mohammad R. Khan, Fawaz Alasmari, Abdulaziz O. Alshehri, Rizwan Ali, Mohamed Boudjelal, Khalid A. Alhosaini, Abdurahman A. Niazy, Tahani K. Alshammari

“…The axon initial segment (AIS), the site of action potential initiation in neurons, is a critical determinant of neuronal excitability. …”
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Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus by Nimat Abuelwafaa, Hana Ahmed, Ilham Omer, Mohamed Abdullah, Ammar Ahmed, Afraa Musa

“…Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. …”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury by Akira Ikumi, Yuki Hara, Eriko Okano, Sho Kohyama, Norihito Arai, Yu Taniguchi, Hisashi Sugaya, Tomokazu Yoshioka, Akihiro Kanamori, Masashi Yamazaki

“…Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed by physical examination, visual analog scale for pain, and nerve conduction study. …”
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Brain neurons internalise polymeric micron-sized capsules: Insights from in vitro and in vivo studies by Olga Kopach, Olga A. Sindeeva, Kaiyu Zheng, Eleanor McGowan, Gleb B. Sukhorukov, Dmitri A. Rusakov

“…Importantly, the presence of internalised microcapsules did not impair neuronal function, as neurons maintained normal firing activity and action potential characteristics. Furthermore, no adverse effects were observed after a week of microcapsule presence in the mouse brain. …”
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Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells by Jan Trieschmann, Moritz Haustein, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes

“…Both native myocardial tissue slices as well as hiPS-CBs showed action potential prolongation after Ik,r blockade, but early afterdepolarisations could be observed in native myocardial tissue slices only. …”
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Mutational Analysis of KCNQ1 Gene in Type 2 Diabetes Mellitus: A Case-control Study by Ankush Ganjewar, Ishwar B Bagoji, Sharan Badiger, Rudragouda B Bulagouda, Gurushnatappa Kadakol

“…Introduction: KCNQ1 (Potassium voltage-gated channel subfamily Q member 1) gene encodes for pore-forming subunit of a voltage-gated K+ channel that is essential for the depolarisation phase of the action potential in cardiac muscle. KCNQ1 is also associated with impaired insulin secretion in Type 2 Diabetes Mellitus (T2DM), suggesting that this impairment might underlie the diabetes susceptibility conferred by rs151290, which is associated with 30-min C-peptide levels during an Oral Glucose Tolerance Test (OGTT) and first-phase insulin secretion. …”
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Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system by Jingrong Yang, Mengfan You, Jingxin Wang, Rongfei Sun, Lili Han, Xiaonan Liu, Kaibin Niu, Kaidi Xing, Juanping Sun, Wenge Su, Yifei Wang

“…Amiodarone, a class III antiarrhythmic agent, is widely used to manage both atrial and ventricular arrhythmias due to its efficacy in prolonging the cardiac action potential and its multiple antiarrhythmic properties. …”
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Predictors of the Short‐Term Outcomes of Guillain–Barré Syndrome: Exploring Electrodiagnostic and Clinical Features by Yi‐Hsiang Chen, Chia‐Lun Wu, Wei‐Chieh Weng, Yi‐Chia Wei

“…Poor outcomes were associated with low compound muscle action potential (CMAP), slow motor nerve conduction velocity (MNCV), abnormal F‐wave latency, and more conduction block and temporal dispersion. …”
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