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    Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy by Li X, Yu B, Li H, Liu Z, Fu X, Jiao P, Wang L

    Published 2025-01-01
    “…Shandong First Medical University @ Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of ChinaCorrespondence: Ping Jiao; Lei Wang, Email jiaopingonlyone@163.com; wanglei1118@sdfmu.edu.cnBackground: Biofilm formation often represents significant challenges in managing of bloodstream infections associated with catheter use.Objective: Antimicrobial lock therapy serves as an adjunctive treatment for catheter-related infections, effectively eradicating or inhibiting biofilm growth.Methods: This review synthesizes the current knowledge on antifungal lock therapy (ALT) targeting clinically common fungi, primarily Candida species, based on both in vitro and in vivo studies (animals and patients) from the past decade.Results: Amphotericin B (AmB) and echinocandins are identified as the most promising antifungal agents for ALT. …”
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