Bimodal Patterns of Locomotor Activity and Sleep in Drosophila: A Model for Their Simulation by Putilov AA, Verevkin EG, Petrovskii DV, Zakharenko LP

“…Arcady A Putilov,1,* Evgeniy G Verevkin,1,* Dmitrii V Petrovskii,2,* Lyudmila P Zakharenko2,* 1Independent Research Group “biomedical Systems Math-Modeling”, Berlin, 12489, Germany; 2Department of Insect Genetics, Institute of Cytology and Genetics of the Siberian Branch, the Russian Academy of Sciences, Novosibirsk, 630090, Russia*These authors contributed equally to this workCorrespondence: Arcady A Putilov, Independent Research Group “Biomedical Systems Math-Modeling, 11, Nipkowstr, Berlin, 12489, Germany, Tel/Fax +0049-30-53674643, Email arcady.putilov@gmail.comPurpose: Two previously proposed modelling approaches to explain the bimodal pattern of activity and/or sleep in Drosophila melanogaster are based on 1) the concept of morning and evening oscillators underlying the peaks of activity in the morning and evening, respectively, and 2) the concept of two cycles of buildup and decay of sleep pressure, gated only by the circadian oscillator. …”
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