Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration by Lingling E, Rongjian Lu, Jianwei Sun, Hongbo Li, Wen Xu, Helin Xing, Xing Wang, Tao Cheng, Shuo Zhang, Xiaocao Ma, Rong Zhang, Hongchen Liu

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Comparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases by Yiming Shi, Yingying Qin, Yunshen Li, Ping Jiang, Kai Wei, Jianan Zhao, Yu Shan, Yixin Zheng, Fuyu Zhao, Mi Zhou, Li Li, Yu Shen, Xinliang Lv, Yuejuan Zheng, Shicheng Guo, Qin Ding, Cen Chang, Dongyi He

“…Methods Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC). …”
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KRASG12C‐inhibitor‐based combination therapies for pancreatic cancer: insights from drug screening by Constanza Tapia Contreras, Jonas Dominik Falke, Dana‐Magdalena Seifert, Carolin Schneider, Lukas Krauß, Xin Fang, Denise Müller, Engin Demirdizen, Melanie Spitzner, Tiago De Oliveira, Christian Schneeweis, Jochen Gaedcke, Silke Kaulfuß, Kimia Mirzakhani, Bernd Wollnik, Karly Conrads, Tim Beißbarth, Gabriela Salinas, Jonas Hügel, Nils Beyer, Sophia Rheinländer, Ulrich Sax, Matthias Wirth, Lena‐Christin Conradi, Maximilian Reichert, Volker Ellenrieder, Philipp Ströbel, Michael Ghadimi, Marian Grade, Dieter Saur, Elisabeth Hessmann, Günter Schneider

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Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort by Charles Dupuy, Thibault Martinez, Olivier Duranteau, Tobias Gauss, Natacha Kapandji, Jean Pasqueron, Mathilde Holleville, Georges Abi Abdallah, Anatole Harrois, Véronique Ramonda, Delphine Huet-Garrigue, Théophane Doublet, Marc Leone, Vincent Legros, Julien Pottecher, Gérard Audibert, Ingrid Millot, Benjamin Popoff, Benjamin Cohen, Fanny Vardon-Bounes, Mathieu Willig, Pierre Gosset, Emilie Angles, Nouchan Mellati, Nicolas Higel, Mathieu Boutonnet, Pierre Pasquier, and the TraumaBase Group®

“…Patients primarily presented with blunt trauma (81.7%), and a 24-h mortality rate of 16.1% was observed. Receiver operating characteristic curve analysis revealed no significant difference in the association with 24-h mortality between the lethal diamond (area under the curve [AUC]: 0.71) and the lethal triad (AUC: 0.72) (p = 0.26). …”
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Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma by Zhong Zheng, Jian-Biao Wang, Rui Sun, Nan Wang, Xiang-Qin Weng, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

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Performance Analysis of Costs and Implementation Time Using Earned Value Method on the Distribution Pipe Network Expansion in Samarinda City by Dedy Sugi Hartawan, Wateno Oetomo, Risma Marleno

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Effectiveness and tolerability of rimegepant in the acute treatment of migraine: a real-world, prospective, multicentric study (GAINER study) by Luigi Francesco Iannone, Gloria Vaghi, Gabriele Sebastianelli, Francesco Casillo, Antonio Russo, Marcello Silvestro, Francesca Pistoia, Giorgio Dalla Volta, Matteo Cortinovis, Alberto Chiarugi, Danilo Antonio Montisano, Maria Pia Prudenzano, Sabina Cevoli, Edoardo Mampreso, Gianluca Avino, Marina Romozzi, Mariarosaria Valente, Carla Fasano, Stefania Battistini, Antonio Granato, Elisa Maria Piella, Innocenzo Rainero, Raffaele Ornello, Roberto De Icco, On behalf of the Italian Headache Registry (RICe) Study Group

“…Using an ad hoc diary, participants prospectively collected migraine attack features at baseline and every 30 min after rimegepant administration, up to 2 h post dose. A 24 h follow up was also collected. Results We enrolled 103 participants with migraine (74.8% female, mean age 44.4 [42.0 – 46.7] years, 24.3% with chronic migraine of whom 44.0% presented a concomitant diagnosis of medication overuse headache). …”
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Comparing Antibody Responses to Homologous vs. Heterologous COVID-19 Vaccination: A Cross-Sectional Analysis in an Urban Bangladeshi Population by Kazi Istiaque Sanin, Mansura Khanam, Azizur Rahman Sharaque, Mahbub Elahi, Bharati Rani Roy, Md. Khaledul Hasan, Goutam Kumar Dutta, Abir Dutta, Md. Nazmul Islam, Md. Safiqul Islam, Md. Nasir Ahmed Khan, Mustufa Mahmud, Nuzhat Nadia, Fablina Noushin, Anjan Kumar Roy, Protim Sarker, Fahmida Tofail

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Discussion: acoustic density and ocular structures rigidity in healthy individuals and patients with primary open-angle glaucoma (response to the article by Kazemi A., Zhou B., Zha... by I.N. Koshits, O.V. Svetlova, A.A. Ryabtseva, M.G. Guseva, M.B. Egemberdiev, P.P. Bakshinsky, M.V. Zaseeva

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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…Ont été inclus dans l’étude tous les enfants de moins de 15 ans, ventilés et sédatés pendant une durée égale ou supérieure à 24 heures. Pour chaque enfant, nous avons recueilli les donnéesdémographiques, lapathologie,le score de gravité, les doses moyennes d’hypnotiques et d’analgésiques, les durées de ventilation et de séjour. …”
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Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity by Xiang-mei Wen, Xiang-mei Wen, Xiang-mei Wen, Zi-jun Xu, Zi-jun Xu, Zi-jun Xu, Ji-chun Ma, Ji-chun Ma, Ji-chun Ma, Min-jie Zhang, Min-jie Zhang, Min-jie Zhang, Ye Jin, Ye Jin, Jiang Lin, Jiang Lin, Jiang Lin, Jun Qian, Jun Qian, Yuan-yuan Fang, Yuan-yuan Fang, Yuan-yuan Fang, Shu-yu Luo, Shu-yu Luo, Shu-yu Luo, Zhen-wei Mao

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A PCR-independent, annealing-free cloning method for the insertion of short DNA fragments by Li Linbo, Yan Jin, Qi Yuan, Xiang Zhenglong, Jiang Na, Yuan Tongkang, Wang Zhenyi, Wang Yuan, Zhan Huaizhe, Liu Shiyi, Zhao Li, Xu Jing, Lei Xiaowei, Liu Yuxuan, Wang Gui, Xie Jiayang, Guo Zhenming, Cai Chunhai, Bian Shan

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Enhancing the efficacy of near-infrared photoimmunotherapy through intratumoural delivery of CD44–targeting antibody–photoabsorber conjugatesResearch in context by Yuichi Adachi, Kotaro Miyake, Kika Ohira, Shingo Satoh, Kentaro Masuhiro, Ryuya Edahiro, Yuya Shirai, Maiko Naito, Yujiro Naito, Takayuki Shiroyama, Shohei Koyama, Haruhiko Hirata, Kota Iwahori, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh

“…The conventional PIT regimen involves the systemic delivery of an antibody–photoabsorber conjugate, followed by a 24-h waiting period to ensure adequate localisation on the target cells. …”
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Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis by Bruley, Apolline, Gaëtan, Juliette, Gugger, Muriel, Pancrace, Claire, Millet, Maxime, Gaschignard, Geoffroy, Dezi, Manuela, Humbert, Jean-François, Leloup, Julie, Skouri-Panet, Fériel, Callebaut, Isabelle, Benzerara, Karim, Duprat, Elodie

“…Here, based on an RNA-Seq approach, we assess the expression of the ccyA gene in Microcystis aeruginosa PCC 7806 during a 24 h day/night cycle. The ccyA gene shows a clear day/night expression pattern with maximum transcript abundances during the second half of the night. …”
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Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…The irritant and anti-angiogenic effects were assessed in ovo on the vascularized chorioallantoic membrane (CAM).ResultsThe as-made MEL-NPs presented a spherical morphology, an average size of 85.61 nm, a broad UV-VIS absorption spectrum, and a strong antioxidant activity. After a 24 h treatment, MEL-NPs exerted a selective cytotoxicity in SH-4 and B164A5 CM cells compared to HEMa, HaCaT, and JB6 Cl 41-5a healthy skin cells, except for the concentration of 100 µg/mL, at which their viability declined under 70%. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…Ont été inclus dans l’étude tous les enfants de moins de 15 ans, ventilés et sédatés pendant une durée égale ou supérieure à 24 heures. Pour chaque enfant, nous avons recueilli les donnéesdémographiques, lapathologie,le score de gravité, les doses moyennes d’hypnotiques et d’analgésiques, les durées de ventilation et de séjour. …”
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Unraveling the depth-dependent causal dynamics of methanogenesis and methanotrophy in a high-latitude fen peatland by Shuai Yang, Jinyun Tang, Zhen Li, Kunxiaojia Yuan, Qiong Wu, Kuang-Yu Chang, Suzanne B Hodgkins, Rachel M Wilson, Qing Zhu, Robert F Grant, William J Riley, Scott R Saleska, Virginia I Rich, Ruth K Varner

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Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis by Qiang Ma, Jin-Lan Tian, Yao Lou, Ran Guo, Xiao-Ru Ma, Jian-Bin Wu, Jing Yang, Bing-Jie Tang, Shun Li, Mengsheng Qiu, Shumin Duan, Jing-Wei Zhao, Jing Zhang, Zhen-Zhong Xu

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Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial by Jing Tan, Yan Liang, Yong Liu, Wei Jiang, Duo Huang, Ning Tan, Chung-Wah Siu, Jo Jo Hai, Xiaoyu Huang, Jianfeng Ye, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Li-Xue Yin, Ming-Liang Zuo, Kui Kai Lau, Zhen Lei, Yingqing Feng, Bryan P Yan, Wen-Sheng Yue, Wen-Jun Zhang, Yuk-Ming Lau, Hin-Wai LUI, Koon-Ho Chan, Toi Meng Mok, Weng-Chio Tam, Kun-Chong Tam, Xiuhua Feng, Xiaofei Jiang, Guanming Tan, Mario Alberto Evora

“…The objective of the study was to explore the use of long-term home-based ECG monitoring for AF detection and stroke prevention in patients with a history of stroke.Methods and analysis This prospective, randomised, open-label trial with blinded endpoint adjudication aimed to evaluate the efficacy of long-term home-based ECG monitoring for AF detection and stroke prevention in a 24-month period. Patients aged >18 years with a history of ischaemic stroke will be stratified according to the time from the index ischaemic stroke: <1, 1–3 and >3 years and then randomised in 1:1 to (1) home-based AF screening and (2) control. …”
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Rural Management Development: Understanding Future Scenarios for Villages in Jiroft County by Mahmoud Falsolayman, Mohammad Hajipour, Atiyeh Salari

“…Research FindingsIn the conducted analyses, a 24x24 matrix was utilized with repeated consideration of factors. …”
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