CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer by Lorenzo Castagnoli, Alma Franceschini, Valeria Cancila, Matteo Dugo, Martina Bigliardi, Claudia Chiodoni, Paolo Toneguzzo, Viola Regondi, Paola A. Corsetto, Filippo Pietrantonio, Serena Mazzucchelli, Fabio Corsi, Antonio Belfiore, Antonio Vingiani, Giancarlo Pruneri, Francesca Ligorio, Mario P. Colombo, Elda Tagliabue, Claudio Tripodo, Claudio Vernieri, Tiziana Triulzi, Serenella M. Pupa

“…Abstract Background Growing evidence shows that the reprogramming of fatty acid (FA) metabolism plays a key role in HER2-positive (HER2 +) breast cancer (BC) aggressiveness, therapy resistance and cancer stemness. …”
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Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

“…Limb or coronary (ST-elevation myocardial infarction, STEMI) thrombi displayed a platelet eoxPL signature while carotid thrombi had a white cell profile. …”
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Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage by Rosemarie D. Mason, Baoshan Zhang, Nicholas C. Morano, Chen-Hsiang Shen, Krisha McKee, Ashley Heimann, Renguang Du, Alexandra F. Nazzari, Shelby Hodges, Tapan Kanai, Bob C. Lin, Mark K. Louder, Nicole A. Doria-Rose, Tongqing Zhou, Lawrence Shapiro, Mario Roederer, Peter D. Kwong, Jason Gorman

“…Here, we investigate the development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage and report cryo-EM structures at 3.4 Å resolution of PGDM1400 and of an improved PGT145 variant (PGT145-R100aS), each bound to the BG505 Env trimer. …”
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Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports by Lena C. Bruhin, Michael Single, Aileen C. Naef, Katrin Petermann, Mario Sousa, Matilde Castelli, Ines Debove, Marie E. Maradan-Gachet, Andreia D. Magalhães, Andreas A. Diamantaras, M. Lenard Lachenmayer, Gerd Tinkhauser, Julia Waskönig, Christopher M. el Achkar, Alia Lemkaddem, Mathieu Lemay, Paul Krack, Tobias Nef, Deborah Amstutz

“…Steps taken per hour, nighttime spent in bed and time spent outside were monitored with a smartwatch and ambient sensors placed in patient homes for an average of 20 days pre- and postoperatively. …”
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Lack of intracranial atherosclerosis in various atherosclerotic mouse models by Diewertje I Bink, Katja Ritz, Claire Mackaaij, Olga Stam, Sanny Scheffer, Mark R Mizee, Hanneke J Ploegmakers, Bert J van het Hof, Onno J de Boer, Judith C Sluimer, Guido R Y De Meyer, Louise van der Weerd, Helga E de Vries, Mat J A P Daemen

“…Since intracranial atherosclerosis is a common cause of stroke and is associated with dementia, a relevant animal model is needed to study these diseases. …”
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Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions. by Miguel Ángel Pérez-Castro, Hasier Eraña, Enric Vidal, Jorge M Charco, Nuria L Lorenzo, Nuno Gonçalves-Anjo, Josu Galarza-Ahumada, Carlos M Díaz-Domínguez, Patricia Piñeiro, Ezequiel González-Miranda, Samanta Giler, Glenn Telling, Manuel A Sánchez-Martín, Joseba Garrido, Mariví Geijo, Jesús R Requena, Joaquín Castilla

“…Prion diseases, particularly sporadic cases, pose a challenge due to their complex nature and heterogeneity. …”
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Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping by Hannah L. Cornman, Martin P. Alphonse, Arbor Dykema, Alexander L. Kollhoff, Kevin K. Lee, Jaya Manjunath, Emily Z Ma, Varsha Parthasarathy, Junwen Deng, Thomas Pritchard, Anusha Kambala, Melika Marani, Kayla A. Parr, Javid P. Mohammed, Madan M. Kwatra, Jay H. Bream, Won Jin Ho, Shawn G. Kwatra

“…Abstract Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. …”
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Radiographic outcomes and subsidence rate in hyperlordotic versus standard lordotic interbody spacers in patients undergoing anterior cervical discectomy and fusion by Rajkishen Narayanan, Nicholas B. Pohl, Jonathan Dalton, Yunsoo Lee, Alexa Tomlak, Anthony Labarbiera, Meryem Guler, Emilie Sawicki, Sebastian I. Fras, Mark F. Kurd, John J. Mangan, Ian David Kaye, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder, Joseph K. Lee

“…Background: Anterior cervical discectomy and fusion (ACDF) is a common surgery for patients with degenerative cervical disease and current interbody spacers utilized vary based on material composition, structure, and angle of lordosis. …”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…However, acquired resistance to PARPi remains a major challenge in the clinic.Methods PARPi-resistant ovarian cancer mouse models were generated by long-term treatment of olaparib in syngeneic Brca1-deficient ovarian tumors. …”
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Out-of-Wedlock Pregnancy Among Single Mothers in Khartoum, Sudan: Sociodemographic Characteristics, Causes, and Consequences by Amal Abdelgadir Ali Mohamed, Elshafee Ahmed Apaker Babiker, Sohair Mohmoud Godat, Salma Mohammed Gomaa Doalbet, Aida AF Ahmed, Maha Hamed Mohamed Ali, Abdalkhaliq Ahmed Obadi, Amna Mohammed Ali Mustafa, Amani Awad Elkarim Taha, Amira Elnour Eltayeb Elbashir, Ragaa Gasim Ahmed, Fahad A Alghamdi, Waled AM Ahmed

“… Background: Out-of-wedlock childbearing is a global phenomenon that has lifelong consequences on the lives of both mothers and their children. …”
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Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase by Bright Obeng, Lucas J. Bennett, Bailey E. West, Dylan J. Wagner, Patrick J. Fleming, Morgan N. Tasker, Madeleine K. Lorenger, Dorothy R. Smith, Tetiana Systuk, Sydni M. Plummer, Jeongwon Eom, Marissa D. Paine, Collin T. Frangos, Michael P. Wilczek, Juyoung K. Shim, Melissa S. Maginnis, Julie A. Gosse

“…Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. …”
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External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Methods The RECOVER study is a comparative effectiveness study that prospectively includes newly diagnosed high-risk (cT3a-bN0M0, ISUP-grade ≥ 4 and/or PSA > 20 ng/mL), non-metastatic PCa patients. …”
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Feeding Behavior, Water Intake, and Physiological Parameters of Feedlot Lambs Fed with Diets Containing Babassu Oil Associated with Sunflower Oil Blend by Laryssa V. da Silva, Gleice Kelle S. M. Vilela, Karlyene S. da Rocha, Hactus S. Cavalcanti, Glayciane C. Gois, Francisco Naysson de S. Santos, Fleming S. Campos, Michelle de O. M. Parente, Anderson de M. Zanine, Daniele de J. Ferreira, Tobyas M. de A. Mariz, Danielle de O. Maia, Henrique N. Parente

“…Thirty-five castrated male lambs (16.6 kg ± 3.9 kg) were distributed in a randomized block design with 5 treatments (diets) and 7 replications. …”
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Physiologists as medical scientists: An early warning from the German academic system by Katrin Streckfuss‐Bömeke, Nicolle Kränkel, Christoph Maack, Renate B. Schnabel, Laura C. Zelarayán, Norbert Frey, Peter Jezzard, Martina Krüger, Nico Lachmann, Susanne Lutz, Claudia Noack, Eric Schoger, Katrin Schröder, Laura C. Sommerfeld, Sabine Steffens, Holger Winkels, Christina Würtz, Tanja Zeller, Eva A. Rog‐Zielinska, Peter Kohl

“…Abstract “Medical scientists” are postgraduate investigators who are engaged in biomedical research, and either hold a biomedical PhD or are qualified in medicine but do not participate in patient care. …”
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Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers by Lothar Häberle, Ramona Erber, Paul Gass, Alexander Hein, Melitta Niklos, Bernhard Volz, Carolin C. Hack, Rüdiger Schulz-Wendtland, Hanna Huebner, Chloë Goossens, Matthias Christgen, Thilo Dörk, Tjoung-Won Park-Simon, Andreas Schneeweiss, Michael Untch, Valentina Nekljudova, Sibylle Loibl, Arndt Hartmann, Matthias W. Beckmann, Peter A. Fasching

“…Results 273 patients (23.4%) achieved a pCR. The most precise model had across-validated area under the curve (AUC) of 0.84, sensitivity of 0.82, and specificity of 0.71. …”
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Chronic cannabis use differentially modulates neural oscillations serving the manipulate versus maintain components of working memory processing by Peihan J. Huang, Jake J. Son, Yasra Arif, Jason A. John, Lucy K. Horne, Mikki Schantell, Seth D. Springer, Maggie P. Rempe, Hannah J. Okelberry, Abraham D. Killanin, Ryan Glesinger, Anna T. Coutant, Thomas W. Ward, Madelyn P. Willett, Hallie J. Johnson, Elizabeth Heinrichs-Graham, Tony W. Wilson

“…Significant oscillatory responses were imaged using a beamformer and subjected to whole-brain ANOVAs. …”
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Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

“…Of these, CCL20, MMP-10, EN-RAGE, and AXIN1 had a log2 fold change of 1.2 or more. There was a modest shift in overall CF protein profiles post-ETI toward the NCF cluster. …”
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Training and onboarding initiatives in high energy physics experiments by Allison Reinsvold Hall, Nicole Skidmore, Gabriele Benelli, Ben Carlson, Ben Carlson, Claire David, Jonathan Davies, Wouter Deconinck, David DeMuth, Peter Elmer, Rocky Bala Garg, Stephan Hageböck, Killian Lieret, Valeriia Lukashenko, Valeriia Lukashenko, Sudhir Malik, Andy Morris, Heidi Schellman, Graeme A. Stewart, Jason Veatch, Michel Hernandez Villanueva

“…Here we document and analyze these in an attempt to determine a set of key considerations for future HEP experiments.…”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…Here, we applied imaging mass cytometry to a balanced cohort of LUAD and LUSC patients, matched for clinical factors such as age, sex, and smoking history, to analyze 204 histopathology images of tumours from 102 individuals with non-small cell lung cancer (NSCLC). …”
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Pathogenic and periodontal bacteria may contribute to the fatal outcome of critically ill elderly COVID-19 patients by L. Johana Madroñero, Eliana P. Calvo, Carolina Coronel-Ruiz, Myriam L. Velandia-Romero, María Angélica Calderón-Peláez, Jhann A. Arturo, Adriana P. Franco-Rodríguez, Ricardo Gutiérrez-Pérez, Lady S. López, Félix G. Delgado, Sigrid J. Camacho-Ortega, Lilia J. Bernal-Cepeda, Sonia P. Bohórquez, Jaime E. Castellanos

“…Our results highlighted a dual relationship between SARS CoV-2 infection and an exacerbated periodontopathogen-induced immune response.…”
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