Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: Multicenter Cross-Sectional Study by Juan S Izquierdo-Condoy, Clara Paz, H A Nati-Castillo, Ricardo Gollini-Mihalopoulos, Telmo Raul Aveiro-Róbalo, Jhino Renson Valeriano Paucar, Sandra Erika Laura Mamami, Juan Felipe Caicedo, Valentina Loaiza-Guevara, Diana Camila Mejía, Camila Salazar-Santoliva, Melissa Villavicencio-Gomezjurado, Cougar Hall, Esteban Ortiz-Prado

“…ObjectiveThis study investigates the prevalence of mobile phone addiction and its association with sleep quality among medical students across 6 Latin American countries. MethodsA descriptive, cross-sectional, multicenter study was conducted between December 2023 and March 2024 using a self-administered online survey. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…Methods We analyze plasma levels of pancreatic enzymes and inflammatory markers in a retrospective cohort study of 120 COVID-19 patients distributed in 3 severity-stratified groups. …”
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Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort st... by Charles Agyemang, Ellis Owusu-Dabo, Erik Beune, Karlijn Meeks, Bert-Jan H van den Born, Liffert Vogt, Felix P Chilunga, Charles F Hayfron-Benjamin, Sampson Twumasi-Ankrah, Muhulo Muhau Mungamba, Eva L van der Linden, Engwa A Godwill, Samuel N Darko, Benedicta N Chungag

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Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients by Rayra P. Santiago, Magda O. S. Carvalho, Camylla V. B. Figueiredo, Luciana M. Fiuza, Rodrigo M. Oliveira, Sètondji C. M. A. Yahouédéhou, Valma M. L. Nascimento, Isa M. Lyra, Théo Araujo-Santos, Nívea F. Luz, Milena M. Aleluia, Caroline C. Guarda, Valéria M. Borges, Marilda S. Goncalves

“…Transforming growth factor beta (TGF-β) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease (SCD), including endothelial and vascular dysfunction, inflammation, and hematopoietic homeostasis. …”
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Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults by Catherine A. Panozzo, Edward E. Walsh, Zhen Yang, Eleanor Wilson, Jaya Goswami, Sonia K. Stoszek, Adrianna Loback, Tony Ng, Beverly M. Francis, Alana K. Simorellis, Wenmei Huang, Linwei Li, Rebecca Vislay-Wade, Zhe Zheng, Evan J. Anderson, Allison August, Grace Chen, Ann R. Falsey

“…Conclusions Dyspnea alone, and in combination with certain other lower respiratory tract disease signs/symptoms, was a leading symptomatic indicator for severe RSV outcomes. …”
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Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission by Mercedes García-Gasalla, Juana M. Ferrer, Pablo A. Fraile-Ribot, Adrián Ferre-Beltrán, Adrián Rodríguez, Natalia Martínez-Pomar, Luisa Ramon-Clar, Amanda Iglesias, Inés Losada-López, Francisco Fanjul, Joan Albert Pou, Isabel Llompart-Alabern, Nuria Toledo, Jaime Pons, Antonio Oliver, Melchor Riera, Javier Murillas

“…Early identification of COVID-19 patients at risk of critical illness is a challenging endeavor for clinicians. We aimed to establish immunological, virological, and routine laboratory markers, which, in combination with clinical information, may allow identifying such patients. …”
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Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury by Achi Haider, Susan Bengs, Angela Portmann, Sandro Fröhlich, Dominik Etter, Monika Maredziak, Geoffrey I. Warnock, Alexander Akhmedov, Sebastian Kozerke, Claudia Keller, Fabrizio Montecucco, Bruno Weber, Linjing Mu, Ronny R. Buechel, Vera Regitz-Zagrosek, Philipp A. Kaufmann, Giovanni G. Camici, Simon M. Ametamey, Catherine Gebhard

“…Mental stress induced ischemia and sympathetic activation have been suggested to play a prominent role in the pathogenesis of MI in younger women, however, the impact of sex hormones on these parameters remains unknown. …”
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Science highlights from the Kjell Henriksen Observatory on Svalbard by Katie Herlingshaw, Noora Partamies, Charlotte M. van Hazendonk, Mikko Syrjäsuo, Lisa J. Baddeley, Magnar G. Johnsen, Nina K. Eriksen, Ian McWhirter, Anasuya Aruliah, Mark J. Engebretson, Kjellmar Oksavik, Fred Sigernes, Dag A. Lorentzen, Takanori Nishiyama, Matthew B. Cooper, John Meriwether, Stein Haaland, Daniel Whiter

“…The Kjell Henriksen Observatory (KHO) is the world’s largest optical observatory for auroral and airglow measurements, operated by the University Centre in Svalbard (UNIS). KHO is a unique site that lies underneath the dayside cusp, a funnel-shaped region where particles from the Sun can directly enter the Earth’s upper atmosphere, including the ionosphere. …”
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Cost Analysis for Robotic and Open Gastrectomy by Yuki Hirata, MD, PhD, Heather G. Lyu, MD, MBI, Ahad M. Azimuddin, MBA, Pamela Lu, MD, Jeeva Ajith, MBA, Jason A. Schmeisser, Elizabeth P. Ninan, MBA, Kyung Hyun Lee, PhD, Brian D. Badgwell, MD, MS, Paul Mansfield, MD, Naruhiko Ikoma, MD, MS

“…To determine the magnitude of the perioperative costs associated with robotic gastrectomy (RG). Background:. A robotic surgery platform has a high implementation cost and requires maintenance costs; however, whether the overall cost of RG, including all perioperative costs, is higher than conventional open gastrectomy (OG) remains unknown. …”
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Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connecto... by Hai Le, Alexandra F. Bonthrone, Alena Uus, Daphna Fenchel, Alexandra Lautarescu, Konstantina Dimitrakopoulou, A. David Edwards, Joseph V. Hajnal, Serena J. Counsell, Lucilio Cordero-Grande, Daan Christiaens, Dafnis Batalle, Maximilian Pietsch, Anthony N. Price, Hamel Patel, Charles Curtis, Harriet Cullen, Maria Deprez, Jacques-Donald Tournier

“…Together, these findings suggest a possible link between autism common variants and early WM development.…”
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Unravelling genomic drivers of speciation in Musa through genome assemblies of wild banana ancestors by Guillaume Martin, Benjamin Istace, Franc-Christophe Baurens, Caroline Belser, Catherine Hervouet, Karine Labadie, Corinne Cruaud, Benjamin Noel, Chantal Guiougou, Frederic Salmon, Joël Mahadeo, Fajarudin Ahmad, Hugo A. Volkaert, Gaëtan Droc, Mathieu Rouard, Julie Sardos, Patrick Wincker, Nabila Yahiaoui, Jean-Marc Aury, Angélique D’Hont

“…The second unknown ancestor partially present in a seventh assembly appears related to M. a. ssp. zebrina. …”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Conclusions In conclusion, our results unveil lactate as a key regulator of immune escape and BM fibrotic transformation in MF patients, suggesting MCT1 blocking as a novel antifibrotic strategy.…”
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Marek's disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius. by Chenyi Bao, Jun Chu, Qi Gao, Shasha Yang, Xiaoyu Gao, Wenwen Chen, Fuchun Yang, Fei Jiang, Chenxi Tong, Mingyi Lei, Linlin Jiao, Jitong Li, Kexin Wei, Xue Lian, Kai Li, Suresh Kumar Tikoo, Nikolaus Osterrieder, Lorne A Babiuk, Yufeng Li, Yong-Sam Jung, Yingjuan Qian

“…Subsequently, rMd5ΔLORF1, a recombinant Md5 virus deficient in pLORF1 expression, was generated by a frameshift mutation in the LORF1 gene. …”
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Imaging and Spectral Fitting of Bright Gamma-Ray Sources with the COSI Balloon Payload by Jarred M. Roberts, Steven Boggs, Thomas Siegert, John A. Tomsick, Marco Ajello, Peter von Ballmoos, Jacqueline Beechert, Floriane Cangemi, Savitri Gallego, Pierre Jean, Chris Karwin, Carolyn Kierans, Hadar Lazar, Alex Lowell, Israel Martinez Castellanos, Sean Pike, Clio Sleator, Yong Sheng, Hiroki Yoneda, Andreas Zoglauer

“…COSI-Balloon had a successful 46 day flight in 2016 during which the instrument observed the Crab Nebula, Cygnus X-1, and Centaurus A. …”
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Author Correction: Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England by Pablo N. Perez-Guzman, Edward Knock, Natsuko Imai, Thomas Rawson, Cosmo Nazzareno Santoni, Joana Alcada, Lilith K. Whittles, Divya Thekke Kanapram, Raphael Sonabend, Katy A. M. Gaythorpe, Wes Hinsley, Richard G. FitzJohn, Erik Volz, Robert Verity, Neil M. Ferguson, Anne Cori, Marc Baguelin

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Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo by Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi

“…With a high expression level of approximately one million receptors per cell, high turnover, and rapid recycling, targeting this receptor with a conventional antibody is a challenge. …”
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Gaps in Capacity in Primary Care in Low-Resource Settings for Implementation of Essential Noncommunicable Disease Interventions by S. Mendis, Igbal Al Bashir, Lanka Dissanayake, Cherian Varghese, Ibtihal Fadhil, Esha Marhe, Boureima Sambo, Firdosi Mehta, Hind Elsayad, Idrisa Sow, Maltie Algoe, Herbert Tennakoon, Lai Die Truong, Le Thi Tuyet Lan, Dismond Huiuinato, Neelamni Hewageegana, Naiema A. W. Fahal, Goitom Mebrhatu, Gado Tshering, Oleg Chestnov

“…The objective was to evaluate the capacity of primary care (PC) facilities to implement basic interventions for prevention and management of major noncommunicable diseases (NCDs), including cardiovascular diseases and diabetes. Methods. A cross-sectional survey was done in eight low- and middle-income countries (Benin, Bhutan, Eritrea, Sri Lanka, Sudan, Suriname, Syria, and Vietnam) in 90 PC facilities randomly selected. …”
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Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure by Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten, Kenneth Dickstein, Nilesh J. Samani, Chim C. Lang, Leong L. Ng, Stefan D. Anker, Macro Metra, Gregoire Preud'homme, Kevin Duarte, Zohra Lamiral, Nicolas Girerd, Patrick Rossignol, Dirk J. vanVeldhuisen, Adriaan A. Voors, Faiez Zannad, João Pedro Ferreira

“…Methods and results We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT‐CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). …”
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Community Involvement and Perceptions of the Community-Based Health Planning and Services (CHPS) Strategy for Improving Health Outcomes in Ghana: Quantitative Comparative Evidence... by Margaret Kweku, Hubert Amu, Martin Adjuik, Emmanuel Manu, Fortress Yayra Aku, Elvis Enowbeyang Tarkang, Joyce Komesuor, Geoffrey Adebayo Asalu, Norbert Ndaah Amuna, Laud Ampomah Boateng, Justine Sefakor Alornyo, Roland Glover, Ayaga A. Bawah, Timothy Letsa, John Koku Awoonor-Williams, S. Patrick Kachur, James F. Phillips, John Owusu Gyapong

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Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…Abstract Investigating venetoclax (VTX) resistance in multiple myeloma (MM) is crucial for the development of novel therapeutic strategies to tackle resistance. We conducted a multi-omic characterization of established VTX-resistant isogenic human myeloma cell lines (HMCL) and primary MM patient samples pre- and post-VTX treatment. …”
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