Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity, we observed increased intake of a high-fat diet (HFD) in offspring of obese mothers that precedes the development of obesity. …”
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Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice by Peter C. Cook, Sheila L. Brown, Emma L. Houlder, Julio Furlong-Silva, Daniel P. Conn, Stefano A. P. Colombo, Syed Baker, Freya R. Svedberg, Gareth Howell, Margherita Bertuzzi, Louis Boon, Joanne E. Konkel, Christopher R. Thornton, Judith E. Allen, Andrew S. MacDonald

“…Abstract Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve type 17 inflammation, which can exacerbate disease causing failure of treatments tailored to inhibit type 2 factors. …”
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Responsible research in health disparities using the Adolescent Brain Cognitive DevelopmentSM (ABCD) study by MR Gonzalez, C Cardenas-Iniguez, DE Linares, S Wonnum, K Bagot, EJ White, A Cuan, S DiMatteo, YD Akiel, P Lindsley, JC Harris, E Perez-Amparan, TD Powell, Comité Organizador Latino de City Heights (COLCH), G Dowling, D Alkire, WK Thompson, TM Murray

“…Conclusion: Adolescence is a critical period of development with subsequent ramifications for health outcomes across the lifespan. …”
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Mental Health and Other Factors Associated with COVID-19 Vaccination Intention toward Children of Military Parents in Lambayeque, Peru by Mario J. Valladares-Garrido, Aldo Alvarez-Risco, Annel B. Rojas-Alvarado, Cinthia Karina Picón-Reátegui, Franccesca Dawson Aguila, Shyla Del-Aguila-Arcentales, Neal M. Davies, Virgilio E. Failoc-Rojas, César Johan Pereira-Victorio, Danai Valladares Garrido, Víctor J. Vera-Ponce, Jaime A. Yáñez

“…Finding mental health support, experiencing burnout syndrome, having a relative who suffers from mental health problems, and being part of the Catholic religion were associated with a higher willingness to immunize the children of Peruvian military members.…”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Conclusion Baseline adiponectin, leptin, and resistin levels are not associated with the likelihood of achieving CDAI remission over 48 weeks of treatment in a large cohort of people with untreated early RA.…”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…It is also a zoonotic disease posing a risk for public health. …”
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Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…We show that this method is able to capture known ISG15 interactors from a complex protein mixture in a site-selective manner, only capturing proteins that specifically interact with the region of ISG15 where the unnatural amino acid was incorporated. …”
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Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal by Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Beth Chaplin, Souleymane MBoup, Adam Abdullahi, Adam Abdullahi, Michelle He, Sydney M. Fisher, Sulaimon Akanmu, Charlotte A. Chang, Donald J. Hamel, Ravindra K. Gupta, Ravindra K. Gupta, Phyllis J. Kanki

“…BackgroundThe COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. …”
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Considering best practice standards for routine whole-genome sequencing for TB care and control by J.T. Denholm, G. de Vries, R. Anthony, E. Robinson, M. Backx, I.F. Laurenson, A.L. Seagar, H. Modestil, L. Trieu, J.S. Meissner, D.H.L. Ng, J.Y. Tay, H.H. Lin, R. Lee, V. Sintchenko, B.J. Marais, E.J. Donnan

“…TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. …”
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No Galaxy-scale [C ii] Fast Outflow in the z = 6.72 Red Quasar HSC J1205–0000 by Mahoshi Sawamura, Takuma Izumi, Kouichiro Nakanishi, Takeshi Okuda, Michael A. Strauss, Masatoshi Imanishi, Yoshiki Matsuoka, Yoshiki Toba, Hideki Umehata, Takuya Hashimoto, Shunsuke Baba, Tomotsugu Goto, Toshihiro Kawaguchi, Kotaro Kohno, Dragan Salak, Taiki Kawamuro, Kazushi Iwasawa, Masafusa Onoue, Chien-Hsiu Lee, Kianhong Lee

“…J1205–0000 has a high FIR luminosity, L _FIR  = 2.5 × 10 ^12 L _⊙ and a total IR luminosity of L _TIR  = 3.5 × 10 ^12 L _⊙ , corresponding to a star formation rate of  ∼528 M _⊙ yr ^−1 . …”
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Convergent evidence for the temperature-dependent emergence of silicification in terrestrial plants by Zhihao Pang, Félix de Tombeur, Sue E. Hartley, Constantin M. Zohner, Miroslav Nikolic, Cyrille Violle, Lidong Mo, Thomas W. Crowther, Dong-Xing Guan, Zhongkui Luo, Yong-Guan Zhu, Yuxiao Wang, Ping Zhang, Hongyun Peng, Caroline A. E. Strömberg, Nina Nikolic, Yongchao Liang

“…We first show that Si is beneficial for rice under high temperature (40 °C), but harmful under low temperature (0 °C), whilst a 2 °C increase results in a 37% increase in leaf Si concentrations. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…Tumor suppressor candidate 5 (TUSC5) is a gene expressed abundantly in white adipose tissue (WAT), brown adipose tissue (BAT), and peripheral afferent neurons. …”
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Analysis of Adverse Events during Intrahospital Transportation of Critically Ill Patients by Francielli Mary Pereira Gimenez, Wesley Henrique Bueno de Camargo, Ana Clara Beraldo Gomes, Thaylla Sumyre Nihei, Monique Walicheki Maria Andrade, Maria Laura de A. F. Sé Valverde, Larissa D’ Epiro de Souza Campos, Debora Carvalho Grion, Josiane Festti, Cintia Magalhães Carvalho Grion

“…The level of significance was set at 5%. Results. A total of 293 patients were analyzed with follow-up of 143 patient transportations and records of 86 adverse events. …”
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Complete Genomic Landscape Reveals Hidden Evolutionary History and Selection Signature in Asian Water Buffaloes (Bubalus bubalis) by Jingfang Si, Dongmei Dai, Neena Amatya Gorkhali, Mingshan Wang, Sheng Wang, Saroj Sapkota, Ram Chandra Kadel, Amir Sadaula, Aashish Dhakal, Md Omar Faruque, Abdullah Ibne Omar, Eka Meutia Sari, Hidayat Ashari, Muhammad Ihsan Andi Dagong, Marnoch Yindee, Hossam E. Rushdi, Hussein Elregalaty, Ahmed Amin, Mohamed A. Radwan, Lan Doan Pham, W. M. M. P. Hulugalla, G. L. L. Pradeepa Silva, Wei Zheng, Shahid Mansoor, Muhammad Basil Ali, Farhad Vahidi, Sahar Ahmed Al‐Bayatti, Alfredo Pauciullo, Johannes A. Lenstra, J. Stuart F. Barker, Lingzhao Fang, Dong‐Dong Wu, Jianlin Han, Yi Zhang

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Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease by Colin Birkenbihl, Madison Cuppels, Rory T. Boyle, Hannah M. Klinger, Oliver Langford, Gillian T. Coughlan, Michael J. Properzi, Jasmeer Chhatwal, Julie C. Price, Aaron P. Schultz, Dorene M. Rentz, Rebecca E. Amariglio, Keith A. Johnson, Rebecca F. Gottesman, Shubhabrata Mukherjee, Paul Maruff, Yen Ying Lim, Colin L. Masters, Alexa Beiser, Susan M. Resnick, Timothy M. Hughes, Samantha Burnham, Ilke Tunali, Susan Landau, Ann D. Cohen, Sterling C. Johnson, Tobey J. Betthauser, Sudha Seshadri, Samuel N. Lockhart, Sid E. O’Bryant, Prashanthi Vemuri, Reisa A. Sperling, Timothy J. Hohman, Michael C. Donohue, Rachel F. Buckley

“…The residual approach has been widely applied to estimate CR, where the degree of resilience is estimated through a linear model’s residuals. We demonstrate that this approach makes specific, uncontrollable assumptions and likely leads to biased and erroneous resilience estimates. …”
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Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer by Mitchell S. von Itzstein, MD, Jialiang Liu, PhD, Hong Mu-Mosley, PhD, Farjana Fattah, PhD, Jason Y. Park, MD, PhD, Jeffrey A. SoRelle, MD, J. David Farrar, PhD, Mary E. Gwin, MD, David Hsiehchen, MD, Yvonne Gloria-McCutchen, Edward K. Wakeland, PhD, Suzanne Cole, MD, Sheena Bhalla, MD, Radhika Kainthla, MD, Igor Puzanov, MD, MSCI, Benjamin Switzer, DO, MHSA, MS, Gregory A. Daniels, MD, PhD, Yousef Zakharia, MD, Montaser Shaheen, MD, Jianjun Zhang, MD, PhD, Yang Xie, PhD, David E. Gerber, MD

“…Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. …”
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Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults by Eman Alshawaf, Sulaiman K. Marafie, Mohamed Abu-Farha, Ahmed N. Albatineh, Tahani Alramah, Aldana Albuhairi, Yafa Al Qassar, Reem Zinoun, Rawan Shalabi, Sarah Behbehani, Dalal Mohammed, Fahad Alajmi, Mohammed A. Abdalla, Ebaa Al-Ozairi, Mohammad Shehab, Muhammad Abdul-Ghani, Fahd Al-Mulla, Jehad Abubaker

“…Isthmin-1 (Ism1) has recently emerged as a potential marker of metabolic health and was shown in animal studies to associate with metabolic-associated fatty liver disease (MAFLD). …”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. …”
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Novel adaptive immune systems in pristine Antarctic soils by Marc W. Van Goethem, Oliver K. I. Bezuidt, Rian Pierneef, Surendra Vikram, David W. Hopkins, Thomas Aspray, Grant Hall, Stephan Woodborne, Ian D. Hogg, Trent R. Northen, Weidong Kong, Daniele Daffonchio, Don A. Cowan, Yves Van de Peer, Manuel Delgado-Baquerizo, Thulani P. Makhalanyane

“…These results underscore the role of viral infection as a key evolutionary driver shaping polar microbiomes.…”
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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

“…In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse model of EHEC infection. LC–MS/MS proteomics of mice injected with a combination of Shiga toxin (Stx) and lipopolysaccharide (LPS) revealed extensive alterations of the brain proteome, in particular enrichment of pathways involved in complement activation and coagulation cascades. …”
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