Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy by Yu Feng, Keziah S. Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I. Lamsifer, Zachary T. Pennington, Lauren M. Vetere, Paul A. Philipsberg, Ivan Soler, Albert Jurkowski, Christin J. Rosado, Nadia N. Khan, Denise J. Cai, Tristan Shuman

“…In contrast, abnormal synchronization within the MEC and between HPC and MEC emerged later, by 8 weeks after Pilo-SE, when spatial memory impairment was more severe. Furthermore, a distinct subpopulation of MEC layer 3 excitatory neurons (active at theta troughs) was specifically impaired in epileptic mice. …”
Get full text

External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB by B.F. Melingui, E. Leroy-Terquem, J.V. Taguebue, T.C. Eap, L. Borand, C. Khosa, R. Moh, J. Mwanga-Amumpaire, S. Beneteau, M.T. Eang, I. Manhiça, A. Mustapha, O. Marcy, E. Wobudeya, P.Y. Norval, M. Bonnet, on behalf of the TB-Speed study group

Get full text

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. by David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

“…Transplantation studies reveal that tif1gamma functions in a cell-autonomous manner during the differentiation of erythroid precursors. …”
Get full text

The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…This study focused on characterizing the sperm morphology of the small wild rodent Akodon cursor and describing the epididymal environment supporting sperm maturation. Eight A. cursor males were captured from a preserved area of the Atlantic Forest in Viçosa (MG, Brazil). …”
Get full text

Spin-orbit interaction driven terahertz nonlinear dynamics in transition metals by Ruslan Salikhov, Markus Lysne, Philipp Werner, Igor Ilyakov, Michael Schüler, Thales V. A. G. de Oliveira, Alexey Ponomaryov, Atiqa Arshad, Gulloo Lal Prajapati, Jan-Christoph Deinert, Pavlo Makushko, Denys Makarov, Thomas Cowan, Jürgen Fassbender, Jürgen Lindner, Aleksandra Lindner, Carmine Ortix, Sergey Kovalev

“…The essential rules for how terahertz fields interact with these systems in a nonlinear way are still not understood. In this work, we demonstrate a universally applicable electronic nonlinearity originating from spin-orbit interactions in conducting materials, wherein the interplay of light-induced spin and orbital textures manifests. …”
Get full text

Health-related Quality of Life and Exercise Capacity in Double Lung Transplant Recipients With Baseline Lung Allograft Dysfunction by Alisha Rullay, BSc, Karina Kaur, BSc, Jennifer Holman, PT, Laura C. van den Bosch, MD, Justin G. Weinkauf, MD, Jayan Nagendran, MD, PhD, Rhea A. Varughese, MD, Alim S. Hirji, MD, Dale C. Lien, MD, Jason C. Weatherald, MD, Kieran M. Halloran, MD

“…We secondarily analyzed the Beck Depression Inventory and Borg dyspnea scores in patients using the available data. We defined BLAD as a failure of both forced expiratory volume in 1 s and forced vital capacity to reach ≥80% predicted of a healthy reference population’s lung function on 2 consecutive tests ≥3 wk apart at any time point posttransplant. …”
Get full text

Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse by Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A. Cartwright, Candice Ashmore-Harris, Alastair M. Kilpatrick, Philip J. Starkey Lewis, Anna Drape, Mark Barnett, Donna Mitchell, Colin McLean, Neil McGowan, Marc Turner, James W. Dear, Stuart J. Forbes

“…Abstract Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). …”
Get full text

The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles by Michiel T.H.M. Henkens, Anne‐Mar vanOmmen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A.J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P.M. vanEmpel, Joline W.J. Beulens, Hester M. denRuijter, Stephane R.B. Heymans

“…Inclusion criteria for this study were (i) age ≥ 45 years and (ii) a left ventricular ejection fraction (LVEF) ≥ 50%, in the absence of a history of HF, coronary artery disease, congenital heart disease, or any previous cardiac interventions. …”
Get full text

Review of Interventional Therapies for Refractory Pediatric Migraine by Jacquelin Peck, Justin Zeien, Megha Patel, Elyse M. Cornett, Amnon A. Berger, Jamal Hasoon, Hisham Kassem, Jai Won Jung, Giovanni F. Ramírez, Paola Colon Fugueroa, Neil R. Singhal, Jaehong Song, Adam M. Kaye, Alan D. Kaye, Sarang S. Koushik, Natalie H. Strand, Latha Ganti

“…This is a review of the latest and seminal evidence in pediatric migraine. …”
Get full text

Pre-existing IgG antibodies to HCoVs NL63 and OC43 Spike increased during the pandemic and after COVID-19 vaccination by Zahra Hasan, Kiran Iqbal Masood, Marc Veldhoen, Shama Qaiser, Marta Alenquer, Mishgan Akhtar, Sadaf Balouch, Junaid Iqbal, Yaqub Wassan, Shahneel Hussain, Khalid Feroz, Sajid Muhammad, Atif Habib, Akbar Kanji, Erum Khan, Afsar Ali Mian, Rabia Hussain, Maria Joao Amorim, Zulfiqar A. Bhutta

“…There is little information regarding endemic human coronaviruses (HCOVs) from Pakistan, which experienced a relatively low COVID-19 morbidity and mortality. …”
Get full text

Clinical risk factors for sarcopenia in acute and chronic pancreatitis by Mitchell L. Ramsey, Andrew Lu, Kristyn Gumpper-Fedus, Stacey Culp, David Bradley, Darwin L. Conwell, Zobeida Cruz-Monserrate, J. Royce Groce, Samuel Han, Somashekar G. Krishna, Peter Lee, Thomas Mace, Georgios I. Papachristou, Kristen M. Roberts, Zarine K. Shah, Phil A. Hart

“…Aims To evaluate risk factors for sarcopenia among individuals with AP or CP. Methods A cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. …”
Get full text

Re-connecting ecosystems: Integrating coral reefs into monitoring of island restoration by Cassandra E. Benkwitt, Kalia S.I. Bistolas, Jayna L. DeVore, Simon Ducatez, Jazmín Prado Gómez, Rosalie Wright, Mayalen Zubia, Pierrick Harnay, Teva Beguet, Lisa M. Wedding, Deron E. Burkepile, Frank Murphy, Nicholas A.J. Graham, Rebecca Vega Thurber, Hannah E. Epstein

Get full text

Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. …”
Get full text

Arthroscopic “V” Configuration Anatomic Reconstruction of Chronic Acromioclavicular Joint Dislocations Using Double-Bundled Autogenous Gracilis Tendon Graft Reinforced With FiberTa... by Ayyappan V. Nair, D.Ortho, D.N.B., M.N.A.M.S., Pramod Kumar Mohan, M.S. Ortho., Ajit Jangale, M.S., M.R.C.S., Pavan Krishna, M.S. Ortho., Prince Shanavas Khan, D.Ortho, M.S. Ortho., Maythilisharan Rambhojun, M.S. Ortho., Sreejith Thampy, M.S. Ortho.

“…The advantage of our technique is the reduced use of implants and also providing stable reconstruction, a good chance for tendon integration into the coracoid, and fewer recurrences due to graft stretching, enabling good stability to the joint.…”
Get full text

Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy by Patrick Hwu, Ravi Murthy, Aung Naing, Sapna P. Patel, Simon Young, Alda Tam, Nina M. Muñoz, Malea Williams, Katherine Dixon, Crystal Dupuis, Amanda McWatters, Rony Avritscher, Soraya Zorro Manrique, Kevin McHugh, David Leach, Jeffrey D. Hartgerink, Punit Prakash, Rahul A. Sheth

“…Background Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers to tumor immunity. …”
Get full text

CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…Here, we demonstrate that mutating the CHD6 chromatin remodeler sensitizes cells to PARP1/2 inhibitors in a manner distinct from BRCA1, and that CHD6 recruitment to DNA damage requires cooperation between PAR- and DNA-binding domains essential for nucleosome sliding activity. …”
Get full text

Mothers at the Intersection of Trauma, Addiction, and Involvement with the Criminal Legal System: An Analysis of Multiple Case Studies by Monica Solinas-Saunders PhD, Maureen L. Petrunich-Rutherford PhD, Mark D. Thomas PhD, Natasha R. Brown PhD, Kevin L. McElmurry PhD, Melissa A. Jones PhD, Abigail M. Cognetti BSc, Lytina Andrews BSc, Amira Zahabi BSc

“…The study focuses on the complex interconnection of race, sexuality, and socioeconomic background in shaping the stories of mothers struggling with addiction disorders as they attempt to recover from traumatic experiences. A sample of 45 mothers was employed in the study. …”
Get full text

Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States by Dazheng Zhang, Bingyu Zhang, Qiong Wu, Ting Zhou, Jiayi Tong, Yiwen Lu, Jiajie Chen, Huiyuan Wang, Deena J. Chisolm, Ravi Jhaveri, Rachel C. Kenney, Russell L. Rothman, Suchitra Rao, David A. Williams, Mady Hornig, Linbo Wang, Jeffrey S. Morris, Christopher B. Forrest, Yong Chen

“…These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study with difference-in-differences analyzes to assess these differences in children and adolescents under the age of 21. …”
Get full text

BSG 2024 IBD guidelines protocol (standard operating procedures) by Philip Smith, Rachel Cooney, Jimmy Limdi, Sreedhar Subramanian, Polychronis Pavlidis, Ajay Verma, Said Din, Gordon W Moran, Naila Arebi, Shahida Din, Morris Gordon, Kamal V Patel, Klaartje Bel Kok, Dennis McGonagle, Matthew Shale, Ana-Maria Darie, Vasiliki Sinopoulou, Newton A C S Wong

“…Introduction In the past 5 years, there have been several advances in the management of inflammatory bowel disease (IBD). We aim for a new guideline to update the most recent guideline published in 2019. …”
Get full text

Acute Myocardial Infarction Reduces Respiration in Rat Cardiac Fibers, despite Adipose Tissue Mesenchymal Stromal Cell Transplant by Camila I. Irion, Eduarda L. Martins, Michelle L. A. Christie, Cherley B. V. de Andrade, Alan C. N. de Moraes, Raphaela P. Ferreira, Cibele F. Pimentel, Grazielle D. Suhett, Antonio Carlos C. de Carvalho, Rafael S. Lindoso, Adalberto Vieyra, Antonio Galina, Regina C. S. Goldenberg

Get full text