Striking the Right Balance by Monica Verdoia, MD, PhD, Rasha Al-Bawardy, MD, Maria Antonieta Albanez A. de Medeiros Lopes, MD, Aaysha Cader, MD, MSc, Mayank Dalakoti, MD, Anas Merdad, MD, Yubrine Moraa Gachemba, MD, Hazel Mburu, MD, Sarah Rosanel, MD, Alan Sigal, MD

Get full text

Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials by Pavlos Msaouel, Ramez Kouzy, Joseph Abi Jaoude, Ethan B Ludmir, Alexander D Sherry, Timothy A Lin, Esther J Beck, Avital M Miller, Adina H Passy, Gabrielle S Kupferman, Eugene J Koay, Clifton David Fuller, Charles R Thomas, Zachary R McCaw

“…Logistic regressions computed ORs for the association between trial-level covariates and the outcome.Results A total of 334 phase III trials enrolling 265 310 patients were included, with publications between 2004 and 2020. …”
Get full text

Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages by Aparecida Donizette Malvezi, Rosiane Valeriano da Silva, Carolina Panis, Lucy Megumi Yamauchi, Maria Isabel Lovo-Martins, Nagela Ghabdan Zanluqui, Vera Lúcia Hideko Tatakihara, Luiz Vicente Rizzo, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Sueli Fumie Yamada-Ogatta, Phileno Pinge-Filho

“…The intracellular protozoan parasite Trypanosoma cruzi causes Chagas disease, a serious disorder that affects millions of people in Latin America. …”
Get full text

Fluorescence images of skin lesions and automated diagnosis using convolutional neural networks by Matheus B. Rocha, Sebastiao Pratavieira, Renan Souza Vieira, Juliana Duarte Geller, Amanda Lima Mutz Stein, Fernanda Sales Soares de Oliveira, Tania R.P. Canuto, Luciana de Paula Vieira, Renan Rossoni, Maria C.S. Santos, Patricia H.L. Frasson, Renato A. Krohling

“…The collected images were annotated and analyzed, creating a new dataset named FLUO-SC. Convolutional neural networks were then applied to classify skin lesions using these fluorescence images. …”
Get full text

Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

“…Health authorities ask that a thorough immunogenicity risk assessment be conducted during drug development to incorporate an appropriate monitoring and mitigation plan in clinical studies. …”
Get full text

Development, validation, and reliability testing of the College Perspectives around Food Insecurity survey. by Jennette Kilgrow, Elyce Gamble, Amanda Meier, Kyle Lyman, Andrea Barney, Cade Kartchner, Paola Martinez, Kanae Lee, Carol Mathusek, Kelly Ang, Brooke M Green, Jinan Banna, Dennis L Eggett, Stephanie Grutzmacher, Jennifer A Jackson, Kendra OoNorasak, Nathan Stokes, Rickelle Richards

“…The objective of this study was to develop and to test the validity and reliability of a survey aimed to evaluate internal and external factors associated with college food insecurity. …”
Get full text

The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration by Thomas Albrecht, Shiqi Zhang, Jana D. Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P. Schmitt, Jacob van den Born, Stephan J. L. Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…Although our data also suggest that (CTG)5 homozygous patients may have a survival advantage on dialysis and in diabetes, this hypothesis needs to be confirmed in a prospective cohort study.…”
Get full text

Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens by Merryn V. E. Macville, Jeroen A. W. M. Van der Laak, Ernst J. M. Speel, Nir Katzir, Yuval Garini, Dirk Soenksen, George McNamara, Peter C. M. de Wilde, Antonius G. J. M. Hanselaar, Anton H.N. Hopman, Thomas Ried

“…The results demonstrate that spectral imaging unambiguously identifies three chromogenic dyes in a single bright‐field microscopic specimen. Serial microscopic fields from the same specimen can be analyzed using a spectral reference library. …”
Get full text

Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…Administration of allogeneic BM MSCs is less desirable in a patient population likely to require a kidney transplant, but potency of autologous MSCs should be confirmed, given previous indications that CKD-induced dysfunction is present. …”
Get full text

Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy by A. Contreras-Sanz, G. L. Negri, M. J. Reike, H. Z. Oo, J. M. Scurll, S. E. Spencer, K. Nielsen, K. Ikeda, G. Wang, C. L. Jackson, S. Gupta, M. E. Roberts, D. M. Berman, R. Seiler, G. B. Morin, P. C. Black

Get full text

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…Importantly, the actions of VPA in MB cells and neurospheres include a reduction in the expression of <i>MYC</i> and an increase in <i>TP53</i>.…”
Get full text

Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States by Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A. Marks, Katherine E. Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B. Araujo

“…Subgroup analyses showed a VE of 56% (95% CI 51–61%) among adults ≥ 65 years and 46% (95% CI 39–52%) in immunocompromised adults. …”
Get full text

Factors Contributing to the Utilization of Adult Mental Health Services in Children and Adolescents Diagnosed with Hyperkinetic Disorder by Hilario Blasco-Fontecilla, Juan J. Carballo, Rebeca Garcia-Nieto, Jorge Lopez-Castroman, Analucia A. Alegria, Ignacio Basurte-Villamor, Juncal Sevilla-Vicente, Rocio Navarro-Jimenez, Teresa Legido-Gil, Consuelo Morant-Ginestar, Miguel Angel Jimenez-Arriero, Jeronimo Saiz-Ruiz, Enrique Baca-Garcia

“…Kaplan-Meier curves were used to assess survival data. A series of logistic regression analyses were performed to study the role of age of diagnosis, gender, psychiatric comorbidity, and treatment modalities. …”
Get full text

Electromyographic correlates of effortful listening in the vestigial auriculomotor system by Andreas Schroeer, Andreas Schroeer, Andreas Schroeer, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Farah I. Corona-Strauss, Ronny Hannemann, Ronny Hannemann, Steven A. Hackley, Daniel J. Strauss, Daniel J. Strauss, Daniel J. Strauss, Daniel J. Strauss

“…EMG signals from the left and right superior and posterior auricular muscles (SAM, PAM) were recorded while participants attended a target podcast in a competing speaker paradigm. …”
Get full text

Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation by E U Wessels, K Kinandu, M Beretta, S Berkenfeld, B Bobat, L Brannigan, R Britz, D Demopoulos, L Doedens, P Gaylard, H Maher, A Mahomed, V Mudau, D Parbhoo, S Rambarran, M Reynders, F van der Schyff, B Ströbele, J Fabian, J Loveland

“…Most adult recipients received a deceased donor graft (79%). Unadjusted recipient one- and three-year survivals were 75% (95% confidence interval (CI) 65 - 83) and 74% (95% CI 65 - 81), respectively. …”
Get full text

Finerenone in the management of diabetes kidney disease by Parijat De, May T Khine, Andrew Frankel, Gabrielle Goldet, Debasish Banerjee, Rosa M Montero, Tahseen A Chowdhury, Damien Fogarty, Janaka Karalliedde, Ritwika Mallik, Dipesh C Patel, Mona Wahba, Peter Winocour, Sagen Zac-Varghese, Stephen Bain, Adnan Sharif, Srikanth Bellary, Indranil Dasgupta

“…Abstract People with type 2 diabetes are at risk of developing progressive diabetic kidney disease (DKD) and end stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. …”
Get full text

Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most I... by Rogelio Molina-Gallardo, Nomely S. Aurelien-Cabezas, Daniel Tiburcio-Jimenez, Jorge E. Plata-Florenzano, Jose Guzman-Esquivel, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Roque Molina-Osorio, Adrian A. De-la-Madrid-Cernas, Jorge Armando Barriguete-Melendez, Ivan Delgado-Enciso

“…But its usefulness remains unclear in patients with or without coronary disease. Methods. A case-control study was carried out on a total of 805 patients with and without cardiovascular risk factors or acute coronary syndrome. …”
Get full text

Water-mediated ion transport in an anion exchange membrane by Zhongyang Wang, Ge Sun, Nicholas H. C. Lewis, Mrinmay Mandal, Abhishek Sharma, Mincheol Kim, Joan M. Montes de Oca, Kai Wang, Aaron Taggart, Alex B. Martinson, Paul A. Kohl, Andrei Tokmakoff, Shrayesh N. Patel, Paul F. Nealey, Juan J. de Pablo

“…Abstract Water is a critical component in polyelectrolyte anion exchange membranes (AEMs). …”
Get full text

Synthesis and Antitubercular Activity of Heteroaromatic Isonicotinoyl and 7-Chloro-4-Quinolinyl Hydrazone Derivatives by Marcelle de L. Ferreira, Raoni S.B. Gonçalves, Laura N. de F. Cardoso, Carlos R. Kaiser, Andre L.P. Candéa, Maria das Graças M. de O. Henriques, Maria C.S. Lourenço, Flávio A.F.M. Bezerra, Marcus V. N. de Souza

“…Two series of N’(E)-heteroaromatic-isonicotinohydrazide derivatives (3a-f and 4a-b) and 1-(7-chloroquinolin-4-yl)-2-[(heteroaromatic)methylene]hydrazone derivatives (5a-f and 6a-b) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. …”
Get full text

PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF LEAF EXTRACT OF Dipteryx lacunifera DUCKE by Krislany A. L. Guedes Araujo, Herbert G. Sousa, João P. da Silva Gomes, Renato Pinto de Sousa, Éverton L. de França Ferreira, Monica T. Pupo, Pedro M. da Silva Costa, Claudia Pessoa, Mahendra Rai, Mariana H. Chaves, Gerardo Magela Vieira Junior

“…The Dipteryx genus, a member of the Fabaceae family with approximately 14 species, is found in Brazil’s Amazon Rainforest, Northeast and Central regions, and Central America. …”
Get full text