Leveraging machine learning and rule extraction for enhanced transparency in emergency department length of stay prediction by Waqar A. Sulaiman, Charithea Stylianides, Andria Nikolaou, Andria Nikolaou, Zinonas Antoniou, Ioannis Constantinou, Lakis Palazis, Anna Vavlitou, Theodoros Kyprianou, Theodoros Kyprianou, Efthyvoulos Kyriacou, Antonis Kakas, Antonis Kakas, Marios S. Pattichis, Andreas S. Panayides, Constantinos S. Pattichis, Constantinos S. Pattichis

“…To enhance interpretability, a novel rule extraction method for GB model was implemented using relevant important predictors, such as triage acuity, comorbidity scores, and arrival methods. …”
Get full text

Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C by Roberta C. Araújo, Fabricio C. Dias, Bruna C. Bertol, Deisy M. Silva, Patrícia H. Almeida, Andreza C. Teixeira, Fernanda F. Souza, Marcia G. Villanova, Leandra N. Z. Ramalho, Eduardo A. Donadi, Ana L. C. Martinelli

“…The pathologist assessed the magnitude of HLA-E expression in a semiquantitative way, attributing scores from 0 to 3. …”
Get full text

Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes by Yuko Nakano, Howard Gamper, Henri McGuigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph A. Piccirilli, Ralph Kleiner, Nicole Nichols, Brian D. Gregory, Ya-Ming Hou

“…Abstract While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. …”
Get full text

Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.…”
Get full text

Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin by Aleksandr G. Chuchalin, Gennadiy G. Onishchenko, Victor P. Kolosov, Olga P. Kurganova, Tatiana A. Zaitseva, Leonid G. Manakov, Galina N. Kholodok, Juliy M. Perelman, Roman S. Kozlov, Natalia M. Ivakhnishina, Olga E. Trotsenko, Albina P. Bondarenko

“…Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society. …”
Get full text

The impact of margins and re‐resection in pediatric synovial sarcoma by Andres F. Espinoza, Priya B. Shetty, Jillian C. Jacobson, Hannah Todd, Kelley Harrell, Alfred F. Trappey, John Doski, Eumenia C. Castro, Nicole I. Montgomery, M. Fatih Okcu, Rajkumar Venkatramani, Dai H. Chung, Sanjeev A. Vasudevan

“…We sought to evaluate the adequate resection margin and the role of re‐resection in predicting outcomes in children with synovial sarcomas. Methods A cohort of 36 patients less than 18 years of age at diagnosis who were treated for localized synovial sarcoma at three tertiary pediatric hospitals between January 2004 and December 2020 were included in this study. …”
Get full text

Telecardiology Application in Jordan: Its Impact on Diagnosis and Disease Management, Patients’ Quality of Life, and Time- and Cost-Savings by Yousef Saleh Khader, Mohamad Ismail Jarrah, Abde-Ellah M. Al-Shudifat, Amjad Shdaifat, Husham Aljanabi, Shadwan Ismeil Al-Fakeh, Elias Emil Turk, Khaled Ali Zayed, Hanadi A. Al Quran, Ziad Mohd Ellauzi, Mohammad Al Tahan

“…Patients were interviewed for relevant information and their quality of life was assessed during the first visit and 8 weeks after the last visit. Results. A total of 76 patients were included in this study. …”
Get full text

Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection by Jes M. Sanders, Barbara L. Banbury, Erika L. Schumacher, Jie He, Yuvaraj Sambandam, Paul A. Fields, Lorenzo Gallon, Lorenzo Gallon, James M. Mathew, James M. Mathew, James M. Mathew, Joseph R. Leventhal, Joseph R. Leventhal

“…DRTC were then tracked in post-transplant biopsies, blood, and urine samples in a cohort of kidney transplant recipients.ResultsIn patients with an abnormal biopsy, the majority of CD8+ DRTC found within the allograft were detected in the circulating pre-transplant repertoire. …”
Get full text

MUC2 expression modulates immune infiltration in colorectal cancer by Christophe M. Raynaud, Ayesha Jabeen, Eiman I. Ahmed, Eiman I. Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A. Al-Shaibi, Bernice Lo, Bernice Lo, Jessica Roelands, Davide Bedognetti, Davide Bedognetti, Wouter Hendrickx, Wouter Hendrickx

“…IntroductionColorectal cancer (CRC) is a prevalent malignancy with significant morbidity and mortality worldwide. …”
Get full text

PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese by Glêbia A. Cardoso, Mateus D. Ribeiro, Bruno R. V. Sousa, Yohanna de Oliveira, Klécia F. Sena, Joane R. E. Batista, Antônio E. M. Almeida, João M. Filho, Raquel S. B. Silva, Darlene C. Persuhn, Alexandre S. Silva

“…However, differences in distribution of respondents or nonresponders according to allele A were identified for fat mass (p≤0.003), percentage fat mass (p≤0.002), the waist (p≤0.009), abdomen (p≤0.000), and hip (p≤0.001), this difference being independent for the fat mass. …”
Get full text

Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Trajectory inference analyses identify a pseudotime variable strongly correlated with ER independence and disease progression; and revealed bifurcated evolutionary trajectories for ER-independent vs. …”
Get full text

Real-World Evidence Evaluation on the Lipid Profile, Therapeutic Goals, and Safety of the Fixed-Dose Combination of Rosuvastatin/Ezetimibe (Trezete®) in Dyslipidemia Patients by Joel Rodríguez-Saldaña, Francisco Padilla-Padilla, Ernesto G. Cardona-Muñoz, Yulia Romero-Antonio, María Marcela Arguedas-Núñez, José G. Sander-Padilla, Alberto Martínez-Muñoz, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vazquez, Jorge González-Canudas

“…Materials and Methods. A real-world evidence study was conducted with retrospective data collection through a review of clinical records from dyslipidemia patients treated with Trezete® in routine medical practice. …”
Get full text

Valley charge-transfer insulator in twisted double bilayer WSe2 by LingNan Wei, Qingxin Li, Majeed Ur Rehman, Yangchen He, Dongdong An, Shiwei Li, Kenji Watanabe, Takashi Taniguchi, Martin Claassen, Kostya S. Novoselov, Dante M. Kennes, Angel Rubio, Daniel A. Rhodes, Lede Xian, Geliang Yu, Lei Wang

“…Abstract In flat-band systems, emergent physics can be substantially modified by the presence of another nearby electronic band. For example, a Mott˘Hubbard insulator can turn into a charge transfer insulator if other electronic states enter between the upper and lower Hubbard bands. …”
Get full text

Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism by Michelle C.D. Bridi, Nancy Luo, Grace Kim, Benjamin J. Menarchek, Rachel A. Lee, Bryan Rodriguez, Daniel Severin, Cristian Moreno, Altagracia Contreras, Christian Wesselborg, Caroline O’Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood

Get full text

Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization by Manuel P. Kainz, Mathias Polz, Daniel Ziesel, Marta Nowakowska, Muammer Üçal, Sabine Kienesberger, Sophie Hasiba-Pappas, Raimund Winter, Nassim Ghaffari Tabrizi-Wizsy, Sarah Kager, Theresa Rienmüller, Julia Fuchs, Michele Terzano, Christian Baumgartner, Gerhard A. Holzapfel

Get full text

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity by Roel A. van der Heijden, Martine C. Morrison, Fareeba Sheedfar, Petra Mulder, Marijke Schreurs, Pascal P. H. Hommelberg, Marten H. Hofker, Casper Schalkwijk, Robert Kleemann, Uwe J. F. Tietge, Debby P. Y. Koonen, Peter Heeringa

“…Results. The switch from a LFD to a HFD lowered the respiratory exchange ratio and increased plasma cholesterol and hepatic lipid content. …”
Get full text

Subjective cognitive deficits and its correlates among patients with bipolar disorder: Findings from the bipolar disorder course and outcome study from India (BiD-CoIN study) by Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Praharaj, Vikas Menon, Raman Deep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, Prosenjit Ghosh, Bhavesh Lakdawala, Ranjan Bhattacharya

“…Compared to those without cognitive complaints, those with cognitive complaints more often had depression as the first episode in their lifetime, had a higher prevalence of alcohol dependence, a higher number of depressive episodes (first five years of illness, lifetime, and per year of illness), a higher number of manic episodes in the first five years of illness, more often had depressive or indeterminate predominant polarity, lower prevalence of at least one-lifetime episode with psychotic symptoms, higher severity of residual symptoms, spent more time in the episodes in the lifetime, had poorer insight and higher disability. …”
Get full text

Efficacy of Fat Supplements with Different Unsaturated/Saturated FA Ratios Undergoing First Postpartum Ovulation in Lactating Anovulatory Goats by Caroline P. Silva, César C. L. Fernandes, Juliana P. M. Alves, Camila M. Cavalcanti, Felipe B. B. Oliveira, Alfredo J. H. Conde, Diana Celia S. N. Pinheiro, Darcio I. A. Teixeira, Anibal C. Rego, Davide Rondina

“…Thirty-eight An-glo-Nubian-crossbred adult goats were allocated into three groups, one with a control diet (<i>n</i> = 12), fed a total mixed ration (TMR) comprising chopped elephant grass and concentrate; an algal diet (<i>n</i> = 13), fed TMR + green microalgae (1% dry matter); and a linseed diet (<i>n</i> = 13), TMR + linseed (12% dry matter). …”
Get full text

Body mass index and B‐lines on lung ultrasonography in chronic and acute heart failure by Philip Brainin, Brian Claggett, Eldrin F. Lewis, Kristin H. Dwyer, Allison A. Merz, Montane B. Silverman, Varsha Swamy, Tor Biering‐Sørensen, Jose Rivero, Susan Cheng, John J.V. McMurray, Scott D. Solomon, Elke Platz

“…Conclusions Despite an inverse relationship between B‐lines and BMI, B‐lines declined to a lesser degree than NT‐proBNP with increasing BMI. …”
Get full text

First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…The specific role of fat sand rats (Psammomys obesus) in the transmission of Cryptosporidium spp. in Egypt and the genotypic characteristics of the circulating species in these animals remain poorly understood.MethodsIn this study, a total of 150 individual fat sand rat stool samples were collected from the saline marsh periurban areas of Abu-Rawash, Giza, Egypt. …”
Get full text