Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease by John McFadden, Julian Matthews, Lauren Scott, Karl Herholz, Ben Dickie, Hamied Haroon, Oliver Sparasci, Saadat Ahmed, Natalia Kyrtata, Geoffrey J.M. Parker, Hedley C.A. Emsley, Joel Handley, Maélène Lohezic, Laura M. Parkes

“…In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO2). …”
Get full text

Aging-regulated TUG1 is dispensable for endothelial cell function. by Anna Theresa Gimbel, Susanne Koziarek, Kosta Theodorou, Jana Felicitas Schulz, Laura Stanicek, Veerle Kremer, Tamer Ali, Stefan Günther, Sandeep Kumar, Hanjoong Jo, Norbert Hübner, Lars Maegdefessel, Stefanie Dimmeler, Sebastiaan van Heesch, Reinier A Boon

“…The evolutionary conserved Taurine Upregulated Gene 1 (TUG1) is a ubiquitously expressed gene that is one of the highest expressed genes in human and rodent endothelial cells (ECs). …”
Get full text

Nitride thin films grown by thermal laser epitaxy by Dong Yeong Kim, Varun Harbola, Seungwon Jung, Jinjoo Lee, Sukanya Roy, Felix V. E. Hensling, Lena N. Majer, Hongguang Wang, Peter A. van Aken, Joao Marcelo J. Lopes, Neha Aggarwal, Jochen Mannhart, Wolfgang Braun

“…The growth of a wide range of binary nitride films with excellent properties is reported. …”
Get full text

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. by William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard, Judd F Hultquist

“…The persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state, and several latency reversal strategies focus on the release of positive transcription elongation factor b (P-TEFb) from sequestration by negative regulatory complexes, such as the 7SK complex and BRD4. …”
Get full text

Connecting Hospitalized Patients with Their Families: Case Series and Commentary by Kourosh Parsapour, Alexander A. Kon, Madan Dharmar, Amy K. McCarthy, Hsuan-Hui Yang, Anthony C. Smith, Janice Carpenter, Candace K. Sadorra, Aron D. Farbstein, Nayla M. Hojman, Gary L. Wold, James P. Marcin

“…We conducted a retrospective chart review of hospitalized patients (primarily children) with extended hospital length of stays. …”
Get full text

Genomic exploration of the journey of Plasmodium vivax in Latin America. by Margaux J M Lefebvre, Fanny Degrugillier, Céline Arnathau, Gustavo A Fontecha, Oscar Noya, Sandrine Houzé, Carlo Severini, Bruno Pradines, Antoine Berry, Jean-François Trape, Fabian E Sáenz, Franck Prugnolle, Michael C Fontaine, Virginie Rougeron

“…Analyses of the genetic structure, diversity, ancestry, coalescent-based inferences, including demographic scenario testing using Approximate Bayesian Computation, have revealed a more complex evolutionary history than previously envisioned. …”
Get full text

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone by Grazia Caleo, Kamalini Lokuge, Katina Kardamanidis, Jane Greig, Jaroslava Belava, Emer Kilbride, Alhaji Sayui Turay, Gbessay Saffa, Ronald Kremer, Francesco Grandesso, Kostas Danis, Armand Sprecher, Gian Luca Di Tanna, Holly Baker, Helen A. Weiss

“…Background There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operational utility of mortality estimated from cluster-sampled studies when the DEFF is high. …”
Get full text

Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina... by Raul Velez-Montoya, Idaira Sanchez-Santos, Mauricio Galvan-Chavez, Lihteh Wu, J. Fernando Arevalo, María H. Berrocal, Arturo A. Alezzandrini, Marta S. Figueroa, Roberto Gallego-Pinazo, Rosa Dolz-Marco, Clara Martinez-Rubio, Roberto Gonzalez-Salinas

“…The study included 939 patients that underwent routine phacoemulsification and had a history of anti-VEGF therapy. We excluded patients with known risk factors for capsular rupture, as well as patients with a history of other retinal procedures. …”
Get full text

Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

“…Utilizing both viral transcript and TME subtypes, we found that the E2/E5 HPV subtype was associated with an immune-enriched TME and had a higher overall survival rate compared to other subtypes. …”
Get full text

Patients’ satisfaction with services provided by family physicians at the Comprehensive Healthcare Centers in Northern Jordan by Hadeel B. Heilat, Muntaha K. Gharaibeh, Wanas M. Shtaiyat, Raghad S. Gharaibeh, Ayah M. Ananbeh, Manar J. Baniyaseen, Shahd M. Alsharaydeh, Aya B. Alqawaba’h, Emad A. Alzu’bi, Nour G. Amayreh, Reem R. Aldawagreh

“…BACKGROUND: Patient satisfaction is a paramount measure of the quality of healthcare system, particularly in the practice of family medicine. …”
Get full text

Evaluation of Biocoagulant “Opuntia ficus-indica and Chitosan” to Improve the Removal of Contaminants in Dairy Effluents through Electrocoagulation by Naysha Y. M. Elguera, Stephanie E. S. Pulcha, Edgar M. M. Ballon, Miriam R. F. Castro, Lilia M. M. Ramos, Victor L. A. Tohalino, Pavel K. D. Sarmiento, Vitor C. Almeida, Hugo G. J. Pacheco

“…The objective of the study was to evaluate the effect of parameters on the percentage of turbidity (TB) removal and chemical oxygen demand (COD), using as pretreatment a combined coagulation process using a biocoagulant composed of chitosan and Opuntia ficus-indica mucilage (OFI): chitosan-mucilage (Q-M from 1 to 9), and an electrocoagulation process with operational variables of biocoagulant dose (0.025, 0.05 y 0.1 g/L), current density (30, 40 y 50 mA/cm2), and time (10, 15 y 20 minutes). …”
Get full text

Performance of Cementless Hip Arthroplasty Stem Types Based on Consolidated Large Registry Data by Logan E. Finger, MD, Matthew F. Gong, MD, Asher Mirvish, BS, Alexandra S. Gabrielli, MD, Ahmad P. Tafti, PhD, Michael J. O’Malley, MD, Brian A. Klatt, MD, Johannes F. Plate, MD, PhD

“…Results: The most utilized stem types were (1) type B2 stems, (2) type A stems, and (3) type C1 stems. The most utilized stem models were the (1) Corail stem (B2), (2) Accolade II (type A), and (3) Taperloc 133 (type A). …”
Get full text

Overview on Cryptosporidium bovis and Its Effect on Calves in Some Governorates in Egypt by Amer R. Abdelaziz, Amin Tahoun, Hanem El-Sharkawy, Moustafa M. Abd El-Salam, Mohammed Alorabi, Ahmed M. El-Shehawi, Rasha A. El Meghanawy, Essam E Toukhy, Ahmed M. Abd El-Salam, Shimaa S. G. Sorour

“…Gene sequencing and phylogenetic analysis of the 18SSU-rRNA gene of the local bovine isolate were performed, and it was found that C. bovis genotype was highly similar to human isolate, which provoke the zoonotic transmission of bovine isolate to humans and identified as a potential source for human cryptosporidiosis infection in Egypt.…”
Get full text

Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). …”
Get full text

Isolation of Cellulose from Wheat Straw Using Alkaline Hydrogen Peroxide and Acidified Sodium Chlorite Treatments: Comparison of Yield and Properties by Umair Qasim, Zulfiqar Ali, Muhammad Shahid Nazir, Sadaf Ul Hassan, Sikander Rafiq, Farrukh Jamil, Ala’a H. Al-Muhtaseb, Muzaffar Ali, Muhammad Bilal Khan Niazi, Nasir M. Ahmad, Sami Ullah, Ahmad Mukhtar, Sidra Saqib

“…A comparative study was carried out based on the yield and properties of extracted cellulose. …”
Get full text

Home Dialysis Prediction Using Artificial Intelligence by Caitlin K. Monaghan, PhD, Joanna Willetts, MS, Hao Han, MS, Sheetal Chaudhuri, PhD, Linda H. Ficociello, DSc, Michael A. Kraus, MD, Harold E. Giles, MD, Len Usvyat, PhD, Joseph Turk, MBA

Get full text

Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy by S. J. Luk, M. E. IJsselsteijn, A. Somarakis, I. Acem, I. Briaire de Bruijn, K. Szuhai, J. V. M. G. Bovee, N. F. C. C. de Miranda, J. H. F. Falkenburg, M. H. M. Heemskerk

“…The immune composition of synovial sarcoma was dominated by CD68+ myeloid cells of which a substantial part was of the CD163+ immunosuppressive phenotype, which increased after chemotherapy or radiotherapy. …”
Get full text

Spatiotemporal analysis of the association between residential eviction and fatal overdose in Rhode Island by Jennifer Ahern, Magdalena Cerdá, William C Goedel, Elizabeth A Samuels, Yu Li, Alexandria Macmadu, Benjamin D Hallowell, Kathryn M Leifheit, Alexandra Skinner, Victoria Jent, Bennett Allen, Abigail R Cartus, Claire Pratty, Brandon DL Marshall

“…We applied a Bayesian spatiotemporal approach using an integrated nested Laplace approximation and adjusted for an a priori determined set of time-varying demographic and policy covariates.Results Descriptively, we observed a direct, dose–response relationship between quintiles of eviction incidence rates over the full study period and fatal overdose. …”
Get full text

Diagnosis and Treatment of Elderly and Senile Chronic Constipation: an Expert Consensus by V. T. Ivashkin, M. G. Mnatsakanyan, V. S. Ostapenko, А. P. Pogromov, V. M. Nekoval, E. A. Poluectova, Yu. V. Kotovskaya, N. K. Runikhina, N. V. Sharashkina, P. V. Tsarkov, N. O. Tkacheva, Yu. N. Belenkov

“…Chronic constipation is a common issue in geriatrics. Aside to age-related physiological bowel disfunction, a higher constipation incidence is conditioned by declined physical activity and frailty, polypharmacy and a series of secondary constipation-developing chronic states and diseases. …”
Get full text

IMA Genome – F19 by Janneke Aylward, Andi M. Wilson, Cobus M. Visagie, Joseph Spraker, Irene Barnes, Carla Buitendag, Callin Ceriani, Lina Del Mar Angel, Deanné du Plessis, Taygen Fuchs, Katharina Gasser, Daniella Krämer, WenWen Li, Kiara Munsamy, Anja Piso, Jenna-Lee Price, Byron Sonnekus, Chanel Thomas, Ariska van der Nest, Alida van Dijk, Alishia van Heerden, Nicole van Vuuren, Neriman Yilmaz, Tuan A. Duong, Nicolaas A. van der Merwe, Michael J. Wingfield, Brenda D. Wingfield

“…Abstract The pace at which Next Generation Sequence data is being produced continues to accelerate as technology improves. As a result, such data are increasingly becoming accessible to biologists outside of the field of bioinformatics. …”
Get full text